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The map label for this gene is groEL [H]

Identifier: 195977293

GI number: 195977293

Start: 157603

End: 159228

Strand: Direct

Name: groEL [H]

Synonym: Sez_0146

Alternate gene names: 195977293

Gene position: 157603-159228 (Clockwise)

Preceding gene: 195977292

Following gene: 195977295

Centisome position: 7.79

GC content: 44.53

Gene sequence:

>1626_bases
ATGGCAAAAGATATAAAATTTTCAGCAGATGCTCGTGAAAGCATGGTACGTGGTGTTGATATTTTGGCGGATACCGTTAA
GGTAACCCTTGGCCCTAAAGGGCGTAATGTAGTCCTTGAAAAGGCCTTTGGTTCTCCTTTGATCACAAATGATGGTGTAA
CGATTGCCAAAGAGATTGAATTAGAAGATCATTTTGAAAATATGGGGGCTAAGCTTGTATCAGAGGTAGCTTCAAAAACA
AATGATATTGCTGGTGACGGGACAACAACAGCTACTGTTTTGACCCAAGCGATTGTGCGTGAAGGGCTTAAAAATGTAAC
AGCAGGTGCTAACCCAATTGGTATTCGTCGTGGGATTGAAGCAGCGACAACGACAGCTGTCGAGGCCTTAAAGGCTGTTG
CTCAACCAGTATCTGGAAAAGAAGCTATTGCTCAAGTAGCTTCGGTGTCATCACGTTCTGAAAAGGTTGGTGACTATATT
TCTGAAGCTATGGAGCGCGTGGGAAATGATGGTGTGATTACTATTGAGGAATCACGTGGTATGGAAACAGAGCTTGAGGT
TGTTGAGGGAATGCAGTTTGACCGCGGCTATTTGTCACAATACATGGTCACTGACAATGAAAAAATGGTTGCTGATCTTG
AAAACCCATTTATCCTGATTACTGATAAGAAAATTTCTAATATCCAAGACATTCTTCCATTGCTTGAGGAGGTGCTTAAG
ACTAGCCGTCCATTGTTGATCATTGCTGATGATGTTGATGGCGAAGCCCTTCCGACCCTAGTGCTTAATAAAATTCGTGG
TACCTTCAATGTTGTAGCGGTTAAAGCGCCTGGCTTTGGAGATCGTCGTAAAGCGATGCTTGAAGACATTGCTGTCTTAA
CTGGTGGTACAGTCATCACTGAGGATCTTGGTCTTGAATTGAAGGATGCTACAATGGCTGCCCTCGGACAAGCGGCTAAA
GTAACTGTTGACAAGGATAATACAGTGATTGTAGAAGGTGCAGGCAGCTCAGAGGCTATTTCAAACCGCGTTAGCCTGAT
CAAATCACAATTAGAAACAACCACATCTGAATTTGATCGTGAAAAATTACAAGAGCGCTTAGCAAAATTAGCAGGTGGTG
TTGCAGTTATCAAGGTGGGTGCAGCTACTGAAACCGAGCTAAAAGAAATGAAGCTTCGTATTGAGGATGCGCTAAATGCA
ACACGCGCTGCAGTTGAAGAAGGCATCGTTGCAGGTGGTGGTACTGCTCTTATCAATGTCATGGATAAGGTTGCAGCCCT
TGAGCTTGATGGTGATGCAGCAACTGGCCGTAATATCGTGCTTCGTGCGCTTGAAGAGCCTGTACGTCAAATTGCTTATA
ACGCTGGCTACGAAGGTTCAGTGATCATTGATAAGCTGAAAAATAGTGCTGCTGGTGTTGGCTTTAATGCAGCAACTGGT
GAATGGGTTGATATGATTGCTACAGGTATCATTGATCCAGTCAAGGTAACACGTTCAGCACTTCAAAATGCAGCCTCTGT
TGCAGGTCTTATCCTGACCACCGAAGCTGTTGTTGCCACTAAGCCAGAGCCTGCTGCACCAGCAATGCCGCAAGGAATGG
ATCCAGGCATGATGGGTGGCTTCTAA

Upstream 100 bases:

>100_bases
CGTGAAGCTGACATTCTTGCAGTTTTAGCTTAATTGTGAATCCCTATCATTTCAGGTAGGATTAACAGATATACATTCAA
ATAGGAATAGAGGAAATAAC

Downstream 100 bases:

>100_bases
CAAGAAGGCCTGTTAGGATAGACTAGTGTGTCTGTCATAGGATATAAAAATAACTTATAAAGACTCCCCTGACGTTAAGG
TGATATGATTATCCCTAAGA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MAKDIKFSADARESMVRGVDILADTVKVTLGPKGRNVVLEKAFGSPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKT
NDIAGDGTTTATVLTQAIVREGLKNVTAGANPIGIRRGIEAATTTAVEALKAVAQPVSGKEAIAQVASVSSRSEKVGDYI
SEAMERVGNDGVITIEESRGMETELEVVEGMQFDRGYLSQYMVTDNEKMVADLENPFILITDKKISNIQDILPLLEEVLK
TSRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAMLEDIAVLTGGTVITEDLGLELKDATMAALGQAAK
VTVDKDNTVIVEGAGSSEAISNRVSLIKSQLETTTSEFDREKLQERLAKLAGGVAVIKVGAATETELKEMKLRIEDALNA
TRAAVEEGIVAGGGTALINVMDKVAALELDGDAATGRNIVLRALEEPVRQIAYNAGYEGSVIIDKLKNSAAGVGFNAATG
EWVDMIATGIIDPVKVTRSALQNAASVAGLILTTEAVVATKPEPAAPAMPQGMDPGMMGGF

Sequences:

>Translated_541_residues
MAKDIKFSADARESMVRGVDILADTVKVTLGPKGRNVVLEKAFGSPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKT
NDIAGDGTTTATVLTQAIVREGLKNVTAGANPIGIRRGIEAATTTAVEALKAVAQPVSGKEAIAQVASVSSRSEKVGDYI
SEAMERVGNDGVITIEESRGMETELEVVEGMQFDRGYLSQYMVTDNEKMVADLENPFILITDKKISNIQDILPLLEEVLK
TSRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAMLEDIAVLTGGTVITEDLGLELKDATMAALGQAAK
VTVDKDNTVIVEGAGSSEAISNRVSLIKSQLETTTSEFDREKLQERLAKLAGGVAVIKVGAATETELKEMKLRIEDALNA
TRAAVEEGIVAGGGTALINVMDKVAALELDGDAATGRNIVLRALEEPVRQIAYNAGYEGSVIIDKLKNSAAGVGFNAATG
EWVDMIATGIIDPVKVTRSALQNAASVAGLILTTEAVVATKPEPAAPAMPQGMDPGMMGGF
>Mature_540_residues
AKDIKFSADARESMVRGVDILADTVKVTLGPKGRNVVLEKAFGSPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKTN
DIAGDGTTTATVLTQAIVREGLKNVTAGANPIGIRRGIEAATTTAVEALKAVAQPVSGKEAIAQVASVSSRSEKVGDYIS
EAMERVGNDGVITIEESRGMETELEVVEGMQFDRGYLSQYMVTDNEKMVADLENPFILITDKKISNIQDILPLLEEVLKT
SRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAMLEDIAVLTGGTVITEDLGLELKDATMAALGQAAKV
TVDKDNTVIVEGAGSSEAISNRVSLIKSQLETTTSEFDREKLQERLAKLAGGVAVIKVGAATETELKEMKLRIEDALNAT
RAAVEEGIVAGGGTALINVMDKVAALELDGDAATGRNIVLRALEEPVRQIAYNAGYEGSVIIDKLKNSAAGVGFNAATGE
WVDMIATGIIDPVKVTRSALQNAASVAGLILTTEAVVATKPEPAAPAMPQGMDPGMMGGF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=525, Percent_Identity=49.9047619047619, Blast_Score=507, Evalue=1e-143,
Organism=Homo sapiens, GI31542947, Length=525, Percent_Identity=49.9047619047619, Blast_Score=507, Evalue=1e-143,
Organism=Homo sapiens, GI24307939, Length=366, Percent_Identity=25.1366120218579, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI38455427, Length=565, Percent_Identity=23.1858407079646, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI302058290, Length=517, Percent_Identity=22.6305609284333, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1790586, Length=524, Percent_Identity=62.2137404580153, Blast_Score=637, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=48.6792452830189, Blast_Score=494, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=47.39336492891, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI25144674, Length=185, Percent_Identity=30.2702702702703, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17564182, Length=551, Percent_Identity=22.8675136116152, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=53.8167938931298, Blast_Score=530, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6322446, Length=533, Percent_Identity=23.4521575984991, Blast_Score=74, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6322524, Length=187, Percent_Identity=27.807486631016, Blast_Score=71, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320058, Length=166, Percent_Identity=28.3132530120482, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641193, Length=525, Percent_Identity=49.9047619047619, Blast_Score=520, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24641191, Length=525, Percent_Identity=49.9047619047619, Blast_Score=520, Evalue=1e-147,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=46.7557251908397, Blast_Score=473, Evalue=1e-133,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=46.7557251908397, Blast_Score=473, Evalue=1e-133,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=46.7557251908397, Blast_Score=473, Evalue=1e-133,
Organism=Drosophila melanogaster, GI17864606, Length=550, Percent_Identity=41.0909090909091, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24584129, Length=539, Percent_Identity=35.9925788497217, Blast_Score=298, Evalue=6e-81,
Organism=Drosophila melanogaster, GI19921262, Length=539, Percent_Identity=35.9925788497217, Blast_Score=298, Evalue=6e-81,
Organism=Drosophila melanogaster, GI17647245, Length=448, Percent_Identity=23.8839285714286, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24652903, Length=436, Percent_Identity=24.0825688073394, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28571140, Length=558, Percent_Identity=24.1935483870968, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI18858175, Length=558, Percent_Identity=24.1935483870968, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24645179, Length=506, Percent_Identity=23.7154150197628, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583944, Length=187, Percent_Identity=28.3422459893048, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 56917; Mature: 56786

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKDIKFSADARESMVRGVDILADTVKVTLGPKGRNVVLEKAFGSPLITNDGVTIAKEIE
CCCCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCEEEEECCCCCEEECCCCEEEEECC
LEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVREGLKNVTAGANPIGIRRGIE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCH
AATTTAVEALKAVAQPVSGKEAIAQVASVSSRSEKVGDYISEAMERVGNDGVITIEESRG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
METELEVVEGMQFDRGYLSQYMVTDNEKMVADLENPFILITDKKISNIQDILPLLEEVLK
CCHHHHHHHCCCCCHHHHHHHEECCCCHHEEECCCCEEEEECCHHHHHHHHHHHHHHHHH
TSRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAMLEDIAVLTGGTVIT
CCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEE
EDLGLELKDATMAALGQAAKVTVDKDNTVIVEGAGSSEAISNRVSLIKSQLETTTSEFDR
CCCCCEEHHHHHHHHCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLAGGVAVIKVGAATETELKEMKLRIEDALNATRAAVEEGIVAGGGTALINV
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
MDKVAALELDGDAATGRNIVLRALEEPVRQIAYNAGYEGSVIIDKLKNSAAGVGFNAATG
HHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCC
EWVDMIATGIIDPVKVTRSALQNAASVAGLILTTEAVVATKPEPAAPAMPQGMDPGMMGG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEECCCEECCCCCCCCCCCCCCCCCCCCC
F
C
>Mature Secondary Structure 
AKDIKFSADARESMVRGVDILADTVKVTLGPKGRNVVLEKAFGSPLITNDGVTIAKEIE
CCCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCEEEEECCCCCEEECCCCEEEEECC
LEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVREGLKNVTAGANPIGIRRGIE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCH
AATTTAVEALKAVAQPVSGKEAIAQVASVSSRSEKVGDYISEAMERVGNDGVITIEESRG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
METELEVVEGMQFDRGYLSQYMVTDNEKMVADLENPFILITDKKISNIQDILPLLEEVLK
CCHHHHHHHCCCCCHHHHHHHEECCCCHHEEECCCCEEEEECCHHHHHHHHHHHHHHHHH
TSRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAMLEDIAVLTGGTVIT
CCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEE
EDLGLELKDATMAALGQAAKVTVDKDNTVIVEGAGSSEAISNRVSLIKSQLETTTSEFDR
CCCCCEEHHHHHHHHCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKLQERLAKLAGGVAVIKVGAATETELKEMKLRIEDALNATRAAVEEGIVAGGGTALINV
HHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
MDKVAALELDGDAATGRNIVLRALEEPVRQIAYNAGYEGSVIIDKLKNSAAGVGFNAATG
HHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCC
EWVDMIATGIIDPVKVTRSALQNAASVAGLILTTEAVVATKPEPAAPAMPQGMDPGMMGG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEECCCEECCCCCCCCCCCCCCCCCCCCC
F
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA