Click here to switch to the map view.

The map label for this gene is ipk

Identifier: 195977253

GI number: 195977253

Start: 107558

End: 108409

Strand: Direct

Name: ipk

Synonym: Sez_0102

Alternate gene names: 195977253

Gene position: 107558-108409 (Clockwise)

Preceding gene: 195977252

Following gene: 195977254

Centisome position: 5.31

GC content: 43.78

Gene sequence:

>852_bases
ATGACTGCAATCATTGAGAGAGCTCCTGCAAAAATAAATCTAGGCTTAGATATTCAAGGCAAGCGACCAGATGGCTATCA
TGATCTGTCTATGGTTCTAGTTAGTGTAGATCTTTGTGATTATATTACAGTGGATCATTTAGAGGAGGATAGGATTTTAT
TGACCTCTAATTGCCCTAGATTGCCTATTAATGAGCACAATGACGTTTACAAGGCGGCTTATTTGCTGAAAGAGCGATTT
CAAATCTCAACAGGTGTCTCTATTTTCTTGGATAAGAGGGTACCTGTTTGTGCTGGTATGGGAGGTGGCTCAAGTGATGC
GGCTGCAGCAATCAGAGCATTGAATCAGCTGTGGCAGCTAAAGCTTAGTCCCCGTCAGATGATTGACATTGGCATGCAGA
TTGGTAGCGATGTGCCTTATTGTCTTTTTGCAGGCTGCGCCCAAGTGACTGGCAAAGGCGAGGTGGTTAAGCCAATCAAT
GGCCGCTTGTCCTCTTGGGTGGTTCTAGTGAAGCCAGAATTTGGCATTTCTACTAGAACGATTTTTTGGGATATTGATTG
TGAGACGATATCTCGAGTGCCAATTGAGGATCTGGTTTCAGCCATTGAGGCAGGTGATTATCAGCGCTTGCTTGCAACGA
TGGGAAATTCCTTAGAGGATATTTCCATTGCTAAACGGCCGTTTATTCAAAAGGTTAAGGATAAAATGTTGCAGTCAGGA
GCAGACATTGCCCTGATGACAGGAAGTGGTCCAACAGTATTTGCCCTATGTCAAACAGAAAAACAGGCCAATCGTGTGGT
GAATAGCCTGAAGGGTTTTTGTAAGGAGGTCTACAAGGTTAGAACACTGTAG

Upstream 100 bases:

>100_bases
ACGCTGTCTATGCATCATTAGATACTAACTGTATTTATTTGAATTTTTCATGAAGATTGTGTATATTTGATACTATAATG
ACATCAAATAAAGGAGTATT

Downstream 100 bases:

>100_bases
ATCAGCCTTGAAGTTGCGTCTTTTGGGGCGTCATGCTATAATTAACTGGTTAATGAGGAGAGGGAAATCATGACAATTTT
AGAAAAAAAGCTTGATAATT

Product: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Products: NA

Alternate protein names: CMK; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MTAIIERAPAKINLGLDIQGKRPDGYHDLSMVLVSVDLCDYITVDHLEEDRILLTSNCPRLPINEHNDVYKAAYLLKERF
QISTGVSIFLDKRVPVCAGMGGGSSDAAAAIRALNQLWQLKLSPRQMIDIGMQIGSDVPYCLFAGCAQVTGKGEVVKPIN
GRLSSWVVLVKPEFGISTRTIFWDIDCETISRVPIEDLVSAIEAGDYQRLLATMGNSLEDISIAKRPFIQKVKDKMLQSG
ADIALMTGSGPTVFALCQTEKQANRVVNSLKGFCKEVYKVRTL

Sequences:

>Translated_283_residues
MTAIIERAPAKINLGLDIQGKRPDGYHDLSMVLVSVDLCDYITVDHLEEDRILLTSNCPRLPINEHNDVYKAAYLLKERF
QISTGVSIFLDKRVPVCAGMGGGSSDAAAAIRALNQLWQLKLSPRQMIDIGMQIGSDVPYCLFAGCAQVTGKGEVVKPIN
GRLSSWVVLVKPEFGISTRTIFWDIDCETISRVPIEDLVSAIEAGDYQRLLATMGNSLEDISIAKRPFIQKVKDKMLQSG
ADIALMTGSGPTVFALCQTEKQANRVVNSLKGFCKEVYKVRTL
>Mature_282_residues
TAIIERAPAKINLGLDIQGKRPDGYHDLSMVLVSVDLCDYITVDHLEEDRILLTSNCPRLPINEHNDVYKAAYLLKERFQ
ISTGVSIFLDKRVPVCAGMGGGSSDAAAAIRALNQLWQLKLSPRQMIDIGMQIGSDVPYCLFAGCAQVTGKGEVVKPING
RLSSWVVLVKPEFGISTRTIFWDIDCETISRVPIEDLVSAIEAGDYQRLLATMGNSLEDISIAKRPFIQKVKDKMLQSGA
DIALMTGSGPTVFALCQTEKQANRVVNSLKGFCKEVYKVRTL

Specific function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol

COG id: COG1947

COG function: function code I; 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. IspE subfamily

Homologues:

Organism=Escherichia coli, GI1787459, Length=281, Percent_Identity=31.6725978647687, Blast_Score=105, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPE_STRE4 (C0MBI2)

Other databases:

- EMBL:   FM204883
- RefSeq:   YP_002745516.1
- ProteinModelPortal:   C0MBI2
- EnsemblBacteria:   EBSTRT00000067266
- GeneID:   7695526
- GenomeReviews:   FM204883_GR
- KEGG:   seu:SEQ_0092
- GeneTree:   EBGT00050000027811
- OMA:   RIYNGLR
- ProtClustDB:   PRK00128
- HAMAP:   MF_00061
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR000870
- InterPro:   IPR004424
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR20861:SF2
- PIRSF:   PIRSF010376
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00154

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.148

Molecular weight: Translated: 31124; Mature: 30992

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: NA

Important sites: ACT_SITE 11-11 ACT_SITE 137-137

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAIIERAPAKINLGLDIQGKRPDGYHDLSMVLVSVDLCDYITVDHLEEDRILLTSNCPR
CCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCC
LPINEHNDVYKAAYLLKERFQISTGVSIFLDKRVPVCAGMGGGSSDAAAAIRALNQLWQL
CCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHC
KLSPRQMIDIGMQIGSDVPYCLFAGCAQVTGKGEVVKPINGRLSSWVVLVKPEFGISTRT
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEECCCCCCCCCEEEEECCCCCCCEEE
IFWDIDCETISRVPIEDLVSAIEAGDYQRLLATMGNSLEDISIAKRPFIQKVKDKMLQSG
EEEEECHHHHCCCCHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
ADIALMTGSGPTVFALCQTEKQANRVVNSLKGFCKEVYKVRTL
CCEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TAIIERAPAKINLGLDIQGKRPDGYHDLSMVLVSVDLCDYITVDHLEEDRILLTSNCPR
CCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCC
LPINEHNDVYKAAYLLKERFQISTGVSIFLDKRVPVCAGMGGGSSDAAAAIRALNQLWQL
CCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHC
KLSPRQMIDIGMQIGSDVPYCLFAGCAQVTGKGEVVKPINGRLSSWVVLVKPEFGISTRT
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEECCCCCCCCCEEEEECCCCCCCEEE
IFWDIDCETISRVPIEDLVSAIEAGDYQRLLATMGNSLEDISIAKRPFIQKVKDKMLQSG
EEEEECHHHHCCCCHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
ADIALMTGSGPTVFALCQTEKQANRVVNSLKGFCKEVYKVRTL
CCEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA