| Definition | Streptococcus equi subsp. zooepidemicus MGCS10565, complete genome. |
|---|---|
| Accession | NC_011134 |
| Length | 2,024,171 |
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The map label for this gene is adh2 [H]
Identifier: 195977195
GI number: 195977195
Start: 53419
End: 56061
Strand: Direct
Name: adh2 [H]
Synonym: Sez_0043
Alternate gene names: 195977195
Gene position: 53419-56061 (Clockwise)
Preceding gene: 195977194
Following gene: 195977196
Centisome position: 2.64
GC content: 42.49
Gene sequence:
>2643_bases ATGACTGAAAAAAATAGTACTGTTGAAACAACATCTGTTGCCGCAACAATTGACGCTCTTGTTCAAAAAGGTTTAGTAGC GCTTGATAAAATGCGCCAATTAACTCAAGAACAGGTTGACTACATTGTAGCGAAGGCCTCTGTTGCTGCTTTGGACGCAC ATGGTGAGTTAGCTAAGCATGCCTATGAAGAAACTGGTCGTGGAGTTTTTGAAGATAAGGCTACCAAAAACCTTTTCGCA TGTGAGCATGTTGTTAATAACATGCGTCACCAAAAAACAGTAGGTATCATTGAAGAAGACGATGTAACAGGTTTGACCTT AATTGCTGAGCCAGTAGGTGTTATTTGTGGGATTACCCCAACAACTAACCCAACGTCAACAGCTATTTTTAAATCTTTAA TCTCCTTAAAAACACGTAACCCTATTATTTTTGCCTTCCACCCATCAGCTCAAGAATCATCAGCTCATGCAGCACGCATT GTTCGTGATGCAGCCATTGCAGCAGGAGCTCCTGAGGACTGTGTTCAATGGATTGAAACCCCATCACTGGAAGCAACTAA CGCTCTGATGAATCATGATGGTATTGCAACAATCCTTGCAACTGGTGGTAATGCTATGGTTAAGGCAGCCTACTCATGTG GTAAGCCAGCTCTTGGGGTTGGTGCTGGTAACGTGCCTGCCTATGTTGAAAAATCCGCTAACATTCGTCAGGCAGCACAC GATATTGTCATGTCTAAATCATTTGACAATGGTATGGTTTGTGCTTCTGAGCAGGCTGTTATTATCGACAAGGAGATTTA TGACGAGTTTGTTAGTGAATTTAAGTCTTACCACACTTACTTTGTCAACAAAAAGGAAAAGGCTCTGTTAGAGGAATTCT GTTTTGGTGCCAAGGCTAATAGTAAAAACTGTGCAGGTGCTAAGCTGAACCCTAATATTGTTGGTAAGCCAGCAGCTTGG ATTGCTGAGCAAGCTGGCTTTACAGTACCAGAAGGAACGAATATCCTTGCAGCAGAATGTAAGGAAGTTTCTGAAAATGA GCCGTTAACACGTGAAAAATTGTCACCAGTTATCGCTGTTTTGAAGGCTGAATCTCGCACAGATGGTGTTGAAAAAGCTC GTCAAATGGTTGAATTTAACGGACTTGGTCACTCAGCCGCTATCCATACTGCTGATGCAGACTTAGCTAAGGAATTTGGG ACAAAAATTCGTGCTATTCGTGTGATTTGGAATTCACCTTCTACATTTGGTGGTATCGGTGATGTTTACAATGCCTTCCT ACCGTCATTAACATTGGGCTGTGGTTCTTATGGACGTAACTCAGTTGGTGATAATGTTAGTGCTGTAAATCTCTTGAATA TCAAAAAAGTAGGAAGACGTAGAAATAATATGCAATGGTTTAAAGTTCCTTCAAAAACATACTTCGAGCGTGATTCAATT CAATACCTTCAAAAATGTCGTGACGTTGAGCGTGTGATGATTGTTACTGACCACGCGATGGTTGAGCTTGGCTTCTTAGA TCGTATCATCGAGCAGCTTGACCTTCGTCGTAATAAGGTTGTTTATCAAATTTTTGCAGATGTCGAGCCAGATCCAGATA TCACAACGGTTATGAAAGGTACTGAGTTGATGCGTACCTTCAAGCCAGATACGATTATCGCTCTTGGTGGAGGTTCTCCA ATGGACGCTGCCAAGGTGATGTGGTTATTCTACGAGCAACCAGAGGTTGACTTCCATGATCTTGTTCAAAAATTCATGGA TATTCGTAAGCGTGCCTTCAAGTTCCCTGAGCTTGGTAAGAAAACAAAATTTGTGGCTATTCCAACAACCTCAGGTACAG GATCAGAGGTTACACCGTTTGCTGTTATCTCAGATAAGGCCAACAACCGCAAGTACCCAATTGCTGACTATTCATTGACA CCAACGGTAGCCATTGTTGACCCAGCGTTGGTGCTTACAGTCCCAGACTTCATTGCAGCTGATACAGGTATGGACGTATT GACCCACGCAACCGAGGCTTATGTATCACAAATGGCTAATGACTTTACAGACGGTTTGGCCCTTCAAGCCATTAAGATTG TCTTTGAAAACCTTGAAAAGTCTGTTAAGGAAGCTGATTTTGAGTCACGTGAAAAAATGCATAATGCCTCAACAATGGCA GGTATGGCCTTTGCTAATGCCTTCCTAGGTATTTCTCACTCAATGGCTCATAAGATTGGTGCACAATTCCATACTGTTCA TGGACGTACCAATGCTATCTTGCTTCCATACGTTATTCGTTACAATGGTACCCGTCCTGCTAAAACAGCAACATGGCCTA AGTACAATTACTATCGCGCTGATGAAAAATATCAAGACATCGCTAAATTGCTAGGGCTTCCAGCATCTACTCCAGAAGAA GGTGTTGAATCCTATGCTAAAGCTGTTTATGATCTTGGCTGCCGCTTAGGCATTAAGATGAATTTCAGAGATCAAGGTAT TGACGAGGAAGAATGGAAGGCACACACTCGTGAGCTTGCTTATCTTGCCTACGAGGATCAATGCTCACCTGCTAACCCGC GCTTACCAATGGTTGAGCACATGGAAGAAATCATGAATGATGCTTATTATGGTTACGCAGAGCGTCCAGGACGTCGGAAA TAA
Upstream 100 bases:
>100_bases TCACAATTTTATTGTGAAATGATTTACAAAATACCAAAAAATGATATAATATTTTTGTAAACAAAATTGTGAAACTTTTA ACAAGGTAAAGGAGTCTCAA
Downstream 100 bases:
>100_bases AATCAATCATTAATAATAAAAATAGGAGCTGCTTGGCTTCTATTTTTTTATCTAGCTATGGAAAGGGCTGTGTTAGATGA AAAAGTCGGCAGTGCCTTGT
Product: bifunctional acetaldehyde-CoA/alcohol dehydrogenase
Products: NA
Alternate protein names: Alcohol dehydrogenase; ADH; Acetaldehyde dehydrogenase [acetylating]; ACDH; Pyruvate-formate-lyase deactivase; PFL deactivase [H]
Number of amino acids: Translated: 880; Mature: 879
Protein sequence:
>880_residues MTEKNSTVETTSVAATIDALVQKGLVALDKMRQLTQEQVDYIVAKASVAALDAHGELAKHAYEETGRGVFEDKATKNLFA CEHVVNNMRHQKTVGIIEEDDVTGLTLIAEPVGVICGITPTTNPTSTAIFKSLISLKTRNPIIFAFHPSAQESSAHAARI VRDAAIAAGAPEDCVQWIETPSLEATNALMNHDGIATILATGGNAMVKAAYSCGKPALGVGAGNVPAYVEKSANIRQAAH DIVMSKSFDNGMVCASEQAVIIDKEIYDEFVSEFKSYHTYFVNKKEKALLEEFCFGAKANSKNCAGAKLNPNIVGKPAAW IAEQAGFTVPEGTNILAAECKEVSENEPLTREKLSPVIAVLKAESRTDGVEKARQMVEFNGLGHSAAIHTADADLAKEFG TKIRAIRVIWNSPSTFGGIGDVYNAFLPSLTLGCGSYGRNSVGDNVSAVNLLNIKKVGRRRNNMQWFKVPSKTYFERDSI QYLQKCRDVERVMIVTDHAMVELGFLDRIIEQLDLRRNKVVYQIFADVEPDPDITTVMKGTELMRTFKPDTIIALGGGSP MDAAKVMWLFYEQPEVDFHDLVQKFMDIRKRAFKFPELGKKTKFVAIPTTSGTGSEVTPFAVISDKANNRKYPIADYSLT PTVAIVDPALVLTVPDFIAADTGMDVLTHATEAYVSQMANDFTDGLALQAIKIVFENLEKSVKEADFESREKMHNASTMA GMAFANAFLGISHSMAHKIGAQFHTVHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRADEKYQDIAKLLGLPASTPEE GVESYAKAVYDLGCRLGIKMNFRDQGIDEEEWKAHTRELAYLAYEDQCSPANPRLPMVEHMEEIMNDAYYGYAERPGRRK
Sequences:
>Translated_880_residues MTEKNSTVETTSVAATIDALVQKGLVALDKMRQLTQEQVDYIVAKASVAALDAHGELAKHAYEETGRGVFEDKATKNLFA CEHVVNNMRHQKTVGIIEEDDVTGLTLIAEPVGVICGITPTTNPTSTAIFKSLISLKTRNPIIFAFHPSAQESSAHAARI VRDAAIAAGAPEDCVQWIETPSLEATNALMNHDGIATILATGGNAMVKAAYSCGKPALGVGAGNVPAYVEKSANIRQAAH DIVMSKSFDNGMVCASEQAVIIDKEIYDEFVSEFKSYHTYFVNKKEKALLEEFCFGAKANSKNCAGAKLNPNIVGKPAAW IAEQAGFTVPEGTNILAAECKEVSENEPLTREKLSPVIAVLKAESRTDGVEKARQMVEFNGLGHSAAIHTADADLAKEFG TKIRAIRVIWNSPSTFGGIGDVYNAFLPSLTLGCGSYGRNSVGDNVSAVNLLNIKKVGRRRNNMQWFKVPSKTYFERDSI QYLQKCRDVERVMIVTDHAMVELGFLDRIIEQLDLRRNKVVYQIFADVEPDPDITTVMKGTELMRTFKPDTIIALGGGSP MDAAKVMWLFYEQPEVDFHDLVQKFMDIRKRAFKFPELGKKTKFVAIPTTSGTGSEVTPFAVISDKANNRKYPIADYSLT PTVAIVDPALVLTVPDFIAADTGMDVLTHATEAYVSQMANDFTDGLALQAIKIVFENLEKSVKEADFESREKMHNASTMA GMAFANAFLGISHSMAHKIGAQFHTVHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRADEKYQDIAKLLGLPASTPEE GVESYAKAVYDLGCRLGIKMNFRDQGIDEEEWKAHTRELAYLAYEDQCSPANPRLPMVEHMEEIMNDAYYGYAERPGRRK >Mature_879_residues TEKNSTVETTSVAATIDALVQKGLVALDKMRQLTQEQVDYIVAKASVAALDAHGELAKHAYEETGRGVFEDKATKNLFAC EHVVNNMRHQKTVGIIEEDDVTGLTLIAEPVGVICGITPTTNPTSTAIFKSLISLKTRNPIIFAFHPSAQESSAHAARIV RDAAIAAGAPEDCVQWIETPSLEATNALMNHDGIATILATGGNAMVKAAYSCGKPALGVGAGNVPAYVEKSANIRQAAHD IVMSKSFDNGMVCASEQAVIIDKEIYDEFVSEFKSYHTYFVNKKEKALLEEFCFGAKANSKNCAGAKLNPNIVGKPAAWI AEQAGFTVPEGTNILAAECKEVSENEPLTREKLSPVIAVLKAESRTDGVEKARQMVEFNGLGHSAAIHTADADLAKEFGT KIRAIRVIWNSPSTFGGIGDVYNAFLPSLTLGCGSYGRNSVGDNVSAVNLLNIKKVGRRRNNMQWFKVPSKTYFERDSIQ YLQKCRDVERVMIVTDHAMVELGFLDRIIEQLDLRRNKVVYQIFADVEPDPDITTVMKGTELMRTFKPDTIIALGGGSPM DAAKVMWLFYEQPEVDFHDLVQKFMDIRKRAFKFPELGKKTKFVAIPTTSGTGSEVTPFAVISDKANNRKYPIADYSLTP TVAIVDPALVLTVPDFIAADTGMDVLTHATEAYVSQMANDFTDGLALQAIKIVFENLEKSVKEADFESREKMHNASTMAG MAFANAFLGISHSMAHKIGAQFHTVHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRADEKYQDIAKLLGLPASTPEEG VESYAKAVYDLGCRLGIKMNFRDQGIDEEEWKAHTRELAYLAYEDQCSPANPRLPMVEHMEEIMNDAYYGYAERPGRRK
Specific function: This enzyme has three activities:ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent
COG id: COG1012
COG function: function code C; NAD-dependent aldehyde dehydrogenases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the iron- containing alcohol dehydrogenase family [H]
Homologues:
Organism=Homo sapiens, GI133922590, Length=270, Percent_Identity=29.6296296296296, Blast_Score=101, Evalue=3e-21, Organism=Escherichia coli, GI1787493, Length=870, Percent_Identity=48.5057471264368, Blast_Score=786, Evalue=0.0, Organism=Escherichia coli, GI1789163, Length=401, Percent_Identity=33.9152119700748, Blast_Score=214, Evalue=2e-56, Organism=Escherichia coli, GI48994951, Length=398, Percent_Identity=33.1658291457286, Blast_Score=192, Evalue=9e-50, Organism=Escherichia coli, GI87082107, Length=422, Percent_Identity=33.175355450237, Blast_Score=190, Evalue=4e-49, Organism=Escherichia coli, GI1788797, Length=385, Percent_Identity=30.1298701298701, Blast_Score=155, Evalue=1e-38, Organism=Escherichia coli, GI1789386, Length=399, Percent_Identity=25.062656641604, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17537053, Length=255, Percent_Identity=29.0196078431373, Blast_Score=115, Evalue=7e-26, Organism=Saccharomyces cerevisiae, GI6321181, Length=418, Percent_Identity=31.3397129186603, Blast_Score=191, Evalue=4e-49, Organism=Drosophila melanogaster, GI24657991, Length=385, Percent_Identity=28.051948051948, Blast_Score=102, Evalue=1e-21,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001670 - InterPro: IPR018211 - InterPro: IPR016161 - InterPro: IPR016163 - InterPro: IPR016162 - InterPro: IPR015590 - InterPro: IPR012079 [H]
Pfam domain/function: PF00171 Aldedh; PF00465 Fe-ADH [H]
EC number: =1.1.1.1; =1.2.1.10 [H]
Molecular weight: Translated: 96808; Mature: 96677
Theoretical pI: Translated: 6.25; Mature: 6.25
Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 3.0 %Met (Translated Protein) 4.3 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 4.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTEKNSTVETTSVAATIDALVQKGLVALDKMRQLTQEQVDYIVAKASVAALDAHGELAKH CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH AYEETGRGVFEDKATKNLFACEHVVNNMRHQKTVGIIEEDDVTGLTLIAEPVGVICGITP HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEEECCHHHEEECCC TTNPTSTAIFKSLISLKTRNPIIFAFHPSAQESSAHAARIVRDAAIAAGAPEDCVQWIET CCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCC PSLEATNALMNHDGIATILATGGNAMVKAAYSCGKPALGVGAGNVPAYVEKSANIRQAAH CCCHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCHHHHCCCHHHHHHH DIVMSKSFDNGMVCASEQAVIIDKEIYDEFVSEFKSYHTYFVNKKEKALLEEFCFGAKAN HHHHHCCCCCCCEEECCCEEEECHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHCCCCCC SKNCAGAKLNPNIVGKPAAWIAEQAGFTVPEGTNILAAECKEVSENEPLTREKLSPVIAV CCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHH LKAESRTDGVEKARQMVEFNGLGHSAAIHTADADLAKEFGTKIRAIRVIWNSPSTFGGIG HHCCCCCCHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHCCCEEEEEEEECCCCCCCCHH DVYNAFLPSLTLGCGSYGRNSVGDNVSAVNLLNIKKVGRRRNNMQWFKVPSKTYFERDSI HHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHCCCCCEEEECCCHHHHCHHHH QYLQKCRDVERVMIVTDHAMVELGFLDRIIEQLDLRRNKVVYQIFADVEPDPDITTVMKG HHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHH TELMRTFKPDTIIALGGGSPMDAAKVMWLFYEQPEVDFHDLVQKFMDIRKRAFKFPELGK HHHHHHCCCCEEEEECCCCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCC KTKFVAIPTTSGTGSEVTPFAVISDKANNRKYPIADYSLTPTVAIVDPALVLTVPDFIAA CCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCEEEEECCHHHHC DTGMDVLTHATEAYVSQMANDFTDGLALQAIKIVFENLEKSVKEADFESREKMHNASTMA CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH GMAFANAFLGISHSMAHKIGAQFHTVHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRA HHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEEEECCCCCCCCCCCCCCCEEEC DEKYQDIAKLLGLPASTPEEGVESYAKAVYDLGCRLGIKMNFRDQGIDEEEWKAHTRELA CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHE YLAYEDQCSPANPRLPMVEHMEEIMNDAYYGYAERPGRRK EEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC >Mature Secondary Structure TEKNSTVETTSVAATIDALVQKGLVALDKMRQLTQEQVDYIVAKASVAALDAHGELAKH CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH AYEETGRGVFEDKATKNLFACEHVVNNMRHQKTVGIIEEDDVTGLTLIAEPVGVICGITP HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEEECCHHHEEECCC TTNPTSTAIFKSLISLKTRNPIIFAFHPSAQESSAHAARIVRDAAIAAGAPEDCVQWIET CCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCC PSLEATNALMNHDGIATILATGGNAMVKAAYSCGKPALGVGAGNVPAYVEKSANIRQAAH CCCHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCHHHHCCCHHHHHHH DIVMSKSFDNGMVCASEQAVIIDKEIYDEFVSEFKSYHTYFVNKKEKALLEEFCFGAKAN HHHHHCCCCCCCEEECCCEEEECHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHCCCCCC SKNCAGAKLNPNIVGKPAAWIAEQAGFTVPEGTNILAAECKEVSENEPLTREKLSPVIAV CCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHH LKAESRTDGVEKARQMVEFNGLGHSAAIHTADADLAKEFGTKIRAIRVIWNSPSTFGGIG HHCCCCCCHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHCCCEEEEEEEECCCCCCCCHH DVYNAFLPSLTLGCGSYGRNSVGDNVSAVNLLNIKKVGRRRNNMQWFKVPSKTYFERDSI HHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHCCCCCEEEECCCHHHHCHHHH QYLQKCRDVERVMIVTDHAMVELGFLDRIIEQLDLRRNKVVYQIFADVEPDPDITTVMKG HHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHH TELMRTFKPDTIIALGGGSPMDAAKVMWLFYEQPEVDFHDLVQKFMDIRKRAFKFPELGK HHHHHHCCCCEEEEECCCCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCC KTKFVAIPTTSGTGSEVTPFAVISDKANNRKYPIADYSLTPTVAIVDPALVLTVPDFIAA CCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCEEEEECCHHHHC DTGMDVLTHATEAYVSQMANDFTDGLALQAIKIVFENLEKSVKEADFESREKMHNASTMA CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH GMAFANAFLGISHSMAHKIGAQFHTVHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRA HHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEEEECCCCCCCCCCCCCCCEEEC DEKYQDIAKLLGLPASTPEEGVESYAKAVYDLGCRLGIKMNFRDQGIDEEEWKAHTRELA CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHE YLAYEDQCSPANPRLPMVEHMEEIMNDAYYGYAERPGRRK EEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]