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The map label for this gene is purM [H]

Identifier: 195977182

GI number: 195977182

Start: 37455

End: 38477

Strand: Direct

Name: purM [H]

Synonym: Sez_0026

Alternate gene names: 195977182

Gene position: 37455-38477 (Clockwise)

Preceding gene: 195977181

Following gene: 195977183

Centisome position: 1.85

GC content: 45.26

Gene sequence:

>1023_bases
ATGTCTAAAAATGCTTATGCTCAATCAGGTGTCGATGTTGAAGCAGGCTATGAGCTTGTTGAGCGAATAAAAAAGCATTC
CGAGCGTAGCAAACGATTGGGTGTTATGGGTGGTCTAGGAGGCTTTGGTGGTCTGTTTGACCTGTCAAAGACTGGTGTTA
AGGAGCCTGTTTTGGTTTCAGGGACAGATGGCGTCGGAACAAAGCTAATGCTTGCAATCCAGTACGATAAGCATGACACG
ATTGGGCAGGATTGTGTGGCAATGTGTGTCAATGATATTATTGCAGCAGGTGCCGAACCCCTGTATTTTCTTGATTACCT
TGCAGCAGGAAAAAATGAGCCTGCCAAATTAGAGCAGGTGATTGCAGGTATTGCTGAGGGCTGTGTTCAAGCAGGTGCTG
CTCTTATCGGTGGAGAAACTGCTGAGATGCCTGGTATGTATGGTCAAGATGACTATGATCTTGCCGGTTTTGCGGTTGGT
ATTGCTGAGAAATCTCAGCTGATTGATGGTTCAAGAGTAGCTGAGGGAGATCATCTCCTAGGTTTGGCATCAAGTGGAGT
TCATTCAAATGGTTATTCCTTGGTTCGTCGTATTTTTGCCGGTTATACTGGTGAGGAGCTGCTTCCAGAGCTTGATGGAA
AAAAGCTTAAGGAGGTACTTCTTGAGCCAACTCGTATTTATGTCAAGGCTGTGTTACCACTCATTAAAAGCGGCTTAGTG
GCAGGAATCGCTCATATTACGGGTGGCGGCTTTATTGAAAACCTACCTCGTATGTTTTCCAAAGAACTAGCCGCTGAAAT
TGAAGAAGCCAGCTTACCTGTGCTGCCCATTTTTAAAGTCCTTGAGACATATGGTAAGATCAATCATGAAGAAATGTTTG
AGATTTTTAATATGGGTATTGGCATGGTGCTTGCTGTCAAGCCTGAGCACGTTGAGCAGGTGAAGGCCTGTCTTGATGAG
CCTGTGTATGACATTGGTCGCGTTGTGACCAGAACAGTTGCTAGTGTGGTGATGAAGCCATGA

Upstream 100 bases:

>100_bases
TAGAAGAAAAGGTAAGCTTTCACATTGATCAGGTGACGAAGTAGCGCTTTATGGCTAACATAGAATAAATGATCTAGGCA
GCTAAAATAAGGAGGAGAAA

Downstream 100 bases:

>100_bases
CAAGAATTGCCGTTTTTGCTTCTGGTAATGGCTCCAATTTTCAAACGATTGCAGAACAGTTTCCGGTTGCCTTTGTTTTT
TCTGATCATTGCGATGCTCA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MSKNAYAQSGVDVEAGYELVERIKKHSERSKRLGVMGGLGGFGGLFDLSKTGVKEPVLVSGTDGVGTKLMLAIQYDKHDT
IGQDCVAMCVNDIIAAGAEPLYFLDYLAAGKNEPAKLEQVIAGIAEGCVQAGAALIGGETAEMPGMYGQDDYDLAGFAVG
IAEKSQLIDGSRVAEGDHLLGLASSGVHSNGYSLVRRIFAGYTGEELLPELDGKKLKEVLLEPTRIYVKAVLPLIKSGLV
AGIAHITGGGFIENLPRMFSKELAAEIEEASLPVLPIFKVLETYGKINHEEMFEIFNMGIGMVLAVKPEHVEQVKACLDE
PVYDIGRVVTRTVASVVMKP

Sequences:

>Translated_340_residues
MSKNAYAQSGVDVEAGYELVERIKKHSERSKRLGVMGGLGGFGGLFDLSKTGVKEPVLVSGTDGVGTKLMLAIQYDKHDT
IGQDCVAMCVNDIIAAGAEPLYFLDYLAAGKNEPAKLEQVIAGIAEGCVQAGAALIGGETAEMPGMYGQDDYDLAGFAVG
IAEKSQLIDGSRVAEGDHLLGLASSGVHSNGYSLVRRIFAGYTGEELLPELDGKKLKEVLLEPTRIYVKAVLPLIKSGLV
AGIAHITGGGFIENLPRMFSKELAAEIEEASLPVLPIFKVLETYGKINHEEMFEIFNMGIGMVLAVKPEHVEQVKACLDE
PVYDIGRVVTRTVASVVMKP
>Mature_339_residues
SKNAYAQSGVDVEAGYELVERIKKHSERSKRLGVMGGLGGFGGLFDLSKTGVKEPVLVSGTDGVGTKLMLAIQYDKHDTI
GQDCVAMCVNDIIAAGAEPLYFLDYLAAGKNEPAKLEQVIAGIAEGCVQAGAALIGGETAEMPGMYGQDDYDLAGFAVGI
AEKSQLIDGSRVAEGDHLLGLASSGVHSNGYSLVRRIFAGYTGEELLPELDGKKLKEVLLEPTRIYVKAVLPLIKSGLVA
GIAHITGGGFIENLPRMFSKELAAEIEEASLPVLPIFKVLETYGKINHEEMFEIFNMGIGMVLAVKPEHVEQVKACLDEP
VYDIGRVVTRTVASVVMKP

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=341, Percent_Identity=49.266862170088, Blast_Score=315, Evalue=3e-86,
Organism=Homo sapiens, GI209869995, Length=341, Percent_Identity=49.266862170088, Blast_Score=315, Evalue=3e-86,
Organism=Homo sapiens, GI209869993, Length=341, Percent_Identity=49.266862170088, Blast_Score=315, Evalue=3e-86,
Organism=Escherichia coli, GI1788845, Length=325, Percent_Identity=53.8461538461538, Blast_Score=338, Evalue=3e-94,
Organism=Caenorhabditis elegans, GI17567511, Length=334, Percent_Identity=43.7125748502994, Blast_Score=248, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6321203, Length=336, Percent_Identity=45.2380952380952, Blast_Score=284, Evalue=1e-77,
Organism=Drosophila melanogaster, GI24582400, Length=290, Percent_Identity=43.448275862069, Blast_Score=211, Evalue=6e-55,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36245; Mature: 36114

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKNAYAQSGVDVEAGYELVERIKKHSERSKRLGVMGGLGGFGGLFDLSKTGVKEPVLVS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCEEEE
GTDGVGTKLMLAIQYDKHDTIGQDCVAMCVNDIIAAGAEPLYFLDYLAAGKNEPAKLEQV
CCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHH
IAGIAEGCVQAGAALIGGETAEMPGMYGQDDYDLAGFAVGIAEKSQLIDGSRVAEGDHLL
HHHHHHHHHHHCHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEE
GLASSGVHSNGYSLVRRIFAGYTGEELLPELDGKKLKEVLLEPTRIYVKAVLPLIKSGLV
EECCCCCCCCHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHH
AGIAHITGGGFIENLPRMFSKELAAEIEEASLPVLPIFKVLETYGKINHEEMFEIFNMGI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHCCC
GMVLAVKPEHVEQVKACLDEPVYDIGRVVTRTVASVVMKP
CEEEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKNAYAQSGVDVEAGYELVERIKKHSERSKRLGVMGGLGGFGGLFDLSKTGVKEPVLVS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCEEEE
GTDGVGTKLMLAIQYDKHDTIGQDCVAMCVNDIIAAGAEPLYFLDYLAAGKNEPAKLEQV
CCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHH
IAGIAEGCVQAGAALIGGETAEMPGMYGQDDYDLAGFAVGIAEKSQLIDGSRVAEGDHLL
HHHHHHHHHHHCHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEE
GLASSGVHSNGYSLVRRIFAGYTGEELLPELDGKKLKEVLLEPTRIYVKAVLPLIKSGLV
EECCCCCCCCHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHH
AGIAHITGGGFIENLPRMFSKELAAEIEEASLPVLPIFKVLETYGKINHEEMFEIFNMGI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHCCC
GMVLAVKPEHVEQVKACLDEPVYDIGRVVTRTVASVVMKP
CEEEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA