Click here to switch to the map view.

The map label for this gene is prs [H]

Identifier: 195977175

GI number: 195977175

Start: 27574

End: 28548

Strand: Direct

Name: prs [H]

Synonym: Sez_0019

Alternate gene names: 195977175

Gene position: 27574-28548 (Clockwise)

Preceding gene: 195977174

Following gene: 195977176

Centisome position: 1.36

GC content: 39.9

Gene sequence:

>975_bases
TTGGAGGAAAAAATGTCTTATTCTGATTTAAAGCTGTTTGCATTATCGTCAAACAAGGAATTAGCAGAAAAAGTTGCTGC
TGCGATGGGAATTCAACTTGGGAAGTCTACGGTTCGCCAGTTTTCAGATGGTGAGATTCAGGTCAATATTGAGGAATCAA
TACGTGGACACCATGTTTTTATTTTGCAGTCAACAAGCTCGCCTGTTAATGATAACCTAATGGAAATTTTAATTATGGTT
GATGCTTTAAAGCGTGCCAGTGCTGAGAAAATTTCTGTGGTAATGCCTTATTATGGCTATGCTCGTCAGGATCGTAAGGC
TCGTTCGCGTGAGCCTATTACCTCTAAATTAGTTGCTAATATGCTAGAGGTGGCGGGTGTTGATCGTTTATTGACTGTTG
ATTTACATGCTGCGCAGATTCAAGGCTTCTTTGATATTCCTGTTGATCATCTCATGGGAGCACCTTTAATTGCTGATTAT
TTTGATCGTCATGGTCTAGTAGGTGATGACGTGGTTGTTGTTAGTCCAGATCATGGTGGTGTGACGCGTGCTCGTAAGCT
GGCCCAATTCCTCCAAACGCCAATTGCTATTATTGATAAGCGTCGTAGTGTTGATAAAATGAATACCAGTGAGGTGATGA
ATATCATTGGTAGTGTTGAAGGTAAAAAATGTATTCTGATTGATGATATGATTGATACTGCTGGCACTATCTGTCATGCT
GCTGATGCGCTTGCTGAAGCAGGAGCAACAGCAGTTTACGCATCATGTACTCACCCAGTGCTGTCAGGACCAGCTCTTGA
TAATATTCAAAAATCAGCGATTGAAAAATTGATTGTTTTGGATACGATCTATTTACCAGAAGAAAGACTGATTGATAAGA
TTGAACAAATCTCTATTGCAGATTTGATTGCAGAAGCTATCATTCGTATCCATGAAAAACGTCCATTGTCACCCCTATTT
GAATTAGGGAAATGA

Upstream 100 bases:

>100_bases
CAAATTAGAAAATAAGTAAAGGTAAGAATCAGGATTCTTACCTTTTTATTTCCATTGAAAAATTGATTGAAAAGGGTTAA
AATGGTATAGGATCAAAACT

Downstream 100 bases:

>100_bases
TAAGGTTAGCCTGAGGTAGTAAGCCTTAGGCTTTTTTATGTTTTAAAAGGCTATTTGATTACCAAAGCAGTGTTTGATTT
AACGCCATAGATAGGCTTCA

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK 1; Phosphoribosyl pyrophosphate synthase 1; P-Rib-PP synthase 1; PRPP synthase 1 [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MEEKMSYSDLKLFALSSNKELAEKVAAAMGIQLGKSTVRQFSDGEIQVNIEESIRGHHVFILQSTSSPVNDNLMEILIMV
DALKRASAEKISVVMPYYGYARQDRKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMGAPLIADY
FDRHGLVGDDVVVVSPDHGGVTRARKLAQFLQTPIAIIDKRRSVDKMNTSEVMNIIGSVEGKKCILIDDMIDTAGTICHA
ADALAEAGATAVYASCTHPVLSGPALDNIQKSAIEKLIVLDTIYLPEERLIDKIEQISIADLIAEAIIRIHEKRPLSPLF
ELGK

Sequences:

>Translated_324_residues
MEEKMSYSDLKLFALSSNKELAEKVAAAMGIQLGKSTVRQFSDGEIQVNIEESIRGHHVFILQSTSSPVNDNLMEILIMV
DALKRASAEKISVVMPYYGYARQDRKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMGAPLIADY
FDRHGLVGDDVVVVSPDHGGVTRARKLAQFLQTPIAIIDKRRSVDKMNTSEVMNIIGSVEGKKCILIDDMIDTAGTICHA
ADALAEAGATAVYASCTHPVLSGPALDNIQKSAIEKLIVLDTIYLPEERLIDKIEQISIADLIAEAIIRIHEKRPLSPLF
ELGK
>Mature_324_residues
MEEKMSYSDLKLFALSSNKELAEKVAAAMGIQLGKSTVRQFSDGEIQVNIEESIRGHHVFILQSTSSPVNDNLMEILIMV
DALKRASAEKISVVMPYYGYARQDRKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMGAPLIADY
FDRHGLVGDDVVVVSPDHGGVTRARKLAQFLQTPIAIIDKRRSVDKMNTSEVMNIIGSVEGKKCILIDDMIDTAGTICHA
ADALAEAGATAVYASCTHPVLSGPALDNIQKSAIEKLIVLDTIYLPEERLIDKIEQISIADLIAEAIIRIHEKRPLSPLF
ELGK

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=315, Percent_Identity=46.3492063492063, Blast_Score=284, Evalue=8e-77,
Organism=Homo sapiens, GI4506127, Length=315, Percent_Identity=46.3492063492063, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI84875539, Length=318, Percent_Identity=45.9119496855346, Blast_Score=278, Evalue=3e-75,
Organism=Homo sapiens, GI28557709, Length=313, Percent_Identity=44.7284345047923, Blast_Score=272, Evalue=3e-73,
Organism=Homo sapiens, GI4506133, Length=355, Percent_Identity=36.056338028169, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI194018537, Length=345, Percent_Identity=33.3333333333333, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI310128524, Length=142, Percent_Identity=35.2112676056338, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI310115209, Length=142, Percent_Identity=35.2112676056338, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI310118259, Length=142, Percent_Identity=35.2112676056338, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI310119946, Length=142, Percent_Identity=35.2112676056338, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1787458, Length=316, Percent_Identity=51.8987341772152, Blast_Score=328, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI17554702, Length=320, Percent_Identity=45.9375, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI71989924, Length=320, Percent_Identity=45.9375, Blast_Score=282, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI25149168, Length=313, Percent_Identity=46.3258785942492, Blast_Score=281, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17554704, Length=310, Percent_Identity=46.4516129032258, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI17570245, Length=339, Percent_Identity=33.3333333333333, Blast_Score=174, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6320946, Length=318, Percent_Identity=43.3962264150943, Blast_Score=248, Evalue=9e-67,
Organism=Saccharomyces cerevisiae, GI6319403, Length=320, Percent_Identity=42.5, Blast_Score=247, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6321776, Length=319, Percent_Identity=42.0062695924765, Blast_Score=243, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6322667, Length=197, Percent_Identity=40.6091370558376, Blast_Score=156, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6324511, Length=114, Percent_Identity=42.9824561403509, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21355239, Length=315, Percent_Identity=46.031746031746, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI45551540, Length=338, Percent_Identity=43.1952662721894, Blast_Score=265, Evalue=4e-71,
Organism=Drosophila melanogaster, GI24651458, Length=360, Percent_Identity=34.1666666666667, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24651456, Length=360, Percent_Identity=34.1666666666667, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI281362873, Length=360, Percent_Identity=34.1666666666667, Blast_Score=178, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24651454, Length=360, Percent_Identity=34.1666666666667, Blast_Score=178, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24651462, Length=379, Percent_Identity=32.1899736147757, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24651464, Length=379, Percent_Identity=32.1899736147757, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI45552010, Length=379, Percent_Identity=32.1899736147757, Blast_Score=170, Evalue=1e-42,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 35530; Mature: 35530

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEKMSYSDLKLFALSSNKELAEKVAAAMGIQLGKSTVRQFSDGEIQVNIEESIRGHHVF
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCCCCEEE
ILQSTSSPVNDNLMEILIMVDALKRASAEKISVVMPYYGYARQDRKARSREPITSKLVAN
EEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHH
MLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMGAPLIADYFDRHGLVGDDVVVVSPDHGG
HHHHHCCCEEEEEEEHHHHHCCCCCCCHHHHCCCHHHHHHHHHCCCCCCCEEEECCCCCC
VTRARKLAQFLQTPIAIIDKRRSVDKMNTSEVMNIIGSVEGKKCILIDDMIDTAGTICHA
HHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHH
ADALAEAGATAVYASCTHPVLSGPALDNIQKSAIEKLIVLDTIYLPEERLIDKIEQISIA
HHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
DLIAEAIIRIHEKRPLSPLFELGK
HHHHHHHHHHHCCCCCCHHHHCCC
>Mature Secondary Structure
MEEKMSYSDLKLFALSSNKELAEKVAAAMGIQLGKSTVRQFSDGEIQVNIEESIRGHHVF
CCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCCCCEEE
ILQSTSSPVNDNLMEILIMVDALKRASAEKISVVMPYYGYARQDRKARSREPITSKLVAN
EEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHH
MLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMGAPLIADYFDRHGLVGDDVVVVSPDHGG
HHHHHCCCEEEEEEEHHHHHCCCCCCCHHHHCCCHHHHHHHHHCCCCCCCEEEECCCCCC
VTRARKLAQFLQTPIAIIDKRRSVDKMNTSEVMNIIGSVEGKKCILIDDMIDTAGTICHA
HHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHH
ADALAEAGATAVYASCTHPVLSGPALDNIQKSAIEKLIVLDTIYLPEERLIDKIEQISIA
HHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
DLIAEAIIRIHEKRPLSPLFELGK
HHHHHHHHHHHCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12354221 [H]