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The map label for this gene is rcsC [H]

Identifier: 195952760

GI number: 195952760

Start: 335984

End: 337147

Strand: Direct

Name: rcsC [H]

Synonym: HY04AAS1_0382

Alternate gene names: 195952760

Gene position: 335984-337147 (Clockwise)

Preceding gene: 195952759

Following gene: 195952777

Centisome position: 21.54

GC content: 30.5

Gene sequence:

>1164_bases
TTGGGATTAGAAGAGAAAAAAGAAAATACCCTTGCCTATCTCACCGTAGTATATAGTCTGGTTATTTTTGCTATAGTTTT
TATATTTTCTATATCGTCGTATTTAGCTTTTAGTATATTGGTAGATAACTTTGTAGCTTCGGATTTGAGACAAGAATTGC
GATATATAAGCGCTCAGAATATTACTGAGAACACGAGATGGCTTACTTTCAGCGATGAATCAATAGCAGTGTTAGATAAA
AGCGGTAATATAATAAGCGTATCAAAGAATTTTCCTAGTTTTAGGTTTTCAAAATTTAAATCTGGTTTTCATCTTGGTTA
TATAAACGGTAAAAGGATTATGTATATAAGGGCTTTGCTACCTAATCATTTTACTGTGATAGTAGCAAGAAACATGACAA
AATTTGAATCTATTAAGAAAAAACTGTTGAGCAGTTTTATATTGGCATTGGTAATACTTTCTGTAATAATAGCTTTTACA
GGATTTTTTATAGCAAAAGCTATAACAAATAGCTTCATAAGTTTCATGGAAAGAATATATACTATGGCGCTTAACTTTTC
CCATGAAGTAAAAACACCCCTAGCTATAATATCTACAAACCTTTCTTTGTTAGAAATTAATCCTGATAAAGCTTATATAG
AAAGAATCTCAAGAGCTCTAAAACAGCTAAATAATCTGTTAAATAAAGTAGTTTTCATAGCAAAAGCAGACGAGTATTCT
ATGTTAAATAAACAAACATTTATGTTGGAAGATGTTGTAATGAAAGCGCTAAAAGAACTTGAGCCTATTATAGAGGAAAA
AGGCTTGAAGATAGAGCTTAACATAGAGCCTATAGAGATTACATCTTCTTGGGAGCTTTATGAAGCTATTGTATCTAATT
TATTGGAAAATGCTGTAAAATATACAAATGAAGGTTATATAAAAATAGCGGTCGTGTCTGATAATAAAAATATAATTATT
AAGGTAGAAGACACCGGTGTTGGCATACCAAAAGAAAAACTCTCTACAATTACTAAAGAGTTTGAAAGAGCCAACATAGA
TAAACCCGGTTTTGGTCTTGGGCTTTTTATAGTATCAAAGTCAATTGGTATATTAAAAGGTAAATTGCATATTGAATCTA
AGGAAAACAAAGGTACCATCATAACGGTTTATATACCGTTTTAG

Upstream 100 bases:

>100_bases
GAAGGCTTATAGATGGCTCCGGATGTCAGATAAGGACAGTCTATGGCATAGGATATTCTATAGAACCCAAAGATAGCTCC
GGTAAAATAGAAGAAACAGA

Downstream 100 bases:

>100_bases
GAAAATTTTTCTTTATATATGTTAAAGGCTGTAATAAGGGTTGTAAATACAATAGGACCTAAAAACATACCCAAGAATCC
CATACTAAACAACCCGCCTA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: Capsular synthesis regulator component C [H]

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MGLEEKKENTLAYLTVVYSLVIFAIVFIFSISSYLAFSILVDNFVASDLRQELRYISAQNITENTRWLTFSDESIAVLDK
SGNIISVSKNFPSFRFSKFKSGFHLGYINGKRIMYIRALLPNHFTVIVARNMTKFESIKKKLLSSFILALVILSVIIAFT
GFFIAKAITNSFISFMERIYTMALNFSHEVKTPLAIISTNLSLLEINPDKAYIERISRALKQLNNLLNKVVFIAKADEYS
MLNKQTFMLEDVVMKALKELEPIIEEKGLKIELNIEPIEITSSWELYEAIVSNLLENAVKYTNEGYIKIAVVSDNKNIII
KVEDTGVGIPKEKLSTITKEFERANIDKPGFGLGLFIVSKSIGILKGKLHIESKENKGTIITVYIPF

Sequences:

>Translated_387_residues
MGLEEKKENTLAYLTVVYSLVIFAIVFIFSISSYLAFSILVDNFVASDLRQELRYISAQNITENTRWLTFSDESIAVLDK
SGNIISVSKNFPSFRFSKFKSGFHLGYINGKRIMYIRALLPNHFTVIVARNMTKFESIKKKLLSSFILALVILSVIIAFT
GFFIAKAITNSFISFMERIYTMALNFSHEVKTPLAIISTNLSLLEINPDKAYIERISRALKQLNNLLNKVVFIAKADEYS
MLNKQTFMLEDVVMKALKELEPIIEEKGLKIELNIEPIEITSSWELYEAIVSNLLENAVKYTNEGYIKIAVVSDNKNIII
KVEDTGVGIPKEKLSTITKEFERANIDKPGFGLGLFIVSKSIGILKGKLHIESKENKGTIITVYIPF
>Mature_386_residues
GLEEKKENTLAYLTVVYSLVIFAIVFIFSISSYLAFSILVDNFVASDLRQELRYISAQNITENTRWLTFSDESIAVLDKS
GNIISVSKNFPSFRFSKFKSGFHLGYINGKRIMYIRALLPNHFTVIVARNMTKFESIKKKLLSSFILALVILSVIIAFTG
FFIAKAITNSFISFMERIYTMALNFSHEVKTPLAIISTNLSLLEINPDKAYIERISRALKQLNNLLNKVVFIAKADEYSM
LNKQTFMLEDVVMKALKELEPIIEEKGLKIELNIEPIEITSSWELYEAIVSNLLENAVKYTNEGYIKIAVVSDNKNIIIK
VEDTGVGIPKEKLSTITKEFERANIDKPGFGLGLFIVSKSIGILKGKLHIESKENKGTIITVYIPF

Specific function: Member of the two-component regulatory system RcsC/RcsB involved in the regulation of the expression of genes involved in colanic acid capsule synthesis. Together with RcsF, RcsC probably functions as a membrane-associated protein kinase that phosphorylat

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=213, Percent_Identity=29.5774647887324, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790551, Length=208, Percent_Identity=28.3653846153846, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1786912, Length=215, Percent_Identity=29.7674418604651, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789149, Length=224, Percent_Identity=29.0178571428571, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1790346, Length=241, Percent_Identity=24.4813278008299, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081816, Length=213, Percent_Identity=25.8215962441315, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790861, Length=213, Percent_Identity=30.0469483568075, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787374, Length=200, Percent_Identity=25.5, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1786783, Length=236, Percent_Identity=25.8474576271186, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788713, Length=224, Percent_Identity=27.2321428571429, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI48994928, Length=220, Percent_Identity=26.3636363636364, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786600, Length=220, Percent_Identity=26.8181818181818, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR000014
- InterPro:   IPR004358
- InterPro:   IPR019017
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09456 RcsC; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 43824; Mature: 43693

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLEEKKENTLAYLTVVYSLVIFAIVFIFSISSYLAFSILVDNFVASDLRQELRYISAQN
CCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ITENTRWLTFSDESIAVLDKSGNIISVSKNFPSFRFSKFKSGFHLGYINGKRIMYIRALL
CCCCCEEEEECCCEEEEEECCCCEEEEECCCCCHHHHHHCCCEEEEEECCCEEEEEEEEC
PNHFTVIVARNMTKFESIKKKLLSSFILALVILSVIIAFTGFFIAKAITNSFISFMERIY
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TMALNFSHEVKTPLAIISTNLSLLEINPDKAYIERISRALKQLNNLLNKVVFIAKADEYS
HHHHCCCCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCHH
MLNKQTFMLEDVVMKALKELEPIIEEKGLKIELNIEPIEITSSWELYEAIVSNLLENAVK
HHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCHHHHHHHHHHHHHHHHH
YTNEGYIKIAVVSDNKNIIIKVEDTGVGIPKEKLSTITKEFERANIDKPGFGLGLFIVSK
HCCCCEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEHHHHHC
SIGILKGKLHIESKENKGTIITVYIPF
CCCEEEEEEEEECCCCCCCEEEEEECC
>Mature Secondary Structure 
GLEEKKENTLAYLTVVYSLVIFAIVFIFSISSYLAFSILVDNFVASDLRQELRYISAQN
CCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ITENTRWLTFSDESIAVLDKSGNIISVSKNFPSFRFSKFKSGFHLGYINGKRIMYIRALL
CCCCCEEEEECCCEEEEEECCCCEEEEECCCCCHHHHHHCCCEEEEEECCCEEEEEEEEC
PNHFTVIVARNMTKFESIKKKLLSSFILALVILSVIIAFTGFFIAKAITNSFISFMERIY
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TMALNFSHEVKTPLAIISTNLSLLEINPDKAYIERISRALKQLNNLLNKVVFIAKADEYS
HHHHCCCCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCHH
MLNKQTFMLEDVVMKALKELEPIIEEKGLKIELNIEPIEITSSWELYEAIVSNLLENAVK
HHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCHHHHHHHHHHHHHHHHH
YTNEGYIKIAVVSDNKNIIIKVEDTGVGIPKEKLSTITKEFERANIDKPGFGLGLFIVSK
HCCCCEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEHHHHHC
SIGILKGKLHIESKENKGTIITVYIPF
CCCEEEEEEEEECCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2404948; 8366025; 9097040; 9278503; 11758943; 11309126; 13129944 [H]