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The map label for this gene is glpG

Identifier: 194738360

GI number: 194738360

Start: 3577535

End: 3578365

Strand: Reverse

Name: glpG

Synonym: SeSA_A3716

Alternate gene names: 194738360

Gene position: 3578365-3577535 (Counterclockwise)

Preceding gene: 194734272

Following gene: 194737752

Centisome position: 75.99

GC content: 54.15

Gene sequence:

>831_bases
ATGTTGATGATTACTTCCTTTGCGAATCCTCGCGTGGCGCAGGCATTTGTTGATTACATGGCCACCCAGGGCGTCATTCT
TACTATTCAGCAACATAATCAAAGCGATATCTGGTTGGCGGATGAATCGCAGGCCGAACGTGTGCGGGTCGAGCTGGCGC
GGTTTATAGAAAATCCCGGCGATCCGCGTTATCTGGCGGCTAGCTGGCAGTCCGGGCAGACGAACAGCGGGCTACGCTAC
CGCCGTTTTCCCTTTCTCGCCACGCTGCGTGAACGAGCCGGCCCTGTTACCTGGATCGTGATGCTCGCCTGCGTGCTGGT
CTATATCGCGATGAGTCTCATCGGCGATCAGACGGTGATGGTGTGGCTGGCGTGGCCGTTCGATCCGGTTTTAAAATTTG
AAGTCTGGCGCTACTTCACCCATATCTTTATGCACTTCTCACTGATGCATATTCTTTTTAACCTGCTGTGGTGGTGGTAT
CTAGGCGGGGCGGTAGAGAAGCGCCTGGGCAGCGGTAAATTAATCGTCATTACGGTGATAAGCGCGCTACTAAGCGGCTA
TGTACAGCAGAAATTTAGCGGCCCGTGGTTTGGCGGGCTGTCTGGCGTCGTCTATGCGCTGATGGGTTACGTGTGGCTGC
GCGGAGAGCGCGATCCGCAAAGCGGAATTTACCTCCAGCGCGGCTTAATTATTTTTGCATTATTGTGGATAGTCGCTGGT
TGGTTTGACTGGTTTGGCATGTCTATGGCGAACGGCGCGCACATCGCCGGGCTTATCGTCGGTTTAGCGATGGCCTTTGT
TGATACGCTGAATGCGCGAAAACGAACGTGA

Upstream 100 bases:

>100_bases
TGCCGATGTCGCAAATGGCGCGTAATCCCATAAAGATGCAGCCTCCGACGAGAAGGGTATATATACTGTCTTCTTTTGTA
TGGACTAAGCGACAGCAATA

Downstream 100 bases:

>100_bases
GGCGTATCCGGCCTGTGGTCGAGATATTTTTCCAGGCCGGGTAGGGCGAATGCCGCTATCCGGCGCAAGGTTGGTTACTT
TCAGAGATTATTCATGAAAC

Product: intramembrane serine protease GlpG

Products: NA

Alternate protein names: Intramembrane serine protease

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDIWLADESQAERVRVELARFIENPGDPRYLAASWQSGQTNSGLRY
RRFPFLATLRERAGPVTWIVMLACVLVYIAMSLIGDQTVMVWLAWPFDPVLKFEVWRYFTHIFMHFSLMHILFNLLWWWY
LGGAVEKRLGSGKLIVITVISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALLWIVAG
WFDWFGMSMANGAHIAGLIVGLAMAFVDTLNARKRT

Sequences:

>Translated_276_residues
MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDIWLADESQAERVRVELARFIENPGDPRYLAASWQSGQTNSGLRY
RRFPFLATLRERAGPVTWIVMLACVLVYIAMSLIGDQTVMVWLAWPFDPVLKFEVWRYFTHIFMHFSLMHILFNLLWWWY
LGGAVEKRLGSGKLIVITVISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALLWIVAG
WFDWFGMSMANGAHIAGLIVGLAMAFVDTLNARKRT
>Mature_276_residues
MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDIWLADESQAERVRVELARFIENPGDPRYLAASWQSGQTNSGLRY
RRFPFLATLRERAGPVTWIVMLACVLVYIAMSLIGDQTVMVWLAWPFDPVLKFEVWRYFTHIFMHFSLMHILFNLLWWWY
LGGAVEKRLGSGKLIVITVISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALLWIVAG
WFDWFGMSMANGAHIAGLIVGLAMAFVDTLNARKRT

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S54 family

Homologues:

Organism=Escherichia coli, GI48994938, Length=276, Percent_Identity=88.768115942029, Blast_Score=512, Evalue=1e-147,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLPG_SALA4 (B5F8P0)

Other databases:

- EMBL:   CP001138
- RefSeq:   YP_002148447.1
- MEROPS:   S54.016
- GeneID:   6793440
- GenomeReviews:   CP001138_GR
- KEGG:   sea:SeAg_B3725
- HOGENOM:   HBG495087
- ProtClustDB:   PRK10907
- HAMAP:   MF_01594
- InterPro:   IPR022732
- InterPro:   IPR002610
- InterPro:   IPR022764
- PANTHER:   PTHR22936

Pfam domain/function: PF12122 DUF3582; PF01694 Rhomboid

EC number: =3.4.21.105

Molecular weight: Translated: 31441; Mature: 31441

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: ACT_SITE 201-201 ACT_SITE 254-254

Signals:

None

Transmembrane regions:

HASH(0x21f3cdcc)-; HASH(0x218684fc)-; HASH(0x225214a4)-; HASH(0x20c482bc)-; HASH(0x2249e178)-; HASH(0x2201f25c)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDIWLADESQAERVRVELARFIENPG
CEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCCC
DPRYLAASWQSGQTNSGLRYRRFPFLATLRERAGPVTWIVMLACVLVYIAMSLIGDQTVM
CCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEE
VWLAWPFDPVLKFEVWRYFTHIFMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITVI
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
SALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALLWIVAG
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
WFDWFGMSMANGAHIAGLIVGLAMAFVDTLNARKRT
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure
MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDIWLADESQAERVRVELARFIENPG
CEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCCC
DPRYLAASWQSGQTNSGLRYRRFPFLATLRERAGPVTWIVMLACVLVYIAMSLIGDQTVM
CCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEE
VWLAWPFDPVLKFEVWRYFTHIFMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITVI
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
SALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALLWIVAG
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
WFDWFGMSMANGAHIAGLIVGLAMAFVDTLNARKRT
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA