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The map label for this gene is vanX [H]

Identifier: 194738322

GI number: 194738322

Start: 1660694

End: 1661464

Strand: Reverse

Name: vanX [H]

Synonym: SeSA_A1717

Alternate gene names: 194738322

Gene position: 1661464-1660694 (Counterclockwise)

Preceding gene: 194737802

Following gene: 194734457

Centisome position: 35.28

GC content: 48.25

Gene sequence:

>771_bases
ATGGTAAAATGCGTATCTTCTTTCCTCCTGTTCAGCCTGTTGTCCGTTCAGGCAATGTCAGCTGAAAACCATATTGATCT
CCACCAGCCAAAAGACTTTGTCGATATTACTACGGTCGCCCCCGACGTACAGGTAGACATGCGATACTTCACTTCCCATA
ACTTTGTTGGTCGCCCCATTAAAGGCTATAACGCGCCTGTTTGCCTGTTAACACGACCAGCCGCGAACGCAGTGAAGCAG
GTCGCCGATCGTTTACGCCCCTTCGGACTTACCTTAAAAATATATGATTGCTATCGTCCGCAAAGCGCAGTGAATGACTT
TATCGCGTGGGCCAAAGATCCTTCTCAAAACCAAATGAAAAACGAATTTTATCCGCTGGTAGAGAAAAAGCGTCTGTTTG
AGGAAGGTTATCTTGCCGCCAGATCCGGCCACAGTCGGGGAAGTACGCTTGATCTAACGATTGTTCCACTCGACAGTAAA
ATACCGATATACCATCCCGGACGACCACTGGTGAATTGTACTGCGTCCGCGGCACAACGCTCGCCAGATAATAGTCTGGA
TTTTGGTACCGGCTTTGACTGTTTTAGTCCGTTATCCCATCCCGATAATGCCATGCTTACCGCTCAGCAACGCGCAAATA
GGTTGTTATTACAAACATTGATGCGTGATGCGGGCTTTACGCCACTGGATACTGAATGGTGGCACTTCTCCCTTACTCAT
GAACCATACCCGAACACCTGGTTTGACTTTCCCGTTAAGCAGAGACCCTGA

Upstream 100 bases:

>100_bases
GGGAATGATGTTTATTTTAACCATCTGTTTAAGCGCTGTCCGCTAATCTTTACCTGCTCAAATACATAATCACCCCTGTG
ACTCTCGCGAGGTGTAACAT

Downstream 100 bases:

>100_bases
AACGGCGTTTTGTTGCGAAATCTAATCATTACGCCTGTTGGAAAGCACCATAACAGTTAGCAAATCGTTGTTAATTTTAA
CAACTGATATACACTGCGGT

Product: D-alanyl-D-alanine dipeptidase

Products: NA

Alternate protein names: D-Ala-D-Ala dipeptidase [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MVKCVSSFLLFSLLSVQAMSAENHIDLHQPKDFVDITTVAPDVQVDMRYFTSHNFVGRPIKGYNAPVCLLTRPAANAVKQ
VADRLRPFGLTLKIYDCYRPQSAVNDFIAWAKDPSQNQMKNEFYPLVEKKRLFEEGYLAARSGHSRGSTLDLTIVPLDSK
IPIYHPGRPLVNCTASAAQRSPDNSLDFGTGFDCFSPLSHPDNAMLTAQQRANRLLLQTLMRDAGFTPLDTEWWHFSLTH
EPYPNTWFDFPVKQRP

Sequences:

>Translated_256_residues
MVKCVSSFLLFSLLSVQAMSAENHIDLHQPKDFVDITTVAPDVQVDMRYFTSHNFVGRPIKGYNAPVCLLTRPAANAVKQ
VADRLRPFGLTLKIYDCYRPQSAVNDFIAWAKDPSQNQMKNEFYPLVEKKRLFEEGYLAARSGHSRGSTLDLTIVPLDSK
IPIYHPGRPLVNCTASAAQRSPDNSLDFGTGFDCFSPLSHPDNAMLTAQQRANRLLLQTLMRDAGFTPLDTEWWHFSLTH
EPYPNTWFDFPVKQRP
>Mature_256_residues
MVKCVSSFLLFSLLSVQAMSAENHIDLHQPKDFVDITTVAPDVQVDMRYFTSHNFVGRPIKGYNAPVCLLTRPAANAVKQ
VADRLRPFGLTLKIYDCYRPQSAVNDFIAWAKDPSQNQMKNEFYPLVEKKRLFEEGYLAARSGHSRGSTLDLTIVPLDSK
IPIYHPGRPLVNCTASAAQRSPDNSLDFGTGFDCFSPLSHPDNAMLTAQQRANRLLLQTLMRDAGFTPLDTEWWHFSLTH
EPYPNTWFDFPVKQRP

Specific function: Hydrolyzes the cellular pool of D-Ala-D-Ala dipeptides. May play a role in immunity or defense against glycopeptide antibiotics (perhaps at a moderate level) in the soil environment. Might confer vancomycin resistance to S.coelicolor [H]

COG id: COG2173

COG function: function code M; D-alanyl-D-alanine dipeptidase

Gene ontology:

Cell location: Secreted (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M15D family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009045
- InterPro:   IPR000755 [H]

Pfam domain/function: PF01427 Peptidase_M15 [H]

EC number: =3.4.13.22 [H]

Molecular weight: Translated: 29007; Mature: 29007

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKCVSSFLLFSLLSVQAMSAENHIDLHQPKDFVDITTVAPDVQVDMRYFTSHNFVGRPI
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEEEHEEECCCCCCCCCC
KGYNAPVCLLTRPAANAVKQVADRLRPFGLTLKIYDCYRPQSAVNDFIAWAKDPSQNQMK
CCCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCCHHHHH
NEFYPLVEKKRLFEEGYLAARSGHSRGSTLDLTIVPLDSKIPIYHPGRPLVNCTASAAQR
HHHHHHHHHHHHHHHCCCEECCCCCCCCEEEEEEEECCCCCCEECCCCCCEECCHHHHHC
SPDNSLDFGTGFDCFSPLSHPDNAMLTAQQRANRLLLQTLMRDAGFTPLDTEWWHFSLTH
CCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECC
EPYPNTWFDFPVKQRP
CCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVKCVSSFLLFSLLSVQAMSAENHIDLHQPKDFVDITTVAPDVQVDMRYFTSHNFVGRPI
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEEEHEEECCCCCCCCCC
KGYNAPVCLLTRPAANAVKQVADRLRPFGLTLKIYDCYRPQSAVNDFIAWAKDPSQNQMK
CCCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCCHHHHH
NEFYPLVEKKRLFEEGYLAARSGHSRGSTLDLTIVPLDSKIPIYHPGRPLVNCTASAAQR
HHHHHHHHHHHHHHHCCCEECCCCCCCCEEEEEEEECCCCCCEECCCCCCEECCHHHHHC
SPDNSLDFGTGFDCFSPLSHPDNAMLTAQQRANRLLLQTLMRDAGFTPLDTEWWHFSLTH
CCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECC
EPYPNTWFDFPVKQRP
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11881895; 12000953 [H]