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The map label for this gene is proY [H]

Identifier: 194738258

GI number: 194738258

Start: 467438

End: 468868

Strand: Direct

Name: proY [H]

Synonym: SeSA_A0458

Alternate gene names: 194738258

Gene position: 467438-468868 (Clockwise)

Preceding gene: 194735402

Following gene: 194736653

Centisome position: 9.93

GC content: 53.95

Gene sequence:

>1431_bases
GTGTACACCACGGGGCTTAACGCCCCGTGGTTTTTTATTGTGTTGATAGGTCAGAAATTGATGGAAAGCAATAATAAGCT
AAAGCGTGGGCTGAGCACCCGGCACATTCGCTTTATGGCATTAGGTTCGGCAATCGGCACCGGCCTGTTTTACGGCTCGG
CGGACGCCATCAAAATGGCGGGGCCGAGCGTGCTGTTGGCCTATATTATTGGCGGGGTCGCGGCATATATCATTATGCGC
GCATTGGGGGAAATGTCCGTTCACAACCCTGCCGCCAGCTCATTTTCGCGCTATGCGCAGGAAAACCTCGGCCCGCTTGC
GGGCTATATTACCGGCTGGACCTACTGTTTTGAGATCCTGATCGTCGCCATTGCCGACGTGACCGCGTTCGGCATTTACA
TGGGAGTCTGGTTCCCCGCCGTGCCGCACTGGATTTGGGTGCTTAGCGTGGTGCTGATCATTTGCGCCATCAACCTGATG
AGCGTCAAGGTGTTCGGCGAGCTGGAGTTTTGGTTCTCCTTCTTCAAAGTCGCCACCATTATTATCATGATTGTCGCGGG
TATCGGCATTATTGTGTGGGGAATTGGCAACGGCGGGCAGCCCACCGGCATTCATAACCTGTGGAGCAACGGCGGCTTCT
TCAGCAATGGCTGGCTGGGAATGATCATGTCGCTGCAAATGGTGATGTTCGCTTACGGCGGGATTGAAATTATCGGTATC
ACCGCCGGGGAAGCGAAAGACCCGGAGAAATCCATTCCGCGCGCTATTAACTCAGTACCGATGCGTATCCTGGTATTTTA
TGTCGGCACGCTGTTCGTCATTATGTCTATCTATCCGTGGAATCAGGTCGGCACAAACGGCAGTCCATTTGTGCTGACGT
TCCAGCATATGGGGATTACCTTCGCCGCCAGCATTCTGAACTTTGTGGTATTGACCGCCTCGCTTTCCGCTATCAACTCC
GATGTGTTTGGTGTAGGCCGTATGCTGCATGGTATGGCGGAGCAGGGGAGCGCGCCGAAAGTCTTTGCCAAAACGTCACG
CCGTGGTATTCCGTGGGTCACTGTGCTGGTGATGACGATTGCGCTGCTGTTTGCGGTTTACCTGAACTACATCATGCCGG
AAAACGTCTTCCTGGTGATTGCCTCGCTGGCGACGTTTGCGACGGTATGGGTATGGATTATGATCCTGCTGTCGCAAATC
GCCTTCCGCCGTCGTTTACCGCCGGAAGAGGTAAAAGCGCTGAAGTTTAAGGTGCCGGGCGGTGTCGTAACGACGATAGC
TGGGCTGATTTTCCTGGTCTTCATTATTGCGCTTATCGGCTACCATCCGGATACCCGCATCTCACTGTATGTGGGCTTCG
CCTGGATAGTTCTGCTGTTGATTGGCTGGATATTTAAACGCCGTCGCGACCGTCAATTGGCGCAGGCGTAG

Upstream 100 bases:

>100_bases
GGTTGATGCCAACGGTGGTGATGGTGATCCTGGCGATTATCTGGGATCGCGCGGCGGGTCGGCAGGTGACCTCCAGCGCT
CACTAAAATCGCTGACATAT

Downstream 100 bases:

>100_bases
TCGTTTTTCTCTGCCTTATCCGGTCTGCAGGCAACGGCAGGCCGGATAAGCGGAGCCGCTTCTCCTCCTGGAGTCTCCTC
CCCTAATAAACCCCTGGATG

Product: putative proline-specific permease

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MYTTGLNAPWFFIVLIGQKLMESNNKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGVAAYIIMR
ALGEMSVHNPAASSFSRYAQENLGPLAGYITGWTYCFEILIVAIADVTAFGIYMGVWFPAVPHWIWVLSVVLIICAINLM
SVKVFGELEFWFSFFKVATIIIMIVAGIGIIVWGIGNGGQPTGIHNLWSNGGFFSNGWLGMIMSLQMVMFAYGGIEIIGI
TAGEAKDPEKSIPRAINSVPMRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGITFAASILNFVVLTASLSAINS
DVFGVGRMLHGMAEQGSAPKVFAKTSRRGIPWVTVLVMTIALLFAVYLNYIMPENVFLVIASLATFATVWVWIMILLSQI
AFRRRLPPEEVKALKFKVPGGVVTTIAGLIFLVFIIALIGYHPDTRISLYVGFAWIVLLLIGWIFKRRRDRQLAQA

Sequences:

>Translated_476_residues
MYTTGLNAPWFFIVLIGQKLMESNNKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGVAAYIIMR
ALGEMSVHNPAASSFSRYAQENLGPLAGYITGWTYCFEILIVAIADVTAFGIYMGVWFPAVPHWIWVLSVVLIICAINLM
SVKVFGELEFWFSFFKVATIIIMIVAGIGIIVWGIGNGGQPTGIHNLWSNGGFFSNGWLGMIMSLQMVMFAYGGIEIIGI
TAGEAKDPEKSIPRAINSVPMRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGITFAASILNFVVLTASLSAINS
DVFGVGRMLHGMAEQGSAPKVFAKTSRRGIPWVTVLVMTIALLFAVYLNYIMPENVFLVIASLATFATVWVWIMILLSQI
AFRRRLPPEEVKALKFKVPGGVVTTIAGLIFLVFIIALIGYHPDTRISLYVGFAWIVLLLIGWIFKRRRDRQLAQA
>Mature_476_residues
MYTTGLNAPWFFIVLIGQKLMESNNKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGVAAYIIMR
ALGEMSVHNPAASSFSRYAQENLGPLAGYITGWTYCFEILIVAIADVTAFGIYMGVWFPAVPHWIWVLSVVLIICAINLM
SVKVFGELEFWFSFFKVATIIIMIVAGIGIIVWGIGNGGQPTGIHNLWSNGGFFSNGWLGMIMSLQMVMFAYGGIEIIGI
TAGEAKDPEKSIPRAINSVPMRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGITFAASILNFVVLTASLSAINS
DVFGVGRMLHGMAEQGSAPKVFAKTSRRGIPWVTVLVMTIALLFAVYLNYIMPENVFLVIASLATFATVWVWIMILLSQI
AFRRRLPPEEVKALKFKVPGGVVTTIAGLIFLVFIIALIGYHPDTRISLYVGFAWIVLLLIGWIFKRRRDRQLAQA

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=349, Percent_Identity=24.6418338108883, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI181337167, Length=338, Percent_Identity=25.1479289940828, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI258645169, Length=429, Percent_Identity=21.9114219114219, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI114326544, Length=459, Percent_Identity=22.2222222222222, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI114326550, Length=459, Percent_Identity=22.2222222222222, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI258614005, Length=430, Percent_Identity=21.8604651162791, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI4507047, Length=380, Percent_Identity=23.4210526315789, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI258614003, Length=430, Percent_Identity=21.8604651162791, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786602, Length=455, Percent_Identity=95.8241758241758, Blast_Score=825, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=453, Percent_Identity=45.916114790287, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI1786302, Length=460, Percent_Identity=43.0434782608696, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI48994972, Length=453, Percent_Identity=45.0331125827815, Blast_Score=368, Evalue=1e-103,
Organism=Escherichia coli, GI1790653, Length=470, Percent_Identity=40.4255319148936, Blast_Score=360, Evalue=1e-100,
Organism=Escherichia coli, GI87081915, Length=453, Percent_Identity=37.0860927152318, Blast_Score=311, Evalue=4e-86,
Organism=Escherichia coli, GI87081708, Length=460, Percent_Identity=35.4347826086957, Blast_Score=301, Evalue=6e-83,
Organism=Escherichia coli, GI1788480, Length=406, Percent_Identity=37.192118226601, Blast_Score=249, Evalue=4e-67,
Organism=Escherichia coli, GI1789017, Length=386, Percent_Identity=35.4922279792746, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI87081869, Length=176, Percent_Identity=27.8409090909091, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI87082023, Length=282, Percent_Identity=25.177304964539, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI2367353, Length=331, Percent_Identity=23.5649546827795, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=428, Percent_Identity=23.5981308411215, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17531343, Length=379, Percent_Identity=25.3298153034301, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17533459, Length=401, Percent_Identity=23.6907730673317, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17540018, Length=467, Percent_Identity=23.5546038543897, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=467, Percent_Identity=31.9057815845824, Blast_Score=207, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6320772, Length=466, Percent_Identity=32.1888412017167, Blast_Score=202, Evalue=9e-53,
Organism=Saccharomyces cerevisiae, GI6324990, Length=444, Percent_Identity=32.6576576576577, Blast_Score=196, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6324924, Length=407, Percent_Identity=31.9410319410319, Blast_Score=179, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6319824, Length=438, Percent_Identity=28.5388127853881, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6324059, Length=406, Percent_Identity=32.2660098522167, Blast_Score=173, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6319542, Length=438, Percent_Identity=28.5388127853881, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6322892, Length=477, Percent_Identity=29.3501048218029, Blast_Score=170, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6320251, Length=438, Percent_Identity=27.6255707762557, Blast_Score=166, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6324553, Length=388, Percent_Identity=32.4742268041237, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320717, Length=404, Percent_Identity=27.2277227722772, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6321629, Length=431, Percent_Identity=27.6102088167053, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6319543, Length=399, Percent_Identity=27.5689223057644, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6321053, Length=426, Percent_Identity=26.2910798122066, Blast_Score=146, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6319608, Length=454, Percent_Identity=25.1101321585903, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6322967, Length=398, Percent_Identity=26.3819095477387, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324981, Length=427, Percent_Identity=25.9953161592506, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320364, Length=505, Percent_Identity=24.1584158415842, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI221512776, Length=422, Percent_Identity=22.5118483412322, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24666159, Length=422, Percent_Identity=22.5118483412322, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI161077963, Length=333, Percent_Identity=25.5255255255255, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52343; Mature: 52343

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTTGLNAPWFFIVLIGQKLMESNNKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMA
CCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHC
GPSVLLAYIIGGVAAYIIMRALGEMSVHNPAASSFSRYAQENLGPLAGYITGWTYCFEIL
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
IVAIADVTAFGIYMGVWFPAVPHWIWVLSVVLIICAINLMSVKVFGELEFWFSFFKVATI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIMIVAGIGIIVWGIGNGGQPTGIHNLWSNGGFFSNGWLGMIMSLQMVMFAYGGIEIIGI
HHHHHHHHHEEEEECCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEE
TAGEAKDPEKSIPRAINSVPMRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGIT
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHH
FAASILNFVVLTASLSAINSDVFGVGRMLHGMAEQGSAPKVFAKTSRRGIPWVTVLVMTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHH
ALLFAVYLNYIMPENVFLVIASLATFATVWVWIMILLSQIAFRRRLPPEEVKALKFKVPG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEEEECCC
GVVTTIAGLIFLVFIIALIGYHPDTRISLYVGFAWIVLLLIGWIFKRRRDRQLAQA
CHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYTTGLNAPWFFIVLIGQKLMESNNKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMA
CCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHC
GPSVLLAYIIGGVAAYIIMRALGEMSVHNPAASSFSRYAQENLGPLAGYITGWTYCFEIL
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
IVAIADVTAFGIYMGVWFPAVPHWIWVLSVVLIICAINLMSVKVFGELEFWFSFFKVATI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIMIVAGIGIIVWGIGNGGQPTGIHNLWSNGGFFSNGWLGMIMSLQMVMFAYGGIEIIGI
HHHHHHHHHEEEEECCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEE
TAGEAKDPEKSIPRAINSVPMRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGIT
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHH
FAASILNFVVLTASLSAINSDVFGVGRMLHGMAEQGSAPKVFAKTSRRGIPWVTVLVMTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHH
ALLFAVYLNYIMPENVFLVIASLATFATVWVWIMILLSQIAFRRRLPPEEVKALKFKVPG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEEEECCC
GVVTTIAGLIFLVFIIALIGYHPDTRISLYVGFAWIVLLLIGWIFKRRRDRQLAQA
CHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]