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The map label for this gene is uvrC [H]

Identifier: 194738201

GI number: 194738201

Start: 2014267

End: 2016099

Strand: Reverse

Name: uvrC [H]

Synonym: SeSA_A2102

Alternate gene names: 194738201

Gene position: 2016099-2014267 (Counterclockwise)

Preceding gene: 194733956

Following gene: 194734816

Centisome position: 42.81

GC content: 53.68

Gene sequence:

>1833_bases
GTGAGTGAAATATTTGACGCAAAGGCGTTTTTGAAAACCGTTACCAGCCAACCCGGTGTCTATCGTATGTATGACGCCGG
CGGTACGGTTATCTATGTTGGTAAAGCAAAAGACCTGAAAAAGCGTCTTTCCAGCTACTTTCGCAGCAACCTGGCTTCGC
GTAAAACCGAAGCGCTAGTTGCGCAAATTCAACACATTGATGTCACGGTAACGCATACCGAAACGGAAGCGCTGCTGCTT
GAGCATAATTACATCAAGTTGTATCAACCGCGTTACAACGTGTTGTTGCGTGATGATAAATCCTATCCTTTTATTTTTCT
GAGCGGCGATACCCATCCGCGTCTGGCGATGCACCGTGGCGCTAAACATGCGAAAGGCGAGTACTTCGGCCCATTTCCTA
ACGGCTATGCCGTGCGGGAAACGCTGGCGCTGTTACAGAAAATTTTCCCTATCCGCCAGTGCGAAAACAGCGTGTATCGC
AACCGCTCGCGTCCTTGCCTGCAATACCAGATTGGCCGCTGCTTAGGCCCCTGCGTTGCAGGACTGGTCAGCGAGGAGGA
GTACACGCAACAGGTGGAGTATGTCCGGTTGTTTTTGTCCGGCAAGGACGACCAGGTCTTAACACAGCTGATTGCCCGGA
TGGAAAAGGCCAGCCAGGATTTGGCATTTGAAGAGGCGGCGCGTATTCGCGATCAGATCCAGGCGGTACGCCGGGTCACG
GAGAGACAGTTTGTCTCCAATGCGGGCGACGATCTCGACGTTATCGGCGTGGCTTTCGATGCGGGTATGGCCTGTGTGCA
TGTGCTGTTTATTCGCCAGGGTAAGGTGCTGGGCAGCCGCAGCTATTTTCCAAAAGTGCCTGGCGGTACGGAACTGGGCG
AAGTGGTGGAAACCTTTGTCGGGCAGTTTTACCTGCAGGGTAGCCAGATGCGCACGCTACCGGGCGAGATACTGCTCGAT
TTTAATCTTAGCGATAAAACGCTGCTCGCCGACTCGTTGTCGGAGCTTGCCGGACGGCGTATTCATGTCCAGACAAAACC
GCGCGGCGATCGCGCCCGTTATCTCAAGCTGGCGCGGACCAACGCGGCAACGGCCTTAATTACAAAACTTTCGCAGCAGT
CCACCATCACGCAGCGTTTGACTGCGCTGGCGGCGGTATTAAAACTTCCTGCTATCAAGCGGATGGAGTGTTTTGACATC
AGCCATACCATGGGGGAGCAAACGGTCGCATCCTGTGTGGTATTTGACGCTAACGGGCCGTTACGCGCCGAGTATCGTCG
TTATAATATCGCGGGCATCACGCCGGGTGATGACTACGCGGCGATGAATCAGGTGCTACGTCGGCGTTATGGCAAGGCCA
TAGAAGAAAGTAAGATTCCGGACGTTATTCTGATCGACGGCGGAAAAGGGCAGCTCGCCCAGGCGAAAGCCGTTTTCGCT
GAGCTGGATGTCCCCTGGGATAAGCATCGCCCTTTGTTGCTCGGCGTCGCCAAAGGCGCAGACAGAAAGGCCGGTCTGGA
AACACTCTTTTTTGAACCGGAAGGAGAGGGGTTTAGCCTGCCGCCGGACTCGCCGGCGCTGCATGTTATTCAGCATATTC
GCGATGAGTCGCACGATCACGCGATCGGCGGACACCGTAAAAAACGCGCAAAGGTTAAAAATACCAGTACGCTGGAAACT
ATTGAAGGCGTTGGGCCTAAACGTCGCCAGATGCTGCTGAAATATATGGGCGGTTTGCAAGGACTACGTAACGCCAGCGT
AGAAGAAATTGCAAAAGTGCCGGGTATTTCGCAAGGTCTGGCAGAAAAGATCTTCTGGTCGTTGAAACATTGA

Upstream 100 bases:

>100_bases
GCTATCGTATGTTCAGTAAATTAAACATTCATGGTGATGTTGAGCTGACTCACCTGGCAATCCGCCATGGCCTGTGTAAT
GCGGAGACGTTAACAAGCCA

Downstream 100 bases:

>100_bases
GGCCACTGTAGCAACATAGGGGTAATTTCACTGACAACAGATAGTTACCCGTCACTATGCAATTTAATATCCCTACGTTG
CTCACGCTGTTTCGCGTCAT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MSEIFDAKAFLKTVTSQPGVYRMYDAGGTVIYVGKAKDLKKRLSSYFRSNLASRKTEALVAQIQHIDVTVTHTETEALLL
EHNYIKLYQPRYNVLLRDDKSYPFIFLSGDTHPRLAMHRGAKHAKGEYFGPFPNGYAVRETLALLQKIFPIRQCENSVYR
NRSRPCLQYQIGRCLGPCVAGLVSEEEYTQQVEYVRLFLSGKDDQVLTQLIARMEKASQDLAFEEAARIRDQIQAVRRVT
ERQFVSNAGDDLDVIGVAFDAGMACVHVLFIRQGKVLGSRSYFPKVPGGTELGEVVETFVGQFYLQGSQMRTLPGEILLD
FNLSDKTLLADSLSELAGRRIHVQTKPRGDRARYLKLARTNAATALITKLSQQSTITQRLTALAAVLKLPAIKRMECFDI
SHTMGEQTVASCVVFDANGPLRAEYRRYNIAGITPGDDYAAMNQVLRRRYGKAIEESKIPDVILIDGGKGQLAQAKAVFA
ELDVPWDKHRPLLLGVAKGADRKAGLETLFFEPEGEGFSLPPDSPALHVIQHIRDESHDHAIGGHRKKRAKVKNTSTLET
IEGVGPKRRQMLLKYMGGLQGLRNASVEEIAKVPGISQGLAEKIFWSLKH

Sequences:

>Translated_610_residues
MSEIFDAKAFLKTVTSQPGVYRMYDAGGTVIYVGKAKDLKKRLSSYFRSNLASRKTEALVAQIQHIDVTVTHTETEALLL
EHNYIKLYQPRYNVLLRDDKSYPFIFLSGDTHPRLAMHRGAKHAKGEYFGPFPNGYAVRETLALLQKIFPIRQCENSVYR
NRSRPCLQYQIGRCLGPCVAGLVSEEEYTQQVEYVRLFLSGKDDQVLTQLIARMEKASQDLAFEEAARIRDQIQAVRRVT
ERQFVSNAGDDLDVIGVAFDAGMACVHVLFIRQGKVLGSRSYFPKVPGGTELGEVVETFVGQFYLQGSQMRTLPGEILLD
FNLSDKTLLADSLSELAGRRIHVQTKPRGDRARYLKLARTNAATALITKLSQQSTITQRLTALAAVLKLPAIKRMECFDI
SHTMGEQTVASCVVFDANGPLRAEYRRYNIAGITPGDDYAAMNQVLRRRYGKAIEESKIPDVILIDGGKGQLAQAKAVFA
ELDVPWDKHRPLLLGVAKGADRKAGLETLFFEPEGEGFSLPPDSPALHVIQHIRDESHDHAIGGHRKKRAKVKNTSTLET
IEGVGPKRRQMLLKYMGGLQGLRNASVEEIAKVPGISQGLAEKIFWSLKH
>Mature_609_residues
SEIFDAKAFLKTVTSQPGVYRMYDAGGTVIYVGKAKDLKKRLSSYFRSNLASRKTEALVAQIQHIDVTVTHTETEALLLE
HNYIKLYQPRYNVLLRDDKSYPFIFLSGDTHPRLAMHRGAKHAKGEYFGPFPNGYAVRETLALLQKIFPIRQCENSVYRN
RSRPCLQYQIGRCLGPCVAGLVSEEEYTQQVEYVRLFLSGKDDQVLTQLIARMEKASQDLAFEEAARIRDQIQAVRRVTE
RQFVSNAGDDLDVIGVAFDAGMACVHVLFIRQGKVLGSRSYFPKVPGGTELGEVVETFVGQFYLQGSQMRTLPGEILLDF
NLSDKTLLADSLSELAGRRIHVQTKPRGDRARYLKLARTNAATALITKLSQQSTITQRLTALAAVLKLPAIKRMECFDIS
HTMGEQTVASCVVFDANGPLRAEYRRYNIAGITPGDDYAAMNQVLRRRYGKAIEESKIPDVILIDGGKGQLAQAKAVFAE
LDVPWDKHRPLLLGVAKGADRKAGLETLFFEPEGEGFSLPPDSPALHVIQHIRDESHDHAIGGHRKKRAKVKNTSTLETI
EGVGPKRRQMLLKYMGGLQGLRNASVEEIAKVPGISQGLAEKIFWSLKH

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=610, Percent_Identity=95.2459016393443, Blast_Score=1207, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF00633 HHH; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 68107; Mature: 67976

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIFDAKAFLKTVTSQPGVYRMYDAGGTVIYVGKAKDLKKRLSSYFRSNLASRKTEALV
CCCHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
AQIQHIDVTVTHTETEALLLEHNYIKLYQPRYNVLLRDDKSYPFIFLSGDTHPRLAMHRG
HHHHHEEEEEEECCCEEEEEECCEEEEECCCCCEEEECCCCCCEEEECCCCCCHHHHHCC
AKHAKGEYFGPFPNGYAVRETLALLQKIFPIRQCENSVYRNRSRPCLQYQIGRCLGPCVA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
GLVSEEEYTQQVEYVRLFLSGKDDQVLTQLIARMEKASQDLAFEEAARIRDQIQAVRRVT
HHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERQFVSNAGDDLDVIGVAFDAGMACVHVLFIRQGKVLGSRSYFPKVPGGTELGEVVETFV
HHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCHHHHHHHHHH
GQFYLQGSQMRTLPGEILLDFNLSDKTLLADSLSELAGRRIHVQTKPRGDRARYLKLART
HHHHCCCCCEECCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHC
NAATALITKLSQQSTITQRLTALAAVLKLPAIKRMECFDISHTMGEQTVASCVVFDANGP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHCHHHHEEEEEECCCCC
LRAEYRRYNIAGITPGDDYAAMNQVLRRRYGKAIEESKIPDVILIDGGKGQLAQAKAVFA
CCCHHEEEEEEECCCCCHHHHHHHHHHHHHCCHHHHCCCCCEEEEECCCCCHHHHHHHHH
ELDVPWDKHRPLLLGVAKGADRKAGLETLFFEPEGEGFSLPPDSPALHVIQHIRDESHDH
HCCCCCCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCC
AIGGHRKKRAKVKNTSTLETIEGVGPKRRQMLLKYMGGLQGLRNASVEEIAKVPGISQGL
CCCCCHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHH
AEKIFWSLKH
HHHHHHHCCC
>Mature Secondary Structure 
SEIFDAKAFLKTVTSQPGVYRMYDAGGTVIYVGKAKDLKKRLSSYFRSNLASRKTEALV
CCHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
AQIQHIDVTVTHTETEALLLEHNYIKLYQPRYNVLLRDDKSYPFIFLSGDTHPRLAMHRG
HHHHHEEEEEEECCCEEEEEECCEEEEECCCCCEEEECCCCCCEEEECCCCCCHHHHHCC
AKHAKGEYFGPFPNGYAVRETLALLQKIFPIRQCENSVYRNRSRPCLQYQIGRCLGPCVA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
GLVSEEEYTQQVEYVRLFLSGKDDQVLTQLIARMEKASQDLAFEEAARIRDQIQAVRRVT
HHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERQFVSNAGDDLDVIGVAFDAGMACVHVLFIRQGKVLGSRSYFPKVPGGTELGEVVETFV
HHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCHHHHHHHHHH
GQFYLQGSQMRTLPGEILLDFNLSDKTLLADSLSELAGRRIHVQTKPRGDRARYLKLART
HHHHCCCCCEECCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHC
NAATALITKLSQQSTITQRLTALAAVLKLPAIKRMECFDISHTMGEQTVASCVVFDANGP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHCHHHHEEEEEECCCCC
LRAEYRRYNIAGITPGDDYAAMNQVLRRRYGKAIEESKIPDVILIDGGKGQLAQAKAVFA
CCCHHEEEEEEECCCCCHHHHHHHHHHHHHCCHHHHCCCCCEEEEECCCCCHHHHHHHHH
ELDVPWDKHRPLLLGVAKGADRKAGLETLFFEPEGEGFSLPPDSPALHVIQHIRDESHDH
HCCCCCCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCC
AIGGHRKKRAKVKNTSTLETIEGVGPKRRQMLLKYMGGLQGLRNASVEEIAKVPGISQGL
CCCCCHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHH
AEKIFWSLKH
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA