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The map label for this gene is sseL [H]

Identifier: 194737909

GI number: 194737909

Start: 2400503

End: 2401525

Strand: Direct

Name: sseL [H]

Synonym: SeSA_A2515

Alternate gene names: 194737909

Gene position: 2400503-2401525 (Clockwise)

Preceding gene: 194734477

Following gene: 194735920

Centisome position: 50.98

GC content: 37.73

Gene sequence:

>1023_bases
ATGAATATATGTGTAAATTCACTTTACCGATTGAGCATACCGCAATTTCACAGCTTATATGCAGAAGAGGTGAGCGATGA
GACGCTTGCGTTGTTGTTTAGCGCCGTAGAGAACGGTGATCAGAATTGTATTGATCTGGTATGCAATCTTGCGTTACGCA
ACGATGATCTGGGACATAGAGTTGAGAAATTTCTTTTTGATCTTTTTAGCGGAAAAAGATTGGGCTCACCAGATATAGAT
AAAAAAATCAATCAGGCTTGCCTTGTATTACATCAAATTGCCAATAACGATATAACAAAAAATAATACTGAGTGGAAAAA
GCTACATGCCCCTTCCAGATTACTTTATATGGCCGGTTCCGCGACAACCGACCTTTCTAAAAAAATAGAAATAGCACATA
AAATTATGGGCGACCAGTTCGCTCAGACAGATCAAGAACAGGTAGGAGTTGAAAACCTTTGGTGTGGTGCGCGAATGATG
TCGTCAGATGAGCTAGCAGCTGCAACGCAAGGTCTGGTTCAAGAATCACCTTTTCTCTCGGTAAACTATCCTATTGGGCT
TATTCATCCTACCACCAAAGAAAATATATTACGCACTCAGCTACTTGAAAAGATGGCTCAATCAGGATTATGTGAAAATG
AAATCTTTCTGATAAATACAGGAGATCACTGGCTTCTCTGTTTATTTTATAAACTTGCAGAAAAAATAAAATGCCTTATA
TTTAATACTTATCATGATTTAAATGAAAATACTAAGCAAGAGATTATAGAAGCAGCAACAATTGCAGGCATATCAGAAAA
AGAAGATATTGATTTTGTTGAGACTAATTTACAAAATAATGTACCCAACGGCTGCGGTCTATTTTGTTACCATACAATTC
AACTCTTATCGAATGCCGGACAAAACGATCCTGCTACCACACTACGAGAGTTTGCGGAAAAGTTCTTAACGCTTTCAGTA
GAGGAACAAACACTATTTAACACCCAAACCCGGCGACAAATATATGAATACAGTCTCCAGTAA

Upstream 100 bases:

>100_bases
ATGCCTGATTTAATATATCCCCCACTAACAATAATATTTTTACAAATAATTATAAATTACATCATATTCGCTACTTTCAC
CTACCAGGAAACAGAGCAAA

Downstream 100 bases:

>100_bases
TGGTGAGTACTTAGAGCCTATCCCATTAGGCTATTTTATTCGCCATTTTGGGACCGGGCAGTGCTCAAAATCCTCACGTA
CTACGTGTACGCTACGGTTT

Product: deubiquitinase

Products: NA

Alternate protein names: Deubiquitinating enzyme; DUB; Deubiquitinating protease; Salmonella secreted effector L [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MNICVNSLYRLSIPQFHSLYAEEVSDETLALLFSAVENGDQNCIDLVCNLALRNDDLGHRVEKFLFDLFSGKRLGSPDID
KKINQACLVLHQIANNDITKNNTEWKKLHAPSRLLYMAGSATTDLSKKIEIAHKIMGDQFAQTDQEQVGVENLWCGARMM
SSDELAAATQGLVQESPFLSVNYPIGLIHPTTKENILRTQLLEKMAQSGLCENEIFLINTGDHWLLCLFYKLAEKIKCLI
FNTYHDLNENTKQEIIEAATIAGISEKEDIDFVETNLQNNVPNGCGLFCYHTIQLLSNAGQNDPATTLREFAEKFLTLSV
EEQTLFNTQTRRQIYEYSLQ

Sequences:

>Translated_340_residues
MNICVNSLYRLSIPQFHSLYAEEVSDETLALLFSAVENGDQNCIDLVCNLALRNDDLGHRVEKFLFDLFSGKRLGSPDID
KKINQACLVLHQIANNDITKNNTEWKKLHAPSRLLYMAGSATTDLSKKIEIAHKIMGDQFAQTDQEQVGVENLWCGARMM
SSDELAAATQGLVQESPFLSVNYPIGLIHPTTKENILRTQLLEKMAQSGLCENEIFLINTGDHWLLCLFYKLAEKIKCLI
FNTYHDLNENTKQEIIEAATIAGISEKEDIDFVETNLQNNVPNGCGLFCYHTIQLLSNAGQNDPATTLREFAEKFLTLSV
EEQTLFNTQTRRQIYEYSLQ
>Mature_340_residues
MNICVNSLYRLSIPQFHSLYAEEVSDETLALLFSAVENGDQNCIDLVCNLALRNDDLGHRVEKFLFDLFSGKRLGSPDID
KKINQACLVLHQIANNDITKNNTEWKKLHAPSRLLYMAGSATTDLSKKIEIAHKIMGDQFAQTDQEQVGVENLWCGARMM
SSDELAAATQGLVQESPFLSVNYPIGLIHPTTKENILRTQLLEKMAQSGLCENEIFLINTGDHWLLCLFYKLAEKIKCLI
FNTYHDLNENTKQEIIEAATIAGISEKEDIDFVETNLQNNVPNGCGLFCYHTIQLLSNAGQNDPATTLREFAEKFLTLSV
EEQTLFNTQTRRQIYEYSLQ

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease targets the host cell ubiquitin pathway by acting as a deubiquitinase in infected host cells [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Host cytoplasm (By similarity). Note=Secreted via type III secretion system 2 (SPI-2 TTSS), and delivered into the host cytoplasm. In phagocytic cells localizes to the Salmonella-containing vacuole (SCV). In epithelial cells localizes to the Sal

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C79 family [H]

Homologues:

Organism=Escherichia coli, GI1788604, Length=366, Percent_Identity=27.5956284153005, Blast_Score=117, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 38449; Mature: 38449

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNICVNSLYRLSIPQFHSLYAEEVSDETLALLFSAVENGDQNCIDLVCNLALRNDDLGHR
CCCHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHH
VEKFLFDLFSGKRLGSPDIDKKINQACLVLHQIANNDITKNNTEWKKLHAPSRLLYMAGS
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCEEEEEECC
ATTDLSKKIEIAHKIMGDQFAQTDQEQVGVENLWCGARMMSSDELAAATQGLVQESPFLS
CCHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHCHHHCCCHHHHHHHHHHHHCCCEEE
VNYPIGLIHPTTKENILRTQLLEKMAQSGLCENEIFLINTGDHWLLCLFYKLAEKIKCLI
EECCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHH
FNTYHDLNENTKQEIIEAATIAGISEKEDIDFVETNLQNNVPNGCGLFCYHTIQLLSNAG
HHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
QNDPATTLREFAEKFLTLSVEEQTLFNTQTRRQIYEYSLQ
CCCHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNICVNSLYRLSIPQFHSLYAEEVSDETLALLFSAVENGDQNCIDLVCNLALRNDDLGHR
CCCHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHH
VEKFLFDLFSGKRLGSPDIDKKINQACLVLHQIANNDITKNNTEWKKLHAPSRLLYMAGS
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCEEEEEECC
ATTDLSKKIEIAHKIMGDQFAQTDQEQVGVENLWCGARMMSSDELAAATQGLVQESPFLS
CCHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHCHHHCCCHHHHHHHHHHHHCCCEEE
VNYPIGLIHPTTKENILRTQLLEKMAQSGLCENEIFLINTGDHWLLCLFYKLAEKIKCLI
EECCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHH
FNTYHDLNENTKQEIIEAATIAGISEKEDIDFVETNLQNNVPNGCGLFCYHTIQLLSNAG
HHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
QNDPATTLREFAEKFLTLSVEEQTLFNTQTRRQIYEYSLQ
CCCHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA