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The map label for this gene is pheP [H]

Identifier: 194737876

GI number: 194737876

Start: 707164

End: 708558

Strand: Direct

Name: pheP [H]

Synonym: SeSA_A0735

Alternate gene names: 194737876

Gene position: 707164-708558 (Clockwise)

Preceding gene: 194736887

Following gene: 194737691

Centisome position: 15.02

GC content: 53.12

Gene sequence:

>1395_bases
GTGAAAAACGCGTCAACTGCATCCGGCGCCAGCGTGTCGGATGCCGCGTCGAAGAATGAACCGACGCTTCAACGGGGGTT
GCAAAACCGCCATATTCAGCTAATTGCGCTGGGCGGCGCCATTGGCACCGGACTGTTTCTGGGCATCGGCCCGGCGATTC
AAATGGCGGGGCCGGCTGTTTTGTTGGGCTATGGCGTTGCCGGGATTATCGCTTTTCTCATTATGCGCCAGTTGGGTGAA
ATGGTCGTGGAAGAGCCGGTTTCCGGATCGTTTGCCCACTTCGCCTGGAAATATTGGGGGCCGTTTGCGGGCTTTTTGTC
GGGCTGGAACTATTGGGTCATGTTTGTGCTGGTCGGGATGGCGGAGCTGACCGCGGCGGGCATCTATATGCAGTACTGGC
TGCCTGACGTACCAACATGGATTTGGGCGGCGGCGTTTTTTATTATCATTAATGCCGTAAATCTGGTGAACGTTCGTCTG
TATGGCGAAACGGAATTCTGGTTCGCGCTCATTAAAGTGCTGGCGATTATCGGCATGATAGGTTTTGGTCTGTGGCTGCT
GTTCTCCGGCCACGGCGGCGAACATGCCAGCATTGATAACCTCTGGCGTTATAACGGTTTCTTCGCTACCGGTTGGCATG
GTTTGCTTCTGTCGCTGGCGGTGATTATGTTTTCTTTTGGCGGACTGGAGCTGATCGGCATTACTGCGGCGGAAGCGCGC
GATCCGCAAAAAAGCATTCCGAAAGCGGTGAATCAGGTGGTATACCGTATTTTGCTGTTCTACATCGGTTCGCTGGTGGT
GTTGCTGGCGCTCTATCCGTGGGTAGAGGTGAAATCCAATAGCAGCCCTTTTGTGATGATCTTCCATAACCTGGACAGTA
ATGTGGTGGCTTCGGCGCTGAATTTCGTTATTCTGGTCGCGTCGCTTTCGGTGTATAACAGCGGCGTTTATTCGAACAGC
CGAATGCTGTTCGGCCTGTCCGTACAAGGCAATGCGCCGAAATTTTTAACCCGCGTCAGCCATCGCGGCGTGCCGGTGAA
CTCGCTGATACTTTCCGGAGCGATTACCTCGCTGGTGGTGCTGATCAACTATCTGTTGCCGCAAAAAGCGTTTAGCCTGT
TGATGGCGCTGGTTGTCGCGACGCTATTGCTAAACTGGATAATGATCTGTCTCGCGCATTTACGTTTTCGCGCGGCGATG
CGTCGTAAAGGGCGCGAGACGCAATTTAAGGCGCTGTTCTATCCCGCCGGAAACTATTTGTGCATTGCGTTTCTGGCGCT
GATTCTGGTGTTAATGTGTACGATGGACGATATGCGATTGTCGGCGATTTTGCTGCCGGTATGGATTGTATTCCTGTTTA
TCGCGTTTACAGTTTTGCGCCGTAAGGCTCATTAA

Upstream 100 bases:

>100_bases
TAACGTCCGGAGTTGAGCCTTGACAAACGATTGCGCCTTGCGGCAGCGAGAGCGAAATGTTAAAAGGTGCCCCTCAATAA
AAACGATACAGGGGTAGGAC

Downstream 100 bases:

>100_bases
CTTTTTTGCCCGATCCCATGCTCATGCGATCGGGCAATCCATTAATGCCGCAATGTCCCTGACAGCGCGCGAATATCGCT
GCCGGTCGGCGTCTGATGAA

Product: phenylalanine transporter

Products: Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MKNASTASGASVSDAASKNEPTLQRGLQNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAVLLGYGVAGIIAFLIMRQLGE
MVVEEPVSGSFAHFAWKYWGPFAGFLSGWNYWVMFVLVGMAELTAAGIYMQYWLPDVPTWIWAAAFFIIINAVNLVNVRL
YGETEFWFALIKVLAIIGMIGFGLWLLFSGHGGEHASIDNLWRYNGFFATGWHGLLLSLAVIMFSFGGLELIGITAAEAR
DPQKSIPKAVNQVVYRILLFYIGSLVVLLALYPWVEVKSNSSPFVMIFHNLDSNVVASALNFVILVASLSVYNSGVYSNS
RMLFGLSVQGNAPKFLTRVSHRGVPVNSLILSGAITSLVVLINYLLPQKAFSLLMALVVATLLLNWIMICLAHLRFRAAM
RRKGRETQFKALFYPAGNYLCIAFLALILVLMCTMDDMRLSAILLPVWIVFLFIAFTVLRRKAH

Sequences:

>Translated_464_residues
MKNASTASGASVSDAASKNEPTLQRGLQNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAVLLGYGVAGIIAFLIMRQLGE
MVVEEPVSGSFAHFAWKYWGPFAGFLSGWNYWVMFVLVGMAELTAAGIYMQYWLPDVPTWIWAAAFFIIINAVNLVNVRL
YGETEFWFALIKVLAIIGMIGFGLWLLFSGHGGEHASIDNLWRYNGFFATGWHGLLLSLAVIMFSFGGLELIGITAAEAR
DPQKSIPKAVNQVVYRILLFYIGSLVVLLALYPWVEVKSNSSPFVMIFHNLDSNVVASALNFVILVASLSVYNSGVYSNS
RMLFGLSVQGNAPKFLTRVSHRGVPVNSLILSGAITSLVVLINYLLPQKAFSLLMALVVATLLLNWIMICLAHLRFRAAM
RRKGRETQFKALFYPAGNYLCIAFLALILVLMCTMDDMRLSAILLPVWIVFLFIAFTVLRRKAH
>Mature_464_residues
MKNASTASGASVSDAASKNEPTLQRGLQNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAVLLGYGVAGIIAFLIMRQLGE
MVVEEPVSGSFAHFAWKYWGPFAGFLSGWNYWVMFVLVGMAELTAAGIYMQYWLPDVPTWIWAAAFFIIINAVNLVNVRL
YGETEFWFALIKVLAIIGMIGFGLWLLFSGHGGEHASIDNLWRYNGFFATGWHGLLLSLAVIMFSFGGLELIGITAAEAR
DPQKSIPKAVNQVVYRILLFYIGSLVVLLALYPWVEVKSNSSPFVMIFHNLDSNVVASALNFVILVASLSVYNSGVYSNS
RMLFGLSVQGNAPKFLTRVSHRGVPVNSLILSGAITSLVVLINYLLPQKAFSLLMALVVATLLLNWIMICLAHLRFRAAM
RRKGRETQFKALFYPAGNYLCIAFLALILVLMCTMDDMRLSAILLPVWIVFLFIAFTVLRRKAH

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of phenylalanine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=286, Percent_Identity=26.2237762237762, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI181337167, Length=351, Percent_Identity=25.3561253561254, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1786789, Length=462, Percent_Identity=93.2900432900433, Blast_Score=860, Evalue=0.0,
Organism=Escherichia coli, GI1786302, Length=448, Percent_Identity=61.8303571428571, Blast_Score=584, Evalue=1e-168,
Organism=Escherichia coli, GI48994972, Length=429, Percent_Identity=44.2890442890443, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI1786602, Length=453, Percent_Identity=45.6953642384106, Blast_Score=350, Evalue=8e-98,
Organism=Escherichia coli, GI1790653, Length=456, Percent_Identity=37.0614035087719, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI87081915, Length=406, Percent_Identity=38.423645320197, Blast_Score=295, Evalue=4e-81,
Organism=Escherichia coli, GI1788480, Length=439, Percent_Identity=36.6742596810934, Blast_Score=268, Evalue=5e-73,
Organism=Escherichia coli, GI87081708, Length=410, Percent_Identity=36.0975609756098, Blast_Score=264, Evalue=1e-71,
Organism=Escherichia coli, GI1789017, Length=431, Percent_Identity=36.1948955916473, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI87081869, Length=175, Percent_Identity=28, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI87082023, Length=366, Percent_Identity=23.4972677595628, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17540018, Length=380, Percent_Identity=22.1052631578947, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17531343, Length=377, Percent_Identity=20.9549071618037, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=449, Percent_Identity=35.1893095768374, Blast_Score=253, Evalue=5e-68,
Organism=Saccharomyces cerevisiae, GI6324061, Length=443, Percent_Identity=34.7629796839729, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6324990, Length=446, Percent_Identity=32.7354260089686, Blast_Score=213, Evalue=5e-56,
Organism=Saccharomyces cerevisiae, GI6324059, Length=460, Percent_Identity=35, Blast_Score=213, Evalue=6e-56,
Organism=Saccharomyces cerevisiae, GI6319824, Length=446, Percent_Identity=31.6143497757848, Blast_Score=210, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6322892, Length=415, Percent_Identity=35.1807228915663, Blast_Score=209, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6324924, Length=415, Percent_Identity=33.4939759036145, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6321629, Length=425, Percent_Identity=31.5294117647059, Blast_Score=206, Evalue=6e-54,
Organism=Saccharomyces cerevisiae, GI6324553, Length=399, Percent_Identity=33.5839598997494, Blast_Score=201, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6320717, Length=404, Percent_Identity=28.7128712871287, Blast_Score=196, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6321053, Length=464, Percent_Identity=31.6810344827586, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6319543, Length=435, Percent_Identity=31.9540229885057, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6320251, Length=480, Percent_Identity=28.125, Blast_Score=186, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6322967, Length=403, Percent_Identity=30.7692307692308, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6319542, Length=466, Percent_Identity=27.0386266094421, Blast_Score=176, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6319608, Length=407, Percent_Identity=29.4840294840295, Blast_Score=172, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6324981, Length=400, Percent_Identity=31.25, Blast_Score=168, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6320364, Length=463, Percent_Identity=28.0777537796976, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24666159, Length=416, Percent_Identity=21.875, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI221512776, Length=416, Percent_Identity=21.875, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI221331183, Length=381, Percent_Identity=24.1469816272966, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17647653, Length=381, Percent_Identity=24.1469816272966, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24664379, Length=381, Percent_Identity=24.1469816272966, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI161077963, Length=408, Percent_Identity=23.2843137254902, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51031; Mature: 51031

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNASTASGASVSDAASKNEPTLQRGLQNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAV
CCCCCCCCCCCCCHHCCCCCCHHHHCCCCCCEEEEEECCHHHHHHHHHCCHHHHHCCCHH
LLGYGVAGIIAFLIMRQLGEMVVEEPVSGSFAHFAWKYWGPFAGFLSGWNYWVMFVLVGM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHCCHHHHHHHHHHHH
AELTAAGIYMQYWLPDVPTWIWAAAFFIIINAVNLVNVRLYGETEFWFALIKVLAIIGMI
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHHHHHH
GFGLWLLFSGHGGEHASIDNLWRYNGFFATGWHGLLLSLAVIMFSFGGLELIGITAAEAR
HHHHHHHCCCCCCCCCCHHHHHHCCCEEECCHHHHHHHHHHHHHHCCCEEEEEEEHHHCC
DPQKSIPKAVNQVVYRILLFYIGSLVVLLALYPWVEVKSNSSPFVMIFHNLDSNVVASAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECCCHHHHHHHH
NFVILVASLSVYNSGVYSNSRMLFGLSVQGNAPKFLTRVSHRGVPVNSLILSGAITSLVV
HHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LINYLLPQKAFSLLMALVVATLLLNWIMICLAHLRFRAAMRRKGRETQFKALFYPAGNYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHH
CIAFLALILVLMCTMDDMRLSAILLPVWIVFLFIAFTVLRRKAH
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKNASTASGASVSDAASKNEPTLQRGLQNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAV
CCCCCCCCCCCCCHHCCCCCCHHHHCCCCCCEEEEEECCHHHHHHHHHCCHHHHHCCCHH
LLGYGVAGIIAFLIMRQLGEMVVEEPVSGSFAHFAWKYWGPFAGFLSGWNYWVMFVLVGM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHCCHHHHHHHHHHHH
AELTAAGIYMQYWLPDVPTWIWAAAFFIIINAVNLVNVRLYGETEFWFALIKVLAIIGMI
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHHHHHH
GFGLWLLFSGHGGEHASIDNLWRYNGFFATGWHGLLLSLAVIMFSFGGLELIGITAAEAR
HHHHHHHCCCCCCCCCCHHHHHHCCCEEECCHHHHHHHHHHHHHHCCCEEEEEEEHHHCC
DPQKSIPKAVNQVVYRILLFYIGSLVVLLALYPWVEVKSNSSPFVMIFHNLDSNVVASAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECCCHHHHHHHH
NFVILVASLSVYNSGVYSNSRMLFGLSVQGNAPKFLTRVSHRGVPVNSLILSGAITSLVV
HHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
LINYLLPQKAFSLLMALVVATLLLNWIMICLAHLRFRAAMRRKGRETQFKALFYPAGNYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHH
CIAFLALILVLMCTMDDMRLSAILLPVWIVFLFIAFTVLRRKAH
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] + L-phenylalanine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1711024; 8905232; 9278503; 8626334 [H]