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The map label for this gene is pdxA [H]

Identifier: 194737808

GI number: 194737808

Start: 191307

End: 192290

Strand: Direct

Name: pdxA [H]

Synonym: SeSA_A0182

Alternate gene names: 194737808

Gene position: 191307-192290 (Clockwise)

Preceding gene: 194737373

Following gene: 194738300

Centisome position: 4.06

GC content: 54.78

Gene sequence:

>984_bases
GTGGAGACTAAAACCGTTGCCATTACCATGGGCGATCCAGCGGGCATTGGGCCGGAAATTATTGTTAAAGCGCTAAGCGA
AGACGGTCTCAACGGCGCGCCGCTGGTGGTTATTGGATGCCTCGCAACGTTGAAACGTTTACAGGCGAAGGGCATTACGC
CGAACGTCGAGTTACGGGCCATTGAACGGGTTGCCGAAGCGCGTTTTGCGCCCGGCATCATTCATGTGATTGATGAGCCG
CTGGCGCAGCCGGAGGCGCTGGAGGCCGGGAAAGTTCAGGCGCAGGCGGGGGATTTAGCGTATCGCTGCGTGAAGCGCGC
CACCGAGTTAGCGTTACGGGGCGACGTACAGGCTATCGCTACCGCGCCGCTGAATAAAGAGGCGCTGCACCTGGCAGGGC
ACAACTATCCGGGCCATACCGAGCTGCTTGCGACCCTGACCCATAGCCGTGATTACGCGATGGTACTTTACACCGATAAA
CTAAAAGTGATTCACGTTTCAACGCATATCGCGCTGCGTAAATTCCTTGATACGTTAAGTACCGCGCGTGTCGAAACGGT
GATTGGTATTGCTGATACTTTCCTCAAGCGTGTGGGTTACGTTAAACCGCGTATCGCCGTGGCAGGCGTGAATCCTCATG
CGGGCGAGAATGGCCTGTTTGGCGATGAAGAGACGCGTATCCTGACGCCAGCCATTACCGATGCCCGCGCAAAAGGTATG
GACGTTTATGGGCCATGCCCGCCGGATACTGTATTTCTCCAGGCTTATGAGGGGCAGTATGATATGGTGGTGGCGATGTA
TCATGACCAGGGGCATATCCCGTTGAAATTGCTTGGATTTTATGATGGTGTGAATATCACCGCGGGGCTGCCATTTATTC
GGACCTCTGCCGATCATGGCACCGCATTTGATATCGCCTGGACGGGAAAAGCAAAATCTGAGAGCATGGCCGTATCGATC
AAACTGGCAATGCAACTGGCATAA

Upstream 100 bases:

>100_bases
AACAGCGAAATTGACGATCTGCCGGTCATTACCAAAGCGGGCGGATTCGGTTCAGACAGTACGTTGTGTGACGCGCTTTA
TTATATTGAGGAGATGTATT

Downstream 100 bases:

>100_bases
TTCCCTGTTATGAAAGGACAACACCGTCTGGATCTCATTGTGGCGTATCTGAAAAACCATACGCTGGTTACGGTAGAACA
GCTGGTTGAGGCGGTTGACG

Product: 4-hydroxythreonine-4-phosphate dehydrogenase 2

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase 2 [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
METKTVAITMGDPAGIGPEIIVKALSEDGLNGAPLVVIGCLATLKRLQAKGITPNVELRAIERVAEARFAPGIIHVIDEP
LAQPEALEAGKVQAQAGDLAYRCVKRATELALRGDVQAIATAPLNKEALHLAGHNYPGHTELLATLTHSRDYAMVLYTDK
LKVIHVSTHIALRKFLDTLSTARVETVIGIADTFLKRVGYVKPRIAVAGVNPHAGENGLFGDEETRILTPAITDARAKGM
DVYGPCPPDTVFLQAYEGQYDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSADHGTAFDIAWTGKAKSESMAVSI
KLAMQLA

Sequences:

>Translated_327_residues
METKTVAITMGDPAGIGPEIIVKALSEDGLNGAPLVVIGCLATLKRLQAKGITPNVELRAIERVAEARFAPGIIHVIDEP
LAQPEALEAGKVQAQAGDLAYRCVKRATELALRGDVQAIATAPLNKEALHLAGHNYPGHTELLATLTHSRDYAMVLYTDK
LKVIHVSTHIALRKFLDTLSTARVETVIGIADTFLKRVGYVKPRIAVAGVNPHAGENGLFGDEETRILTPAITDARAKGM
DVYGPCPPDTVFLQAYEGQYDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSADHGTAFDIAWTGKAKSESMAVSI
KLAMQLA
>Mature_327_residues
METKTVAITMGDPAGIGPEIIVKALSEDGLNGAPLVVIGCLATLKRLQAKGITPNVELRAIERVAEARFAPGIIHVIDEP
LAQPEALEAGKVQAQAGDLAYRCVKRATELALRGDVQAIATAPLNKEALHLAGHNYPGHTELLATLTHSRDYAMVLYTDK
LKVIHVSTHIALRKFLDTLSTARVETVIGIADTFLKRVGYVKPRIAVAGVNPHAGENGLFGDEETRILTPAITDARAKGM
DVYGPCPPDTVFLQAYEGQYDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSADHGTAFDIAWTGKAKSESMAVSI
KLAMQLA

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=329, Percent_Identity=37.0820668693009, Blast_Score=198, Evalue=5e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 35065; Mature: 35065

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METKTVAITMGDPAGIGPEIIVKALSEDGLNGAPLVVIGCLATLKRLQAKGITPNVELRA
CCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHH
IERVAEARFAPGIIHVIDEPLAQPEALEAGKVQAQAGDLAYRCVKRATELALRGDVQAIA
HHHHHHHHCCCCCCEECCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCCEEEE
TAPLNKEALHLAGHNYPGHTELLATLTHSRDYAMVLYTDKLKVIHVSTHIALRKFLDTLS
ECCCCCCEEEECCCCCCCHHHHHHHHHCCCCEEEEEEECCEEEEEEHHHHHHHHHHHHHH
TARVETVIGIADTFLKRVGYVKPRIAVAGVNPHAGENGLFGDEETRILTPAITDARAKGM
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCHHHCCC
DVYGPCPPDTVFLQAYEGQYDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSADHG
CCCCCCCCCEEEEEEECCCEEEEEEEEECCCCCCEEEEEEECCCEEEECCCEEEECCCCC
TAFDIAWTGKAKSESMAVSIKLAMQLA
CEEEEEECCCCCCCCEEEEEEEEEEEC
>Mature Secondary Structure
METKTVAITMGDPAGIGPEIIVKALSEDGLNGAPLVVIGCLATLKRLQAKGITPNVELRA
CCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHH
IERVAEARFAPGIIHVIDEPLAQPEALEAGKVQAQAGDLAYRCVKRATELALRGDVQAIA
HHHHHHHHCCCCCCEECCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCCEEEE
TAPLNKEALHLAGHNYPGHTELLATLTHSRDYAMVLYTDKLKVIHVSTHIALRKFLDTLS
ECCCCCCEEEECCCCCCCHHHHHHHHHCCCCEEEEEEECCEEEEEEHHHHHHHHHHHHHH
TARVETVIGIADTFLKRVGYVKPRIAVAGVNPHAGENGLFGDEETRILTPAITDARAKGM
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCHHHCCC
DVYGPCPPDTVFLQAYEGQYDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSADHG
CCCCCCCCCEEEEEEECCCEEEEEEEEECCCCCCEEEEEEECCCEEEECCCEEEECCCCC
TAFDIAWTGKAKSESMAVSIKLAMQLA
CEEEEEECCCCCCCCEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]