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The map label for this gene is aes [H]

Identifier: 194737806

GI number: 194737806

Start: 4118826

End: 4119755

Strand: Reverse

Name: aes [H]

Synonym: SeSA_A4243

Alternate gene names: 194737806

Gene position: 4119755-4118826 (Counterclockwise)

Preceding gene: 194738106

Following gene: 194737092

Centisome position: 87.49

GC content: 56.13

Gene sequence:

>930_bases
ATGCCACTGGAAAAAGGAATTGCCGAACTGGTCGCCGGGTTTATCGCTGCGGGCCGCCCCTCTTCACGAGAGCAGAATAT
TGATGATCGGAGGGCGGGTTATATTGCCAGCACGTCGCTGGCGGGCGAGAAAGAGATTCGCGTAAAATCTGAAGATATCG
TGCTGGAAGGGATGACATTTCGCGTCGTTTCGCCGCTAAACGCATCAGGTTCGCTACCCTGTATCCTCTACTATCACGGC
GGCTGTTTTGTTAGCGGCGGCTTTCTGACTCATGACCCCCAGCTACGGCAACTGGCCTGGAAAAGCGGCTGTAAGGTGAT
TGCCATTCAGTATCGCCTTGCGCCAGAGCACACCTTCCCTGCGGCTCATGACGACGCTGAACGCGGAGCCAATATCGTCC
ATCAATACGCGGAGCAGTTAGGTATCGATCGTGAACGTATCACGCTTGCTGGCGATAGCGCAGGCGGGCATTTGGCATTG
GTCAGCGCGCTACGCCTGAAATCCACCGCCCACTGGTCTCCGGCGAAGCTGCTGTTGATCTACCCGATGCTTGACGCTAC
TGCCAGTTTCCCCAGCTATGCCAGCAACGGGCAAGACTACATCATCACCCGCGACACACTACTATCAGGCTTCGAAATGT
ATCTCCAGGGTACCGACCTCCGTCACCCGGAAGCCAGTCCGATATGGCGTGAAGATTTTGCCGGTTTACCGCCGGTGCAT
ATCCTCACCGCAGAGTTCGACCCACTGCGTGATGAAGGCGAAGCGCTATATCACCGTCTGAACGACCAGGGCGTGGCGTG
TACTTGCCAGCGCTATCTCGGCGTTATCCACGGTTTTTTCCAATTGGGCGGCGTGAGCAAGACGGCACGAAGCGCCATGC
GAGATGTGGCCTGGCGTGTTGTAAGTCCATCAACAGGCAAAATGACCTAA

Upstream 100 bases:

>100_bases
CGAACCTCTATCCAGAATCATTATCCCCTCATTTCACCACTTTCCATCCCCAACAAATCAGGTTATAAACTGTACATACA
TACAGCTTAAGGAGCCTTAT

Downstream 100 bases:

>100_bases
AATTCAATTTTGTTTTCAACTTGAAAACTGGATAACGTTGCGCTAAATTGTTTTCAGGTTGAAAACTTTGTAATGGAACT
ACATTGTGCATGTTATCAGC

Product: acetyl esterase

Products: alcohol; a carboxylate [C]

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MPLEKGIAELVAGFIAAGRPSSREQNIDDRRAGYIASTSLAGEKEIRVKSEDIVLEGMTFRVVSPLNASGSLPCILYYHG
GCFVSGGFLTHDPQLRQLAWKSGCKVIAIQYRLAPEHTFPAAHDDAERGANIVHQYAEQLGIDRERITLAGDSAGGHLAL
VSALRLKSTAHWSPAKLLLIYPMLDATASFPSYASNGQDYIITRDTLLSGFEMYLQGTDLRHPEASPIWREDFAGLPPVH
ILTAEFDPLRDEGEALYHRLNDQGVACTCQRYLGVIHGFFQLGGVSKTARSAMRDVAWRVVSPSTGKMT

Sequences:

>Translated_309_residues
MPLEKGIAELVAGFIAAGRPSSREQNIDDRRAGYIASTSLAGEKEIRVKSEDIVLEGMTFRVVSPLNASGSLPCILYYHG
GCFVSGGFLTHDPQLRQLAWKSGCKVIAIQYRLAPEHTFPAAHDDAERGANIVHQYAEQLGIDRERITLAGDSAGGHLAL
VSALRLKSTAHWSPAKLLLIYPMLDATASFPSYASNGQDYIITRDTLLSGFEMYLQGTDLRHPEASPIWREDFAGLPPVH
ILTAEFDPLRDEGEALYHRLNDQGVACTCQRYLGVIHGFFQLGGVSKTARSAMRDVAWRVVSPSTGKMT
>Mature_308_residues
PLEKGIAELVAGFIAAGRPSSREQNIDDRRAGYIASTSLAGEKEIRVKSEDIVLEGMTFRVVSPLNASGSLPCILYYHGG
CFVSGGFLTHDPQLRQLAWKSGCKVIAIQYRLAPEHTFPAAHDDAERGANIVHQYAEQLGIDRERITLAGDSAGGHLALV
SALRLKSTAHWSPAKLLLIYPMLDATASFPSYASNGQDYIITRDTLLSGFEMYLQGTDLRHPEASPIWREDFAGLPPVHI
LTAEFDPLRDEGEALYHRLNDQGVACTCQRYLGVIHGFFQLGGVSKTARSAMRDVAWRVVSPSTGKMT

Specific function: Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons). Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin), but not trioleylglycerol (triolein) or cholesterol oleate. Negatively

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI206597554, Length=267, Percent_Identity=26.2172284644195, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI21328446, Length=127, Percent_Identity=37.7952755905512, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786682, Length=226, Percent_Identity=36.7256637168142, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17567059, Length=277, Percent_Identity=27.7978339350181, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71996133, Length=174, Percent_Identity=29.8850574712644, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17540028, Length=169, Percent_Identity=31.3609467455621, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI72001146, Length=142, Percent_Identity=31.6901408450704, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: 3.1.1.- [C]

Molecular weight: Translated: 33814; Mature: 33683

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS01174 LIPASE_GDXG_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLEKGIAELVAGFIAAGRPSSREQNIDDRRAGYIASTSLAGEKEIRVKSEDIVLEGMTF
CCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCEEEECCCCCCCEEEEECCCEEEECCEE
RVVSPLNASGSLPCILYYHGGCFVSGGFLTHDPQLRQLAWKSGCKVIAIQYRLAPEHTFP
EEECCCCCCCCCCEEEEEECCEEEECCEECCCHHHHHHHHHCCCEEEEEEEEECCCCCCC
AAHDDAERGANIVHQYAEQLGIDRERITLAGDSAGGHLALVSALRLKSTAHWSPAKLLLI
CCCCCHHHHHHHHHHHHHHHCCCHHEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEE
YPMLDATASFPSYASNGQDYIITRDTLLSGFEMYLQGTDLRHPEASPIWREDFAGLPPVH
EEEHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHEEECCCCCCCCCCCCCHHHCCCCCCEE
ILTAEFDPLRDEGEALYHRLNDQGVACTCQRYLGVIHGFFQLGGVSKTARSAMRDVAWRV
EEECCCCCCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEE
VSPSTGKMT
ECCCCCCCC
>Mature Secondary Structure 
PLEKGIAELVAGFIAAGRPSSREQNIDDRRAGYIASTSLAGEKEIRVKSEDIVLEGMTF
CHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCEEEECCCCCCCEEEEECCCEEEECCEE
RVVSPLNASGSLPCILYYHGGCFVSGGFLTHDPQLRQLAWKSGCKVIAIQYRLAPEHTFP
EEECCCCCCCCCCEEEEEECCEEEECCEECCCHHHHHHHHHCCCEEEEEEEEECCCCCCC
AAHDDAERGANIVHQYAEQLGIDRERITLAGDSAGGHLALVSALRLKSTAHWSPAKLLLI
CCCCCHHHHHHHHHHHHHHHCCCHHEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEE
YPMLDATASFPSYASNGQDYIITRDTLLSGFEMYLQGTDLRHPEASPIWREDFAGLPPVH
EEEHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHEEECCCCCCCCCCCCCHHHCCCCCCEE
ILTAEFDPLRDEGEALYHRLNDQGVACTCQRYLGVIHGFFQLGGVSKTARSAMRDVAWRV
EEECCCCCCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEE
VSPSTGKMT
ECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Carboxylic ester; H2O [C]

Specific reaction: Carboxylic ester + H2O = an alcohol + carboxylate [C]

General reaction: Hydrolase; Acting on ester bonds; Carboxylic ester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA