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The map label for this gene is ilvD [H]

Identifier: 194737799

GI number: 194737799

Start: 3988023

End: 3989873

Strand: Direct

Name: ilvD [H]

Synonym: SeSA_A4114

Alternate gene names: 194737799

Gene position: 3988023-3989873 (Clockwise)

Preceding gene: 194738273

Following gene: 194734502

Centisome position: 84.69

GC content: 57.64

Gene sequence:

>1851_bases
ATGCCTAAGTACCGTTCCGCCACCACCACTCATGGTCGTAATATGGCGGGTGCCCGCGCGCTGTGGCGCGCCACCGGAAT
GACCGACAGTGATTTTGGCAAACCGATTATCGCCGTGGTGAACTCATTCACTCAGTTTGTGCCGGGTCACGTTCATCTGC
GCGATCTCGGTAAGCTGGTCGCCGAACAGATTGAAGCTTCCGGCGGTGTGGCGAAAGAGTTCAACACTATTGCCGTGGAT
GACGGGATCGCCATGGGGCACGGGGGTATGCTCTATTCACTGCCGTCGCGCGAGCTGATCGCCGACTCCGTGGAGTACAT
GGTGAACGCTCACTGCGCTGACGCGATGGTGTGTATCTCTAACTGCGACAAAATCACCCCAGGGATGCTCATGGCCTCGC
TGCGCCTGAATATTCCGGTGATCTTTGTTTCCGGCGGACCGATGGAAGCCGGGAAAACCAAACTGTCCGATCAGATCATC
AAGCTCGATCTGGTTGATGCCATGATTCAGGGCGCGGACCCGAAAGTCTCTGACGATCAAAGTAACCAGGTTGAGCGCTC
CGCGTGTCCAACCTGCGGCTCCTGCTCCGGCATGTTTACCGCTAACTCCATGAATTGCCTGACCGAAGCGCTGGGCCTGT
CGCAGCCGGGCAACGGTTCGCTGCTGGCGACCCATGCTGACCGGAAGCAGTTGTTCCTCAATGCCGGTAAGCGGATTGTT
GAACTGACTAAACGCTATTACGAGCAGGATGACGAAAGTGCACTGCCGCGTAACATCGCCAGCAAAGCCGCGTTTGAGAA
TGCGATGACGCTGGATATTGCGATGGGCGGTTCGACCAATACCGTTCTGCATCTACTGGCGGCGGCGCAGGAAGCGGAAA
TCGACTTCACCATGAGTGATATCGACAAGCTGTCCCGCAAGGTGCCGCAGCTGTGTAAAGTGGCGCCAAGTACCCAGAAA
TACCATATGGAAGACGTTCACCGTGCCGGCGGTGTGCTGGGTATTTTAGGCGAGCTGGATCGCGCCGGGCTGCTGAACCG
CAACGTGAAAAACGTATTAGGCCTGACGCTGCCACAAACGCTGGAACAGTACGACATCACGGTTACGCAGGACGAAGCGG
TTAAAAAAATGTTCCGTGCTGGCCCTGCCGGTATTCGTACTACCCAGGCATTCTCGCAGGATTGTCGCTGGGATTCGCTG
GATGACGACCGCGCAGCGGGTTGCATCCGCTCGCTGGAATATGCCTATAGCAAAGACGGCGGTCTGGCGGTGCTGTATGG
CAACTTCGCCGAAAACGGCTGCATCGTTAAAACCGCGGGCGTCGATGATAGCATCCTTAAATTCACCGGCCCGGCGAAAG
TATATGAAAGCCAGGACGACGCGGTAGAGGCGATTCTCGGCGGCAAAGTAGTGGAAGGCGATGTAGTCGTGATCCGCTAC
GAAGGGCCGAAAGGCGGGCCGGGAATGCAGGAAATGCTCTATCCGACCAGTTTCCTGAAGTCGATGGGGCTGGGCAAAGC
CTGCGCGCTCATCACCGATGGGCGTTTCTCCGGCGGTACTTCGGGTCTTTCCATCGGCCACGTCTCGCCGGAAGCGGCCA
GCGGCGGCACTATTGCGCTGATTGAAGATGGCGACACCATTGCGATTGATATCCCGAACCGCAGCATTCAGTTGCAGTTG
AACGAGGCTGAAATCGCCGCACGCCGCGAGGCGCAAGAAGCTCGTGGCGACAAAGCCTGGACGCCGAAAAATCGTCAGCG
TCAGGTTTCGTTTGCCCTGCGTGCCTACGCCAGCCTGGCGACCAGCGCCGATAAAGGCGCGGTGCGCGATAAATCGAAAC
TGGGAGGTTGA

Upstream 100 bases:

>100_bases
AATCCCCAGGGCTTACTGTAGTAAGTGACTGGGGTGAGTGAGGCAGCCAACGCACCTGTGGCGTGAAGTATGAAGGGAAA
AGATGGGGAGTAAATAAAGC

Downstream 100 bases:

>100_bases
TGATGGCGGAATCTCAACCTCTGTCAGTCGCGCCGGAAGGGGCGGAGTATCTGCGCGCGGTGCTACGCGCGCCAGTATAC
GAAGCGGCGCAGGTGACGCC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 616; Mature: 615

Protein sequence:

>616_residues
MPKYRSATTTHGRNMAGARALWRATGMTDSDFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIEASGGVAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDQII
KLDLVDAMIQGADPKVSDDQSNQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLNAGKRIV
ELTKRYYEQDDESALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMSDIDKLSRKVPQLCKVAPSTQK
YHMEDVHRAGGVLGILGELDRAGLLNRNVKNVLGLTLPQTLEQYDITVTQDEAVKKMFRAGPAGIRTTQAFSQDCRWDSL
DDDRAAGCIRSLEYAYSKDGGLAVLYGNFAENGCIVKTAGVDDSILKFTGPAKVYESQDDAVEAILGGKVVEGDVVVIRY
EGPKGGPGMQEMLYPTSFLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGTIALIEDGDTIAIDIPNRSIQLQL
NEAEIAARREAQEARGDKAWTPKNRQRQVSFALRAYASLATSADKGAVRDKSKLGG

Sequences:

>Translated_616_residues
MPKYRSATTTHGRNMAGARALWRATGMTDSDFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIEASGGVAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDQII
KLDLVDAMIQGADPKVSDDQSNQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLNAGKRIV
ELTKRYYEQDDESALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMSDIDKLSRKVPQLCKVAPSTQK
YHMEDVHRAGGVLGILGELDRAGLLNRNVKNVLGLTLPQTLEQYDITVTQDEAVKKMFRAGPAGIRTTQAFSQDCRWDSL
DDDRAAGCIRSLEYAYSKDGGLAVLYGNFAENGCIVKTAGVDDSILKFTGPAKVYESQDDAVEAILGGKVVEGDVVVIRY
EGPKGGPGMQEMLYPTSFLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGTIALIEDGDTIAIDIPNRSIQLQL
NEAEIAARREAQEARGDKAWTPKNRQRQVSFALRAYASLATSADKGAVRDKSKLGG
>Mature_615_residues
PKYRSATTTHGRNMAGARALWRATGMTDSDFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIEASGGVAKEFNTIAVDD
GIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDQIIK
LDLVDAMIQGADPKVSDDQSNQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLNAGKRIVE
LTKRYYEQDDESALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMSDIDKLSRKVPQLCKVAPSTQKY
HMEDVHRAGGVLGILGELDRAGLLNRNVKNVLGLTLPQTLEQYDITVTQDEAVKKMFRAGPAGIRTTQAFSQDCRWDSLD
DDRAAGCIRSLEYAYSKDGGLAVLYGNFAENGCIVKTAGVDDSILKFTGPAKVYESQDDAVEAILGGKVVEGDVVVIRYE
GPKGGPGMQEMLYPTSFLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGTIALIEDGDTIAIDIPNRSIQLQLN
EAEIAARREAQEARGDKAWTPKNRQRQVSFALRAYASLATSADKGAVRDKSKLGG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=616, Percent_Identity=95.7792207792208, Blast_Score=1228, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=539, Percent_Identity=29.8701298701299, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI2367371, Length=546, Percent_Identity=28.7545787545788, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1786464, Length=533, Percent_Identity=29.8311444652908, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6322476, Length=615, Percent_Identity=36.5853658536585, Blast_Score=337, Evalue=3e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65731; Mature: 65599

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKYRSATTTHGRNMAGARALWRATGMTDSDFGKPIIAVVNSFTQFVPGHVHLRDLGKLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AEQIEASGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHCCCCCCCCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDQIIKLDLVDAMIQGADPKVSDDQ
CCCCCCHHHHHHHEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
SNQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLNAGKRIV
CCCHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHH
ELTKRYYEQDDESALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMSD
HHHHHHHCCCCCHHCCHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEHHH
IDKLSRKVPQLCKVAPSTQKYHMEDVHRAGGVLGILGELDRAGLLNRNVKNVLGLTLPQT
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEEHHHHHHHHHHCCCHHHHHCCCCHHH
LEQYDITVTQDEAVKKMFRAGPAGIRTTQAFSQDCRWDSLDDDRAAGCIRSLEYAYSKDG
HHHHCCEEEHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCC
GLAVLYGNFAENGCIVKTAGVDDSILKFTGPAKVYESQDDAVEAILGGKVVEGDVVVIRY
CEEEEECCCCCCCCEEEECCCCCCCEEECCCHHHHCCCHHHHHHHHCCEEEECCEEEEEE
EGPKGGPGMQEMLYPTSFLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGTIAL
CCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEE
IEDGDTIAIDIPNRSIQLQLNEAEIAARREAQEARGDKAWTPKNRQRQVSFALRAYASLA
EECCCEEEEECCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
TSADKGAVRDKSKLGG
CCCCCCCCCCHHHCCC
>Mature Secondary Structure 
PKYRSATTTHGRNMAGARALWRATGMTDSDFGKPIIAVVNSFTQFVPGHVHLRDLGKLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AEQIEASGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHCCCCCCCCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDQIIKLDLVDAMIQGADPKVSDDQ
CCCCCCHHHHHHHEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
SNQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLNAGKRIV
CCCHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHH
ELTKRYYEQDDESALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMSD
HHHHHHHCCCCCHHCCHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEHHH
IDKLSRKVPQLCKVAPSTQKYHMEDVHRAGGVLGILGELDRAGLLNRNVKNVLGLTLPQT
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEEHHHHHHHHHHCCCHHHHHCCCCHHH
LEQYDITVTQDEAVKKMFRAGPAGIRTTQAFSQDCRWDSLDDDRAAGCIRSLEYAYSKDG
HHHHCCEEEHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCC
GLAVLYGNFAENGCIVKTAGVDDSILKFTGPAKVYESQDDAVEAILGGKVVEGDVVVIRY
CEEEEECCCCCCCCEEEECCCCCCCEEECCCHHHHCCCHHHHHHHHCCEEEECCEEEEEE
EGPKGGPGMQEMLYPTSFLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGTIAL
CCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEE
IEDGDTIAIDIPNRSIQLQLNEAEIAARREAQEARGDKAWTPKNRQRQVSFALRAYASLA
EECCCEEEEECCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
TSADKGAVRDKSKLGG
CCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA