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The map label for this gene is hemF [H]

Identifier: 194737732

GI number: 194737732

Start: 2563453

End: 2564352

Strand: Direct

Name: hemF [H]

Synonym: SeSA_A2687

Alternate gene names: 194737732

Gene position: 2563453-2564352 (Clockwise)

Preceding gene: 194734579

Following gene: 194734430

Centisome position: 54.44

GC content: 57.33

Gene sequence:

>900_bases
ATGAAACCCGATGCACATCACGTAAAACAGTTTCTGCTACGCCTGCAGGATGATATTTGCCAAAAGTTATCCGCTGCGGA
TGGCGCAAACTTTGTCGAAGATAGCTGGCGACGCGAAGCGGGCGGCGGCGGACGCAGCCGGGTATTACGCAACGGCGGGA
TTTTCGAACAGGCGGGCGTTAATTTCTCTCACGTTCACGGCGATGCAATGCCCGCGTCCGCCACCGCGCATCGGCCAGAA
CTGGCCGGGCGTAGTTTTGAAGCGATGGGCGTATCGCTGGTGGTGCATCCGCACAATCCGTATATTCCCACCAGCCATGC
TAACGTGCGCTTTTTTATTGCCGAAAAACCGGGCGCCGATCCGGTGTGGTGGTTTGGCGGCGGGTTCGATTTAACGCCCT
ACTACGGCTTTGAAGAGGATGCCGTTCACTGGCACCGCACCGCCCGCGACCTGTGCCAGCCGTTTGGCGACGATGTGTAT
CCGCGTTATAAAAAGTGGTGCGACGACTACTTTTTCCTCAAGCATCGTAACGAGCAGCGCGGCGTTGGCGGCCTTTTTTT
TGACGATTTGAATACGCCGGATTTCGACCACTGTTTTGCTTTTATGCAGGCGGTCGGTAACGGCTACACCCAGGCGTATT
TACCGATTGTCGAACGACGCAAAGCGATGGTCTGGGGCGAGCGGGAGCGTAATTTTCAACTTTATCGCCGCGGGCGCTAC
GTGGAGTTCAACCTGGTGTGGGACAGAGGCACCCTGTTTGGTCTGCAAACCGGCGGGCGCACTGAATCTATCCTGATGTC
GATGCCGCCGCTGGTGCGCTGGGAGTACGACTGGCAGCCAGAAGCGGGTAGCCCGGAAGCGGCGCTGAGCGAGTTTATTC
AGGTACGCGACTGGGTGTAA

Upstream 100 bases:

>100_bases
CGGCGTTTCGCCAGAAAATCGCTACGGCGATCGCCAACGGCATCATCAGTTATTTTCACTGGTTTGATAATCAGAAAGCA
CACACGAAGAAACGGTAATC

Downstream 100 bases:

>100_bases
TTGCCTGATAGCGCTACGCTTATCAGGCCTACAACCACAACGGCACCGCCCCGTAGGCCGGATAAGACGCAAAGCGTCGC
ATCCGGCACAAGAATGCCAT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MKPDAHHVKQFLLRLQDDICQKLSAADGANFVEDSWRREAGGGGRSRVLRNGGIFEQAGVNFSHVHGDAMPASATAHRPE
LAGRSFEAMGVSLVVHPHNPYIPTSHANVRFFIAEKPGADPVWWFGGGFDLTPYYGFEEDAVHWHRTARDLCQPFGDDVY
PRYKKWCDDYFFLKHRNEQRGVGGLFFDDLNTPDFDHCFAFMQAVGNGYTQAYLPIVERRKAMVWGERERNFQLYRRGRY
VEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDWQPEAGSPEAALSEFIQVRDWV

Sequences:

>Translated_299_residues
MKPDAHHVKQFLLRLQDDICQKLSAADGANFVEDSWRREAGGGGRSRVLRNGGIFEQAGVNFSHVHGDAMPASATAHRPE
LAGRSFEAMGVSLVVHPHNPYIPTSHANVRFFIAEKPGADPVWWFGGGFDLTPYYGFEEDAVHWHRTARDLCQPFGDDVY
PRYKKWCDDYFFLKHRNEQRGVGGLFFDDLNTPDFDHCFAFMQAVGNGYTQAYLPIVERRKAMVWGERERNFQLYRRGRY
VEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDWQPEAGSPEAALSEFIQVRDWV
>Mature_299_residues
MKPDAHHVKQFLLRLQDDICQKLSAADGANFVEDSWRREAGGGGRSRVLRNGGIFEQAGVNFSHVHGDAMPASATAHRPE
LAGRSFEAMGVSLVVHPHNPYIPTSHANVRFFIAEKPGADPVWWFGGGFDLTPYYGFEEDAVHWHRTARDLCQPFGDDVY
PRYKKWCDDYFFLKHRNEQRGVGGLFFDDLNTPDFDHCFAFMQAVGNGYTQAYLPIVERRKAMVWGERERNFQLYRRGRY
VEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDWQPEAGSPEAALSEFIQVRDWV

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=299, Percent_Identity=48.1605351170569, Blast_Score=281, Evalue=4e-76,
Organism=Escherichia coli, GI1788777, Length=299, Percent_Identity=90.9698996655518, Blast_Score=579, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6320249, Length=317, Percent_Identity=42.2712933753943, Blast_Score=251, Evalue=1e-67,
Organism=Drosophila melanogaster, GI17864388, Length=304, Percent_Identity=46.3815789473684, Blast_Score=281, Evalue=3e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 34343; Mature: 34343

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPDAHHVKQFLLRLQDDICQKLSAADGANFVEDSWRREAGGGGRSRVLRNGGIFEQAGV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHCCCCCHHCCC
NFSHVHGDAMPASATAHRPELAGRSFEAMGVSLVVHPHNPYIPTSHANVRFFIAEKPGAD
CEEEECCCCCCCCCCCCCCHHCCCCEEECCEEEEEECCCCCCCCCCCCEEEEEEECCCCC
PVWWFGGGFDLTPYYGFEEDAVHWHRTARDLCQPFGDDVYPRYKKWCDDYFFLKHRNEQR
CEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCHHEEEECCCCCC
GVGGLFFDDLNTPDFDHCFAFMQAVGNGYTQAYLPIVERRKAMVWGERERNFQLYRRGRY
CCCCEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHEECCCCE
VEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDWQPEAGSPEAALSEFIQVRDWV
EEEEEEECCCEEEEECCCCCCHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKPDAHHVKQFLLRLQDDICQKLSAADGANFVEDSWRREAGGGGRSRVLRNGGIFEQAGV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHCCCCCHHCCC
NFSHVHGDAMPASATAHRPELAGRSFEAMGVSLVVHPHNPYIPTSHANVRFFIAEKPGAD
CEEEECCCCCCCCCCCCCCHHCCCCEEECCEEEEEECCCCCCCCCCCCEEEEEEECCCCC
PVWWFGGGFDLTPYYGFEEDAVHWHRTARDLCQPFGDDVYPRYKKWCDDYFFLKHRNEQR
CEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCHHEEEECCCCCC
GVGGLFFDDLNTPDFDHCFAFMQAVGNGYTQAYLPIVERRKAMVWGERERNFQLYRRGRY
CCCCEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHEECCCCE
VEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDWQPEAGSPEAALSEFIQVRDWV
EEEEEEECCCEEEEECCCCCCHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA