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The map label for this gene is hemN [H]

Identifier: 194737437

GI number: 194737437

Start: 4099193

End: 4100434

Strand: Reverse

Name: hemN [H]

Synonym: SeSA_A4222

Alternate gene names: 194737437

Gene position: 4100434-4099193 (Counterclockwise)

Preceding gene: 194734374

Following gene: 194737434

Centisome position: 87.08

GC content: 48.15

Gene sequence:

>1242_bases
ATGAATAACAATGATATTTATCGTCAGTATATGTACAGTTATCCGCATAAGACGGCTTATCGGGAGCTGGAGAACGTCAG
CTTTAGCGAAGTAAAACCGCGCATTTACGAGCACGACACACATCTGTATGTTCATATGCCCTTTTGTCAAAGTCGCTGCG
GGTTCTGTAATTTATTTACCTGCACAGGCGCAGATAATACGTTCATTGATAGCTATATCGATGCGATTATTACCCAGGGC
CGACAAATGGCGCTGGCGCCCGTCCACTGGGCAAGCTTTACCGTAGGCGGCGGCACGCCTCTGCTATTAAACATTGCGCA
ATTAGAAAAGTTATTTTTTTCCGTCTTTGAGGTGCTCAATGTTGACTGGAATATTTATAAAACAATTGAAACTTCCCCTA
CGGATACCACAGCAGAAAAAGTAGCGCTATTAAACGCCTTTTCCGTTAATCGCGTCAGTATTGGCGTACAAAGTTTTCAT
GATAGCGAGTTACATACGCTGCATCGCCGCCACAATGCCGCCAGCGCGCACCAGGCGCTGGAGTGGCTAAAGGCGGGTCA
TTTTCCATCACTCAATATTGATATTATTTACGGCATTCCCGGCCAGACTCACGCAAGCCTGACGGAATCGTTACATCAGG
CGCTCGTTTATCAACCGGAAGAGCTGTTTATTTATCCGCTTTATAATATGCCTCGCCAGGAAAATATGCATAGCTACTAC
GTTGTAGCCCGCGATCTTTTACGCAACGCGGGCTACACCCAAACGTCCATGCGCCGTTTCGTCCTTAATCCAGCGCCATT
CGCCGCGGCGGAAAGCTGCGGATTTGAAAACTCACTGGCGCTCGGCGCGGGCGGCAGAAGTTATCTTGGCAATCTGCATT
ACTGTTCGCCGTGGTCGTCGAACCTGCAAACATCACGAAAAATCATTCAGGCGTTTATCGACAGCGCGGATAAAACCGTC
ATTAATCACGGTTATCTGCTCCCCCCTGATGAAATGAAACGCCGCTTTATCATTAAAAATCTATTTTTCTGGCAGGGACT
TTCTCTTAGCGATTATCAGCAATATTTTGCCAGCGATGCGCTAAGGGATTTCCCCGACCTTGAACTCTTCATACGGCAGG
GTTACTGCTATCAGAATGGCAGTCGCCTCCGGCTAACGGAGACCGGTATGGCATTATCCGATTGCCTTGCTCCTGTGTTC
GTTTCGCCTGAGGTGATGCTACGGGAGAATCGGCAGAGATGA

Upstream 100 bases:

>100_bases
ACCTGCTATGGCGAAGACGGGAAATATTTCCATAGTTTTAACCATCCGATCGTTAATACCGTTCCCTATATGCATTTCTT
GCTGAGCTGTAATCATTAAT

Downstream 100 bases:

>100_bases
GCATCCCCGCCCTGCGCGATATTCACACGCTGTTTTATCGCGGCTACCTTAAATCGTGTAATTATCATTGCGGCTATTGC
CCGTTCCATAAACACGCCCG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MNNNDIYRQYMYSYPHKTAYRELENVSFSEVKPRIYEHDTHLYVHMPFCQSRCGFCNLFTCTGADNTFIDSYIDAIITQG
RQMALAPVHWASFTVGGGTPLLLNIAQLEKLFFSVFEVLNVDWNIYKTIETSPTDTTAEKVALLNAFSVNRVSIGVQSFH
DSELHTLHRRHNAASAHQALEWLKAGHFPSLNIDIIYGIPGQTHASLTESLHQALVYQPEELFIYPLYNMPRQENMHSYY
VVARDLLRNAGYTQTSMRRFVLNPAPFAAAESCGFENSLALGAGGRSYLGNLHYCSPWSSNLQTSRKIIQAFIDSADKTV
INHGYLLPPDEMKRRFIIKNLFFWQGLSLSDYQQYFASDALRDFPDLELFIRQGYCYQNGSRLRLTETGMALSDCLAPVF
VSPEVMLRENRQR

Sequences:

>Translated_413_residues
MNNNDIYRQYMYSYPHKTAYRELENVSFSEVKPRIYEHDTHLYVHMPFCQSRCGFCNLFTCTGADNTFIDSYIDAIITQG
RQMALAPVHWASFTVGGGTPLLLNIAQLEKLFFSVFEVLNVDWNIYKTIETSPTDTTAEKVALLNAFSVNRVSIGVQSFH
DSELHTLHRRHNAASAHQALEWLKAGHFPSLNIDIIYGIPGQTHASLTESLHQALVYQPEELFIYPLYNMPRQENMHSYY
VVARDLLRNAGYTQTSMRRFVLNPAPFAAAESCGFENSLALGAGGRSYLGNLHYCSPWSSNLQTSRKIIQAFIDSADKTV
INHGYLLPPDEMKRRFIIKNLFFWQGLSLSDYQQYFASDALRDFPDLELFIRQGYCYQNGSRLRLTETGMALSDCLAPVF
VSPEVMLRENRQR
>Mature_413_residues
MNNNDIYRQYMYSYPHKTAYRELENVSFSEVKPRIYEHDTHLYVHMPFCQSRCGFCNLFTCTGADNTFIDSYIDAIITQG
RQMALAPVHWASFTVGGGTPLLLNIAQLEKLFFSVFEVLNVDWNIYKTIETSPTDTTAEKVALLNAFSVNRVSIGVQSFH
DSELHTLHRRHNAASAHQALEWLKAGHFPSLNIDIIYGIPGQTHASLTESLHQALVYQPEELFIYPLYNMPRQENMHSYY
VVARDLLRNAGYTQTSMRRFVLNPAPFAAAESCGFENSLALGAGGRSYLGNLHYCSPWSSNLQTSRKIIQAFIDSADKTV
INHGYLLPPDEMKRRFIIKNLFFWQGLSLSDYQQYFASDALRDFPDLELFIRQGYCYQNGSRLRLTETGMALSDCLAPVF
VSPEVMLRENRQR

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=267, Percent_Identity=26.5917602996255, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI87082341, Length=235, Percent_Identity=28.5106382978723, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1789325, Length=234, Percent_Identity=26.9230769230769, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 47276; Mature: 47276

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNNDIYRQYMYSYPHKTAYRELENVSFSEVKPRIYEHDTHLYVHMPFCQSRCGFCNLFT
CCCCHHHHHHHHHCCCHHHHHHHHCCCHHHHCCCEEECCCEEEEECCHHHCCCCEEEEEE
CTGADNTFIDSYIDAIITQGRQMALAPVHWASFTVGGGTPLLLNIAQLEKLFFSVFEVLN
ECCCCCHHHHHHHHHHHHCCCCEEEEEEEEHEEEECCCCHHEEEHHHHHHHHHHHHHHHC
VDWNIYKTIETSPTDTTAEKVALLNAFSVNRVSIGVQSFHDSELHTLHRRHNAASAHQAL
CCCEEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEHHHCCCHHHHHHHHHHCHHHHHHHH
EWLKAGHFPSLNIDIIYGIPGQTHASLTESLHQALVYQPEELFIYPLYNMPRQENMHSYY
HHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHH
VVARDLLRNAGYTQTSMRRFVLNPAPFAAAESCGFENSLALGAGGRSYLGNLHYCSPWSS
HHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHCCCCCCEEECCCCHHHHCCCEECCCCCC
NLQTSRKIIQAFIDSADKTVINHGYLLPPDEMKRRFIIKNLFFWQGLSLSDYQQYFASDA
HHHHHHHHHHHHHCCCCCEECCCCEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LRDFPDLELFIRQGYCYQNGSRLRLTETGMALSDCLAPVFVSPEVMLRENRQR
HHCCCCHHHHHHCCEEEECCCEEEEEECCCHHHHHHHHHHCCCHHHHHCCCCC
>Mature Secondary Structure
MNNNDIYRQYMYSYPHKTAYRELENVSFSEVKPRIYEHDTHLYVHMPFCQSRCGFCNLFT
CCCCHHHHHHHHHCCCHHHHHHHHCCCHHHHCCCEEECCCEEEEECCHHHCCCCEEEEEE
CTGADNTFIDSYIDAIITQGRQMALAPVHWASFTVGGGTPLLLNIAQLEKLFFSVFEVLN
ECCCCCHHHHHHHHHHHHCCCCEEEEEEEEHEEEECCCCHHEEEHHHHHHHHHHHHHHHC
VDWNIYKTIETSPTDTTAEKVALLNAFSVNRVSIGVQSFHDSELHTLHRRHNAASAHQAL
CCCEEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEHHHCCCHHHHHHHHHHCHHHHHHHH
EWLKAGHFPSLNIDIIYGIPGQTHASLTESLHQALVYQPEELFIYPLYNMPRQENMHSYY
HHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHH
VVARDLLRNAGYTQTSMRRFVLNPAPFAAAESCGFENSLALGAGGRSYLGNLHYCSPWSS
HHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHCCCCCCEEECCCCHHHHCCCEECCCCCC
NLQTSRKIIQAFIDSADKTVINHGYLLPPDEMKRRFIIKNLFFWQGLSLSDYQQYFASDA
HHHHHHHHHHHHHCCCCCEECCCCEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LRDFPDLELFIRQGYCYQNGSRLRLTETGMALSDCLAPVFVSPEVMLRENRQR
HHCCCCHHHHHHCCEEEECCCEEEEEECCCHHHHHHHHHHCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]