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The map label for this gene is mscM [H]

Identifier: 194737417

GI number: 194737417

Start: 708600

End: 709847

Strand: Reverse

Name: mscM [H]

Synonym: SeSA_A0736

Alternate gene names: 194737417

Gene position: 709847-708600 (Counterclockwise)

Preceding gene: 194738400

Following gene: 194736420

Centisome position: 15.07

GC content: 49.6

Gene sequence:

>1248_bases
ATGCAGGAATTGATATCCCAGGTAGAAGATTTAGCGGGAATTGAAATGAATCACACCACGTCGCTGGTGGTGATATTTGG
TATTATTTTTCTGACGGCAGTTGTCGTGCATATTATTTTGCACTGGATAGTACTGCGCGCTTTCGAAAAACGTGCCAGCG
CCAGTTCCCGCCTGTGGCTGCAAATTATTACCCAGAATAAATTATTCCATCGTCTGGCTTTTACGCTGCAAGGCATCATT
GTCAATATTCAGGCCGCGCTCTGGCTACAAAAAGGCAGTGAGGCTGCGGATATCCTGACGACCTGCGCGCAGTTATGGAT
TATGACCTACGCCCTGCTGTCGTTATTTTCTCTGCTGGACGTGATTTTCAATCTATCGCAAAAATGGCCCGCCGCCTCTC
AGTTACCGCTAAAAGGAATATTTCAGGGCATTAAGCTCATCGGCGCTATTATCGTCGGCATTCTGATGATCTCACTGCTG
ATTGGCCAGTCACCAGCAATTTTAATCAGCGGGCTGGGCGCGATGGCCGCGGTATTAATGCTGGTCTTTAAAGACCCGAT
TCTTGGCCTGGTTGCCGGTATCCAGCTTTCCGCCAACGATATGCTCAAACTGGGCGACTGGCTGGAAATGCCGAAATATG
GCGCAGATGGCGCGGTCATTGATATTGGCTTAACCACGGTAAAAGTACGCAACTGGGATAATACCATCACCACCATTCCC
ACCTGGTCACTGGTTTCCGACTCGTTCAAAAACTGGAGCGGCATGTCTGCGTCCGGCGGACGCCGGATTAAACGCAGCAT
TAATATTGACGCGACCAGTATCCATTTTCTGGATGCTGATGAAAAACAGCGGCTGTTAACCGCGCAACTGTTAAAGCCGT
ACCTTACCAGCCGTCATCAGGAAATCGATGAATGGAATAAACAACTGGATGCGCCGGAATCAGCCTTAAATCACCGCCGA
ATGACCAATATCGGGACATTTCGCGCCTATCTGAACGAATATTTACGCCACCATCCGCGCATCCGTAAAGATATGACGCT
GATGGTACGCCAACTGGCGCCTGACGATCATGGTTTGCCGATAGAGATCTACGCCTTTACCAATACCGTCGTGTGGCTGG
AATATGAGAGCATTCAGGCCGATATTTTCGACCATATATTTGCGGTGGTGGAAGAGTTCGGCTTGCGTATTCATCAGACG
CCGACCGGCAGCGATATTCGCGCGCTGTCAGGGACATTGCGGCATTAA

Upstream 100 bases:

>100_bases
TTACCCGTCTGTTGCTGATTATGCCTGAAGCGCGAGCGTCCTGATTTGCATAAATGCCATTCAGCAGTCATCATAGGCTG
CTGTTTATAAAGGAGAGATT

Downstream 100 bases:

>100_bases
TGGATTGCCCGATCGCATGAGCATGGGATCGGGCAAAAAAGTTAATGAGCCTTACGGCGCAAAACTGTAAACGCGATAAA
CAGGAATACAATCCATACCG

Product: transporter small conductance mechanosensitive ion channel

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MQELISQVEDLAGIEMNHTTSLVVIFGIIFLTAVVVHIILHWIVLRAFEKRASASSRLWLQIITQNKLFHRLAFTLQGII
VNIQAALWLQKGSEAADILTTCAQLWIMTYALLSLFSLLDVIFNLSQKWPAASQLPLKGIFQGIKLIGAIIVGILMISLL
IGQSPAILISGLGAMAAVLMLVFKDPILGLVAGIQLSANDMLKLGDWLEMPKYGADGAVIDIGLTTVKVRNWDNTITTIP
TWSLVSDSFKNWSGMSASGGRRIKRSINIDATSIHFLDADEKQRLLTAQLLKPYLTSRHQEIDEWNKQLDAPESALNHRR
MTNIGTFRAYLNEYLRHHPRIRKDMTLMVRQLAPDDHGLPIEIYAFTNTVVWLEYESIQADIFDHIFAVVEEFGLRIHQT
PTGSDIRALSGTLRH

Sequences:

>Translated_415_residues
MQELISQVEDLAGIEMNHTTSLVVIFGIIFLTAVVVHIILHWIVLRAFEKRASASSRLWLQIITQNKLFHRLAFTLQGII
VNIQAALWLQKGSEAADILTTCAQLWIMTYALLSLFSLLDVIFNLSQKWPAASQLPLKGIFQGIKLIGAIIVGILMISLL
IGQSPAILISGLGAMAAVLMLVFKDPILGLVAGIQLSANDMLKLGDWLEMPKYGADGAVIDIGLTTVKVRNWDNTITTIP
TWSLVSDSFKNWSGMSASGGRRIKRSINIDATSIHFLDADEKQRLLTAQLLKPYLTSRHQEIDEWNKQLDAPESALNHRR
MTNIGTFRAYLNEYLRHHPRIRKDMTLMVRQLAPDDHGLPIEIYAFTNTVVWLEYESIQADIFDHIFAVVEEFGLRIHQT
PTGSDIRALSGTLRH
>Mature_415_residues
MQELISQVEDLAGIEMNHTTSLVVIFGIIFLTAVVVHIILHWIVLRAFEKRASASSRLWLQIITQNKLFHRLAFTLQGII
VNIQAALWLQKGSEAADILTTCAQLWIMTYALLSLFSLLDVIFNLSQKWPAASQLPLKGIFQGIKLIGAIIVGILMISLL
IGQSPAILISGLGAMAAVLMLVFKDPILGLVAGIQLSANDMLKLGDWLEMPKYGADGAVIDIGLTTVKVRNWDNTITTIP
TWSLVSDSFKNWSGMSASGGRRIKRSINIDATSIHFLDADEKQRLLTAQLLKPYLTSRHQEIDEWNKQLDAPESALNHRR
MTNIGTFRAYLNEYLRHHPRIRKDMTLMVRQLAPDDHGLPIEIYAFTNTVVWLEYESIQADIFDHIFAVVEEFGLRIHQT
PTGSDIRALSGTLRH

Specific function: Mechanosensitive channel of miniconductance that confers protection against mild hypoosmotic shock. Overexpression confers protection against severe shocks [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1786791, Length=415, Percent_Identity=88.6746987951807, Blast_Score=757, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685 [H]

Pfam domain/function: PF00924 MS_channel [H]

EC number: NA

Molecular weight: Translated: 46523; Mature: 46523

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQELISQVEDLAGIEMNHTTSLVVIFGIIFLTAVVVHIILHWIVLRAFEKRASASSRLWL
CHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
QIITQNKLFHRLAFTLQGIIVNIQAALWLQKGSEAADILTTCAQLWIMTYALLSLFSLLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIFNLSQKWPAASQLPLKGIFQGIKLIGAIIVGILMISLLIGQSPAILISGLGAMAAVLM
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LVFKDPILGLVAGIQLSANDMLKLGDWLEMPKYGADGAVIDIGLTTVKVRNWDNTITTIP
HHHHCHHHHHHHCCEECCCHHHHHHHHHHCCCCCCCCCEEEECEEEEEEECCCCCEEECC
TWSLVSDSFKNWSGMSASGGRRIKRSINIDATSIHFLDADEKQRLLTAQLLKPYLTSRHQ
CHHHHHHHHCCCCCCCCCCCHHHHHEECCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHH
EIDEWNKQLDAPESALNHRRMTNIGTFRAYLNEYLRHHPRIRKDMTLMVRQLAPDDHGLP
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCC
IEIYAFTNTVVWLEYESIQADIFDHIFAVVEEFGLRIHQTPTGSDIRALSGTLRH
EEEEEEECEEEEEEEHHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MQELISQVEDLAGIEMNHTTSLVVIFGIIFLTAVVVHIILHWIVLRAFEKRASASSRLWL
CHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
QIITQNKLFHRLAFTLQGIIVNIQAALWLQKGSEAADILTTCAQLWIMTYALLSLFSLLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIFNLSQKWPAASQLPLKGIFQGIKLIGAIIVGILMISLLIGQSPAILISGLGAMAAVLM
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LVFKDPILGLVAGIQLSANDMLKLGDWLEMPKYGADGAVIDIGLTTVKVRNWDNTITTIP
HHHHCHHHHHHHCCEECCCHHHHHHHHHHCCCCCCCCCEEEECEEEEEEECCCCCEEECC
TWSLVSDSFKNWSGMSASGGRRIKRSINIDATSIHFLDADEKQRLLTAQLLKPYLTSRHQ
CHHHHHHHHCCCCCCCCCCCHHHHHEECCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHH
EIDEWNKQLDAPESALNHRRMTNIGTFRAYLNEYLRHHPRIRKDMTLMVRQLAPDDHGLP
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCC
IEIYAFTNTVVWLEYESIQADIFDHIFAVVEEFGLRIHQTPTGSDIRALSGTLRH
EEEEEEECEEEEEEEHHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 7813889 [H]