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The map label for this gene is uhpC [H]

Identifier: 194737383

GI number: 194737383

Start: 3869426

End: 3870754

Strand: Reverse

Name: uhpC [H]

Synonym: SeSA_A3998

Alternate gene names: 194737383

Gene position: 3870754-3869426 (Counterclockwise)

Preceding gene: 194734624

Following gene: 194734414

Centisome position: 82.2

GC content: 59.89

Gene sequence:

>1329_bases
ATGCTTTCGTTTTTAAAAGCCCCGGCCAACGCGCCGCTCATCACCGATAAGCACGAGGTTGACGCCCGCTATCGCTACTG
GCGGCGGCACATCCTGATCACCATTTGGTTGGGTTATGCGCTGTTCTATTTCACCCGTAAAAGCTTTAACGCCGCCGCGC
CGGAAATCCTTGCCAGCGGCATTCTGACCCGCAGCGATATCGGCCTGCTGGCGACGCTGTTTTACATCACCTACGGGGTG
TCGAAATTTGTTTCCGGCATCGTTAGCGATCGCTCCAACGCTCGCTATTTTATGGGCATCGGGCTGATTGCGACCGGCGT
AGTGAATATTCTGTTCGGCTTCTCGACCTCGCTGTGGGCCTTTGCTCTGCTATGGGCGTTGAATGCCTTTTTCCAGGGGT
TTGGATCGCCGGTTTGCGCCCGTTTGCTGACCGCCTGGTACTCGCGTACCGAACGCGGCGGCTGGTGGGCGTTATGGAAC
ACCGCGCATAATGTCGGCGGGGCGCTGATCCCTCTCGTCATGGCCGCTGTCGCCCTGCATTATGGCTGGCGCGTCGGAAT
GATGGTGGCCGGATTGCTTGCCATCGGGGTGGGCATGGTCCTCTGCTGGCGGCTGCGCGACCGTCCGCAGGCGATTGGTT
TACCGCCGGTAGGCGACTGGCGGCACGATGCGCTGGAGGTAGCCCAACAGCAAGAGGGCGCGGGGCTAAGCCGCAAAGAA
ATCCTCGCTAAATATGTGCTGTTGAATCCCTATATCTGGCTGCTTTCGCTGTGTTACGTCTTAGTGTACGTGGTGCGCGC
GGCGATCAATGACTGGGGCAACCTGTATATGTCCGAGACGCTGGGCGTAGATTTGGTCACGGCCAACACGGCAGTATCGA
TGTTTGAGCTGGGGGGATTTATCGGCGCGCTGGTGGCGGGCTGGGGCTCGGACAAACTCTTCAACGGCAACCGCGGACCG
ATGAATTTAATCTTCGCCGCCGGGATTCTGCTCTCTGTGGGTTCGCTGTGGCTGATGCCGTTCGCCAGTTACGTGATGCA
GGCGGCCTGTTTCTTCACCACCGGTTTCTTTGTTTTCGGCCCGCAGATGCTCATTGGCATGGCGGCGGCGGAGTGCTCGC
ATAAAGAGGCGGCGGGCGCGGCCACCGGCTTTGTCGGCCTGTTCGCCTATCTCGGCGCGTCGCTTTCCGGCTGGCCGTTA
GCGAAAGTGCTGGAGATCTGGCACTGGACCGGTTTTTTTGCGGTCATCGCCATCGCGGCGGGGATCTCCGCGCTATTGCT
GCTGCCATTTCTGAACGCCCAGGCCCCACGCGAGACCAGCGAAGCGTGA

Upstream 100 bases:

>100_bases
CGAACGCGTGTCGGCGCTCGGCGGGACGCTAACCATCTCTTGTACCCACGGTACGCGGGTGAGCGTCTCGTTGCCCCAGC
GTTACGTTTAAGGAAGGATA

Downstream 100 bases:

>100_bases
CGCACCTCACCTTTTTGCGCTGAATGGGGCAAAACTAAGAAATTTTCCCGGTTTTGCCTGGACGCTGTCGCAGGCCACTT
TTCCTGTGGATTTTTACAAT

Product: regulatory protein UhpC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MLSFLKAPANAPLITDKHEVDARYRYWRRHILITIWLGYALFYFTRKSFNAAAPEILASGILTRSDIGLLATLFYITYGV
SKFVSGIVSDRSNARYFMGIGLIATGVVNILFGFSTSLWAFALLWALNAFFQGFGSPVCARLLTAWYSRTERGGWWALWN
TAHNVGGALIPLVMAAVALHYGWRVGMMVAGLLAIGVGMVLCWRLRDRPQAIGLPPVGDWRHDALEVAQQQEGAGLSRKE
ILAKYVLLNPYIWLLSLCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVSMFELGGFIGALVAGWGSDKLFNGNRGP
MNLIFAAGILLSVGSLWLMPFASYVMQAACFFTTGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLSGWPL
AKVLEIWHWTGFFAVIAIAAGISALLLLPFLNAQAPRETSEA

Sequences:

>Translated_442_residues
MLSFLKAPANAPLITDKHEVDARYRYWRRHILITIWLGYALFYFTRKSFNAAAPEILASGILTRSDIGLLATLFYITYGV
SKFVSGIVSDRSNARYFMGIGLIATGVVNILFGFSTSLWAFALLWALNAFFQGFGSPVCARLLTAWYSRTERGGWWALWN
TAHNVGGALIPLVMAAVALHYGWRVGMMVAGLLAIGVGMVLCWRLRDRPQAIGLPPVGDWRHDALEVAQQQEGAGLSRKE
ILAKYVLLNPYIWLLSLCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVSMFELGGFIGALVAGWGSDKLFNGNRGP
MNLIFAAGILLSVGSLWLMPFASYVMQAACFFTTGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLSGWPL
AKVLEIWHWTGFFAVIAIAAGISALLLLPFLNAQAPRETSEA
>Mature_442_residues
MLSFLKAPANAPLITDKHEVDARYRYWRRHILITIWLGYALFYFTRKSFNAAAPEILASGILTRSDIGLLATLFYITYGV
SKFVSGIVSDRSNARYFMGIGLIATGVVNILFGFSTSLWAFALLWALNAFFQGFGSPVCARLLTAWYSRTERGGWWALWN
TAHNVGGALIPLVMAAVALHYGWRVGMMVAGLLAIGVGMVLCWRLRDRPQAIGLPPVGDWRHDALEVAQQQEGAGLSRKE
ILAKYVLLNPYIWLLSLCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVSMFELGGFIGALVAGWGSDKLFNGNRGP
MNLIFAAGILLSVGSLWLMPFASYVMQAACFFTTGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLSGWPL
AKVLEIWHWTGFFAVIAIAAGISALLLLPFLNAQAPRETSEA

Specific function: UhpC is required for uhpT expression, it may act jointly with the uhpB signaling protein [H]

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family [H]

Homologues:

Organism=Homo sapiens, GI256219598, Length=440, Percent_Identity=29.3181818181818, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI4503847, Length=440, Percent_Identity=29.3181818181818, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI256219483, Length=440, Percent_Identity=29.3181818181818, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI256219543, Length=455, Percent_Identity=28.5714285714286, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI256219564, Length=371, Percent_Identity=28.0323450134771, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI46361976, Length=390, Percent_Identity=23.5897435897436, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI14150047, Length=291, Percent_Identity=23.3676975945017, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI38093649, Length=470, Percent_Identity=23.4042553191489, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI223717983, Length=470, Percent_Identity=23.4042553191489, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI87082310, Length=438, Percent_Identity=90.6392694063927, Blast_Score=819, Evalue=0.0,
Organism=Escherichia coli, GI1788573, Length=447, Percent_Identity=35.1230425055928, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI2367259, Length=459, Percent_Identity=30.9368191721133, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI2367379, Length=362, Percent_Identity=21.5469613259669, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI133930953, Length=453, Percent_Identity=23.6203090507726, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI133901856, Length=441, Percent_Identity=22.6757369614512, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI133901854, Length=441, Percent_Identity=22.6757369614512, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17542316, Length=451, Percent_Identity=23.9467849223947, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24656866, Length=414, Percent_Identity=26.8115942028986, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI45550478, Length=414, Percent_Identity=26.8115942028986, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24656861, Length=414, Percent_Identity=26.8115942028986, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48205; Mature: 48205

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS50850 MFS ; PS00942 GLPT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSFLKAPANAPLITDKHEVDARYRYWRRHILITIWLGYALFYFTRKSFNAAAPEILASG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ILTRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGVVNILFGFSTSLWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
FALLWALNAFFQGFGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPLVMAAVALH
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHCCHHHHHHHHHHHHHH
YGWRVGMMVAGLLAIGVGMVLCWRLRDRPQAIGLPPVGDWRHDALEVAQQQEGAGLSRKE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHH
ILAKYVLLNPYIWLLSLCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVSMFELGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHH
IGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGSLWLMPFASYVMQAACFFTTGFFVFG
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLSGWPLAKVLEIWHWTGFFAVIAIAA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GISALLLLPFLNAQAPRETSEA
HHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MLSFLKAPANAPLITDKHEVDARYRYWRRHILITIWLGYALFYFTRKSFNAAAPEILASG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ILTRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGVVNILFGFSTSLWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
FALLWALNAFFQGFGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPLVMAAVALH
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHCCHHHHHHHHHHHHHH
YGWRVGMMVAGLLAIGVGMVLCWRLRDRPQAIGLPPVGDWRHDALEVAQQQEGAGLSRKE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHH
ILAKYVLLNPYIWLLSLCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVSMFELGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHH
IGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGSLWLMPFASYVMQAACFFTTGFFVFG
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLSGWPLAKVLEIWHWTGFFAVIAIAA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GISALLLLPFLNAQAPRETSEA
HHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1569007; 11677609 [H]