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The map label for this gene is phoR [H]

Identifier: 194737079

GI number: 194737079

Start: 464400

End: 465695

Strand: Direct

Name: phoR [H]

Synonym: SeSA_A0455

Alternate gene names: 194737079

Gene position: 464400-465695 (Clockwise)

Preceding gene: 194736716

Following gene: 194735402

Centisome position: 9.86

GC content: 53.7

Gene sequence:

>1296_bases
GTGCTGGAACGGCTGTCATGGAAAAGGCTGGTGCTGGAGCTGGTGCTCTGTTGCATCCCCGCGCTTATCCTTAGCGCTTT
TTTTGGTTATCTGCCGTGGTTTTTACTGGCGGCGGTGACGGGACTGCTTGTCTGGCATTTCTGGAATTTATTACGCCTCT
CCTGGTGGCTTTGGGTCGACAGAAGTATGACGCCGCCGCCGGGACGGGGAAGTTGGGAACCGCTGTTATACGGTTTACAC
CAGATGCAGTTGCGAAATAAGAAGCGGCGCCGCGAGCTGGGGAACCTGATTAAACGTTTTCGCAGCGGCGCGGAGTCGCT
GCCTGATGCCGTGGTACTGACCACAGAAGAGGGCGGTATTTTTTGGTGTAACGGTTTGGCGCAACAGATACTGGGGCTAC
GCTGGCCGGATGACAACGGGCAGAATATTCTCAATCTACTGCGTTATCCGGAGTTTACCCAGTATTTAAAAACGCGTGAT
TTCACCCGTCCGCTTCATTTGGTGCTCAATACCGGGCGGCATCTGGAGATCCGCGTCATGCCTTATACCGATAAACAACT
CCTGATGGTGGCGCGCGATGTGACGCAAATGCATCAGCTTGAAGGCGCCAGACGTAACTTTTTCGCCAACGTTAGCCATG
AGTTGCGTACGCCCTTGACGGTATTGCAAGGCTATCTGGAAATGATGCAGGAACAGGCGCTGGAGGGGGCGACGCGAGAG
AAAGCGCTGCATACGATGCGCGAGCAAACGTATCGTATGGAAGGGCTGGTAAAACAACTGCTTACGCTGTCTAAAATTGA
GGCGGCCCCGGCGCTGTTATTAAATGAAAAAGTGGATGTACCGATGATGCTGCGGGTCGTGGAGCGTGAAGCGCAGACGC
TCAGCCAGCAGAAACATACCTTTACGTTTGAGGTCGACGATAGTCTTAGCGTTCTGGGCAATGAAGAGCAGCTACGTAGC
GCGATCTCAAACCTGGTGTATAACGCAGTAAACCATACGCCGGCGGGAACGCATATTACGGTGAGCTGGCGACGTGCCGC
GCATGGCGCTGAATTTTGCATTCAAGATAACGGTCCGGGGATTGCTGCCGAGCATATTCCTCGTCTGACCGAACGCTTCT
ACCGCGTCGATAAAGCGCGTTCGCGGCAAACGGGCGGCAGCGGCCTGGGATTGGCGATTGTGAAACATGCGTTGAATCAC
CATGAAAGCCGCCTTGAAATCGACAGTTCGCCTGGCAAAGGAACGCGATTTAGCTTTGTGCTGCCGGAACGTTTAATTGC
CAAAAATAGCGATTAA

Upstream 100 bases:

>100_bases
GACAGGGTATCGTTTTTCGACCCGCTTTTAATGCCTTTTCCGCCAGTAGAACACAGGTTTCTGGCGGAGAAGGCTTTCCA
TTCTTGAGGGAGTATGACGC

Downstream 100 bases:

>100_bases
TTGCCTTTCGTAAGTATAACTTTCCATAAGCCAGCGGATGCTGGCTTATTTTCTTTGCAGTTAAGACGGGCTCGTTGAAA
CATTCAACGTTTGGTGATTT

Product: phosphate regulon sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MLERLSWKRLVLELVLCCIPALILSAFFGYLPWFLLAAVTGLLVWHFWNLLRLSWWLWVDRSMTPPPGRGSWEPLLYGLH
QMQLRNKKRRRELGNLIKRFRSGAESLPDAVVLTTEEGGIFWCNGLAQQILGLRWPDDNGQNILNLLRYPEFTQYLKTRD
FTRPLHLVLNTGRHLEIRVMPYTDKQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQEQALEGATRE
KALHTMREQTYRMEGLVKQLLTLSKIEAAPALLLNEKVDVPMMLRVVEREAQTLSQQKHTFTFEVDDSLSVLGNEEQLRS
AISNLVYNAVNHTPAGTHITVSWRRAAHGAEFCIQDNGPGIAAEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALNH
HESRLEIDSSPGKGTRFSFVLPERLIAKNSD

Sequences:

>Translated_431_residues
MLERLSWKRLVLELVLCCIPALILSAFFGYLPWFLLAAVTGLLVWHFWNLLRLSWWLWVDRSMTPPPGRGSWEPLLYGLH
QMQLRNKKRRRELGNLIKRFRSGAESLPDAVVLTTEEGGIFWCNGLAQQILGLRWPDDNGQNILNLLRYPEFTQYLKTRD
FTRPLHLVLNTGRHLEIRVMPYTDKQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQEQALEGATRE
KALHTMREQTYRMEGLVKQLLTLSKIEAAPALLLNEKVDVPMMLRVVEREAQTLSQQKHTFTFEVDDSLSVLGNEEQLRS
AISNLVYNAVNHTPAGTHITVSWRRAAHGAEFCIQDNGPGIAAEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALNH
HESRLEIDSSPGKGTRFSFVLPERLIAKNSD
>Mature_431_residues
MLERLSWKRLVLELVLCCIPALILSAFFGYLPWFLLAAVTGLLVWHFWNLLRLSWWLWVDRSMTPPPGRGSWEPLLYGLH
QMQLRNKKRRRELGNLIKRFRSGAESLPDAVVLTTEEGGIFWCNGLAQQILGLRWPDDNGQNILNLLRYPEFTQYLKTRD
FTRPLHLVLNTGRHLEIRVMPYTDKQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQEQALEGATRE
KALHTMREQTYRMEGLVKQLLTLSKIEAAPALLLNEKVDVPMMLRVVEREAQTLSQQKHTFTFEVDDSLSVLGNEEQLRS
AISNLVYNAVNHTPAGTHITVSWRRAAHGAEFCIQDNGPGIAAEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALNH
HESRLEIDSSPGKGTRFSFVLPERLIAKNSD

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=431, Percent_Identity=90.9512761020882, Blast_Score=795, Evalue=0.0,
Organism=Escherichia coli, GI1786783, Length=263, Percent_Identity=30.7984790874525, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1788393, Length=250, Percent_Identity=30, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1790346, Length=230, Percent_Identity=29.5652173913043, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI145693157, Length=238, Percent_Identity=27.7310924369748, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1789149, Length=243, Percent_Identity=30.4526748971193, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788713, Length=227, Percent_Identity=27.3127753303965, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI48994928, Length=275, Percent_Identity=27.6363636363636, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1787894, Length=229, Percent_Identity=28.82096069869, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789403, Length=263, Percent_Identity=28.8973384030418, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1790436, Length=226, Percent_Identity=26.1061946902655, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1788549, Length=243, Percent_Identity=26.7489711934156, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789808, Length=281, Percent_Identity=29.1814946619217, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1790861, Length=204, Percent_Identity=29.9019607843137, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082128, Length=228, Percent_Identity=26.7543859649123, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790551, Length=215, Percent_Identity=28.8372093023256, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790300, Length=243, Percent_Identity=28.8065843621399, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1786912, Length=331, Percent_Identity=24.1691842900302, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1787374, Length=267, Percent_Identity=20.5992509363296, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49428; Mature: 49428

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERLSWKRLVLELVLCCIPALILSAFFGYLPWFLLAAVTGLLVWHFWNLLRLSWWLWVD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
RSMTPPPGRGSWEPLLYGLHQMQLRNKKRRRELGNLIKRFRSGAESLPDAVVLTTEEGGI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCE
FWCNGLAQQILGLRWPDDNGQNILNLLRYPEFTQYLKTRDFTRPLHLVLNTGRHLEIRVM
EEEHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHCCCCEEEEEEE
PYTDKQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQEQALEGATRE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHHHHCCHHHH
KALHTMREQTYRMEGLVKQLLTLSKIEAAPALLLNEKVDVPMMLRVVEREAQTLSQQKHT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCE
FTFEVDDSLSVLGNEEQLRSAISNLVYNAVNHTPAGTHITVSWRRAAHGAEFCIQDNGPG
EEEEECCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHCCCCCEEEECCCCC
IAAEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALNHHESRLEIDSSPGKGTRFSFV
CHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHCEEECCCCCCCCEEEEE
LPERLIAKNSD
CHHHHHCCCCC
>Mature Secondary Structure
MLERLSWKRLVLELVLCCIPALILSAFFGYLPWFLLAAVTGLLVWHFWNLLRLSWWLWVD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
RSMTPPPGRGSWEPLLYGLHQMQLRNKKRRRELGNLIKRFRSGAESLPDAVVLTTEEGGI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCE
FWCNGLAQQILGLRWPDDNGQNILNLLRYPEFTQYLKTRDFTRPLHLVLNTGRHLEIRVM
EEEHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHCCCCEEEEEEE
PYTDKQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQEQALEGATRE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHHHHCCHHHH
KALHTMREQTYRMEGLVKQLLTLSKIEAAPALLLNEKVDVPMMLRVVEREAQTLSQQKHT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCE
FTFEVDDSLSVLGNEEQLRSAISNLVYNAVNHTPAGTHITVSWRRAAHGAEFCIQDNGPG
EEEEECCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHCCCCCEEEECCCCC
IAAEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALNHHESRLEIDSSPGKGTRFSFV
CHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHCEEECCCCCCCCEEEEE
LPERLIAKNSD
CHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3550103; 9278503; 2187152; 8391104 [H]