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The map label for this gene is hemH [H]

Identifier: 194737077

GI number: 194737077

Start: 555153

End: 556115

Strand: Direct

Name: hemH [H]

Synonym: SeSA_A0551

Alternate gene names: 194737077

Gene position: 555153-556115 (Clockwise)

Preceding gene: 194737401

Following gene: 194737171

Centisome position: 11.79

GC content: 57.01

Gene sequence:

>963_bases
ATGCGTCAGACGAAAACCGGTATCCTGCTGGCTAACCTTGGCACGCCAGATGCCCCAACTTCCGAAGCGGTAAAGCGCTA
CCTGAAACAATTTTTAAGCGACAGACGCGTGGTGGATACTCCTCGTCTGCTGTGGTGGCCGCTGCTGCGTGGCGTTATTT
TACCGCTGCGTTCGCCGCGCGTCGCGAAACTCTATCAATCTATCTGGATGGATGGCGGTTCGCCGCTCATGGTATATAGC
CGCGAACAGCAACAGGCGCTGGCCGCGCGGCTGCCAGACACGCCCGTCGCGCTGGGGATGAGCTACGGCTCGCCCTCGCT
GGAAAGCGCTGTCGATGAACTGTTAGCAAGCGACGTCGACCATATCGTCGTGCTGCCGTTGTACCCGCAATACTCTTGCT
CAACGGTGGGCGCAGTCTGGGACGAACTGGGGCGGATACTGGCGCGTAAACGCCGTATTCCCGGTATCTCATTTATTCGC
GATTACGCGGATGACGGCGCTTATATCGATGCGCTGGCGAAAAGCGCGCGTGAGTCGTTCGCCAGACACGGCGAGCCGGA
TGTGCTTCTGCTCTCCTATCACGGCATTCCACAACGTTATGCGGATGAAGGCGATGACTACCCGCAGCGCTGTCGCGATA
CCACGCGCGAACTGGTTTCCGCATTGGGACTGCCGCCGGAAAAGGTAATGATGACGTTCCAGTCGCGCTTTGGCCGTGAA
CCGTGGCTGACGCCGTACACCGATGAAACGCTAAAAATGTTGGGTGAAAAGGGGACTGGCCATATTCAGGTCATGTGTCC
GGGATTTGCCGCGGATTGTCTGGAGACGCTGGAAGAGATAGCGGAACAGAACCGCGAGATTTTCCTTGAAGCGGGCGGTA
AAAAATATGCGTACATTCCGGCGCTGAACGCGACGCCGGAACATATTGATATGATGTTAAAACTCACGGCGCCGTACCGT
TAA

Upstream 100 bases:

>100_bases
GCCATTCGGCAAATTCTCGTCTTACCTCTCGCAGCAATTAGTTCTTCTTTATCACTTTTCCGCTACAATTATCAACAATT
TGAATAGATAAGAGGCGGCA

Downstream 100 bases:

>100_bases
CGCGGCGTCTTCATCCTCGCCATAAAGAAGCGCGCGCCGTCCTGCAAGGCATCGTCGGCGATTGTCATCATTCGCGAATA
GTGCAGAAAGGCGTGCAGCG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MRQTKTGILLANLGTPDAPTSEAVKRYLKQFLSDRRVVDTPRLLWWPLLRGVILPLRSPRVAKLYQSIWMDGGSPLMVYS
REQQQALAARLPDTPVALGMSYGSPSLESAVDELLASDVDHIVVLPLYPQYSCSTVGAVWDELGRILARKRRIPGISFIR
DYADDGAYIDALAKSARESFARHGEPDVLLLSYHGIPQRYADEGDDYPQRCRDTTRELVSALGLPPEKVMMTFQSRFGRE
PWLTPYTDETLKMLGEKGTGHIQVMCPGFAADCLETLEEIAEQNREIFLEAGGKKYAYIPALNATPEHIDMMLKLTAPYR

Sequences:

>Translated_320_residues
MRQTKTGILLANLGTPDAPTSEAVKRYLKQFLSDRRVVDTPRLLWWPLLRGVILPLRSPRVAKLYQSIWMDGGSPLMVYS
REQQQALAARLPDTPVALGMSYGSPSLESAVDELLASDVDHIVVLPLYPQYSCSTVGAVWDELGRILARKRRIPGISFIR
DYADDGAYIDALAKSARESFARHGEPDVLLLSYHGIPQRYADEGDDYPQRCRDTTRELVSALGLPPEKVMMTFQSRFGRE
PWLTPYTDETLKMLGEKGTGHIQVMCPGFAADCLETLEEIAEQNREIFLEAGGKKYAYIPALNATPEHIDMMLKLTAPYR
>Mature_320_residues
MRQTKTGILLANLGTPDAPTSEAVKRYLKQFLSDRRVVDTPRLLWWPLLRGVILPLRSPRVAKLYQSIWMDGGSPLMVYS
REQQQALAARLPDTPVALGMSYGSPSLESAVDELLASDVDHIVVLPLYPQYSCSTVGAVWDELGRILARKRRIPGISFIR
DYADDGAYIDALAKSARESFARHGEPDVLLLSYHGIPQRYADEGDDYPQRCRDTTRELVSALGLPPEKVMMTFQSRFGRE
PWLTPYTDETLKMLGEKGTGHIQVMCPGFAADCLETLEEIAEQNREIFLEAGGKKYAYIPALNATPEHIDMMLKLTAPYR

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=324, Percent_Identity=27.7777777777778, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI60499021, Length=323, Percent_Identity=27.8637770897833, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1786681, Length=320, Percent_Identity=88.4375, Blast_Score=568, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6324750, Length=294, Percent_Identity=26.8707482993197, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17864156, Length=336, Percent_Identity=26.7857142857143, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24651774, Length=269, Percent_Identity=27.8810408921933, Blast_Score=95, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 35905; Mature: 35905

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQTKTGILLANLGTPDAPTSEAVKRYLKQFLSDRRVVDTPRLLWWPLLRGVILPLRSPR
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCH
VAKLYQSIWMDGGSPLMVYSREQQQALAARLPDTPVALGMSYGSPSLESAVDELLASDVD
HHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCC
HIVVLPLYPQYSCSTVGAVWDELGRILARKRRIPGISFIRDYADDGAYIDALAKSARESF
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHH
ARHGEPDVLLLSYHGIPQRYADEGDDYPQRCRDTTRELVSALGLPPEKVMMTFQSRFGRE
HHCCCCCEEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
PWLTPYTDETLKMLGEKGTGHIQVMCPGFAADCLETLEEIAEQNREIFLEAGGKKYAYIP
CCCCCCCHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEE
ALNATPEHIDMMLKLTAPYR
CCCCCHHHHHHHHEECCCCC
>Mature Secondary Structure
MRQTKTGILLANLGTPDAPTSEAVKRYLKQFLSDRRVVDTPRLLWWPLLRGVILPLRSPR
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCH
VAKLYQSIWMDGGSPLMVYSREQQQALAARLPDTPVALGMSYGSPSLESAVDELLASDVD
HHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCC
HIVVLPLYPQYSCSTVGAVWDELGRILARKRRIPGISFIRDYADDGAYIDALAKSARESF
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHH
ARHGEPDVLLLSYHGIPQRYADEGDDYPQRCRDTTRELVSALGLPPEKVMMTFQSRFGRE
HHCCCCCEEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
PWLTPYTDETLKMLGEKGTGHIQVMCPGFAADCLETLEEIAEQNREIFLEAGGKKYAYIP
CCCCCCCHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEE
ALNATPEHIDMMLKLTAPYR
CCCCCHHHHHHHHEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA