Click here to switch to the map view.

The map label for this gene is mdtM

Identifier: 194736781

GI number: 194736781

Start: 4635142

End: 4636383

Strand: Reverse

Name: mdtM

Synonym: SeSA_A4774

Alternate gene names: 194736781

Gene position: 4636383-4635142 (Counterclockwise)

Preceding gene: 194735176

Following gene: 194738270

Centisome position: 98.46

GC content: 57.57

Gene sequence:

>1242_bases
ATGCAACGGATTATTCAGTTTTTCTCCCAACGCGCCACAACGTTATTTTTCCCGATGGCGCTGATTTTGTACGATTTTGC
CGCCTATCTGACGACGGATCTGATTCAGCCTGGCATCATTAACGTCGTGCGCGATTTTAATGCTGACGTCAGTCTTGCGC
CGGCCTCGGTCAGTCTCTATCTGGCGGGCGGAATGGCGTTGCAATGGCTTCTGGGGCCGCTATCCGACAGGATTGGCCGC
CGGCCAGTGCTGATCGCAGGGGCATTAATTTTTACTCTCGCCTGCGCGGCAACGCTGTTGACGACCTCAATGACGCAGTT
TCTGGTTGCCCGTTTTGTGCAGGGCACCAGCATTTGCTTTATCGCAACGGTCGGCTACGTCACGGTACAGGAGGCCTTCG
GTCAAACCAAAGCCATTAAGCTGATGGCGATTATTACCTCCATTGTGCTGGTCGCTCCGGTTATCGGCCCGCTCTCCGGC
GCCGCGCTGATGCACTTCGTTCACTGGAAGGTGCTGTTCGGTATTATTGCGGTGATGGGACTGTTGGCGTTGTGCGGCCT
GCTGCTGGCGATGCCAGAAACGGTGCAACGCGGCGCGGTGCCGTTCAGTGCGGTGAGCGTACTGCGCGATTTTCGTAATG
TGTTTCGCAACCCGATTTTTCTCACCGGGGCGGCGACGCTGTCGTTGAGCTACATCCCGATGATGAGCTGGGTGGCGGTG
TCGCCGGTGATCCTGATCGATGCCGGCGGGATGAGTACTTCGCAATTCGCCTGGGCGCAGGTGCCCGTATTCGGCGCGGT
GATCGTGGCCAATATGATCGTTGTGCGCCTGGTGAAAGATCCGACCCGACCGCGTTTTATCTGGCGCGCCGTACCAATTC
AGTTAAGCGGGCTGGCGACATTACTCCTCGGTAATCTTCTTCTGCCGCACGTCTGGCTTTGGTCTGTGCTGGGCACCAGC
CTGTACGCGTTCGGCATTGGAATGATTTTCCCGACGCTGTTTCGCTTCACGCTTTTCTCCAACAACTTGCCAAAAGGGAC
GGTTTCGGCCTCGCTGAACATGGTGATTCTGACGGTGATGGCGGTGTCGGTCGAAGTTGGCCGCTGGCTGTGGTTTCACG
GCGGGAGACTGCCGTTTCACCTGCTGGCAGCGGTGGCCGGGGTGATTGTGGTCTTCACCCTGGCGACATTATTACAGCGC
GTGCGCCAGCATGAGGCGGCAGAACTGGCCGCTGAGAAGTAA

Upstream 100 bases:

>100_bases
CATCCGCAGCCGCTGTTTCCATCGCCTGCCTGACGTCACGATGACGGTATTGAGTTTCGCTGTCCCATCATGGGGTTCTC
CGACATGGAGCGCATTTTTT

Downstream 100 bases:

>100_bases
ACACTCTGCCGGATAGAGGCTTATCCGGCACAGAATCATCTGATGTTTTTTGCACGTTCCTGCCGTCTGGCTCTATCCTT
AACCCTATGAATAAAATCGC

Product: multidrug resistance protein MdtM

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MQRIIQFFSQRATTLFFPMALILYDFAAYLTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGR
RPVLIAGALIFTLACAATLLTTSMTQFLVARFVQGTSICFIATVGYVTVQEAFGQTKAIKLMAIITSIVLVAPVIGPLSG
AALMHFVHWKVLFGIIAVMGLLALCGLLLAMPETVQRGAVPFSAVSVLRDFRNVFRNPIFLTGAATLSLSYIPMMSWVAV
SPVILIDAGGMSTSQFAWAQVPVFGAVIVANMIVVRLVKDPTRPRFIWRAVPIQLSGLATLLLGNLLLPHVWLWSVLGTS
LYAFGIGMIFPTLFRFTLFSNNLPKGTVSASLNMVILTVMAVSVEVGRWLWFHGGRLPFHLLAAVAGVIVVFTLATLLQR
VRQHEAAELAAEK

Sequences:

>Translated_413_residues
MQRIIQFFSQRATTLFFPMALILYDFAAYLTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGR
RPVLIAGALIFTLACAATLLTTSMTQFLVARFVQGTSICFIATVGYVTVQEAFGQTKAIKLMAIITSIVLVAPVIGPLSG
AALMHFVHWKVLFGIIAVMGLLALCGLLLAMPETVQRGAVPFSAVSVLRDFRNVFRNPIFLTGAATLSLSYIPMMSWVAV
SPVILIDAGGMSTSQFAWAQVPVFGAVIVANMIVVRLVKDPTRPRFIWRAVPIQLSGLATLLLGNLLLPHVWLWSVLGTS
LYAFGIGMIFPTLFRFTLFSNNLPKGTVSASLNMVILTVMAVSVEVGRWLWFHGGRLPFHLLAAVAGVIVVFTLATLLQR
VRQHEAAELAAEK
>Mature_413_residues
MQRIIQFFSQRATTLFFPMALILYDFAAYLTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGR
RPVLIAGALIFTLACAATLLTTSMTQFLVARFVQGTSICFIATVGYVTVQEAFGQTKAIKLMAIITSIVLVAPVIGPLSG
AALMHFVHWKVLFGIIAVMGLLALCGLLLAMPETVQRGAVPFSAVSVLRDFRNVFRNPIFLTGAATLSLSYIPMMSWVAV
SPVILIDAGGMSTSQFAWAQVPVFGAVIVANMIVVRLVKDPTRPRFIWRAVPIQLSGLATLLLGNLLLPHVWLWSVLGTS
LYAFGIGMIFPTLFRFTLFSNNLPKGTVSASLNMVILTVMAVSVEVGRWLWFHGGRLPFHLLAAVAGVIVVFTLATLLQR
VRQHEAAELAAEK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily

Homologues:

Organism=Escherichia coli, GI1790794, Length=408, Percent_Identity=86.0294117647059, Blast_Score=708, Evalue=0.0,
Organism=Escherichia coli, GI1787065, Length=395, Percent_Identity=39.4936708860759, Blast_Score=308, Evalue=3e-85,
Organism=Escherichia coli, GI48994889, Length=223, Percent_Identity=29.5964125560538, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790146, Length=227, Percent_Identity=29.5154185022026, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788509, Length=230, Percent_Identity=22.6086956521739, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87082312, Length=189, Percent_Identity=27.5132275132275, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MDTM_SALTI (Q8XFG0)

Other databases:

- EMBL:   AE014613
- EMBL:   AL627284
- RefSeq:   NP_458943.1
- RefSeq:   NP_808146.1
- ProteinModelPortal:   Q8XFG0
- GeneID:   1067109
- GeneID:   1251074
- GenomeReviews:   AE014613_GR
- GenomeReviews:   AL513382_GR
- KEGG:   stt:t4568
- KEGG:   sty:STY4874
- HOGENOM:   HBG289858
- OMA:   PLMSWVA
- ProtClustDB:   PRK15403
- BioCyc:   SENT209261:T4568-MONOMER
- BioCyc:   SENT220341:STY4874-MONOMER
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829

Pfam domain/function: PF07690 MFS_1; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 44792; Mature: 44792

Theoretical pI: Translated: 10.74; Mature: 10.74

Prosite motif: PS50850 MFS; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x23761df4)-; HASH(0x231659f4)-; HASH(0x23af7590)-; HASH(0x2459afec)-; HASH(0x24590ce4)-; HASH(0x4166a438)-; HASH(0x416cb470)-; HASH(0x23864f6c)-; HASH(0x24641e04)-; HASH(0x23799ec0)-; HASH(0x23de9098)-; HASH(0x239bac6c)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRIIQFFSQRATTLFFPMALILYDFAAYLTTDLIQPGIINVVRDFNADVSLAPASVSLY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEECCCCEEEE
LAGGMALQWLLGPLSDRIGRRPVLIAGALIFTLACAATLLTTSMTQFLVARFVQGTSICF
EECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
IATVGYVTVQEAFGQTKAIKLMAIITSIVLVAPVIGPLSGAALMHFVHWKVLFGIIAVMG
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LLALCGLLLAMPETVQRGAVPFSAVSVLRDFRNVFRNPIFLTGAATLSLSYIPMMSWVAV
HHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHH
SPVILIDAGGMSTSQFAWAQVPVFGAVIVANMIVVRLVKDPTRPRFIWRAVPIQLSGLAT
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHH
LLLGNLLLPHVWLWSVLGTSLYAFGIGMIFPTLFRFTLFSNNLPKGTVSASLNMVILTVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
AVSVEVGRWLWFHGGRLPFHLLAAVAGVIVVFTLATLLQRVRQHEAAELAAEK
HHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MQRIIQFFSQRATTLFFPMALILYDFAAYLTTDLIQPGIINVVRDFNADVSLAPASVSLY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEECCCCEEEE
LAGGMALQWLLGPLSDRIGRRPVLIAGALIFTLACAATLLTTSMTQFLVARFVQGTSICF
EECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
IATVGYVTVQEAFGQTKAIKLMAIITSIVLVAPVIGPLSGAALMHFVHWKVLFGIIAVMG
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LLALCGLLLAMPETVQRGAVPFSAVSVLRDFRNVFRNPIFLTGAATLSLSYIPMMSWVAV
HHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHH
SPVILIDAGGMSTSQFAWAQVPVFGAVIVANMIVVRLVKDPTRPRFIWRAVPIQLSGLAT
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHH
LLLGNLLLPHVWLWSVLGTSLYAFGIGMIFPTLFRFTLFSNNLPKGTVSASLNMVILTVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
AVSVEVGRWLWFHGGRLPFHLLAAVAGVIVVFTLATLLQRVRQHEAAELAAEK
HHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504