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The map label for this gene is ilvG [H]

Identifier: 194736754

GI number: 194736754

Start: 3985010

End: 3986656

Strand: Direct

Name: ilvG [H]

Synonym: SeSA_A4111

Alternate gene names: 194736754

Gene position: 3985010-3986656 (Clockwise)

Preceding gene: 194733980

Following gene: 194735286

Centisome position: 84.62

GC content: 55.92

Gene sequence:

>1647_bases
ATGAACGGGGCACAGTGGGTGGTACATGCTTTGCGAGCGCAGGGGGTGAAAACCGTATTTGGTTATCCTGGTGGCGCAAT
TATGCCGGTTTACGACGCGTTGTATGACGGTGGTGTGGAGCATTTGTTGTGCCGACACGAGCAGGGTGCCGCAATGGCGG
CAATCGGTTATGCCCGTTCTACCGGCAAAACCGGTGTTTGTATCGCCACTTCCGGCCCTGGCGCCACTAACCTGATCACT
GGCCTGGCGGATGCGTTGTTAGATTCGGTCCCCGTCGTCGCGATCACGGGTCAGGTTTCCGCCCCGTTCATCGGCACTGA
TGCGTTCCAGGAGGTGGATGTGTTAGGGCTGTCGCTGGCCTGTACCAAACACAGCTTCCTGGTGCAGTCGCTGGCAGAGC
TGCCTCGTATCATGGCGGAGGCTTTTGAAGTCGCCAACGCTGGTCGTCCTGGCCCGGTTCTGGTGGATATCCCGAAAGAT
ATCCAGTTGGCCAGCGGTGAGCTGGAACCCTGGTTTACTACCGTTGATAACGAAGCGACTTTCCCGCAGGCTGATGTGGA
ACAGGCGCGCCAGATGCTGGAACAGGCGAAAAAACCCATGCTGTACGTCGGCGGTGGAGTTGGTATGGCGCAGGCGGTTC
CGGCGCTGCGTAAATTTATCGCGGTAACGCAAATGCCAGTTACCTGCACGCTGAAAGGGCTGGGAGCTGTTGAAGCTGAT
TATCCGTACTATCTGGGCATGCTGGGAATGCACGGTACTAAAGCGGCTAATTTCGCGGTGCAAGAGTGTGATTTACTGAT
CGCCGTTGGTGCACGTTTTGATGACCGGGTGACCGGTAAGCTGAATACGTTTGCGCCGAACGCCAGCGTAATCCATATGG
ATATCGACCCGGCGGAAATGAACAAACTGCGTCAGGCACACGTCGCGTTGCAGGGCGATTTAAATTCGCTGTTGCCGGCA
TTACAGCAACCGCTGAAGATCGACGCATGGCGTCAGTCCTGTGCAGAGCTGCGCGCAGAAAACGCCTGGCGCTATGACCA
TCCTGGCGAGACTATCTATGCGCCGTTGTTGTTGAAGCAATTGTCGGAACGCAAACCCGCAGACAGCGTGGTGACGACGG
ATGTGGGGCAGCATCAGATGTGGTCAGCCCAGCATATGACTTACACCCGCCCGGAGAACTTCATCACTTCCAGCGGTCTG
GGGACGATGGGATTCGGCTTACCGGCGGCCGTTGGCGCGCAGGTAGCGCGACCGAATGATACCGTTATCTGTATCTCCGG
TGACGGCTCATTCATGATGAATGTTCAGGAGTTGGGCACCGTAAAACGCAAGCAGTTACCGTTGAAGATAGTCTTACTCG
ACAACCAGCGGTTAGGGATGGTTCGACAATGGCAGCAACTGTTTTTCCAGGAGCGATATAGCGAAACCACCCTGACCGAT
AACCCCGATTTCCTCATGCTGGCCAGCGCCTTCGGCATTCCAGGCCAGCACATTACTCGTAAAGACCAGGTTGAAGCGGC
ACTCGACACGATGTTGGCAAGCGAAGGGCCGTACCTGCTTCACGTCTCAATCGACGAACTTGAAAATGTCTGGCCGTTGG
TGCCGCCTGGCGCCAGTAACTCTGAAATGCTGGAGAAATTATCATGA

Upstream 100 bases:

>100_bases
GTCCGGGGGTTTTTTTTGGCCTGAAAAACTTAAGCGAGGAGCAGAGCGTGAATAACAGCATAAAATTCTGTTTCTCAAGA
TTTACGACGGGGATGTAACT

Downstream 100 bases:

>100_bases
TGCAACATCAGGTCAATGTATCGGCACGCTTTAATCCAGAAACCTTAGAACGTGTTTTACGCGTGGTGCGCCATCGTGGT
TTTCAGGTGTGCTCCATGAA

Product: acetolactate synthase 2 catalytic subunit

Products: NA

Alternate protein names: AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit [H]

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MNGAQWVVHALRAQGVKTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARSTGKTGVCIATSGPGATNLIT
GLADALLDSVPVVAITGQVSAPFIGTDAFQEVDVLGLSLACTKHSFLVQSLAELPRIMAEAFEVANAGRPGPVLVDIPKD
IQLASGELEPWFTTVDNEATFPQADVEQARQMLEQAKKPMLYVGGGVGMAQAVPALRKFIAVTQMPVTCTLKGLGAVEAD
YPYYLGMLGMHGTKAANFAVQECDLLIAVGARFDDRVTGKLNTFAPNASVIHMDIDPAEMNKLRQAHVALQGDLNSLLPA
LQQPLKIDAWRQSCAELRAENAWRYDHPGETIYAPLLLKQLSERKPADSVVTTDVGQHQMWSAQHMTYTRPENFITSSGL
GTMGFGLPAAVGAQVARPNDTVICISGDGSFMMNVQELGTVKRKQLPLKIVLLDNQRLGMVRQWQQLFFQERYSETTLTD
NPDFLMLASAFGIPGQHITRKDQVEAALDTMLASEGPYLLHVSIDELENVWPLVPPGASNSEMLEKLS

Sequences:

>Translated_548_residues
MNGAQWVVHALRAQGVKTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARSTGKTGVCIATSGPGATNLIT
GLADALLDSVPVVAITGQVSAPFIGTDAFQEVDVLGLSLACTKHSFLVQSLAELPRIMAEAFEVANAGRPGPVLVDIPKD
IQLASGELEPWFTTVDNEATFPQADVEQARQMLEQAKKPMLYVGGGVGMAQAVPALRKFIAVTQMPVTCTLKGLGAVEAD
YPYYLGMLGMHGTKAANFAVQECDLLIAVGARFDDRVTGKLNTFAPNASVIHMDIDPAEMNKLRQAHVALQGDLNSLLPA
LQQPLKIDAWRQSCAELRAENAWRYDHPGETIYAPLLLKQLSERKPADSVVTTDVGQHQMWSAQHMTYTRPENFITSSGL
GTMGFGLPAAVGAQVARPNDTVICISGDGSFMMNVQELGTVKRKQLPLKIVLLDNQRLGMVRQWQQLFFQERYSETTLTD
NPDFLMLASAFGIPGQHITRKDQVEAALDTMLASEGPYLLHVSIDELENVWPLVPPGASNSEMLEKLS
>Mature_548_residues
MNGAQWVVHALRAQGVKTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARSTGKTGVCIATSGPGATNLIT
GLADALLDSVPVVAITGQVSAPFIGTDAFQEVDVLGLSLACTKHSFLVQSLAELPRIMAEAFEVANAGRPGPVLVDIPKD
IQLASGELEPWFTTVDNEATFPQADVEQARQMLEQAKKPMLYVGGGVGMAQAVPALRKFIAVTQMPVTCTLKGLGAVEAD
YPYYLGMLGMHGTKAANFAVQECDLLIAVGARFDDRVTGKLNTFAPNASVIHMDIDPAEMNKLRQAHVALQGDLNSLLPA
LQQPLKIDAWRQSCAELRAENAWRYDHPGETIYAPLLLKQLSERKPADSVVTTDVGQHQMWSAQHMTYTRPENFITSSGL
GTMGFGLPAAVGAQVARPNDTVICISGDGSFMMNVQELGTVKRKQLPLKIVLLDNQRLGMVRQWQQLFFQERYSETTLTD
NPDFLMLASAFGIPGQHITRKDQVEAALDTMLASEGPYLLHVSIDELENVWPLVPPGASNSEMLEKLS

Specific function: Catalyzes the first step in the biosynthesis of branched-chain amino acids [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=560, Percent_Identity=24.1071428571429, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI21361361, Length=498, Percent_Identity=25.1004016064257, Blast_Score=141, Evalue=2e-33,
Organism=Escherichia coli, GI1790104, Length=552, Percent_Identity=46.5579710144928, Blast_Score=511, Evalue=1e-146,
Organism=Escherichia coli, GI87081685, Length=563, Percent_Identity=42.9840142095915, Blast_Score=465, Evalue=1e-132,
Organism=Escherichia coli, GI1786717, Length=565, Percent_Identity=29.3805309734513, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI1787096, Length=541, Percent_Identity=28.8354898336414, Blast_Score=199, Evalue=5e-52,
Organism=Escherichia coli, GI1788716, Length=549, Percent_Identity=27.1402550091075, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17531301, Length=552, Percent_Identity=27.8985507246377, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17531299, Length=552, Percent_Identity=27.8985507246377, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17542570, Length=572, Percent_Identity=24.3006993006993, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323755, Length=579, Percent_Identity=44.0414507772021, Blast_Score=461, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6320816, Length=481, Percent_Identity=24.1164241164241, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6323163, Length=488, Percent_Identity=23.5655737704918, Blast_Score=90, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6321524, Length=481, Percent_Identity=22.4532224532225, Blast_Score=83, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6323073, Length=480, Percent_Identity=23.5416666666667, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI19922626, Length=565, Percent_Identity=26.9026548672566, Blast_Score=179, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 59188; Mature: 59188

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGAQWVVHALRAQGVKTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARS
CCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCHHHHHHHCCCCCEEEEEHHHCC
TGKTGVCIATSGPGATNLITGLADALLDSVPVVAITGQVSAPFIGTDAFQEVDVLGLSLA
CCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHEEEEH
CTKHSFLVQSLAELPRIMAEAFEVANAGRPGPVLVDIPKDIQLASGELEPWFTTVDNEAT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCCCCEEECCCCCC
FPQADVEQARQMLEQAKKPMLYVGGGVGMAQAVPALRKFIAVTQMPVTCTLKGLGAVEAD
CCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
YPYYLGMLGMHGTKAANFAVQECDLLIAVGARFDDRVTGKLNTFAPNASVIHMDIDPAEM
CCHHHHHHCCCCCCHHHHHHHHCCEEEEECCCCCCCCCCCEEEECCCCEEEEEECCHHHH
NKLRQAHVALQGDLNSLLPALQQPLKIDAWRQSCAELRAENAWRYDHPGETIYAPLLLKQ
HHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
LSERKPADSVVTTDVGQHQMWSAQHMTYTRPENFITSSGLGTMGFGLPAAVGAQVARPND
HHCCCCCCCEEECCCCCHHHCCCCCCEEECCCCCEECCCCCCCCCCCHHHHCCEECCCCC
TVICISGDGSFMMNVQELGTVKRKQLPLKIVLLDNQRLGMVRQWQQLFFQERYSETTLTD
EEEEEECCCCEEEEHHHHCCHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCC
NPDFLMLASAFGIPGQHITRKDQVEAALDTMLASEGPYLLHVSIDELENVWPLVPPGASN
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCCCCCC
SEMLEKLS
HHHHHHCC
>Mature Secondary Structure
MNGAQWVVHALRAQGVKTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARS
CCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCHHHHHHHCCCCCEEEEEHHHCC
TGKTGVCIATSGPGATNLITGLADALLDSVPVVAITGQVSAPFIGTDAFQEVDVLGLSLA
CCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHEEEEH
CTKHSFLVQSLAELPRIMAEAFEVANAGRPGPVLVDIPKDIQLASGELEPWFTTVDNEAT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCCCCEEECCCCCC
FPQADVEQARQMLEQAKKPMLYVGGGVGMAQAVPALRKFIAVTQMPVTCTLKGLGAVEAD
CCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
YPYYLGMLGMHGTKAANFAVQECDLLIAVGARFDDRVTGKLNTFAPNASVIHMDIDPAEM
CCHHHHHHCCCCCCHHHHHHHHCCEEEEECCCCCCCCCCCEEEECCCCEEEEEECCHHHH
NKLRQAHVALQGDLNSLLPALQQPLKIDAWRQSCAELRAENAWRYDHPGETIYAPLLLKQ
HHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
LSERKPADSVVTTDVGQHQMWSAQHMTYTRPENFITSSGLGTMGFGLPAAVGAQVARPND
HHCCCCCCCEEECCCCCHHHCCCCCCEEECCCCCEECCCCCCCCCCCHHHHCCEECCCCC
TVICISGDGSFMMNVQELGTVKRKQLPLKIVLLDNQRLGMVRQWQQLFFQERYSETTLTD
EEEEEECCCCEEEEHHHHCCHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCC
NPDFLMLASAFGIPGQHITRKDQVEAALDTMLASEGPYLLHVSIDELENVWPLVPPGASN
CCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCCCCCC
SEMLEKLS
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3550695; 1379743; 9278503; 1995430; 6154938; 7015336; 3897211 [H]