Click here to switch to the map view.

The map label for this gene is cobQ [H]

Identifier: 194736613

GI number: 194736613

Start: 2079211

End: 2080731

Strand: Reverse

Name: cobQ [H]

Synonym: SeSA_A2188

Alternate gene names: 194736613

Gene position: 2080731-2079211 (Counterclockwise)

Preceding gene: 194737966

Following gene: 194737416

Centisome position: 44.19

GC content: 55.69

Gene sequence:

>1521_bases
ATGACGCAGGCAGTTATGTTGCAGGGGACGGCATCCGACGTCGGCAAAAGTGTGCTGGCGGCGGGTTTATGCCGCATTTT
TTATCAGGATGGTCTGCGTACCGCGCCGTTTAAATCGCAAAATATGGCGCTTAATTCTGGTATTACGCCGGATGGCAAAG
AGATGGGGCGGGCGCAGATTTTTCAGGCGGAAGCCGCGGGGATCACGCCAGATGTGCGTATGAATCCGGTGCTGCTCAAA
CCGACCAGCGATCGCCAGGCGCAGGTCGTGCTGATGGGGAAAGTGGCGACCAATATGGATGCGGTTAGTTACCATGACTA
TAAACCGCGTTTGCGTGAGCAAATCCTTGCGGTCTATAACAGCCTGGCGCAGGAATATGACGTTATTGTGCTGGAAGGCG
CCGGAAGCCCGGCGGAAATCAATCTGCGCGATCGCGATATCGTCAATATGGGAATGGCGGAAATGGCCCAGTGTCCGGTT
ATTCTGGTGGCGGATATCGACCGGGGCGGCGTATTCGCCGCTATTTATGGCACGCTGGCGCTGTTGCATAAACAGGAGCG
TGACAGAGTAAAGGGCGTCATTATCAACAAATTCCGCGGCGACGTGGCACTACTCTATTCCGGTATCGAACAAATCGAAT
CGCTTACCGGCGTCCCGGTCCTGGGCGTGATGCCGTGGCTGGATGTGGATCTGGAAGATGAGGATGGCGTCGCGCTGCAA
AACGATAAATATCGCGGTAACGCCCCCCGTGATATCACTATTGCCATTGTGCAACTGCCACATATTTCTAACTTTACGGA
TTTTAACGCTCTGGCGGCGCAGCCGGATGTGCGCATACGCTATATTCGCCGCCCGGAAGCATTGACTGACGTTGATCTGG
TGATCCTGCCGGGCAGTAAGAATACGCTGAGCGACCTCGCCTGGCTGCGCGAAAGCGGGATGGCGGATGCGGTATTGCAG
ACACATCGGCAGGGCGTGCCGGTGATGGGAATTTGCGGCGGCTACCAGATGCTGGGCGACACCATTGTGGATGAGGTGGA
GTCGGGGCTGGGTACGCAGCCGGGCCTGGGGCTGCTTAATACGATCACTCGCTTTGCACAGGATAAAACCACGACGCAGG
TTAACGCGACAATGTCAGACGAGCTGCCCGGCTGGCTGGCTGCCGCAGCGGGGCTACCGGTACGCGGTTATGAAATTCAC
ATGGGGGAAACGGTGCTGCAGGAAGGATGCTGTACGGCCATGACGTTACAGAAAAATGGATGCTCTGTGGCGGATGGTGC
GGTCACCGCCGACGGACTGGCGTTTGGCACTTACCTTCACGGCCTGTTTGACAGCGATGCGTTTACCCGTGCGGTGGTCA
ATGGGTTACGGGCACGAAAAGGGCTTGCGCCGTGGGAAACGACTTTTTGTTATGCGGAGCATAAAGCGCGGCAATTTGAT
CTGCTGGCGGAAGCGATGCGGCAACATATTGATATTGATAAAATTTATACCATCATGCAACAATATCAGGAGCCGGTATG
A

Upstream 100 bases:

>100_bases
CCTGGCTGGTCAAACTTCATACTCAACTGGGACTGCCGCTGTGTAAAACAGAAACGGAGTTTTTTCATCGAATGCAAAAG
TGCGCATTCAGGGAGGCGTC

Downstream 100 bases:

>100_bases
TGATTCTGGTGACGGGCGGGGCGCGTAGTGGTAAAAGCCGTCATGCTGAAACCTTAATTGGCGATGCGCCGCAGGTACTG
TATATCGCCACCTCGCACAT

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MTQAVMLQGTASDVGKSVLAAGLCRIFYQDGLRTAPFKSQNMALNSGITPDGKEMGRAQIFQAEAAGITPDVRMNPVLLK
PTSDRQAQVVLMGKVATNMDAVSYHDYKPRLREQILAVYNSLAQEYDVIVLEGAGSPAEINLRDRDIVNMGMAEMAQCPV
ILVADIDRGGVFAAIYGTLALLHKQERDRVKGVIINKFRGDVALLYSGIEQIESLTGVPVLGVMPWLDVDLEDEDGVALQ
NDKYRGNAPRDITIAIVQLPHISNFTDFNALAAQPDVRIRYIRRPEALTDVDLVILPGSKNTLSDLAWLRESGMADAVLQ
THRQGVPVMGICGGYQMLGDTIVDEVESGLGTQPGLGLLNTITRFAQDKTTTQVNATMSDELPGWLAAAAGLPVRGYEIH
MGETVLQEGCCTAMTLQKNGCSVADGAVTADGLAFGTYLHGLFDSDAFTRAVVNGLRARKGLAPWETTFCYAEHKARQFD
LLAEAMRQHIDIDKIYTIMQQYQEPV

Sequences:

>Translated_506_residues
MTQAVMLQGTASDVGKSVLAAGLCRIFYQDGLRTAPFKSQNMALNSGITPDGKEMGRAQIFQAEAAGITPDVRMNPVLLK
PTSDRQAQVVLMGKVATNMDAVSYHDYKPRLREQILAVYNSLAQEYDVIVLEGAGSPAEINLRDRDIVNMGMAEMAQCPV
ILVADIDRGGVFAAIYGTLALLHKQERDRVKGVIINKFRGDVALLYSGIEQIESLTGVPVLGVMPWLDVDLEDEDGVALQ
NDKYRGNAPRDITIAIVQLPHISNFTDFNALAAQPDVRIRYIRRPEALTDVDLVILPGSKNTLSDLAWLRESGMADAVLQ
THRQGVPVMGICGGYQMLGDTIVDEVESGLGTQPGLGLLNTITRFAQDKTTTQVNATMSDELPGWLAAAAGLPVRGYEIH
MGETVLQEGCCTAMTLQKNGCSVADGAVTADGLAFGTYLHGLFDSDAFTRAVVNGLRARKGLAPWETTFCYAEHKARQFD
LLAEAMRQHIDIDKIYTIMQQYQEPV
>Mature_505_residues
TQAVMLQGTASDVGKSVLAAGLCRIFYQDGLRTAPFKSQNMALNSGITPDGKEMGRAQIFQAEAAGITPDVRMNPVLLKP
TSDRQAQVVLMGKVATNMDAVSYHDYKPRLREQILAVYNSLAQEYDVIVLEGAGSPAEINLRDRDIVNMGMAEMAQCPVI
LVADIDRGGVFAAIYGTLALLHKQERDRVKGVIINKFRGDVALLYSGIEQIESLTGVPVLGVMPWLDVDLEDEDGVALQN
DKYRGNAPRDITIAIVQLPHISNFTDFNALAAQPDVRIRYIRRPEALTDVDLVILPGSKNTLSDLAWLRESGMADAVLQT
HRQGVPVMGICGGYQMLGDTIVDEVESGLGTQPGLGLLNTITRFAQDKTTTQVNATMSDELPGWLAAAAGLPVRGYEIHM
GETVLQEGCCTAMTLQKNGCSVADGAVTADGLAFGTYLHGLFDSDAFTRAVVNGLRARKGLAPWETTFCYAEHKARQFDL
LAEAMRQHIDIDKIYTIMQQYQEPV

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: 6.3.5.10

Molecular weight: Translated: 55066; Mature: 54935

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQAVMLQGTASDVGKSVLAAGLCRIFYQDGLRTAPFKSQNMALNSGITPDGKEMGRAQI
CCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCHHHHCHHHE
FQAEAAGITPDVRMNPVLLKPTSDRQAQVVLMGKVATNMDAVSYHDYKPRLREQILAVYN
EEHHCCCCCCCCCCCCEEECCCCCCCEEEEEEEEHHCCCCCEEECCCCHHHHHHHHHHHH
SLAQEYDVIVLEGAGSPAEINLRDRDIVNMGMAEMAQCPVILVADIDRGGVFAAIYGTLA
HHHHHCCEEEEECCCCCCEEEECCCHHHHCCHHHHHCCCEEEEEECCCCCCHHHHHHHHH
LLHKQERDRVKGVIINKFRGDVALLYSGIEQIESLTGVPVLGVMPWLDVDLEDEDGVALQ
HHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCEEE
NDKYRGNAPRDITIAIVQLPHISNFTDFNALAAQPDVRIRYIRRPEALTDVDLVILPGSK
CCCCCCCCCCEEEEEEEEECCCCCCCCCCHHHCCCCCEEEEEECCCCCCCCEEEEECCCC
NTLSDLAWLRESGMADAVLQTHRQGVPVMGICGGYQMLGDTIVDEVESGLGTQPGLGLLN
CHHHHHHHHHHCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHH
TITRFAQDKTTTQVNATMSDELPGWLAAAAGLPVRGYEIHMGETVLQEGCCTAMTLQKNG
HHHHHHCCCCCEEEECEECCCCCCHHHHHCCCCCCCEEEECCHHHHHCCCCEEEEEECCC
CSVADGAVTADGLAFGTYLHGLFDSDAFTRAVVNGLRARKGLAPWETTFCYAEHKARQFD
CCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHEEEHHHHHHHHH
LLAEAMRQHIDIDKIYTIMQQYQEPV
HHHHHHHHHCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TQAVMLQGTASDVGKSVLAAGLCRIFYQDGLRTAPFKSQNMALNSGITPDGKEMGRAQI
CCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCHHHHCHHHE
FQAEAAGITPDVRMNPVLLKPTSDRQAQVVLMGKVATNMDAVSYHDYKPRLREQILAVYN
EEHHCCCCCCCCCCCCEEECCCCCCCEEEEEEEEHHCCCCCEEECCCCHHHHHHHHHHHH
SLAQEYDVIVLEGAGSPAEINLRDRDIVNMGMAEMAQCPVILVADIDRGGVFAAIYGTLA
HHHHHCCEEEEECCCCCCEEEECCCHHHHCCHHHHHCCCEEEEEECCCCCCHHHHHHHHH
LLHKQERDRVKGVIINKFRGDVALLYSGIEQIESLTGVPVLGVMPWLDVDLEDEDGVALQ
HHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCEEE
NDKYRGNAPRDITIAIVQLPHISNFTDFNALAAQPDVRIRYIRRPEALTDVDLVILPGSK
CCCCCCCCCCEEEEEEEEECCCCCCCCCCHHHCCCCCEEEEEECCCCCCCCEEEEECCCC
NTLSDLAWLRESGMADAVLQTHRQGVPVMGICGGYQMLGDTIVDEVESGLGTQPGLGLLN
CHHHHHHHHHHCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHH
TITRFAQDKTTTQVNATMSDELPGWLAAAAGLPVRGYEIHMGETVLQEGCCTAMTLQKNG
HHHHHHCCCCCEEEECEECCCCCCHHHHHCCCCCCCEEEECCHHHHHCCCCEEEEEECCC
CSVADGAVTADGLAFGTYLHGLFDSDAFTRAVVNGLRARKGLAPWETTFCYAEHKARQFD
CCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHEEEHHHHHHHHH
LLAEAMRQHIDIDKIYTIMQQYQEPV
HHHHHHHHHCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8501034; 11677609 [H]