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The map label for this gene is fruA [H]

Identifier: 194736592

GI number: 194736592

Start: 3940802

End: 3942175

Strand: Reverse

Name: fruA [H]

Synonym: SeSA_A4067

Alternate gene names: 194736592

Gene position: 3942175-3940802 (Counterclockwise)

Preceding gene: 194735709

Following gene: 194734204

Centisome position: 83.71

GC content: 56.19

Gene sequence:

>1374_bases
ATGACTAAAAAAATTGTTGCTGTGACGGCCTGTCCGACGGGCGTCGCCCATACCTTTATGGCGGCAGAAGCGTTGGAAAT
TGAAGCCCGCAAGCGTGGTGACTGGATCAAGGTTGAAACCCGCGGTTCCGTCGGGGCGAAGAACACGCTGACCGCGGAAG
AGATAGCGCAGGCGGATGTGGTGATTATCGCGGCGGATATTGAACTGGATCTGTCAGGCTTTGTTGGCAAAAGACTCTAT
CGCACCAGTACCGGCGCGGCGCTAAAAAAGAGTGCGCAGGAAATGGATAATGCTTTCAATAGCGCCGAGGTCTATCAGGG
GAGTGCCGGGCGCTCTTCTTCAGCTGGTAAAACAGAGCTACCCGGCGTTTATAAGCATTTAATGACCGGCGTATCCCATA
TGCTTCCCCTGGTGGTTGCGGGAGGGTTGTGTATCGCGCTCTCTTTTGTCTTCGGTATCCAGGCCTTCAACGAGCCGGAC
ACGCTGGCGGCTGCGTTATTTCAAATCGGCGGTAAGGCGGCCTTTGCGCTGATGGTGCCGGTACTGGCTGGGTTTATTGC
CTTCTCAATTGCCGATCGTCCGGGTCTGGCCCCGGGGCTTATTGGCGGGATGTTGGCCAGCCTGTGCGGCGCTGGTTTCC
TGGGTGGGATTGTGGCCGGTTTTCTGGCCGGTTACAGCGTACGGTTTCTGGCGCAAAATATTAAGCTGCCGGCGTCGATG
GAAGCGCTTAAACCTGTGCTGGTTCTGCCGCTACTGTCTACGCTGATTATCGGCCTTATCATGATTTACGTGGTGGGTGG
CCCCGTTTCTGCGGTGATGGAGGGGCTGACGACGTTCCTGGGGAATATGACCTCTACGAATGCGATCTTGCTGGGAATGT
TGCTGGGCGCAATGCAAGGTTTTGACCTTGGCGGGCCGGTGAATAAAGCTGCGTATACCTTCGGCGTTGGTTTACTGGCT
TCTCATTCTTATATGCCAATGGCGGCTATTATGGCGGCAGGGATGGTACCGGCATTAGGAATGGGCGTCGCAACCTGGGC
GGCCAGAGCGAAATTCAATGCCGCTGAGCATGAAGCGGGTAATGCATCTTTTATCCTGGGGCTGTGCTTTATCTCTGAAG
GGGCGATTCCCTTCGCCGCGCGAGACCCGATGCGCGTCATCCCTTCCACGATGGTCGGTGGCGCAATCGCCGGGGGACTG
TCCATGTATTTCGGTTGTACACTGATGGCGCCACACGGCGGCCTCTTTGTCCTGGCGATCCCGCATGCGGTGGAACATGT
GATGCAGTACCTGCTCTCGATTGCCCTGGGCACGATTGTCTGCGGCCTGATGTACGCGCTATTGAAACCGTCTGTGGTTG
CGCAAACAGTTTAA

Upstream 100 bases:

>100_bases
CGCCCGGATGACGCGCTGTTCCAGAAAGCCGCGGCCTGGTCACGTCTGTAACATTTTTTTCCCGCTTTTTCTTTAAATTA
AAAGAACAGGGTACCCTACT

Downstream 100 bases:

>100_bases
TTCATCTCCCCCTGCAGGCTGGTCTGGTGTCTCCCCGGGCCAGCTTTTTTATTTCCATTGTCATCAAACCGTCATAATCA
AGACATATAACTGTCATCAA

Product: pts system fructose-specific eiibc component

Products: NA

Alternate protein names: EIIBC-Fru; Fructose-specific phosphotransferase enzyme IIB component; EIII-Fru; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MTKKIVAVTACPTGVAHTFMAAEALEIEARKRGDWIKVETRGSVGAKNTLTAEEIAQADVVIIAADIELDLSGFVGKRLY
RTSTGAALKKSAQEMDNAFNSAEVYQGSAGRSSSAGKTELPGVYKHLMTGVSHMLPLVVAGGLCIALSFVFGIQAFNEPD
TLAAALFQIGGKAAFALMVPVLAGFIAFSIADRPGLAPGLIGGMLASLCGAGFLGGIVAGFLAGYSVRFLAQNIKLPASM
EALKPVLVLPLLSTLIIGLIMIYVVGGPVSAVMEGLTTFLGNMTSTNAILLGMLLGAMQGFDLGGPVNKAAYTFGVGLLA
SHSYMPMAAIMAAGMVPALGMGVATWAARAKFNAAEHEAGNASFILGLCFISEGAIPFAARDPMRVIPSTMVGGAIAGGL
SMYFGCTLMAPHGGLFVLAIPHAVEHVMQYLLSIALGTIVCGLMYALLKPSVVAQTV

Sequences:

>Translated_457_residues
MTKKIVAVTACPTGVAHTFMAAEALEIEARKRGDWIKVETRGSVGAKNTLTAEEIAQADVVIIAADIELDLSGFVGKRLY
RTSTGAALKKSAQEMDNAFNSAEVYQGSAGRSSSAGKTELPGVYKHLMTGVSHMLPLVVAGGLCIALSFVFGIQAFNEPD
TLAAALFQIGGKAAFALMVPVLAGFIAFSIADRPGLAPGLIGGMLASLCGAGFLGGIVAGFLAGYSVRFLAQNIKLPASM
EALKPVLVLPLLSTLIIGLIMIYVVGGPVSAVMEGLTTFLGNMTSTNAILLGMLLGAMQGFDLGGPVNKAAYTFGVGLLA
SHSYMPMAAIMAAGMVPALGMGVATWAARAKFNAAEHEAGNASFILGLCFISEGAIPFAARDPMRVIPSTMVGGAIAGGL
SMYFGCTLMAPHGGLFVLAIPHAVEHVMQYLLSIALGTIVCGLMYALLKPSVVAQTV
>Mature_456_residues
TKKIVAVTACPTGVAHTFMAAEALEIEARKRGDWIKVETRGSVGAKNTLTAEEIAQADVVIIAADIELDLSGFVGKRLYR
TSTGAALKKSAQEMDNAFNSAEVYQGSAGRSSSAGKTELPGVYKHLMTGVSHMLPLVVAGGLCIALSFVFGIQAFNEPDT
LAAALFQIGGKAAFALMVPVLAGFIAFSIADRPGLAPGLIGGMLASLCGAGFLGGIVAGFLAGYSVRFLAQNIKLPASME
ALKPVLVLPLLSTLIIGLIMIYVVGGPVSAVMEGLTTFLGNMTSTNAILLGMLLGAMQGFDLGGPVNKAAYTFGVGLLAS
HSYMPMAAIMAAGMVPALGMGVATWAARAKFNAAEHEAGNASFILGLCFISEGAIPFAARDPMRVIPSTMVGGAIAGGLS
MYFGCTLMAPHGGLFVLAIPHAVEHVMQYLLSIALGTIVCGLMYALLKPSVVAQTV

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=455, Percent_Identity=65.9340659340659, Blast_Score=602, Evalue=1e-173,
Organism=Escherichia coli, GI1786951, Length=433, Percent_Identity=38.568129330254, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI87082348, Length=428, Percent_Identity=35.0467289719626, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI1790386, Length=318, Percent_Identity=41.5094339622642, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1788729, Length=403, Percent_Identity=28.7841191066998, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1790387, Length=89, Percent_Identity=52.8089887640449, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1788730, Length=94, Percent_Identity=43.6170212765958, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790390, Length=65, Percent_Identity=49.2307692307692, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 47011; Mature: 46880

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKIVAVTACPTGVAHTFMAAEALEIEARKRGDWIKVETRGSVGAKNTLTAEEIAQADV
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHCCCCE
VIIAADIELDLSGFVGKRLYRTSTGAALKKSAQEMDNAFNSAEVYQGSAGRSSSAGKTEL
EEEEEECEECHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCC
PGVYKHLMTGVSHMLPLVVAGGLCIALSFVFGIQAFNEPDTLAAALFQIGGKAAFALMVP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHH
VLAGFIAFSIADRPGLAPGLIGGMLASLCGAGFLGGIVAGFLAGYSVRFLAQNIKLPASM
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
EALKPVLVLPLLSTLIIGLIMIYVVGGPVSAVMEGLTTFLGNMTSTNAILLGMLLGAMQG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
FDLGGPVNKAAYTFGVGLLASHSYMPMAAIMAAGMVPALGMGVATWAARAKFNAAEHEAG
CCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCC
NASFILGLCFISEGAIPFAARDPMRVIPSTMVGGAIAGGLSMYFGCTLMAPHGGLFVLAI
CHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCEEEECCCCCEEEEEC
PHAVEHVMQYLLSIALGTIVCGLMYALLKPSVVAQTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCC
>Mature Secondary Structure 
TKKIVAVTACPTGVAHTFMAAEALEIEARKRGDWIKVETRGSVGAKNTLTAEEIAQADV
CCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHCCCCE
VIIAADIELDLSGFVGKRLYRTSTGAALKKSAQEMDNAFNSAEVYQGSAGRSSSAGKTEL
EEEEEECEECHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCC
PGVYKHLMTGVSHMLPLVVAGGLCIALSFVFGIQAFNEPDTLAAALFQIGGKAAFALMVP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHH
VLAGFIAFSIADRPGLAPGLIGGMLASLCGAGFLGGIVAGFLAGYSVRFLAQNIKLPASM
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
EALKPVLVLPLLSTLIIGLIMIYVVGGPVSAVMEGLTTFLGNMTSTNAILLGMLLGAMQG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
FDLGGPVNKAAYTFGVGLLASHSYMPMAAIMAAGMVPALGMGVATWAARAKFNAAEHEAG
CCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCC
NASFILGLCFISEGAIPFAARDPMRVIPSTMVGGAIAGGLSMYFGCTLMAPHGGLFVLAI
CHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCEEEECCCCCEEEEEC
PHAVEHVMQYLLSIALGTIVCGLMYALLKPSVVAQTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3076173; 9278503; 9097040; 1981619 [H]