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The map label for this gene is sppA [H]

Identifier: 194736488

GI number: 194736488

Start: 1339582

End: 1341438

Strand: Reverse

Name: sppA [H]

Synonym: SeSA_A1389

Alternate gene names: 194736488

Gene position: 1341438-1339582 (Counterclockwise)

Preceding gene: 194736629

Following gene: 194737093

Centisome position: 28.49

GC content: 56.11

Gene sequence:

>1857_bases
ATGCGAACCCTGTGGCGATTTATTGCCGGATTTTTTAAATGGACGTGGCGAGTGTTGAACTTCGTCCGTGAAATGGTACT
CAACCTGTTCTTTATTTTTCTGGTCCTGGTGGGCGTTGGGATCTGGATGCAGATCGGTAACGGCAGCAACAGTGAGCAAA
CCGCGCGCGGCGCTCTGCTGCTGGATATTTCCGGCGTCATTGTGGATAAACCGTCCACCAATCACCGTCTGGGCGCGCTG
GGTCGCCAGTTATTTGGCGCCAGCTCCGACCGTCTGCAGGAAAACTCCCTGTTTGACATCGTCAACGCTATTCGTCAGGC
GAAAGATGACCGTAGCATCACTGGTATCGTTCTGGATCTGAAAAACTTCACCGGCGCCGATCAGCCGTCAATGCGCTATA
TCGGTAAAGCGCTGCGCGAATTCCGCGACAGCGGCAAACCGATTTTTGCCGTGGGTGAAAACTACAGCCAGGGTCAGTAT
TACCTCGCCAGTTTCGCCAATAAAATTTGGCTTTCCCCACAGGGTCAGGTAGATCTTCACGGCTTCGCTACGAATGGCCT
GTACTACAAAACGCTGCTGGATAAGCTGAAAGTCTCTACCCACGTTTTCCGGGTCGGCACCTATAAATCCGCCGTCGAGC
CGTTTATCCGCGACGATATGTCGCCCGCCGCCCGCGAGGCCGACAGCCACTGGATAGGCGAACTGTGGCAGAACTACCTG
CATACCGTTTCCGCCAATCGCCAGATTTCGCCGCAACAACTCTTCCCCGGCGCGCAGGCTATTATCGACGGGTTAACCAG
CGTGGGCGGCGACACCGCCAAATATGCGCTCGACCATAAACTGGTGGACGCCCTCGCCTCCAGCGCAGATGTTGAAAAAG
CGCTGACGAAGCAGTTTGGCTGGAGCAAAACTGAAAATAACTATCGCGCGATCAGCTATTACGATTATTCGCTGAAAACG
CCTGCGGATACCGGCGGTACTATTGCGGTTATTTTCGCCAATGGCGCGATTATGGATGGCGAAGAAACGCCAGGGAATGT
CGGCGGCGACACTACGGCATCGCAGATCCGCGACGCACGCCTTGATCCTAAAGTGAAAGCGATTGTGCTGCGCGTCAATA
GCCCAGGCGGGAGCGTCAACGCCTCCGAAGTTATCCGCGCCGAACTGGCGGCGGCAAAAGCGGCCGGCAAACCGGTGGTG
GTCTCAATGGGCGGCATGGCGGCCTCCGGCGGTTACTGGATCTCTACGCCGGCAAACTATATCGTGGCCAGCCCCAGCAC
GCTGACGGGTTCAATTGGCATCTTCGGCGTCATCAATACGGTAGAAAACAGCCTGTCGTCGATTGGCGTACACAGCGACG
GCGTTTCCACCTCGCCGCTGGCGGATATTTCGATGACCAAAGCGCTGTCACCGGAAGTGCAGCAGATGATGCAACTCAGT
ATTGAGTACGGCTACAAACGCTTTATCACGCTGGTGGCAGACGCGCGTAAGCGTACGCCGGAGCAGATTGATAAAATCGC
ACAAGGCCATGTCTGGACCGGAGAAGACGCGAAAGCCAATGGTCTGGTGGACAGTCTCGGCGACTTTGACGACGCCGTCG
CCAAAGCGGCGGAGCTGGCGAAACTGAAACAGTGGCATCTTGATTACTATCAGGACGAACCGACGGTCCTTGATATGGTC
ATGGACAGTATGACCGGATCAGTACGCGCCATGCTGCCGGAGGCCATTCAGGCGATGCTCCCGGCGCCGCTCGTTTCCGC
CGCCAACACGGTGAAGGCCGAGGGGGATAAACTGGCGGCATTTAACGATCCGCAAAACCGTTATGCGTTCTGTTTGACTT
GCGCGAACGTTCGCTAA

Upstream 100 bases:

>100_bases
ATTCCTGCTGACAACTGCCTGATGGGTCATTACGATAGCCACATCTTAATGCTTTATCCTCACCAAGGTATAAGCGTTGT
TACTCAGATAGGGAGAATAC

Downstream 100 bases:

>100_bases
TGCTTCATCAATAGCCATACCGGATGGCGGCGTCTGCTCATAGCCGCCATCCGATAATCATTAATACGTCCTTCGCGACA
CGACTGAACATTATCATGCA

Product: protease 4

Products: NA

Alternate protein names: Endopeptidase IV; Protease IV; Signal peptide peptidase [H]

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MRTLWRFIAGFFKWTWRVLNFVREMVLNLFFIFLVLVGVGIWMQIGNGSNSEQTARGALLLDISGVIVDKPSTNHRLGAL
GRQLFGASSDRLQENSLFDIVNAIRQAKDDRSITGIVLDLKNFTGADQPSMRYIGKALREFRDSGKPIFAVGENYSQGQY
YLASFANKIWLSPQGQVDLHGFATNGLYYKTLLDKLKVSTHVFRVGTYKSAVEPFIRDDMSPAAREADSHWIGELWQNYL
HTVSANRQISPQQLFPGAQAIIDGLTSVGGDTAKYALDHKLVDALASSADVEKALTKQFGWSKTENNYRAISYYDYSLKT
PADTGGTIAVIFANGAIMDGEETPGNVGGDTTASQIRDARLDPKVKAIVLRVNSPGGSVNASEVIRAELAAAKAAGKPVV
VSMGGMAASGGYWISTPANYIVASPSTLTGSIGIFGVINTVENSLSSIGVHSDGVSTSPLADISMTKALSPEVQQMMQLS
IEYGYKRFITLVADARKRTPEQIDKIAQGHVWTGEDAKANGLVDSLGDFDDAVAKAAELAKLKQWHLDYYQDEPTVLDMV
MDSMTGSVRAMLPEAIQAMLPAPLVSAANTVKAEGDKLAAFNDPQNRYAFCLTCANVR

Sequences:

>Translated_618_residues
MRTLWRFIAGFFKWTWRVLNFVREMVLNLFFIFLVLVGVGIWMQIGNGSNSEQTARGALLLDISGVIVDKPSTNHRLGAL
GRQLFGASSDRLQENSLFDIVNAIRQAKDDRSITGIVLDLKNFTGADQPSMRYIGKALREFRDSGKPIFAVGENYSQGQY
YLASFANKIWLSPQGQVDLHGFATNGLYYKTLLDKLKVSTHVFRVGTYKSAVEPFIRDDMSPAAREADSHWIGELWQNYL
HTVSANRQISPQQLFPGAQAIIDGLTSVGGDTAKYALDHKLVDALASSADVEKALTKQFGWSKTENNYRAISYYDYSLKT
PADTGGTIAVIFANGAIMDGEETPGNVGGDTTASQIRDARLDPKVKAIVLRVNSPGGSVNASEVIRAELAAAKAAGKPVV
VSMGGMAASGGYWISTPANYIVASPSTLTGSIGIFGVINTVENSLSSIGVHSDGVSTSPLADISMTKALSPEVQQMMQLS
IEYGYKRFITLVADARKRTPEQIDKIAQGHVWTGEDAKANGLVDSLGDFDDAVAKAAELAKLKQWHLDYYQDEPTVLDMV
MDSMTGSVRAMLPEAIQAMLPAPLVSAANTVKAEGDKLAAFNDPQNRYAFCLTCANVR
>Mature_618_residues
MRTLWRFIAGFFKWTWRVLNFVREMVLNLFFIFLVLVGVGIWMQIGNGSNSEQTARGALLLDISGVIVDKPSTNHRLGAL
GRQLFGASSDRLQENSLFDIVNAIRQAKDDRSITGIVLDLKNFTGADQPSMRYIGKALREFRDSGKPIFAVGENYSQGQY
YLASFANKIWLSPQGQVDLHGFATNGLYYKTLLDKLKVSTHVFRVGTYKSAVEPFIRDDMSPAAREADSHWIGELWQNYL
HTVSANRQISPQQLFPGAQAIIDGLTSVGGDTAKYALDHKLVDALASSADVEKALTKQFGWSKTENNYRAISYYDYSLKT
PADTGGTIAVIFANGAIMDGEETPGNVGGDTTASQIRDARLDPKVKAIVLRVNSPGGSVNASEVIRAELAAAKAAGKPVV
VSMGGMAASGGYWISTPANYIVASPSTLTGSIGIFGVINTVENSLSSIGVHSDGVSTSPLADISMTKALSPEVQQMMQLS
IEYGYKRFITLVADARKRTPEQIDKIAQGHVWTGEDAKANGLVDSLGDFDDAVAKAAELAKLKQWHLDYYQDEPTVLDMV
MDSMTGSVRAMLPEAIQAMLPAPLVSAANTVKAEGDKLAAFNDPQNRYAFCLTCANVR

Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=618, Percent_Identity=85.5987055016181, Blast_Score=1093, Evalue=0.0,
Organism=Escherichia coli, GI1787527, Length=180, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004634
- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 67130; Mature: 67130

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLWRFIAGFFKWTWRVLNFVREMVLNLFFIFLVLVGVGIWMQIGNGSNSEQTARGALL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHCCEEE
LDISGVIVDKPSTNHRLGALGRQLFGASSDRLQENSLFDIVNAIRQAKDDRSITGIVLDL
EEECCEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEE
KNFTGADQPSMRYIGKALREFRDSGKPIFAVGENYSQGQYYLASFANKIWLSPQGQVDLH
CCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHEECCCCCCEEEE
GFATNGLYYKTLLDKLKVSTHVFRVGTYKSAVEPFIRDDMSPAAREADSHWIGELWQNYL
EEEECCCHHHHHHHHHHHHHHEEEECCHHHHHHHHHHCCCCHHHHHHCHHHHHHHHHHHH
HTVSANRQISPQQLFPGAQAIIDGLTSVGGDTAKYALDHKLVDALASSADVEKALTKQFG
HHHCCCCCCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
WSKTENNYRAISYYDYSLKTPADTGGTIAVIFANGAIMDGEETPGNVGGDTTASQIRDAR
CCCCCCCEEEEEEEEEEECCCCCCCCEEEEEEECCEEECCCCCCCCCCCCCHHHHHHHCC
LDPKVKAIVLRVNSPGGSVNASEVIRAELAAAKAAGKPVVVSMGGMAASGGYWISTPANY
CCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCEEECCCEEEECCCCE
IVASPSTLTGSIGIFGVINTVENSLSSIGVHSDGVSTSPLADISMTKALSPEVQQMMQLS
EEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHH
IEYGYKRFITLVADARKRTPEQIDKIAQGHVWTGEDAKANGLVDSLGDFDDAVAKAAELA
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEECCCCCCCCCCHHHHCCHHHHHHHHHHHH
KLKQWHLDYYQDEPTVLDMVMDSMTGSVRAMLPEAIQAMLPAPLVSAANTVKAEGDKLAA
HHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHCHHHHCCCCEEEE
FNDPQNRYAFCLTCANVR
CCCCCCCEEEEEEECCCC
>Mature Secondary Structure
MRTLWRFIAGFFKWTWRVLNFVREMVLNLFFIFLVLVGVGIWMQIGNGSNSEQTARGALL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHCCEEE
LDISGVIVDKPSTNHRLGALGRQLFGASSDRLQENSLFDIVNAIRQAKDDRSITGIVLDL
EEECCEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEE
KNFTGADQPSMRYIGKALREFRDSGKPIFAVGENYSQGQYYLASFANKIWLSPQGQVDLH
CCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHEECCCCCCEEEE
GFATNGLYYKTLLDKLKVSTHVFRVGTYKSAVEPFIRDDMSPAAREADSHWIGELWQNYL
EEEECCCHHHHHHHHHHHHHHEEEECCHHHHHHHHHHCCCCHHHHHHCHHHHHHHHHHHH
HTVSANRQISPQQLFPGAQAIIDGLTSVGGDTAKYALDHKLVDALASSADVEKALTKQFG
HHHCCCCCCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
WSKTENNYRAISYYDYSLKTPADTGGTIAVIFANGAIMDGEETPGNVGGDTTASQIRDAR
CCCCCCCEEEEEEEEEEECCCCCCCCEEEEEEECCEEECCCCCCCCCCCCCHHHHHHHCC
LDPKVKAIVLRVNSPGGSVNASEVIRAELAAAKAAGKPVVVSMGGMAASGGYWISTPANY
CCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCEEECCCEEEECCCCE
IVASPSTLTGSIGIFGVINTVENSLSSIGVHSDGVSTSPLADISMTKALSPEVQQMMQLS
EEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHH
IEYGYKRFITLVADARKRTPEQIDKIAQGHVWTGEDAKANGLVDSLGDFDDAVAKAAELA
HHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEECCCCCCCCCCHHHHCCHHHHHHHHHHHH
KLKQWHLDYYQDEPTVLDMVMDSMTGSVRAMLPEAIQAMLPAPLVSAANTVKAEGDKLAA
HHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHCHHHHCCCCEEEE
FNDPQNRYAFCLTCANVR
CCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]