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The map label for this gene is clpB [H]

Identifier: 194736447

GI number: 194736447

Start: 2754780

End: 2757353

Strand: Reverse

Name: clpB [H]

Synonym: SeSA_A2856

Alternate gene names: 194736447

Gene position: 2757353-2754780 (Counterclockwise)

Preceding gene: 194735394

Following gene: 194737527

Centisome position: 58.55

GC content: 53.46

Gene sequence:

>2574_bases
ATGCGTCTGGATCGTCTTACTAACAAATTCCAGCTTGCTCTTGCCGATGCCCAGTCGCTTGCGCTGGGGCACGACAACCA
ATTCATCGAACCTCTTCATTTAATGAGCGCCTTGCTGAACCAGGAAGGGGGATCGATACGTCCTTTATTAACCTCCGCCG
GCATTAATGCTGGCCAGTTGCGCACCGCTATCGATCAGGCGCTGAGCCGTTTACCGCAGGTGGAAGGCACCGGCGGCGAC
GTACAGCCTTCTTCGGAACTGGTACGCGTACTGAACCTTTGCGACAAGCTGGCGCAAAAACGGGGGGACAATTTTATTTC
GTCAGAGCTGTTTGTTCTGGCGGCGCTTGAGTCTCGCGGCACGTTAACCGATCTGCTGAAATCAGCCGGTGCGACCACGG
CCAATATCACTCAGGCAATTGAACAGATGCGCGGAGGTGAAAGCGTGAACGATCAAGGGGCTGAAGACCAACGTCAGGCC
TTGAAAAAATATACCGTCGATCTGACCGAGCGCGCCGAACAGGGCAAGCTCGATCCGGTTATCGGTCGTGATGAAGAAAT
TCGCCGCACCATTCAGGTGCTGCAACGTCGTACTAAAAACAACCCAGTGTTAATCGGTGAGCCAGGGGTCGGTAAAACGG
CAATTGTTGAAGGGCTGGCGCAGCGCATTATTAATGGTGAAGTCCCTGAAGGCTTAAAAGGTCGCCGCGTACTGGCGCTG
GATATGGGCGCGCTGGTGGCCGGGGCGAAATATCGCGGCGAATTTGAAGAGCGTCTGAAAGGCGTGCTGAACGACCTCGC
AAAACAGGAAGGCAACGTCATCCTGTTTATCGATGAGCTGCACACCATGGTTGGCGCAGGTAAGGCCGATGGCGCAATGG
ACGCCGGGAATATGCTGAAACCGGCGCTGGCGCGTGGTGAACTGCACTGTGTGGGCGCCACCACGCTGGATGAATACCGT
CAGTACATTGAAAAAGACGCGGCGCTGGAACGTCGTTTTCAAAAAGTGTTTGTCGCAGAACCCTCAGTGGAAGACACCAT
CGCTATTCTGCGTGGCCTGAAAGAACGTTACGAGCTGCACCACCATGTGCAGATCACTGACCCGGCGATTGTGGCGGCGG
CAACATTATCTCACCGCTATATCGCCGACCGTCAGTTGCCGGATAAAGCTATCGACCTCATCGATGAAGCGGCATCCAGC
ATTCGTATGCAGATTGACTCTAAGCCGGAGGAGCTGGACAGGCTCGACCGCCGCATTATTCAGCTCAAACTGGAACAGCA
GGCGTTGATGAAAGAGTCTGACGAGGCGAGTAAAAAACGTCTCGATATGCTCAACGAAGAACTGGACGATAAAGAGCGCC
AGTACTCTGAGTTAGAAGAAGAGTGGAAAGCGGAAAAAGCGTCGCTCTCTGGTACGCAAACTATTAAAGCGGAGCTGGAG
CAGGCGAAGATCGCCATTGAGCAGGCGCGTCGTGTGGGCGATCTGGCGCGAATGTCTGAACTGCAGTACGGCAAAATTCC
GGAGCTGGAAAAACAGTTGGAAGCCGCGACCCAGTCGGAAGGTAAAACCATGCGTCTGTTACGTAACAAAGTAACGGATG
CGGAAATTGCCGAAGTGCTGGCGCGCTGGACCGGTATTCCGGTTGCCAGAATGCTGGAAGGCGAACGTGAAAAACTGTTG
CGTATGGAACAAGAGTTACACAGCCGTGTGATCGGGCAGAATGAAGCCGTTGAAGCAGTATCGAACGCCATACGTCGTAG
CCGCGCGGGGCTGTCCGATCCGAATCGTCCGATTGGTTCCTTCTTGTTCCTTGGGCCGACGGGGGTCGGTAAAACCGAAC
TGTGTAAAGCGCTGGCTAACTTTATGTTTGACAGCGACGACGCGATGGTGCGTATCGACATGTCTGAGTTTATGGAGAAA
CACTCCGTGTCTCGTTTGGTCGGGGCGCCTCCGGGATATGTCGGCTATGAAGAAGGCGGTTATTTGACGGAAGCGGTGCG
CCGTCGCCCTTATTCCGTCATCTTGTTGGATGAAGTGGAAAAAGCGCATCCGGATGTATTCAACATTCTGTTGCAGGTGC
TGGACGACGGTCGACTGACTGACGGGCAGGGGAGAACGGTCGACTTCCGTAATACGGTGGTCATTATGACTTCTAACCTC
GGTTCCGATCTCATTCAGGAGCGCTTTGGCGAACTGGATTACGGTCGAATGAAAGAGATGGTGCTGGGTGTGGTTAGCCA
AAACTTCCGTCCGGAATTTATCAACCGTATTGATGAAGTTGTGGTATTCCATCCGTTAGGTGAACAACACATCGCTTCTA
TTGCTCAGATCCAGCTGCAGCGTCTGTACAAACGTCTGGAAGAACGTGGTTATGAAATCCATATCTCCGACGAGGCGCTG
AAACTGTTGAGCGCCAACGGTTACGATCCGGTCTACGGGGCGCGTCCGTTAAAACGTGCTATTCAACAGCAGATCGAAAA
CCCACTGGCGCAGCAAATCCTGTCTGGTGAACTGGTTCCTGGCAAAGTGATTCGCCTTGAAGCCAATGATGATCGTATTG
TGGCAGTGCAGTAA

Upstream 100 bases:

>100_bases
TAACTTTCTTTTCACATAATTCAGGTCATTCACCTTGAATAATTGAGGGATGACCTCATTTAATCTCCAGTAGCAATTTT
GACCTGTTATGGGAGGAGTT

Downstream 100 bases:

>100_bases
GTCACAAATTTGAATAAAACGGGCCCTGACGGGCTCGTTTTTGTTTAAAAACCAGGCGAAAATAGGCTTTTGGTTCAAAT
GTTGTTTGAAAAGTGAACGG

Product: protein disaggregation chaperone

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 857; Mature: 857

Protein sequence:

>857_residues
MRLDRLTNKFQLALADAQSLALGHDNQFIEPLHLMSALLNQEGGSIRPLLTSAGINAGQLRTAIDQALSRLPQVEGTGGD
VQPSSELVRVLNLCDKLAQKRGDNFISSELFVLAALESRGTLTDLLKSAGATTANITQAIEQMRGGESVNDQGAEDQRQA
LKKYTVDLTERAEQGKLDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKGRRVLAL
DMGALVAGAKYRGEFEERLKGVLNDLAKQEGNVILFIDELHTMVGAGKADGAMDAGNMLKPALARGELHCVGATTLDEYR
QYIEKDAALERRFQKVFVAEPSVEDTIAILRGLKERYELHHHVQITDPAIVAAATLSHRYIADRQLPDKAIDLIDEAASS
IRMQIDSKPEELDRLDRRIIQLKLEQQALMKESDEASKKRLDMLNEELDDKERQYSELEEEWKAEKASLSGTQTIKAELE
QAKIAIEQARRVGDLARMSELQYGKIPELEKQLEAATQSEGKTMRLLRNKVTDAEIAEVLARWTGIPVARMLEGEREKLL
RMEQELHSRVIGQNEAVEAVSNAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKALANFMFDSDDAMVRIDMSEFMEK
HSVSRLVGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNL
GSDLIQERFGELDYGRMKEMVLGVVSQNFRPEFINRIDEVVVFHPLGEQHIASIAQIQLQRLYKRLEERGYEIHISDEAL
KLLSANGYDPVYGARPLKRAIQQQIENPLAQQILSGELVPGKVIRLEANDDRIVAVQ

Sequences:

>Translated_857_residues
MRLDRLTNKFQLALADAQSLALGHDNQFIEPLHLMSALLNQEGGSIRPLLTSAGINAGQLRTAIDQALSRLPQVEGTGGD
VQPSSELVRVLNLCDKLAQKRGDNFISSELFVLAALESRGTLTDLLKSAGATTANITQAIEQMRGGESVNDQGAEDQRQA
LKKYTVDLTERAEQGKLDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKGRRVLAL
DMGALVAGAKYRGEFEERLKGVLNDLAKQEGNVILFIDELHTMVGAGKADGAMDAGNMLKPALARGELHCVGATTLDEYR
QYIEKDAALERRFQKVFVAEPSVEDTIAILRGLKERYELHHHVQITDPAIVAAATLSHRYIADRQLPDKAIDLIDEAASS
IRMQIDSKPEELDRLDRRIIQLKLEQQALMKESDEASKKRLDMLNEELDDKERQYSELEEEWKAEKASLSGTQTIKAELE
QAKIAIEQARRVGDLARMSELQYGKIPELEKQLEAATQSEGKTMRLLRNKVTDAEIAEVLARWTGIPVARMLEGEREKLL
RMEQELHSRVIGQNEAVEAVSNAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKALANFMFDSDDAMVRIDMSEFMEK
HSVSRLVGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNL
GSDLIQERFGELDYGRMKEMVLGVVSQNFRPEFINRIDEVVVFHPLGEQHIASIAQIQLQRLYKRLEERGYEIHISDEAL
KLLSANGYDPVYGARPLKRAIQQQIENPLAQQILSGELVPGKVIRLEANDDRIVAVQ
>Mature_857_residues
MRLDRLTNKFQLALADAQSLALGHDNQFIEPLHLMSALLNQEGGSIRPLLTSAGINAGQLRTAIDQALSRLPQVEGTGGD
VQPSSELVRVLNLCDKLAQKRGDNFISSELFVLAALESRGTLTDLLKSAGATTANITQAIEQMRGGESVNDQGAEDQRQA
LKKYTVDLTERAEQGKLDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKGRRVLAL
DMGALVAGAKYRGEFEERLKGVLNDLAKQEGNVILFIDELHTMVGAGKADGAMDAGNMLKPALARGELHCVGATTLDEYR
QYIEKDAALERRFQKVFVAEPSVEDTIAILRGLKERYELHHHVQITDPAIVAAATLSHRYIADRQLPDKAIDLIDEAASS
IRMQIDSKPEELDRLDRRIIQLKLEQQALMKESDEASKKRLDMLNEELDDKERQYSELEEEWKAEKASLSGTQTIKAELE
QAKIAIEQARRVGDLARMSELQYGKIPELEKQLEAATQSEGKTMRLLRNKVTDAEIAEVLARWTGIPVARMLEGEREKLL
RMEQELHSRVIGQNEAVEAVSNAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKALANFMFDSDDAMVRIDMSEFMEK
HSVSRLVGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNL
GSDLIQERFGELDYGRMKEMVLGVVSQNFRPEFINRIDEVVVFHPLGEQHIASIAQIQLQRLYKRLEERGYEIHISDEAL
KLLSANGYDPVYGARPLKRAIQQQIENPLAQQILSGELVPGKVIRLEANDDRIVAVQ

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=319, Percent_Identity=38.2445141065831, Blast_Score=218, Evalue=2e-56,
Organism=Escherichia coli, GI1788943, Length=857, Percent_Identity=96.732788798133, Blast_Score=1684, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=419, Percent_Identity=40.3341288782816, Blast_Score=281, Evalue=9e-77,
Organism=Saccharomyces cerevisiae, GI6320464, Length=770, Percent_Identity=50.5194805194805, Blast_Score=768, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=838, Percent_Identity=43.7947494033413, Blast_Score=701, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 95422; Mature: 95422

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLDRLTNKFQLALADAQSLALGHDNQFIEPLHLMSALLNQEGGSIRPLLTSAGINAGQL
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHH
RTAIDQALSRLPQVEGTGGDVQPSSELVRVLNLCDKLAQKRGDNFISSELFVLAALESRG
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEEHHCCC
TLTDLLKSAGATTANITQAIEQMRGGESVNDQGAEDQRQALKKYTVDLTERAEQGKLDPV
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
IGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKGRRVLAL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
DMGALVAGAKYRGEFEERLKGVLNDLAKQEGNVILFIDELHTMVGAGKADGAMDAGNMLK
EHHHHHHCCHHCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCCHHHH
PALARGELHCVGATTLDEYRQYIEKDAALERRFQKVFVAEPSVEDTIAILRGLKERYELH
HHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
HHVQITDPAIVAAATLSHRYIADRQLPDKAIDLIDEAASSIRMQIDSKPEELDRLDRRII
HCEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHH
QLKLEQQALMKESDEASKKRLDMLNEELDDKERQYSELEEEWKAEKASLSGTQTIKAELE
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QAKIAIEQARRVGDLARMSELQYGKIPELEKQLEAATQSEGKTMRLLRNKVTDAEIAEVL
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHH
ARWTGIPVARMLEGEREKLLRMEQELHSRVIGQNEAVEAVSNAIRRSRAGLSDPNRPIGS
HHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
FLFLGPTGVGKTELCKALANFMFDSDDAMVRIDMSEFMEKHSVSRLVGAPPGYVGYEEGG
EEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCC
YLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNL
HHHHHHHCCCCEEEEECCHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEECCC
GSDLIQERFGELDYGRMKEMVLGVVSQNFRPEFINRIDEVVVFHPLGEQHIASIAQIQLQ
CHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHEEEECCCCHHHHHHHHHHHHH
RLYKRLEERGYEIHISDEALKLLSANGYDPVYGARPLKRAIQQQIENPLAQQILSGELVP
HHHHHHHHCCCEEEECHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
GKVIRLEANDDRIVAVQ
CEEEEEECCCCEEEEEC
>Mature Secondary Structure
MRLDRLTNKFQLALADAQSLALGHDNQFIEPLHLMSALLNQEGGSIRPLLTSAGINAGQL
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHH
RTAIDQALSRLPQVEGTGGDVQPSSELVRVLNLCDKLAQKRGDNFISSELFVLAALESRG
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEEHHCCC
TLTDLLKSAGATTANITQAIEQMRGGESVNDQGAEDQRQALKKYTVDLTERAEQGKLDPV
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
IGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKGRRVLAL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
DMGALVAGAKYRGEFEERLKGVLNDLAKQEGNVILFIDELHTMVGAGKADGAMDAGNMLK
EHHHHHHCCHHCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCCHHHH
PALARGELHCVGATTLDEYRQYIEKDAALERRFQKVFVAEPSVEDTIAILRGLKERYELH
HHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
HHVQITDPAIVAAATLSHRYIADRQLPDKAIDLIDEAASSIRMQIDSKPEELDRLDRRII
HCEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHH
QLKLEQQALMKESDEASKKRLDMLNEELDDKERQYSELEEEWKAEKASLSGTQTIKAELE
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
QAKIAIEQARRVGDLARMSELQYGKIPELEKQLEAATQSEGKTMRLLRNKVTDAEIAEVL
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHH
ARWTGIPVARMLEGEREKLLRMEQELHSRVIGQNEAVEAVSNAIRRSRAGLSDPNRPIGS
HHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
FLFLGPTGVGKTELCKALANFMFDSDDAMVRIDMSEFMEKHSVSRLVGAPPGYVGYEEGG
EEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCC
YLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNL
HHHHHHHCCCCEEEEECCHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEECCC
GSDLIQERFGELDYGRMKEMVLGVVSQNFRPEFINRIDEVVVFHPLGEQHIASIAQIQLQ
CHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHEEEECCCCHHHHHHHHHHHHH
RLYKRLEERGYEIHISDEALKLLSANGYDPVYGARPLKRAIQQQIENPLAQQILSGELVP
HHHHHHHHCCCEEEECHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
GKVIRLEANDDRIVAVQ
CEEEEEECCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]