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The map label for this gene is flk

Identifier: 194736417

GI number: 194736417

Start: 2486693

End: 2487694

Strand: Direct

Name: flk

Synonym: SeSA_A2601

Alternate gene names: 194736417

Gene position: 2486693-2487694 (Clockwise)

Preceding gene: 194734948

Following gene: 194735460

Centisome position: 52.81

GC content: 55.09

Gene sequence:

>1002_bases
ATGCATCCCATCTCCGGCGCCCCTGCACAGCCTCCAGGCGAAGGGCGTAATCCTCTTTCCGCTGCGAGCGAGCAGCCGCT
TTCCATGCAACAGCGTACGGTACTGGAAAGGCTGATCACGCGCCTGATTTCACTGACCCAGCAGCAAAGCGCGGAAGTAT
GGGCCGGAATGAAACACGATCTGGGGATAAAAAATGACGCGCCGCTACTGTCGCGCCACTTCCCCGCCGCTGAACAGAAT
CTTACCCAGCGTCTGGGCGTAGCGCAGCAAAATCACGCCAATCGTCAGGTACTTTCACAGCTAACAGAGCTGCTTGGCGT
CGGGAATAATCGTCAGGCCGTCAGCGATTTTATCCGTCAGCAATACGGTCAAACCGCGCTTAGCCAGCTTACGCCCGATC
AACTCAAAAACGTGCTGACGCTCCTGCAACAGGGGCAGCTTTCCATTCCGCAGCCGCAGCAACGTCCGGCAACGGATCGG
CCATTATTGCCTGCTGAACATAATACGTTGAATCAGTTGGTGACGAAGCTGGCAGCCGCGACCGGCGAGTCAAACAAACT
TATCTGGCAATCAATGCTGGAACTCTCCGGCGTGAAAAGCGGCGAGCTCATTCCGGCAAAACAGTTTACTCATCTGGCGA
CATGGCTACAGGCGCGGCAGACGCTGTCACTACAACACGCGCCTACGCTACATACGCTGCAGGCTGCGTTAAAACAACCG
CTTGAGCCGGACGAGCTCACAGCGATCAAAGAGTATGCCCAACACACTTATCAAATTCAGCCGCAAACGGTGTTGACCAC
CGCCCAGGTGCAGGACTTACTTAACCATATTTTCCTGCGTCGCGTAGAGCGGGAGGCGGATGAGCTGGAACCGCTCTCTA
TTCAACCCATCTACCGTCCGTTCGCGCCGATGATTGAAACCGTGAAAAATCTGTCTGCGCGACCAGGCCTGTTGTTTATC
GCGCTAATAATTGTACTGGCGCTTTTCTGGCTGGTTTCTTAA

Upstream 100 bases:

>100_bases
TGTCGTACCTGTTTGAGAACGAGAGTTAACCGGACAAGTGTGCCATAATCTGGCCGCCAGGCATATATTGCTCAGATTTA
TGGTTAAAGGATAATTAATT

Downstream 100 bases:

>100_bases
CCACGCCGGAACGATAATATCGTCACCAGGATGCCAACCACTGCGGAGATCGCTCCCGCGAGAAATACGGAAGGATAGCC
GCATGACGTGGCCAGCATGC

Product: flagella biosynthesis regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MHPISGAPAQPPGEGRNPLSAASEQPLSMQQRTVLERLITRLISLTQQQSAEVWAGMKHDLGIKNDAPLLSRHFPAAEQN
LTQRLGVAQQNHANRQVLSQLTELLGVGNNRQAVSDFIRQQYGQTALSQLTPDQLKNVLTLLQQGQLSIPQPQQRPATDR
PLLPAEHNTLNQLVTKLAAATGESNKLIWQSMLELSGVKSGELIPAKQFTHLATWLQARQTLSLQHAPTLHTLQAALKQP
LEPDELTAIKEYAQHTYQIQPQTVLTTAQVQDLLNHIFLRRVEREADELEPLSIQPIYRPFAPMIETVKNLSARPGLLFI
ALIIVLALFWLVS

Sequences:

>Translated_333_residues
MHPISGAPAQPPGEGRNPLSAASEQPLSMQQRTVLERLITRLISLTQQQSAEVWAGMKHDLGIKNDAPLLSRHFPAAEQN
LTQRLGVAQQNHANRQVLSQLTELLGVGNNRQAVSDFIRQQYGQTALSQLTPDQLKNVLTLLQQGQLSIPQPQQRPATDR
PLLPAEHNTLNQLVTKLAAATGESNKLIWQSMLELSGVKSGELIPAKQFTHLATWLQARQTLSLQHAPTLHTLQAALKQP
LEPDELTAIKEYAQHTYQIQPQTVLTTAQVQDLLNHIFLRRVEREADELEPLSIQPIYRPFAPMIETVKNLSARPGLLFI
ALIIVLALFWLVS
>Mature_333_residues
MHPISGAPAQPPGEGRNPLSAASEQPLSMQQRTVLERLITRLISLTQQQSAEVWAGMKHDLGIKNDAPLLSRHFPAAEQN
LTQRLGVAQQNHANRQVLSQLTELLGVGNNRQAVSDFIRQQYGQTALSQLTPDQLKNVLTLLQQGQLSIPQPQQRPATDR
PLLPAEHNTLNQLVTKLAAATGESNKLIWQSMLELSGVKSGELIPAKQFTHLATWLQARQTLSLQHAPTLHTLQAALKQP
LEPDELTAIKEYAQHTYQIQPQTVLTTAQVQDLLNHIFLRRVEREADELEPLSIQPIYRPFAPMIETVKNLSARPGLLFI
ALIIVLALFWLVS

Specific function: Acts as a regulator of flagellar gene expression by modulating the protein level of the anti sigma factor flgM upon sensing ring completion or hook elongation. Flk could inhibit flgM secretion by acting as a braking system for the flagellar- associated ty

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the flk family

Homologues:

Organism=Escherichia coli, GI1788661, Length=313, Percent_Identity=60.702875399361, Blast_Score=373, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FLK_SALTY (Q7CQ37)

Other databases:

- EMBL:   U77618
- EMBL:   AE006468
- RefSeq:   NP_461313.1
- GeneID:   1253893
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM2371
- HOGENOM:   HBG417065
- OMA:   SQGNNRQ
- ProtClustDB:   PRK10715
- BioCyc:   STYP99287:STM2371-MONOMER

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 37056; Mature: 37056

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1fc655c8)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPISGAPAQPPGEGRNPLSAASEQPLSMQQRTVLERLITRLISLTQQQSAEVWAGMKHD
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHC
LGIKNDAPLLSRHFPAAEQNLTQRLGVAQQNHANRQVLSQLTELLGVGNNRQAVSDFIRQ
CCCCCCCCHHHHCCCHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
QYGQTALSQLTPDQLKNVLTLLQQGQLSIPQPQQRPATDRPLLPAEHNTLNQLVTKLAAA
HHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
TGESNKLIWQSMLELSGVKSGELIPAKQFTHLATWLQARQTLSLQHAPTLHTLQAALKQP
CCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
LEPDELTAIKEYAQHTYQIQPQTVLTTAQVQDLLNHIFLRRVEREADELEPLSIQPIYRP
CCCHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
FAPMIETVKNLSARPGLLFIALIIVLALFWLVS
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MHPISGAPAQPPGEGRNPLSAASEQPLSMQQRTVLERLITRLISLTQQQSAEVWAGMKHD
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHC
LGIKNDAPLLSRHFPAAEQNLTQRLGVAQQNHANRQVLSQLTELLGVGNNRQAVSDFIRQ
CCCCCCCCHHHHCCCHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
QYGQTALSQLTPDQLKNVLTLLQQGQLSIPQPQQRPATDRPLLPAEHNTLNQLVTKLAAA
HHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
TGESNKLIWQSMLELSGVKSGELIPAKQFTHLATWLQARQTLSLQHAPTLHTLQAALKQP
CCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
LEPDELTAIKEYAQHTYQIQPQTVLTTAQVQDLLNHIFLRRVEREADELEPLSIQPIYRP
CCCHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
FAPMIETVKNLSARPGLLFIALIIVLALFWLVS
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9079927; 11677609