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The map label for this gene is umuC [H]

Identifier: 194736288

GI number: 194736288

Start: 2057065

End: 2058333

Strand: Reverse

Name: umuC [H]

Synonym: SeSA_A2158

Alternate gene names: 194736288

Gene position: 2058333-2057065 (Counterclockwise)

Preceding gene: 194736107

Following gene: 194736742

Centisome position: 43.71

GC content: 54.77

Gene sequence:

>1269_bases
ATGTTCGCGCTCTGCGATGTTAATAGCTTTTACGCCTCCTGCGAAACGGTCTTTCGTCCTGATTTATGTGGCCGACCGGT
GGTGGTGTTATCAAACAATGATGGCTGCGTTATCGCGTGTAGCGCCGAGGCGAAACAGCTTGGTATCGCACCAGGTGAGC
CATTCTTCAAACAGAAAGAACGCTTCCGGCGATCCGGTGTTGTTTGCTTCAGCAGTAATTACGAGCTTTACGCTGATATG
TCGAACCGGGTAATGACCACACTCGAGGAGATGGCGCCGCGGGTAGAAATTTACAGCATTGATGAGGCTTTTTGTGATCT
GACGGGAGTACGAAACTGCCGGGATCTGACAGATTTCGGGCGCGAGATAAGAGCGACGGTCCTGAAGCGCACGCACCTGA
CTGTCGGTGTAGGCATTGCCCAGACGAAAACCCTTGCCAAGCTGGCTAACCATGCTGCGAAAAAGTGGCAGCGCCAGACC
GGCGGGGTGGTTGACCTATCGAACATCGATCGCCAGCGTCGGCTACTGGCCCTGATACCCGTAGAGGATGTCTGGGGTGT
CGGCAGGCGCATCAGTAAGAAGCTCAATGCCCTGGGCATCAAGACTGCTCTCGATCTCTCTGAACAAAGTACCTGGATCA
TCAGGAAACACTTCAATGTCGTGCTGGAGCGTACCGTGAGAGAGCTTCGCGGAGAGCCATGTCTGGAGCTTGAAGAGTTT
GCGCCGGCAAAGCAGGAAATCGTTTGTAGCCGCTCTTTCGGCGAGCGGGTCACAGACTATGAGGAAATGCGCCAGGCTGT
TTACAGCTACGCTGCGCGCGCGGCAGAAAAACTCCGCGGCGAGCACCAGTACTGCCGTTTCATTTCAACATTCGTCAAAA
CATCACCCTTTGCCCTGAACAAGCCCTACTACGGTAACAGCGCCGCGGTGACGCTTCTCACCCCCACGCAGGATTCACGC
GACATTATCAATGCGGCTGTGAAGTGCCTGGATAAAATATGGCGCGACGGCCATCGCTACCAGAAAGCGGGGGTGATGCT
GGGTGACTTCTTCAGTCAGGGCGTAGCGCAACTCAACCTTTTCGACGATAACGCGCCGCGCGCCGGTAGTGCGAAGTTGA
TGGAAGTACTGGACCATCTTAACGCAAAAGCCGGGAAGGGGACGCTGTACTTCGCCGGGCAGGGGATGTCGCAACAGTGG
GCTATGAAGCGAGAAATGCTTTCGCCTCGGTACACCACAAGATACTCTGATCTACTGCGTGTTAAGTAA

Upstream 100 bases:

>100_bases
TCCCCATGAACGGCGCCTATCGACCTATACCTGTCGGCAGTGAAGACACGCTCGACATATTCGGGGTGGTGACCTTTATC
ATTAAAGCGGTCAGTTGATT

Downstream 100 bases:

>100_bases
CTTGTGCGATCAATGCATGAGATAGTTGCCAAATCATCCCCGTTCTCTAACCGGTTTTGGTCGCACAAGATCACAGGAAC
CTCTCACGATGATGCGCATG

Product: DNA polymerase V subunit UmuC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MFALCDVNSFYASCETVFRPDLCGRPVVVLSNNDGCVIACSAEAKQLGIAPGEPFFKQKERFRRSGVVCFSSNYELYADM
SNRVMTTLEEMAPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRATVLKRTHLTVGVGIAQTKTLAKLANHAAKKWQRQT
GGVVDLSNIDRQRRLLALIPVEDVWGVGRRISKKLNALGIKTALDLSEQSTWIIRKHFNVVLERTVRELRGEPCLELEEF
APAKQEIVCSRSFGERVTDYEEMRQAVYSYAARAAEKLRGEHQYCRFISTFVKTSPFALNKPYYGNSAAVTLLTPTQDSR
DIINAAVKCLDKIWRDGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRAGSAKLMEVLDHLNAKAGKGTLYFAGQGMSQQW
AMKREMLSPRYTTRYSDLLRVK

Sequences:

>Translated_422_residues
MFALCDVNSFYASCETVFRPDLCGRPVVVLSNNDGCVIACSAEAKQLGIAPGEPFFKQKERFRRSGVVCFSSNYELYADM
SNRVMTTLEEMAPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRATVLKRTHLTVGVGIAQTKTLAKLANHAAKKWQRQT
GGVVDLSNIDRQRRLLALIPVEDVWGVGRRISKKLNALGIKTALDLSEQSTWIIRKHFNVVLERTVRELRGEPCLELEEF
APAKQEIVCSRSFGERVTDYEEMRQAVYSYAARAAEKLRGEHQYCRFISTFVKTSPFALNKPYYGNSAAVTLLTPTQDSR
DIINAAVKCLDKIWRDGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRAGSAKLMEVLDHLNAKAGKGTLYFAGQGMSQQW
AMKREMLSPRYTTRYSDLLRVK
>Mature_422_residues
MFALCDVNSFYASCETVFRPDLCGRPVVVLSNNDGCVIACSAEAKQLGIAPGEPFFKQKERFRRSGVVCFSSNYELYADM
SNRVMTTLEEMAPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRATVLKRTHLTVGVGIAQTKTLAKLANHAAKKWQRQT
GGVVDLSNIDRQRRLLALIPVEDVWGVGRRISKKLNALGIKTALDLSEQSTWIIRKHFNVVLERTVRELRGEPCLELEEF
APAKQEIVCSRSFGERVTDYEEMRQAVYSYAARAAEKLRGEHQYCRFISTFVKTSPFALNKPYYGNSAAVTLLTPTQDSR
DIINAAVKCLDKIWRDGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRAGSAKLMEVLDHLNAKAGKGTLYFAGQGMSQQW
AMKREMLSPRYTTRYSDLLRVK

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=422, Percent_Identity=83.6492890995261, Blast_Score=753, Evalue=0.0,
Organism=Escherichia coli, GI1786425, Length=217, Percent_Identity=23.963133640553, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: 3.4.21.-

Molecular weight: Translated: 47581; Mature: 47581

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFALCDVNSFYASCETVFRPDLCGRPVVVLSNNDGCVIACSAEAKQLGIAPGEPFFKQKE
CEEEECCHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCHHHCCCCCCCHHHHHHH
RFRRSGVVCFSSNYELYADMSNRVMTTLEEMAPRVEIYSIDEAFCDLTGVRNCRDLTDFG
HHHHCCEEEEECCCEEEECCHHHHHHHHHHHCCCEEEEECHHHHHHHHCCCCHHHHHHHH
REIRATVLKRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNIDRQRRLLALIP
HHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHCCCCCCEEEEEC
VEDVWGVGRRISKKLNALGIKTALDLSEQSTWIIRKHFNVVLERTVRELRGEPCLELEEF
CHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
APAKQEIVCSRSFGERVTDYEEMRQAVYSYAARAAEKLRGEHQYCRFISTFVKTSPFALN
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCC
KPYYGNSAAVTLLTPTQDSRDIINAAVKCLDKIWRDGHRYQKAGVMLGDFFSQGVAQLNL
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHCCHHEEEE
FDDNAPRAGSAKLMEVLDHLNAKAGKGTLYFAGQGMSQQWAMKREMLSPRYTTRYSDLLR
ECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHC
VK
CC
>Mature Secondary Structure
MFALCDVNSFYASCETVFRPDLCGRPVVVLSNNDGCVIACSAEAKQLGIAPGEPFFKQKE
CEEEECCHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCHHHCCCCCCCHHHHHHH
RFRRSGVVCFSSNYELYADMSNRVMTTLEEMAPRVEIYSIDEAFCDLTGVRNCRDLTDFG
HHHHCCEEEEECCCEEEECCHHHHHHHHHHHCCCEEEEECHHHHHHHHCCCCHHHHHHHH
REIRATVLKRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNIDRQRRLLALIP
HHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHCCCCCCEEEEEC
VEDVWGVGRRISKKLNALGIKTALDLSEQSTWIIRKHFNVVLERTVRELRGEPCLELEEF
CHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
APAKQEIVCSRSFGERVTDYEEMRQAVYSYAARAAEKLRGEHQYCRFISTFVKTSPFALN
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCC
KPYYGNSAAVTLLTPTQDSRDIINAAVKCLDKIWRDGHRYQKAGVMLGDFFSQGVAQLNL
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHCCHHEEEE
FDDNAPRAGSAKLMEVLDHLNAKAGKGTLYFAGQGMSQQWAMKREMLSPRYTTRYSDLLR
ECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHC
VK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2144275; 2203737; 11677609 [H]