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The map label for this gene is cho

Identifier: 194736134

GI number: 194736134

Start: 1355789

End: 1356670

Strand: Reverse

Name: cho

Synonym: SeSA_A1405

Alternate gene names: 194736134

Gene position: 1356670-1355789 (Counterclockwise)

Preceding gene: 194734313

Following gene: 194733972

Centisome position: 28.81

GC content: 56.01

Gene sequence:

>882_bases
GTGGTACGGCGTCAATCAGCCCCCCGCCTTGAGTTTGAAGCGGCGGCCATTTACGAATATCCAGAACATTTACGTCCTTT
CCTCAGCGAAGCGCCAGCCTTACCGGGCGTCTATATATTTCATAGCGAAAGCGATACGCTGCCGCTTTATATCGGTAAAA
GCGTAAATATTCGCAGCCGGGTGCTCTCACATCTGCGAACGCCTGACGAGGCCGCTATGCTGCGACAGGCGCGGCGGATA
AGCTGGATCTGCACCGCTGGGGAAATGGGCGCGTTGCTGCTGGAGGCGCGGCTGATCAAAGAACAACAGCCGCTGTTTAA
CAAGCGGTTACGGCGTAATCGCCAGCTTTGCTCTCTACAGTTGAGCGAACAAAAGATTGAGGTCGTTTCCGCCCGCAGCG
TCGATTTTTCCCATGAGCCGAACCTGTTTGGGCTCTTCGCCAACCGTCGGGCGGCGCTGCAAAGCTTACAGAACCTCGCC
GATGAACAAAAATTGTGTTATGGCCTGCTGGGGCTTGAACCGGTAAGCCGTGGGCGCGCCTGTTTTCGTTTCGCTCTGAA
GCGCTGCGCTGGCGCGTGCTGTGGGCAAGAAACCCCGCAGGCGCATTTTCTTCGTCTGCAGGCCTCGCTGGAACGGTTAC
GTGTGGTTTGCTGGCCCTGGAAAGGCGCTATCGCGTTAAAAGAGAGCCGCCCACAAATGACCCAGTTCCACATTATCAAC
AACTGGTTATGGCTGGGGGCGGTCCCCTCGCTGGATGAGGCCGCCACCCTGGTGCGCACCCCTGCGGGCTTTGATCAGGA
TGGCTATAAAATTCTCTGTAAGCCACTAATGTCAGGTCAATATGAGATCATTGAACTGCACACCGACTGTCGCCAGTCAT
AA

Upstream 100 bases:

>100_bases
CGGATATCGCTCGTCTATCCGGCCTCCTCTCTTCCCAGCCTCTTTTTTAATCACCCATCCGCTGTTATACTGGATGAATA
ACCAGTTAACGGAGATCACT

Downstream 100 bases:

>100_bases
AGAAAACCGCCGATCCTGTCCACCTCAACGATTGTGTTGTCGACAAGACCGGCGGTCTTAAATTATGCGGAAAGTTATTC
TGCCGCAGCAGGCATTTTAC

Product: nucleotide excision repair endonuclease

Products: NA

Alternate protein names: Endonuclease cho; UvrC homolog protein

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MVRRQSAPRLEFEAAAIYEYPEHLRPFLSEAPALPGVYIFHSESDTLPLYIGKSVNIRSRVLSHLRTPDEAAMLRQARRI
SWICTAGEMGALLLEARLIKEQQPLFNKRLRRNRQLCSLQLSEQKIEVVSARSVDFSHEPNLFGLFANRRAALQSLQNLA
DEQKLCYGLLGLEPVSRGRACFRFALKRCAGACCGQETPQAHFLRLQASLERLRVVCWPWKGAIALKESRPQMTQFHIIN
NWLWLGAVPSLDEAATLVRTPAGFDQDGYKILCKPLMSGQYEIIELHTDCRQS

Sequences:

>Translated_293_residues
MVRRQSAPRLEFEAAAIYEYPEHLRPFLSEAPALPGVYIFHSESDTLPLYIGKSVNIRSRVLSHLRTPDEAAMLRQARRI
SWICTAGEMGALLLEARLIKEQQPLFNKRLRRNRQLCSLQLSEQKIEVVSARSVDFSHEPNLFGLFANRRAALQSLQNLA
DEQKLCYGLLGLEPVSRGRACFRFALKRCAGACCGQETPQAHFLRLQASLERLRVVCWPWKGAIALKESRPQMTQFHIIN
NWLWLGAVPSLDEAATLVRTPAGFDQDGYKILCKPLMSGQYEIIELHTDCRQS
>Mature_293_residues
MVRRQSAPRLEFEAAAIYEYPEHLRPFLSEAPALPGVYIFHSESDTLPLYIGKSVNIRSRVLSHLRTPDEAAMLRQARRI
SWICTAGEMGALLLEARLIKEQQPLFNKRLRRNRQLCSLQLSEQKIEVVSARSVDFSHEPNLFGLFANRRAALQSLQNLA
DEQKLCYGLLGLEPVSRGRACFRFALKRCAGACCGQETPQAHFLRLQASLERLRVVCWPWKGAIALKESRPQMTQFHIIN
NWLWLGAVPSLDEAATLVRTPAGFDQDGYKILCKPLMSGQYEIIELHTDCRQS

Specific function: Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than uvrC. Not able to incise the 5' site of a lesion. When a lesion remains because uvrC is not able to induce the 3' incision, cho

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrC C-terminal domain

Homologues:

Organism=Escherichia coli, GI1788037, Length=286, Percent_Identity=81.4685314685315, Blast_Score=496, Evalue=1e-142,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CHO_SALTI (Q8Z6G5)

Other databases:

- EMBL:   AL627271
- EMBL:   AE014613
- PIR:   AD0709
- ProteinModelPortal:   Q8Z6G5
- SMR:   Q8Z6G5
- GenomeReviews:   AE014613_GR
- GenomeReviews:   AL513382_GR
- KEGG:   stt:t1188
- KEGG:   sty:STY1804
- HOGENOM:   HBG336547
- OMA:   RQSRRIT
- ProtClustDB:   PRK10545
- BioCyc:   SENT209261:T1188-MONOMER
- BioCyc:   SENT220341:STY1804-MONOMER
- GO:   GO:0005622
- InterPro:   IPR000305
- SMART:   SM00465

Pfam domain/function: PF01541 GIY-YIG; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 33333; Mature: 33333

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: PS50164 UVRC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRRQSAPRLEFEAAAIYEYPEHLRPFLSEAPALPGVYIFHSESDTLPLYIGKSVNIRSR
CCCCCCCCCCEEHHHHHHHCHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCHHHH
VLSHLRTPDEAAMLRQARRISWICTAGEMGALLLEARLIKEQQPLFNKRLRRNRQLCSLQ
HHHHHCCCHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHEEE
LSEQKIEVVSARSVDFSHEPNLFGLFANRRAALQSLQNLADEQKLCYGLLGLEPVSRGRA
HHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
CFRFALKRCAGACCGQETPQAHFLRLQASLERLRVVCWPWKGAIALKESRPQMTQFHIIN
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEEEECCCCCEEEECCCCCHHEEHHHH
NWLWLGAVPSLDEAATLVRTPAGFDQDGYKILCKPLMSGQYEIIELHTDCRQS
CEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MVRRQSAPRLEFEAAAIYEYPEHLRPFLSEAPALPGVYIFHSESDTLPLYIGKSVNIRSR
CCCCCCCCCCEEHHHHHHHCHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCHHHH
VLSHLRTPDEAAMLRQARRISWICTAGEMGALLLEARLIKEQQPLFNKRLRRNRQLCSLQ
HHHHHCCCHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHCHHHHEEE
LSEQKIEVVSARSVDFSHEPNLFGLFANRRAALQSLQNLADEQKLCYGLLGLEPVSRGRA
HHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
CFRFALKRCAGACCGQETPQAHFLRLQASLERLRVVCWPWKGAIALKESRPQMTQFHIIN
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEEEECCCCCEEEECCCCCHHEEHHHH
NWLWLGAVPSLDEAATLVRTPAGFDQDGYKILCKPLMSGQYEIIELHTDCRQS
CEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504