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The map label for this gene is tkt [H]

Identifier: 194736024

GI number: 194736024

Start: 2583180

End: 2585180

Strand: Direct

Name: tkt [H]

Synonym: SeSA_A2707

Alternate gene names: 194736024

Gene position: 2583180-2585180 (Clockwise)

Preceding gene: 194734430

Following gene: 194737948

Centisome position: 54.86

GC content: 56.22

Gene sequence:

>2001_bases
ATGTCCCGTAAAGACCTTGCCAATGCGATTCGTGCGCTGAGCATGGATGCCGTTCAAAAAGCCAATTCCGGGCACCCCGG
CGCGCCGATGGGGATGGCGGATATCGCTGAAGTGCTATGGAACGATTTTCTTAAACATAACCCCACCGATCCGACCTGGT
ATGACCGTGATCGTTTTATCCTTTCCAACGGTCACGCCTCCATGCTGCTCTATAGTCTGCTGCATTTAACCGGTTATGAC
CTGCCGCTGGAGGAGTTAAAAAACTTCCGTCAACTGCACTCTAAAACGCCCGGTCACCCGGAGATTGGCTATACGCCCGG
CGTTGAAACCACCACCGGGCCGCTGGGCCAGGGGCTGGCGAATGCCGTCGGGCTGGCGATTGCCGAGCGTACGTTAGGCG
CACAGTTCAACCGGCCGGACCATGAGATTGTCGACCACTACACCTATGTCTTTATGGGCGACGGCTGTCTGATGGAGGGG
ATCTCGCATGAGGTGTGTTCGCTGGCTGGTACGCTGGGGCTGGGCAAACTGATCGGCTTTTACGATCACAACGGCATCTC
CATTGATGGCGAAACCGAAGGCTGGTTTACCGACGATACCGCCAAACGTTTTGAAGCCTACCACTGGCATGTCGTGCATG
ACATTGACGGGCACGATCCGGAGGCGGTGAAAAAAGCCATTCTGGAAGCCCAGAGCGTAAAAGACAAACCTTCGCTAATT
ATCTGTCGGACGGTGATAGGTTTTGGCTCGCCGAATAAAGCCGGGAAGGAGGAGTCGCACGGCGCGGCGCTGGGCGAAGA
AGAGGTGGCTCTGACCCGCCAGAAGCTGGGATGGCATCATCCGGCGTTTGAGATCCCAAAAGAAATTTACCGCGCGTGGG
ATGGCCGTGAAAAAGGCGAGAAAGCGCAGCAGCAGTGGCAGGAAAAGTTTGCTGCTTATAAGAAGGCTTATCCTGAGCTG
GCCGCAGAGTTTACCCGCCGGATGAGCGGCGGATTGCCGGAGGCATGGGAATCCGCCACGCAAAAATTTATTAACGACTT
GCAGGCTAATCCGGCCAAAATCGCCACCCGTAAAGCATCGCAAAATACGCTCAATGCCTACGGTCCCCTGTTGCCGGAAC
TGTTGGGCGGATCGGCGGATCTGGCGCCGAGCAACCTGACTATCTGGAAAGGTTCGACCTCGTTGAAAGAGGATCCGGCA
GGTAATTACATCCACTATGGCGTGCGCGAATTCGGCATGACCGCCATTGCCAACGGCATCGCCCACCACGGCGGCTTTGT
ACCGTATACCGCCACGTTTCTGATGTTTGTCGAATATGCGCGTAACGCGGCGCGTATGGCGGCCTTAATGAAAGCCCGGC
AGATTATGGTCTATACCCACGACTCCATCGGTTTGGGCGAAGATGGCCCGACGCACCAGGCCGTGGAACAACTGGCGAGC
CTGCGCTTAACGCCAAACTTCAGCACCTGGCGTCCCTGCGATCAGGTTGAGGCGGCGGTCGGCTGGAAGCTGGCCATTGA
ACGTCAGCACGGGCCGACGGCGTTGATTCTCTCGCGGCAGAATCTGGCGCAGGTGGAACGCACGCCGGAACAGGTGAAAG
AAATTGCTCGCGGCGGTTATATTCTGAAGGATAGCGGCGGCAAGCCGGATATCATTCTGATCGCTACCGGATCGGAAATG
GAAATTACCCTCCAGGCGGCGGAAAAATTGACTGGCGAGGGGCATAACGTTCGCGTGGTGTCGTTGCCTTCAACGGATAT
TTTCGATGCGCAGGACGAGGCATATCGCGAATCAGTGCTACCGGCGCACGTGACCGCCCGCGTCGCGGTGGAAGCCGGTA
TAGCCGACTACTGGTATAAATATGTTGGCCTAAAAGGCGCAATTATCGGCATGACGGGATACGGTGAATCCGCCCCGGCT
GACAAACTGTTCCCGTATTTTGGCTTTACCGTGGAAAATATTGTAGAAAAAGCCCGCCGGGTGCTGAACATCAAAGGCTA
A

Upstream 100 bases:

>100_bases
GTAGAGAAGCTGTCGGAAGGTATCCGTCTTTTTGCCGTTGACCAGCGCAAACTGGAAGACCTGCTTGCCGCCAAACTATA
AACCTTGCATGGAGTGATTT

Downstream 100 bases:

>100_bases
GGCGAGCGTTAGCAACACAGACTTTGCGCAGTCTGCAGACCTGTTCTGTAGGCTGTGCAAAATTACTTCGTAGACTCAGG
CGCATCTGACTGCCCGATGA

Product: transketolase

Products: NA

Alternate protein names: TK 2 [H]

Number of amino acids: Translated: 666; Mature: 665

Protein sequence:

>666_residues
MSRKDLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPTDPTWYDRDRFILSNGHASMLLYSLLHLTGYD
LPLEELKNFRQLHSKTPGHPEIGYTPGVETTTGPLGQGLANAVGLAIAERTLGAQFNRPDHEIVDHYTYVFMGDGCLMEG
ISHEVCSLAGTLGLGKLIGFYDHNGISIDGETEGWFTDDTAKRFEAYHWHVVHDIDGHDPEAVKKAILEAQSVKDKPSLI
ICRTVIGFGSPNKAGKEESHGAALGEEEVALTRQKLGWHHPAFEIPKEIYRAWDGREKGEKAQQQWQEKFAAYKKAYPEL
AAEFTRRMSGGLPEAWESATQKFINDLQANPAKIATRKASQNTLNAYGPLLPELLGGSADLAPSNLTIWKGSTSLKEDPA
GNYIHYGVREFGMTAIANGIAHHGGFVPYTATFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAVEQLAS
LRLTPNFSTWRPCDQVEAAVGWKLAIERQHGPTALILSRQNLAQVERTPEQVKEIARGGYILKDSGGKPDIILIATGSEM
EITLQAAEKLTGEGHNVRVVSLPSTDIFDAQDEAYRESVLPAHVTARVAVEAGIADYWYKYVGLKGAIIGMTGYGESAPA
DKLFPYFGFTVENIVEKARRVLNIKG

Sequences:

>Translated_666_residues
MSRKDLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPTDPTWYDRDRFILSNGHASMLLYSLLHLTGYD
LPLEELKNFRQLHSKTPGHPEIGYTPGVETTTGPLGQGLANAVGLAIAERTLGAQFNRPDHEIVDHYTYVFMGDGCLMEG
ISHEVCSLAGTLGLGKLIGFYDHNGISIDGETEGWFTDDTAKRFEAYHWHVVHDIDGHDPEAVKKAILEAQSVKDKPSLI
ICRTVIGFGSPNKAGKEESHGAALGEEEVALTRQKLGWHHPAFEIPKEIYRAWDGREKGEKAQQQWQEKFAAYKKAYPEL
AAEFTRRMSGGLPEAWESATQKFINDLQANPAKIATRKASQNTLNAYGPLLPELLGGSADLAPSNLTIWKGSTSLKEDPA
GNYIHYGVREFGMTAIANGIAHHGGFVPYTATFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAVEQLAS
LRLTPNFSTWRPCDQVEAAVGWKLAIERQHGPTALILSRQNLAQVERTPEQVKEIARGGYILKDSGGKPDIILIATGSEM
EITLQAAEKLTGEGHNVRVVSLPSTDIFDAQDEAYRESVLPAHVTARVAVEAGIADYWYKYVGLKGAIIGMTGYGESAPA
DKLFPYFGFTVENIVEKARRVLNIKG
>Mature_665_residues
SRKDLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPTDPTWYDRDRFILSNGHASMLLYSLLHLTGYDL
PLEELKNFRQLHSKTPGHPEIGYTPGVETTTGPLGQGLANAVGLAIAERTLGAQFNRPDHEIVDHYTYVFMGDGCLMEGI
SHEVCSLAGTLGLGKLIGFYDHNGISIDGETEGWFTDDTAKRFEAYHWHVVHDIDGHDPEAVKKAILEAQSVKDKPSLII
CRTVIGFGSPNKAGKEESHGAALGEEEVALTRQKLGWHHPAFEIPKEIYRAWDGREKGEKAQQQWQEKFAAYKKAYPELA
AEFTRRMSGGLPEAWESATQKFINDLQANPAKIATRKASQNTLNAYGPLLPELLGGSADLAPSNLTIWKGSTSLKEDPAG
NYIHYGVREFGMTAIANGIAHHGGFVPYTATFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAVEQLASL
RLTPNFSTWRPCDQVEAAVGWKLAIERQHGPTALILSRQNLAQVERTPEQVKEIARGGYILKDSGGKPDIILIATGSEME
ITLQAAEKLTGEGHNVRVVSLPSTDIFDAQDEAYRESVLPAHVTARVAVEAGIADYWYKYVGLKGAIIGMTGYGESAPAD
KLFPYFGFTVENIVEKARRVLNIKG

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=579, Percent_Identity=29.3609671848014, Blast_Score=179, Evalue=8e-45,
Organism=Homo sapiens, GI4507521, Length=579, Percent_Identity=29.3609671848014, Blast_Score=179, Evalue=8e-45,
Organism=Homo sapiens, GI133778974, Length=678, Percent_Identity=26.9911504424779, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI225637459, Length=676, Percent_Identity=21.7455621301775, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI225637461, Length=646, Percent_Identity=21.3622291021672, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI225637463, Length=572, Percent_Identity=22.027972027972, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI1788808, Length=666, Percent_Identity=93.2432432432432, Blast_Score=1304, Evalue=0.0,
Organism=Escherichia coli, GI48994911, Length=661, Percent_Identity=75.9455370650529, Blast_Score=1084, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=673, Percent_Identity=24.81426448737, Blast_Score=155, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6325331, Length=666, Percent_Identity=47.8978978978979, Blast_Score=592, Evalue=1e-170,
Organism=Saccharomyces cerevisiae, GI6319593, Length=669, Percent_Identity=45.2914798206278, Blast_Score=549, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45551847, Length=592, Percent_Identity=28.0405405405405, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI45550715, Length=592, Percent_Identity=28.0405405405405, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24666278, Length=587, Percent_Identity=25.7240204429302, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24645119, Length=552, Percent_Identity=27.7173913043478, Blast_Score=145, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 73118; Mature: 72986

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKDLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPTDPTWYDRDRFI
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
LSNGHASMLLYSLLHLTGYDLPLEELKNFRQLHSKTPGHPEIGYTPGVETTTGPLGQGLA
EECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHH
NAVGLAIAERTLGAQFNRPDHEIVDHYTYVFMGDGCLMEGISHEVCSLAGTLGLGKLIGF
HHHHHHHHHHHHCCCCCCCCHHHHHCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHE
YDHNGISIDGETEGWFTDDTAKRFEAYHWHVVHDIDGHDPEAVKKAILEAQSVKDKPSLI
ECCCCEEECCCCCCCCCCHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEE
ICRTVIGFGSPNKAGKEESHGAALGEEEVALTRQKLGWHHPAFEIPKEIYRAWDGREKGE
EEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHH
KAQQQWQEKFAAYKKAYPELAAEFTRRMSGGLPEAWESATQKFINDLQANPAKIATRKAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCC
QNTLNAYGPLLPELLGGSADLAPSNLTIWKGSTSLKEDPAGNYIHYGVREFGMTAIANGI
CCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHH
AHHGGFVPYTATFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAVEQLAS
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHH
LRLTPNFSTWRPCDQVEAAVGWKLAIERQHGPTALILSRQNLAQVERTPEQVKEIARGGY
EECCCCCCCCCCHHHHHHHCCEEEEEECCCCCEEEEEECHHHHHHHCCHHHHHHHHHCCE
ILKDSGGKPDIILIATGSEMEITLQAAEKLTGEGHNVRVVSLPSTDIFDAQDEAYRESVL
EEECCCCCCCEEEEEECCCEEEEHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHCC
PAHVTARVAVEAGIADYWYKYVGLKGAIIGMTGYGESAPADKLFPYFGFTVENIVEKARR
CHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHCCHHHCCCHHHHHHHHHH
VLNIKG
HHCCCC
>Mature Secondary Structure 
SRKDLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPTDPTWYDRDRFI
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
LSNGHASMLLYSLLHLTGYDLPLEELKNFRQLHSKTPGHPEIGYTPGVETTTGPLGQGLA
EECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHH
NAVGLAIAERTLGAQFNRPDHEIVDHYTYVFMGDGCLMEGISHEVCSLAGTLGLGKLIGF
HHHHHHHHHHHHCCCCCCCCHHHHHCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHE
YDHNGISIDGETEGWFTDDTAKRFEAYHWHVVHDIDGHDPEAVKKAILEAQSVKDKPSLI
ECCCCEEECCCCCCCCCCHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEE
ICRTVIGFGSPNKAGKEESHGAALGEEEVALTRQKLGWHHPAFEIPKEIYRAWDGREKGE
EEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHH
KAQQQWQEKFAAYKKAYPELAAEFTRRMSGGLPEAWESATQKFINDLQANPAKIATRKAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCC
QNTLNAYGPLLPELLGGSADLAPSNLTIWKGSTSLKEDPAGNYIHYGVREFGMTAIANGI
CCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHH
AHHGGFVPYTATFLMFVEYARNAARMAALMKARQIMVYTHDSIGLGEDGPTHQAVEQLAS
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHH
LRLTPNFSTWRPCDQVEAAVGWKLAIERQHGPTALILSRQNLAQVERTPEQVKEIARGGY
EECCCCCCCCCCHHHHHHHCCEEEEEECCCCCEEEEEECHHHHHHHCCHHHHHHHHHCCE
ILKDSGGKPDIILIATGSEMEITLQAAEKLTGEGHNVRVVSLPSTDIFDAQDEAYRESVL
EEECCCCCCCEEEEEECCCEEEEHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHCC
PAHVTARVAVEAGIADYWYKYVGLKGAIIGMTGYGESAPADKLFPYFGFTVENIVEKARR
CHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHCCHHHCCCHHHHHHHHHH
VLNIKG
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8396116; 9205837; 9278503 [H]