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The map label for this gene is dnaX [H]

Identifier: 194735928

GI number: 194735928

Start: 549036

End: 550964

Strand: Direct

Name: dnaX [H]

Synonym: SeSA_A0544

Alternate gene names: 194735928

Gene position: 549036-550964 (Clockwise)

Preceding gene: 194734405

Following gene: 194735445

Centisome position: 11.66

GC content: 58.84

Gene sequence:

>1929_bases
ATGAGTTATCAGGTCTTAGCCAGAAAATGGCGCCCACAAACCTTTGCTGACGTCGTCGGCCAGGAACATGTGCTGACCGC
ACTGGCGAACGGCTTGTCGTTAGGGCGCATTCATCACGCATATCTTTTTTCCGGCACGCGCGGCGTCGGTAAAACCTCTA
TCGCCCGACTGCTGGCGAAGGGGCTGAACTGCGAAACCGGTATTACCGCGACGCCGTGCGGCGTTTGCGATAATTGTCGG
GAAATTGAGCAGGGGCGTTTTGTCGATCTCATTGAGATTGACGCCGCATCGCGTACCAAAGTCGAAGACACCCGCGACCT
GCTGGATAACGTCCAGTACGCGCCTGCGCGCGGTCGCTTTAAAGTCTATCTGATCGATGAAGTCCACATGCTGTCGCGCC
ACAGCTTTAATGCGTTACTTAAAACGCTTGAAGAGCCGCCAGCGCATGTGAAATTTTTACTGGCGACCACCGATCCGCAG
AAGCTGCCGGTGACCATTTTGTCGCGCTGCCTACAGTTTCATCTCAAAGCTCTGGATGTTGAACAGATTCGCCATCAGCT
TGAGCATATTCTCAATGAGGAACATATCGCTCACGAACCCCGCGCGTTGCAGTTGTTATCACGTGCGGCTGACGGCAGCC
TGCGCGATGCATTAAGTCTGACTGACCAGGCGATCGCCAGCGGCGACGGGCAGGTTTCGACGCAGGCGGTAAGCGCCATG
CTCGGTACGCTGGACGACGACCAGGCTTTGTCATTAGTCGAGGCAGTGGTTGACGCTAACGGCGAACGCGTCATGTCGCT
TATCAACGAGGCGGCGGCGCGCGGTATTGAATGGGAAGCGCTGCTGGTCGAAATGCTTAGCCTGCTGCACCGTATTGCGA
TGGTGCAACTTTCGCCTGCCGCGTTAGGCAGCGATATGGCGGCTATCGAGCAACGGATGCGCGAACTTGCCCGGACGGTG
CCTCCCGGCGACCTTCAGCTCTATTATCAGACGTTGTTGATTGGTCGCAAAGAATTGCCCTGGGCGCCGGACCGGCGGAT
GGGCGTTGAAATGACGTTACTGCGTGCGCTGGCGTTTCACCCGCGTATGCCCTTGCCGGAGCCTGAAACGCCGCGGCAGT
CTTTTGCGGCTGTGGCCCCAACGGCGGTAATGACGCCGCCACAGGTGCAGCAGCAGTCGGCGCCCGCGCCGCAGACATCG
CCAACGCCGCTGCCGGCGTCTACCAGTCAGGTGCTGGCGGCGCGCAATCAGCTACAGCGCGCGCAGGGAGTAACCAAAAC
AAAAAAGAGTGAACCGGCAGCCGCATCCCGCGCGCGGCCGGTGAATAACTCTGCGCTGGAGCGGCTGGCCTCGGTTTCGG
AGCGCGTACAGGCGCGCCCGACGCCGTCTGCGCTGGAAACGGCGCCAGTAAAGAAAGAGGCTTATCGCTGGAAGGCCACC
ACGCCGGTAGTACAAACCAAAGAAGTGGTGGCTACGCCAAAAGCGCTTAAGAAAGCTCTGGAGCATGAAAAAACGCCGGA
GCTGGCGGCTAAACTGGCGGCGGAGGCGATTGAGCGCGATCCGTGGGCGGCGCAGGTAAGCCAGCTTTCTTTGCCTAAGC
TGGTGGAGCAGGTGGCGCTCAATGCCTGGAAGGAGCAGAACGGCAACGCGGTTTGTCTGCATCTGCGCTCGACGCAGCGG
CACCTCAATTCCAGCGGCGCGCAGCAAAAGCTGGCGCAAGCGCTCAGCGATCTGACGGGAACGACGGTTGAACTGACCAT
CGTTGAAGATGATAATCCCGCGGTGCGTACGCCGCTGGAATGGCGTCAGGCCATTTATGAAGAGAAACTCGCGCAAGCGC
GTGAGTCAATTATCGCGGATAATAACATTCAGACGCTGCGTCGATTCTTCGACGCCGAGCTGGATGAAGAGAGTATCCGC
CCCATTTGA

Upstream 100 bases:

>100_bases
CACTGCTATTTTAGCCAGAGAGACAACCTCGCTGTATCGGCGAGGTTGTGTTAGCATTACCCTTCTATGAATCCACCTTC
CAGCGTTTCAGAGCCTGCCA

Downstream 100 bases:

>100_bases
TCGTAAGCCTGGCTTGCGATTGTGAACCATCAAGAGAGAGAGCTTATGTTTGGAAAAGGCGGTCTGGGCAATCTGATGAA
ACAGGCCCAGCAGATGCAGG

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 642; Mature: 641

Protein sequence:

>642_residues
MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCR
EIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPAHVKFLLATTDPQ
KLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLSRAADGSLRDALSLTDQAIASGDGQVSTQAVSAM
LGTLDDDQALSLVEAVVDANGERVMSLINEAAARGIEWEALLVEMLSLLHRIAMVQLSPAALGSDMAAIEQRMRELARTV
PPGDLQLYYQTLLIGRKELPWAPDRRMGVEMTLLRALAFHPRMPLPEPETPRQSFAAVAPTAVMTPPQVQQQSAPAPQTS
PTPLPASTSQVLAARNQLQRAQGVTKTKKSEPAAASRARPVNNSALERLASVSERVQARPTPSALETAPVKKEAYRWKAT
TPVVQTKEVVATPKALKKALEHEKTPELAAKLAAEAIERDPWAAQVSQLSLPKLVEQVALNAWKEQNGNAVCLHLRSTQR
HLNSSGAQQKLAQALSDLTGTTVELTIVEDDNPAVRTPLEWRQAIYEEKLAQARESIIADNNIQTLRRFFDAELDEESIR
PI

Sequences:

>Translated_642_residues
MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCR
EIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPAHVKFLLATTDPQ
KLPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLSRAADGSLRDALSLTDQAIASGDGQVSTQAVSAM
LGTLDDDQALSLVEAVVDANGERVMSLINEAAARGIEWEALLVEMLSLLHRIAMVQLSPAALGSDMAAIEQRMRELARTV
PPGDLQLYYQTLLIGRKELPWAPDRRMGVEMTLLRALAFHPRMPLPEPETPRQSFAAVAPTAVMTPPQVQQQSAPAPQTS
PTPLPASTSQVLAARNQLQRAQGVTKTKKSEPAAASRARPVNNSALERLASVSERVQARPTPSALETAPVKKEAYRWKAT
TPVVQTKEVVATPKALKKALEHEKTPELAAKLAAEAIERDPWAAQVSQLSLPKLVEQVALNAWKEQNGNAVCLHLRSTQR
HLNSSGAQQKLAQALSDLTGTTVELTIVEDDNPAVRTPLEWRQAIYEEKLAQARESIIADNNIQTLRRFFDAELDEESIR
PI
>Mature_641_residues
SYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCRE
IEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPAHVKFLLATTDPQK
LPVTILSRCLQFHLKALDVEQIRHQLEHILNEEHIAHEPRALQLLSRAADGSLRDALSLTDQAIASGDGQVSTQAVSAML
GTLDDDQALSLVEAVVDANGERVMSLINEAAARGIEWEALLVEMLSLLHRIAMVQLSPAALGSDMAAIEQRMRELARTVP
PGDLQLYYQTLLIGRKELPWAPDRRMGVEMTLLRALAFHPRMPLPEPETPRQSFAAVAPTAVMTPPQVQQQSAPAPQTSP
TPLPASTSQVLAARNQLQRAQGVTKTKKSEPAAASRARPVNNSALERLASVSERVQARPTPSALETAPVKKEAYRWKATT
PVVQTKEVVATPKALKKALEHEKTPELAAKLAAEAIERDPWAAQVSQLSLPKLVEQVALNAWKEQNGNAVCLHLRSTQRH
LNSSGAQQKLAQALSDLTGTTVELTIVEDDNPAVRTPLEWRQAIYEEKLAQARESIIADNNIQTLRRFFDAELDEESIRP
I

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=311, Percent_Identity=24.1157556270096, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI194306571, Length=314, Percent_Identity=23.8853503184713, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI194306567, Length=314, Percent_Identity=23.8853503184713, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1786676, Length=643, Percent_Identity=92.3794712286159, Blast_Score=1172, Evalue=0.0,
Organism=Escherichia coli, GI1787341, Length=139, Percent_Identity=32.3741007194245, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324039, Length=323, Percent_Identity=24.4582043343653, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322528, Length=278, Percent_Identity=24.4604316546763, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI18859927, Length=275, Percent_Identity=24.7272727272727, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 70648; Mature: 70516

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAK
CCHHHHHHHCCCCHHHHHHCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHH
GLNCETGITATPCGVCDNCREIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRF
CCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSRHSFNALLKTLEEPPAHVKFLLATTDPQKLPVTILSRCLQFHLKALDV
EEEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCH
EQIRHQLEHILNEEHIAHEPRALQLLSRAADGSLRDALSLTDQAIASGDGQVSTQAVSAM
HHHHHHHHHHHCHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LGTLDDDQALSLVEAVVDANGERVMSLINEAAARGIEWEALLVEMLSLLHRIAMVQLSPA
HHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHH
ALGSDMAAIEQRMRELARTVPPGDLQLYYQTLLIGRKELPWAPDRRMGVEMTLLRALAFH
HHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHC
PRMPLPEPETPRQSFAAVAPTAVMTPPQVQQQSAPAPQTSPTPLPASTSQVLAARNQLQR
CCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
AQGVTKTKKSEPAAASRARPVNNSALERLASVSERVQARPTPSALETAPVKKEAYRWKAT
HHCCHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHCCCCC
TPVVQTKEVVATPKALKKALEHEKTPELAAKLAAEAIERDPWAAQVSQLSLPKLVEQVAL
CCCHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHH
NAWKEQNGNAVCLHLRSTQRHLNSSGAQQKLAQALSDLTGTTVELTIVEDDNPAVRTPLE
HHHHCCCCCEEEEEECHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHH
WRQAIYEEKLAQARESIIADNNIQTLRRFFDAELDEESIRPI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAK
CHHHHHHHCCCCHHHHHHCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHH
GLNCETGITATPCGVCDNCREIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRF
CCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSRHSFNALLKTLEEPPAHVKFLLATTDPQKLPVTILSRCLQFHLKALDV
EEEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCH
EQIRHQLEHILNEEHIAHEPRALQLLSRAADGSLRDALSLTDQAIASGDGQVSTQAVSAM
HHHHHHHHHHHCHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LGTLDDDQALSLVEAVVDANGERVMSLINEAAARGIEWEALLVEMLSLLHRIAMVQLSPA
HHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHH
ALGSDMAAIEQRMRELARTVPPGDLQLYYQTLLIGRKELPWAPDRRMGVEMTLLRALAFH
HHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHC
PRMPLPEPETPRQSFAAVAPTAVMTPPQVQQQSAPAPQTSPTPLPASTSQVLAARNQLQR
CCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
AQGVTKTKKSEPAAASRARPVNNSALERLASVSERVQARPTPSALETAPVKKEAYRWKAT
HHCCHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHCCCCC
TPVVQTKEVVATPKALKKALEHEKTPELAAKLAAEAIERDPWAAQVSQLSLPKLVEQVAL
CCCHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHH
NAWKEQNGNAVCLHLRSTQRHLNSSGAQQKLAQALSDLTGTTVELTIVEDDNPAVRTPLE
HHHHCCCCCEEEEEECHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHH
WRQAIYEEKLAQARESIIADNNIQTLRRFFDAELDEESIRPI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]