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The map label for this gene is mdtG [H]

Identifier: 194735879

GI number: 194735879

Start: 1199553

End: 1200767

Strand: Reverse

Name: mdtG [H]

Synonym: SeSA_A1221

Alternate gene names: 194735879

Gene position: 1200767-1199553 (Counterclockwise)

Preceding gene: 194733926

Following gene: 194735209

Centisome position: 25.5

GC content: 54.65

Gene sequence:

>1215_bases
ATGTCACCCTCTGATGTCCCCATAAACTGGAAACGCAATCTAACCGTTACCTGGTTGGGCTGTTTTTTAACCGGCGCGGC
ATTCAGTCTGGTCATGCCTTTTCTCCCTCTCTACGTTGAGCAACTCGGCGTAACAGGCCATAGCGCGCTCAACATGTGGT
CCGGGCTGGTCTTTAGTATTACGTTCCTCTTTTCAGCTATCGCTTCCCCTTTTTGGGGCGGTCTGGCGGATCGTAAAGGG
CGTAAGATTATGCTGTTGCGTTCCGCTCTCGGCATGGCCATTGTGATGCTGTTAATGGGCATGGCGCAAAATATCTGGCA
ATTTCTGATCCTCCGCGCGTTATTAGGCCTGCTGGGCGGATTTATTCCCAACGCCAATGCGCTCATCGCCACTCAGGTGC
CGCGCCATAAAAGCGGCTGGGCGTTAGGGACGCTCTCTACTGGCGGCGTCAGCGGCGCTCTGCTTGGCCCACTTGCGGGC
GGTCTGCTCGCCGACCATTACGGCCTTCGCCCGGTCTTTTTTATTACCGCCAGCGTGTTGTTTATCTGTTTTCTGCTCAC
CTTCTTTTTTATTCGCGAGAATTTCCTGCCGGTGAGCAAAAAAGAGATGCTTCACGTTCGGGAAGTGGTCGCCTCGTTAA
AAAATCCCCGCCTGGTGTTAAGCCTGTTTGTCACCACGCTGATTATTCAGGTGGCGACGGGGTCTATTGCGCCCATCCTG
ACGCTCTATGTGCGCGAACTCGCGGGAAATGTCAGTAATATTGCGTTCATTAGCGGGATGATAGCGTCCGTTCCCGGCGT
GGCGGCATTACTTAGCGCCCCCCGACTCGGCAAGCTCGGCGACAAAATTGGCCCGGAAAAGATCCTTATCGTCGCGCTGA
TTATTTCCGTACTGCTGCTGATTCCAATGTCTTTTGTGCAAACGCCGTGGCAGCTCGCGCTATTGCGGTTTCTGCTTGGC
GCGGCGGATGGCGCGCTGCTGCCAGCCGTTCAAACTCTGCTGGTTTACAACTCTACCAACCAGATAGCCGGGCGCATATT
CAGTTACAACCAATCTTTCCGCGATATCGGCAACGTCACCGGCCCTCTCATGGGCGCCGCAATTTCCGCGAGCTATGGCT
TCCGCGCCGTATTCTGCGTCACGGCAGGCGTGGTGTTGTTCAATGCTATCTATTCATGGAACAGCTTACGACGGCGCAGA
CTGGCAATAGAATGA

Upstream 100 bases:

>100_bases
CCCACATTGCGAGGCTGGTAAGGTCGGCGCATAATTATAATTAGTACGCTCATAATTAAATTGATGATAGCGCAAACCGC
GCATCATACTGTGGAACGCT

Downstream 100 bases:

>100_bases
TTTTTGCGCTTTCATACTTGCAATATCACAGAATCAGCTATTCTTTCCCTAAATACCTCGTCAAATCAAAGGGAGACACT
GATGACCATGTATGCCACGC

Product: drug efflux system protein MdtG

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MSPSDVPINWKRNLTVTWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGLVFSITFLFSAIASPFWGGLADRKG
RKIMLLRSALGMAIVMLLMGMAQNIWQFLILRALLGLLGGFIPNANALIATQVPRHKSGWALGTLSTGGVSGALLGPLAG
GLLADHYGLRPVFFITASVLFICFLLTFFFIRENFLPVSKKEMLHVREVVASLKNPRLVLSLFVTTLIIQVATGSIAPIL
TLYVRELAGNVSNIAFISGMIASVPGVAALLSAPRLGKLGDKIGPEKILIVALIISVLLLIPMSFVQTPWQLALLRFLLG
AADGALLPAVQTLLVYNSTNQIAGRIFSYNQSFRDIGNVTGPLMGAAISASYGFRAVFCVTAGVVLFNAIYSWNSLRRRR
LAIE

Sequences:

>Translated_404_residues
MSPSDVPINWKRNLTVTWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGLVFSITFLFSAIASPFWGGLADRKG
RKIMLLRSALGMAIVMLLMGMAQNIWQFLILRALLGLLGGFIPNANALIATQVPRHKSGWALGTLSTGGVSGALLGPLAG
GLLADHYGLRPVFFITASVLFICFLLTFFFIRENFLPVSKKEMLHVREVVASLKNPRLVLSLFVTTLIIQVATGSIAPIL
TLYVRELAGNVSNIAFISGMIASVPGVAALLSAPRLGKLGDKIGPEKILIVALIISVLLLIPMSFVQTPWQLALLRFLLG
AADGALLPAVQTLLVYNSTNQIAGRIFSYNQSFRDIGNVTGPLMGAAISASYGFRAVFCVTAGVVLFNAIYSWNSLRRRR
LAIE
>Mature_403_residues
SPSDVPINWKRNLTVTWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGLVFSITFLFSAIASPFWGGLADRKGR
KIMLLRSALGMAIVMLLMGMAQNIWQFLILRALLGLLGGFIPNANALIATQVPRHKSGWALGTLSTGGVSGALLGPLAGG
LLADHYGLRPVFFITASVLFICFLLTFFFIRENFLPVSKKEMLHVREVVASLKNPRLVLSLFVTTLIIQVATGSIAPILT
LYVRELAGNVSNIAFISGMIASVPGVAALLSAPRLGKLGDKIGPEKILIVALIISVLLLIPMSFVQTPWQLALLRFLLGA
ADGALLPAVQTLLVYNSTNQIAGRIFSYNQSFRDIGNVTGPLMGAAISASYGFRAVFCVTAGVVLFNAIYSWNSLRRRRL
AIE

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787291, Length=403, Percent_Identity=90.3225806451613, Blast_Score=699, Evalue=0.0,
Organism=Escherichia coli, GI87082404, Length=302, Percent_Identity=25.8278145695364, Blast_Score=76, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6319871, Length=153, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005828
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1; PF00083 Sugar_tr [H]

EC number: NA

Molecular weight: Translated: 43569; Mature: 43438

Theoretical pI: Translated: 11.01; Mature: 11.01

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPSDVPINWKRNLTVTWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGLVFSI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
TFLFSAIASPFWGGLADRKGRKIMLLRSALGMAIVMLLMGMAQNIWQFLILRALLGLLGG
HHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FIPNANALIATQVPRHKSGWALGTLSTGGVSGALLGPLAGGLLADHYGLRPVFFITASVL
CCCCCCEEEEECCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
FICFLLTFFFIRENFLPVSKKEMLHVREVVASLKNPRLVLSLFVTTLIIQVATGSIAPIL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHH
TLYVRELAGNVSNIAFISGMIASVPGVAALLSAPRLGKLGDKIGPEKILIVALIISVLLL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCHHHHHHHHHHHHHHHH
IPMSFVQTPWQLALLRFLLGAADGALLPAVQTLLVYNSTNQIAGRIFSYNQSFRDIGNVT
HHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHH
GPLMGAAISASYGFRAVFCVTAGVVLFNAIYSWNSLRRRRLAIE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SPSDVPINWKRNLTVTWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGLVFSI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
TFLFSAIASPFWGGLADRKGRKIMLLRSALGMAIVMLLMGMAQNIWQFLILRALLGLLGG
HHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FIPNANALIATQVPRHKSGWALGTLSTGGVSGALLGPLAGGLLADHYGLRPVFFITASVL
CCCCCCEEEEECCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
FICFLLTFFFIRENFLPVSKKEMLHVREVVASLKNPRLVLSLFVTTLIIQVATGSIAPIL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHH
TLYVRELAGNVSNIAFISGMIASVPGVAALLSAPRLGKLGDKIGPEKILIVALIISVLLL
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCHHHHHHHHHHHHHHHH
IPMSFVQTPWQLALLRFLLGAADGALLPAVQTLLVYNSTNQIAGRIFSYNQSFRDIGNVT
HHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHH
GPLMGAAISASYGFRAVFCVTAGVVLFNAIYSWNSLRRRRLAIE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA