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The map label for this gene is aidB [H]

Identifier: 194735634

GI number: 194735634

Start: 4518076

End: 4519698

Strand: Direct

Name: aidB [H]

Synonym: SeSA_A4645

Alternate gene names: 194735634

Gene position: 4518076-4519698 (Clockwise)

Preceding gene: 194738142

Following gene: 194737159

Centisome position: 95.94

GC content: 56.62

Gene sequence:

>1623_bases
ATGTCCTGGCAAACACATACCGTCTTTAATCAACCTGCTCCGCTCAATAACAGTAACTTATTCCTGTCTGATGGCGCGCT
GTGTGAAGCGGTTTCCCGGGAAGGCGCGGGATGGGATAGCGATCTTCTCGCCAGCATTGGCCAACAACTGGGAACGGCGG
AATCACTGGAACTGGGTCGTTTGGCGAATGCGTATCCTCCTGAGTTGCTGCGTTACGATCCCCAGGGGCAACGTCTGGAT
GACGTTCGCTTTCATCCCGCCTGGCACCTGTTGATGCAGGGGCTTTGCGCTAATCGGGTACATAACCTGGCCTGGGAGGA
GGAGGCAAGGGCGGGAAGTTTTGTCGCCCGGGCGGCGCGTTTTGTATTACATGCTCAGGTAGAAGCGGGAACACTCTGTC
CTGTCACGATGACCTTTGCCGCGACGCCGTTGCTATTGCAGATGCTTCCCGCCACTTTCCATGACTGGCTGGCGCCGCTG
CGCAGCGATCGCTACGATTCGCATTTGCTGCCGGGCGGGCAAAAACGGGGCCTGCTCATCGGCATGGGAATGACGGAAAA
GCAGGGCGGATCGGACGTACTCAGTAATACGACCCACGCGGAGCGGCTGGCGGATGATTCATATCGGCTGGTGGGACATA
AATGGTTTTTCTCTGTGCCGCAAAGTGATGCGCACCTCGTGCTGGCGCAGGCAAAAGGAGGATTATCCTGTTTCTTTGTG
CCGCGTTTCCTGCCAGACGGGCAACGGAACTCTGTTCGTCTTGAACGCCTGAAAGATAAACTCGGTAATCGATCTAATGC
CAGCGCCGAAGTCGAGTTTCAGGATGCCGTCGGCTGGCGTCTGGGAGAAGAGGGCGACGGGATTCGGCATATCTTAAAGA
TGGGCGGTATGACGCGTCTTGACTGCGCGCTCGGGAGTCATGGCTTAATGCGGCGTGCGTTTTCAGTCGCGATTTACCAT
GCTCATCAGCGTCAGGCTTTTGGTAAGCCGCTGATCGAACAACCGTTGATGCGACAAACCTTAAGTCGTATGGCGCTATG
CCTGGAGGGGCAGACGGCGCTTTTGTTTCGGCTGGCGCGCGCCTGGGAGCAACGTCGCGAGGCGAAAGAGGCATTATGGG
CGCGATTATTCACGCCAGCGGCGAAATTCGCCATCTGTAAGCAGGGAATCCCTTTTGTGGCTGAGGCGATGGAGGTTCTC
GGCGGGATGGGGTATTGCGAAGAGAGCGAACTCCCTCGCCTGTACCGTGAAATGCCGGTGAACAGTATCTGGGAAGGTTC
CGGCAATATCATGTGTCTGGATGTACTTCGGGTGCTGACAAAACAACACGGCGTCTATGACGTATTGAGTGAAGCTTTTG
CGGAAGTCAAAGGTCAGGATCGCCATTACGACCGCGCGGTACGTCAGCTACAGCAACGTTTACGCAAACCGGACGAAGCA
ATGGGCAGAGAGATTACGCAGCAGCTTTTCCTGCTGGGATGCGGAGCGGAAATGCTGCGTCATGCCTCGCCGCCGCTGGC
GCAAGCGTGGTGTCAGATGATGCTGGATACACGCGGCGAAATGCCGCTGCCTGCCCAGGTGCAAAATGATTTACTGTTAA
GGGCGACCGGGGGACTGCGGTAA

Upstream 100 bases:

>100_bases
TTATATTGCCGGTTAATCATACTTTTGTGATCTTGCTCCGGCGTCAATGGCGCAGTCATGACCATACTTGACTTCAGCGC
CATTGAAGGAGGGAGACACC

Downstream 100 bases:

>100_bases
CGTTTGGCCTGTGGTACATGCCATCCGGCGCGAGCCACGCGGCATCAGGCATAGAGTATCGCCTGTACGCGCCAGTTATC
CGACTGTTGTTCTTCATACA

Product: isovaleryl CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MSWQTHTVFNQPAPLNNSNLFLSDGALCEAVSREGAGWDSDLLASIGQQLGTAESLELGRLANAYPPELLRYDPQGQRLD
DVRFHPAWHLLMQGLCANRVHNLAWEEEARAGSFVARAARFVLHAQVEAGTLCPVTMTFAATPLLLQMLPATFHDWLAPL
RSDRYDSHLLPGGQKRGLLIGMGMTEKQGGSDVLSNTTHAERLADDSYRLVGHKWFFSVPQSDAHLVLAQAKGGLSCFFV
PRFLPDGQRNSVRLERLKDKLGNRSNASAEVEFQDAVGWRLGEEGDGIRHILKMGGMTRLDCALGSHGLMRRAFSVAIYH
AHQRQAFGKPLIEQPLMRQTLSRMALCLEGQTALLFRLARAWEQRREAKEALWARLFTPAAKFAICKQGIPFVAEAMEVL
GGMGYCEESELPRLYREMPVNSIWEGSGNIMCLDVLRVLTKQHGVYDVLSEAFAEVKGQDRHYDRAVRQLQQRLRKPDEA
MGREITQQLFLLGCGAEMLRHASPPLAQAWCQMMLDTRGEMPLPAQVQNDLLLRATGGLR

Sequences:

>Translated_540_residues
MSWQTHTVFNQPAPLNNSNLFLSDGALCEAVSREGAGWDSDLLASIGQQLGTAESLELGRLANAYPPELLRYDPQGQRLD
DVRFHPAWHLLMQGLCANRVHNLAWEEEARAGSFVARAARFVLHAQVEAGTLCPVTMTFAATPLLLQMLPATFHDWLAPL
RSDRYDSHLLPGGQKRGLLIGMGMTEKQGGSDVLSNTTHAERLADDSYRLVGHKWFFSVPQSDAHLVLAQAKGGLSCFFV
PRFLPDGQRNSVRLERLKDKLGNRSNASAEVEFQDAVGWRLGEEGDGIRHILKMGGMTRLDCALGSHGLMRRAFSVAIYH
AHQRQAFGKPLIEQPLMRQTLSRMALCLEGQTALLFRLARAWEQRREAKEALWARLFTPAAKFAICKQGIPFVAEAMEVL
GGMGYCEESELPRLYREMPVNSIWEGSGNIMCLDVLRVLTKQHGVYDVLSEAFAEVKGQDRHYDRAVRQLQQRLRKPDEA
MGREITQQLFLLGCGAEMLRHASPPLAQAWCQMMLDTRGEMPLPAQVQNDLLLRATGGLR
>Mature_539_residues
SWQTHTVFNQPAPLNNSNLFLSDGALCEAVSREGAGWDSDLLASIGQQLGTAESLELGRLANAYPPELLRYDPQGQRLDD
VRFHPAWHLLMQGLCANRVHNLAWEEEARAGSFVARAARFVLHAQVEAGTLCPVTMTFAATPLLLQMLPATFHDWLAPLR
SDRYDSHLLPGGQKRGLLIGMGMTEKQGGSDVLSNTTHAERLADDSYRLVGHKWFFSVPQSDAHLVLAQAKGGLSCFFVP
RFLPDGQRNSVRLERLKDKLGNRSNASAEVEFQDAVGWRLGEEGDGIRHILKMGGMTRLDCALGSHGLMRRAFSVAIYHA
HQRQAFGKPLIEQPLMRQTLSRMALCLEGQTALLFRLARAWEQRREAKEALWARLFTPAAKFAICKQGIPFVAEAMEVLG
GMGYCEESELPRLYREMPVNSIWEGSGNIMCLDVLRVLTKQHGVYDVLSEAFAEVKGQDRHYDRAVRQLQQRLRKPDEAM
GREITQQLFLLGCGAEMLRHASPPLAQAWCQMMLDTRGEMPLPAQVQNDLLLRATGGLR

Specific function: May help to prevent alkylation damage by protecting DNA and destroying alkylating agents [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=290, Percent_Identity=30.6896551724138, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI7656849, Length=269, Percent_Identity=28.996282527881, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI4557231, Length=278, Percent_Identity=28.4172661870504, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI226958412, Length=271, Percent_Identity=26.5682656826568, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI226958414, Length=271, Percent_Identity=26.5682656826568, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI187960098, Length=278, Percent_Identity=28.4172661870504, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI4501859, Length=252, Percent_Identity=25, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI87082384, Length=539, Percent_Identity=85.3432282003711, Blast_Score=963, Evalue=0.0,
Organism=Escherichia coli, GI1786223, Length=332, Percent_Identity=25.9036144578313, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081958, Length=271, Percent_Identity=26.5682656826568, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI86563381, Length=539, Percent_Identity=30.9833024118738, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI86563383, Length=539, Percent_Identity=30.9833024118738, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17538396, Length=271, Percent_Identity=29.1512915129151, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17508101, Length=270, Percent_Identity=26.2962962962963, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17506239, Length=270, Percent_Identity=24.8148148148148, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17569725, Length=270, Percent_Identity=25.5555555555556, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71985184, Length=266, Percent_Identity=25.187969924812, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17551932, Length=292, Percent_Identity=23.972602739726, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17505929, Length=290, Percent_Identity=25.8620689655172, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21356377, Length=325, Percent_Identity=26.7692307692308, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21355753, Length=260, Percent_Identity=30.3846153846154, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24646207, Length=276, Percent_Identity=27.536231884058, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281363737, Length=290, Percent_Identity=24.4827586206897, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24660351, Length=275, Percent_Identity=26.1818181818182, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24666513, Length=277, Percent_Identity=24.187725631769, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M [H]

EC number: NA

Molecular weight: Translated: 60303; Mature: 60172

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWQTHTVFNQPAPLNNSNLFLSDGALCEAVSREGAGWDSDLLASIGQQLGTAESLELGR
CCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHH
LANAYPPELLRYDPQGQRLDDVRFHPAWHLLMQGLCANRVHNLAWEEEARAGSFVARAAR
HCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVLHAQVEAGTLCPVTMTFAATPLLLQMLPATFHDWLAPLRSDRYDSHLLPGGQKRGLLI
HHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEE
GMGMTEKQGGSDVLSNTTHAERLADDSYRLVGHKWFFSVPQSDAHLVLAQAKGGLSCFFV
ECCCCCCCCCCHHHHCCHHHHHHCCCCCEEEEEEEEEECCCCCCEEEEEECCCCCEEEEE
PRFLPDGQRNSVRLERLKDKLGNRSNASAEVEFQDAVGWRLGEEGDGIRHILKMGGMTRL
HHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEHHHCCCCCCCCCHHHHHHHHHCCCCEE
DCALGSHGLMRRAFSVAIYHAHQRQAFGKPLIEQPLMRQTLSRMALCLEGQTALLFRLAR
HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
AWEQRREAKEALWARLFTPAAKFAICKQGIPFVAEAMEVLGGMGYCEESELPRLYREMPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCC
NSIWEGSGNIMCLDVLRVLTKQHGVYDVLSEAFAEVKGQDRHYDRAVRQLQQRLRKPDEA
CCEECCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHH
MGREITQQLFLLGCGAEMLRHASPPLAQAWCQMMLDTRGEMPLPAQVQNDLLLRATGGLR
HHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHCCCEEEEECCCCC
>Mature Secondary Structure 
SWQTHTVFNQPAPLNNSNLFLSDGALCEAVSREGAGWDSDLLASIGQQLGTAESLELGR
CCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHH
LANAYPPELLRYDPQGQRLDDVRFHPAWHLLMQGLCANRVHNLAWEEEARAGSFVARAAR
HCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVLHAQVEAGTLCPVTMTFAATPLLLQMLPATFHDWLAPLRSDRYDSHLLPGGQKRGLLI
HHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEE
GMGMTEKQGGSDVLSNTTHAERLADDSYRLVGHKWFFSVPQSDAHLVLAQAKGGLSCFFV
ECCCCCCCCCCHHHHCCHHHHHHCCCCCEEEEEEEEEECCCCCCEEEEEECCCCCEEEEE
PRFLPDGQRNSVRLERLKDKLGNRSNASAEVEFQDAVGWRLGEEGDGIRHILKMGGMTRL
HHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEHHHCCCCCCCCCHHHHHHHHHCCCCEE
DCALGSHGLMRRAFSVAIYHAHQRQAFGKPLIEQPLMRQTLSRMALCLEGQTALLFRLAR
HHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
AWEQRREAKEALWARLFTPAAKFAICKQGIPFVAEAMEVLGGMGYCEESELPRLYREMPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCC
NSIWEGSGNIMCLDVLRVLTKQHGVYDVLSEAFAEVKGQDRHYDRAVRQLQQRLRKPDEA
CCEECCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHH
MGREITQQLFLLGCGAEMLRHASPPLAQAWCQMMLDTRGEMPLPAQVQNDLLLRATGGLR
HHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961409; 7610040; 9278503 [H]