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The map label for this gene is mutH

Identifier: 194735588

GI number: 194735588

Start: 3067657

End: 3068352

Strand: Direct

Name: mutH

Synonym: SeSA_A3169

Alternate gene names: 194735588

Gene position: 3067657-3068352 (Clockwise)

Preceding gene: 194737899

Following gene: 194736050

Centisome position: 65.14

GC content: 58.05

Gene sequence:

>696_bases
ATGTCCGCTCTTTGTCCGCTACTGACTCCGCCTGCTTCGGAAGCATTGCTGTTAGCCCAGGCGCGGCAGCTTTCCGGCTA
TACGTTAGGCGAGCTGGCGGCGATGGCCGGCATTACCACGCCTAAAGATTTGAAGCGAGACAAAGGCTGGATCGGCGTCT
TGCTGGAGATCTGGCTCGGCGCCAGCGCCGGGAGCAAGCCGGAGCAGGATTTCGCCGCGTTAGGCGTAGAACTGAAAACC
ATCCCGGTGGATAGTCTGGGTCGTCCTCTGGAAACAACCTTTGTTTGCGTGGCGCCGTTAACCGGTAACAGCGGCGTGAC
CTGGGAGACAAGTCACGTACGGCATAAATTGAAGCGCGTGCTATGGGTACCGGTCGAAGGCGATCGCAGCATACCGTTAG
CCGAACGCCGCGTAGGTTCGCCGCTACTCTGGAGTCCGAGTGAAGAAGAGGACAGGCAGCTACGCCTCGACTGGGAAGAG
CTGATGGACATGATAGTGCTGGGCCAGGTGGAACGCATTACCGCCCGCCATGGCGAAGTCTTGCAACTGCGACCCAAAGC
CGCCAATGCCAGGGCGCTCACCGAGGCTATCGGCGCGCGCGGGGAACCTATTTTGACGCTACCGCGTGGATTTTATCTGA
AAAAAAATTTTACGCAGGCGCTGCTGGCTCGCCATTTTTTATTGCAGAATCCGTAA

Upstream 100 bases:

>100_bases
GCAATAAAAATCAGTCTATTGAATATAAGACACAGAAAAAGATAAACTCTGCCCATACGGTATAAAATCACTGCTCACTT
TTTGACCTAAGGTAATTGTC

Downstream 100 bases:

>100_bases
CGTCCATTACACGCAAATGCGCCTCCGCTATGGCTACGCATCGGGCCGATGCCGGATAAACGTAAGCGTATTGTCGCCGC
TATTTTACACCGTTCCTGGT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: Methyl-directed mismatch repair protein

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MSALCPLLTPPASEALLLAQARQLSGYTLGELAAMAGITTPKDLKRDKGWIGVLLEIWLGASAGSKPEQDFAALGVELKT
IPVDSLGRPLETTFVCVAPLTGNSGVTWETSHVRHKLKRVLWVPVEGDRSIPLAERRVGSPLLWSPSEEEDRQLRLDWEE
LMDMIVLGQVERITARHGEVLQLRPKAANARALTEAIGARGEPILTLPRGFYLKKNFTQALLARHFLLQNP

Sequences:

>Translated_231_residues
MSALCPLLTPPASEALLLAQARQLSGYTLGELAAMAGITTPKDLKRDKGWIGVLLEIWLGASAGSKPEQDFAALGVELKT
IPVDSLGRPLETTFVCVAPLTGNSGVTWETSHVRHKLKRVLWVPVEGDRSIPLAERRVGSPLLWSPSEEEDRQLRLDWEE
LMDMIVLGQVERITARHGEVLQLRPKAANARALTEAIGARGEPILTLPRGFYLKKNFTQALLARHFLLQNP
>Mature_230_residues
SALCPLLTPPASEALLLAQARQLSGYTLGELAAMAGITTPKDLKRDKGWIGVLLEIWLGASAGSKPEQDFAALGVELKTI
PVDSLGRPLETTFVCVAPLTGNSGVTWETSHVRHKLKRVLWVPVEGDRSIPLAERRVGSPLLWSPSEEEDRQLRLDWEEL
MDMIVLGQVERITARHGEVLQLRPKAANARALTEAIGARGEPILTLPRGFYLKKNFTQALLARHFLLQNP

Specific function: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair

COG id: COG3066

COG function: function code L; DNA mismatch repair protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mutH family

Homologues:

Organism=Escherichia coli, GI1789196, Length=229, Percent_Identity=88.646288209607, Blast_Score=412, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTH_SALA4 (B5F4U9)

Other databases:

- EMBL:   CP001138
- RefSeq:   YP_002147914.1
- ProteinModelPortal:   B5F4U9
- SMR:   B5F4U9
- GeneID:   6796794
- GenomeReviews:   CP001138_GR
- KEGG:   sea:SeAg_B3152
- HOGENOM:   HBG296591
- OMA:   QDWEELM
- ProtClustDB:   PRK05070
- GO:   GO:0005737
- HAMAP:   MF_00759
- InterPro:   IPR004230
- InterPro:   IPR011337
- InterPro:   IPR011335
- Gene3D:   G3DSA:3.40.600.10
- SMART:   SM00927
- TIGRFAMs:   TIGR02248

Pfam domain/function: PF02976 MutH; SSF52980 Restrict_endonuc_II-like_core

EC number: NA

Molecular weight: Translated: 25410; Mature: 25279

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALCPLLTPPASEALLLAQARQLSGYTLGELAAMAGITTPKDLKRDKGWIGVLLEIWLG
CCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHC
ASAGSKPEQDFAALGVELKTIPVDSLGRPLETTFVCVAPLTGNSGVTWETSHVRHKLKRV
CCCCCCCCHHHHHHCCEEEEECHHHCCCCCCEEEEEEEEEECCCCCEECHHHHHHHHHHE
LWVPVEGDRSIPLAERRVGSPLLWSPSEEEDRQLRLDWEELMDMIVLGQVERITARHGEV
EEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCE
LQLRPKAANARALTEAIGARGEPILTLPRGFYLKKNFTQALLARHFLLQNP
EEECCCCCCHHHHHHHHCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SALCPLLTPPASEALLLAQARQLSGYTLGELAAMAGITTPKDLKRDKGWIGVLLEIWLG
CCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHC
ASAGSKPEQDFAALGVELKTIPVDSLGRPLETTFVCVAPLTGNSGVTWETSHVRHKLKRV
CCCCCCCCHHHHHHCCEEEEECHHHCCCCCCEEEEEEEEEECCCCCEECHHHHHHHHHHE
LWVPVEGDRSIPLAERRVGSPLLWSPSEEEDRQLRLDWEELMDMIVLGQVERITARHGEV
EEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCE
LQLRPKAANARALTEAIGARGEPILTLPRGFYLKKNFTQALLARHFLLQNP
EEECCCCCCHHHHHHHHCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA