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The map label for this gene is tyrB [H]

Identifier: 194735410

GI number: 194735410

Start: 4359858

End: 4361051

Strand: Direct

Name: tyrB [H]

Synonym: SeSA_A4497

Alternate gene names: 194735410

Gene position: 4359858-4361051 (Clockwise)

Preceding gene: 194735891

Following gene: 194734461

Centisome position: 92.58

GC content: 55.53

Gene sequence:

>1194_bases
GTGTTTCAAAAAGTTGACGCCTATGCCGGCGATCCGATTCTTTCACTGATGGAGCGTTTTAAAGACGACTCCCGTCACGA
CAAAGTAAATCTGAGCATTGGCCTGTATTACAACGAAGACGGGATTATCCCACAGCTCAAAACGGTGGCCGAAGCCGAAG
CCCGGCTTAACGCGCAGCCGCATGGCGCTTCGCTGTACCTGCCGATGGAAGGACTCAATACTTATCGCCATACTATCGCG
CCTTTGCTCTTTGGCGCCGATCACCCGGTTCTTCAGCAACAGCGCGTGGCTACTATCCAGACATTAGGCGGTTCCGGCGC
GCTGAAAGTGGGCGCGGATTTCCTGAAGCGTTATTTCCCCGACGCAGGCGTATGGGTGAGCGACCCTACCTGGGAAAACC
ATATTGCGATATTTGCCGGGGCAGGATTCGAAGTGAGTACTTACCCCTGGTATGACGACGCGACCAACGGCATCCGTTTT
AACGATCTGCTGGCCACGCTGAATACGTTACCTGCGCGCAGTATCGTGCTGCTGCACCCCTGTTGTCACAACCCGACCGG
GGCGGATTTAACGCCTTCGCAATGGGATGCGGTAATTGAAATAGTGAAAGCGCGCGATCTGATTCCGTTCCTTGATATTG
CCTATCAGGGGTTTGGCGCAGGCATGGACGAGGATGCTTACGCTATTCGCGCCATTGCCAGCGCTGGGTTACCTGCGTTA
GTCAGTAATTCTTTTTCGAAGATTTTCTCGCTGTACGGCGAGCGCGTCGGCGGCCTGTCCGTGGTGTGTGAAGATGCTGA
AATTGCCGCGCGGGTTCTGGGACAGCTAAAAGCGACGGTGCGCCGAATTTACTCCAGTCCGCCGTGTTTCGGCGCTCAGG
TGGTCGCTACGGTCCTGGGCGATGAGGCGTTAAAAGCGGGCTGGCTGGCGGAAGTCGACGCGATGCGTAACCGCATTATA
TCGATGCGCCAGACGCTGGTGAAGGAGCTGAAGGCGGAGATGCCTGACCGCAACTTTGATTACTTGTTAGAGCAGCGCGG
TATGTTCAGCTATACCGGGTTAAGCGAGGAGCAGGTCGAGCGGTTGCGCGATGAGTTTGGCGTTTACCTGATTGCCAGTG
GCCGTATGTGTGTCGCCGGGCTTAATGCTTCAAATGTACACCGCGTGGCGAAGGCATTTGCCGCTGTCATGTAA

Upstream 100 bases:

>100_bases
TCCGGCAATATGCGCATCCACCACAACATCCTCTCGATCTTCTCGTCCTTCCGGTTTATTGTGTTATTTCCTGCCCTCTG
TAAACCTGGAGAACCATCGC

Downstream 100 bases:

>100_bases
TATTCAGGCCGGACGGCGATAACATTGCCCTCCGGTCTGACAATAGCTGTTGTGATCATCCTCTTTTTTCGTAACAAAAC
CGCAGATAATCCTTCCTTTT

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: ARAT; AROAT [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MFQKVDAYAGDPILSLMERFKDDSRHDKVNLSIGLYYNEDGIIPQLKTVAEAEARLNAQPHGASLYLPMEGLNTYRHTIA
PLLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFPDAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDATNGIRF
NDLLATLNTLPARSIVLLHPCCHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGMDEDAYAIRAIASAGLPAL
VSNSFSKIFSLYGERVGGLSVVCEDAEIAARVLGQLKATVRRIYSSPPCFGAQVVATVLGDEALKAGWLAEVDAMRNRII
SMRQTLVKELKAEMPDRNFDYLLEQRGMFSYTGLSEEQVERLRDEFGVYLIASGRMCVAGLNASNVHRVAKAFAAVM

Sequences:

>Translated_397_residues
MFQKVDAYAGDPILSLMERFKDDSRHDKVNLSIGLYYNEDGIIPQLKTVAEAEARLNAQPHGASLYLPMEGLNTYRHTIA
PLLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFPDAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDATNGIRF
NDLLATLNTLPARSIVLLHPCCHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGMDEDAYAIRAIASAGLPAL
VSNSFSKIFSLYGERVGGLSVVCEDAEIAARVLGQLKATVRRIYSSPPCFGAQVVATVLGDEALKAGWLAEVDAMRNRII
SMRQTLVKELKAEMPDRNFDYLLEQRGMFSYTGLSEEQVERLRDEFGVYLIASGRMCVAGLNASNVHRVAKAFAAVM
>Mature_397_residues
MFQKVDAYAGDPILSLMERFKDDSRHDKVNLSIGLYYNEDGIIPQLKTVAEAEARLNAQPHGASLYLPMEGLNTYRHTIA
PLLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFPDAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDATNGIRF
NDLLATLNTLPARSIVLLHPCCHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGMDEDAYAIRAIASAGLPAL
VSNSFSKIFSLYGERVGGLSVVCEDAEIAARVLGQLKATVRRIYSSPPCFGAQVVATVLGDEALKAGWLAEVDAMRNRII
SMRQTLVKELKAEMPDRNFDYLLEQRGMFSYTGLSEEQVERLRDEFGVYLIASGRMCVAGLNASNVHRVAKAFAAVM

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=388, Percent_Identity=42.5257731958763, Blast_Score=323, Evalue=1e-88,
Organism=Homo sapiens, GI4504067, Length=390, Percent_Identity=41.025641025641, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI117414139, Length=381, Percent_Identity=26.509186351706, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI1790488, Length=397, Percent_Identity=88.4130982367758, Blast_Score=734, Evalue=0.0,
Organism=Escherichia coli, GI1787159, Length=397, Percent_Identity=42.8211586901763, Blast_Score=343, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI71981858, Length=396, Percent_Identity=38.6363636363636, Blast_Score=307, Evalue=7e-84,
Organism=Caenorhabditis elegans, GI25147133, Length=390, Percent_Identity=41.5384615384615, Blast_Score=306, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17569539, Length=393, Percent_Identity=38.1679389312977, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI17569537, Length=390, Percent_Identity=31.2820512820513, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17550384, Length=263, Percent_Identity=35.7414448669202, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI25147136, Length=206, Percent_Identity=37.8640776699029, Blast_Score=144, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6323055, Length=405, Percent_Identity=36.7901234567901, Blast_Score=283, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6322743, Length=424, Percent_Identity=34.4339622641509, Blast_Score=234, Evalue=2e-62,
Organism=Drosophila melanogaster, GI19922362, Length=387, Percent_Identity=40.0516795865633, Blast_Score=302, Evalue=3e-82,
Organism=Drosophila melanogaster, GI24654046, Length=387, Percent_Identity=40.0516795865633, Blast_Score=301, Evalue=4e-82,
Organism=Drosophila melanogaster, GI24580970, Length=397, Percent_Identity=38.5390428211587, Blast_Score=290, Evalue=9e-79,
Organism=Drosophila melanogaster, GI24580972, Length=397, Percent_Identity=38.5390428211587, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI19920542, Length=388, Percent_Identity=38.9175257731959, Blast_Score=289, Evalue=2e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.57 [H]

Molecular weight: Translated: 43528; Mature: 43528

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQKVDAYAGDPILSLMERFKDDSRHDKVNLSIGLYYNEDGIIPQLKTVAEAEARLNAQP
CCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCC
HGASLYLPMEGLNTYRHTIAPLLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFP
CCCEEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
DAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDATNGIRFNDLLATLNTLPARSIVLLHP
CCCCEECCCCCCCCEEEEEECCCEECCCCCCCCCCCCEEHHHHHHHHHHCCCCCEEEEEC
CCHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGMDEDAYAIRAIASAGLPAL
CCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHH
VSNSFSKIFSLYGERVGGLSVVCEDAEIAARVLGQLKATVRRIYSSPPCFGAQVVATVLG
HHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
DEALKAGWLAEVDAMRNRIISMRQTLVKELKAEMPDRNFDYLLEQRGMFSYTGLSEEQVE
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEECCCCHHHHH
RLRDEFGVYLIASGRMCVAGLNASNVHRVAKAFAAVM
HHHHHCCEEEEECCCEEEEECCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFQKVDAYAGDPILSLMERFKDDSRHDKVNLSIGLYYNEDGIIPQLKTVAEAEARLNAQP
CCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCC
HGASLYLPMEGLNTYRHTIAPLLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFP
CCCEEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
DAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDATNGIRFNDLLATLNTLPARSIVLLHP
CCCCEECCCCCCCCEEEEEECCCEECCCCCCCCCCCCEEHHHHHHHHHHCCCCCEEEEEC
CCHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGMDEDAYAIRAIASAGLPAL
CCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHH
VSNSFSKIFSLYGERVGGLSVVCEDAEIAARVLGQLKATVRRIYSSPPCFGAQVVATVLG
HHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
DEALKAGWLAEVDAMRNRIISMRQTLVKELKAEMPDRNFDYLLEQRGMFSYTGLSEEQVE
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEECCCCHHHHH
RLRDEFGVYLIASGRMCVAGLNASNVHRVAKAFAAVM
HHHHHCCEEEEECCCEEEEECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8809108; 11677609 [H]