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The map label for this gene is yiaY [H]

Identifier: 194735387

GI number: 194735387

Start: 3748983

End: 3750134

Strand: Reverse

Name: yiaY [H]

Synonym: SeSA_A3881

Alternate gene names: 194735387

Gene position: 3750134-3748983 (Counterclockwise)

Preceding gene: 194735632

Following gene: 194736923

Centisome position: 79.64

GC content: 52.52

Gene sequence:

>1152_bases
ATGGCAGCTTCAACGTTTTTTATTCCTTCCGTGAATGTAATTGGTACCGATTCATTAAAGAACGCAATGAATACGATGGC
GGAATATGGTTTTCGCCGTACATTAATTGTTACGGATGCTATGCTGACAAAATTAGGGATGGCGGGTGATATTCAAAAAG
CGCTACAGGAACGTGATATTTTTAGCGTGATTTATGATGGTACGCAGCCTAACCCTACCACCAGCAATGTGGCAGCTGGG
TTGAAGCTTCTGAAAGAAAATGGCTGCGACAGCGTTATCTCGCTGGGCGGCGGTTCCCCGCACGACTGTGCGAAAGGTAT
CGCTCTGGTGGCGGCGAATGGCGGCGATATTCGTGACTATGAAGGCGTTGACCGCTCCGCGAAACCGCAGTTGCCGATGA
TTGCGATTAATACGACCGCCGGCACCGCGTCTGAAATGACCCGTTTTTGTATCATCACCGACGAAGAACGTCATATTAAA
ATGGCTATCGTCGATAAACACGTTACGCCGCTGCTCTCTGTCAACGACTCCTCTTTAATGGTTGGTATGCCGAAATCCCT
GACGGCGGCAACCGGTATGGATGCGTTAACCCACGCGATTGAAGCTTATGTTTCCGTTGCGGCAACGCCTATTACCGATG
CCTGCGCGTTGAAAGCGGTAACGATGATTGCGGAAAATCTGGTTGTTGCGGTTGAAGAGGGGAGCAATGTCCAGGCGCGT
GAAGCGATGGCTTATGCTCAGTTTCTGGCGGGAATGGCGTTTAACAATGCGTCGCTGGGCTACGTTCATGCTATGGCGCA
CCAACTTGGCGGTTTCTACAACCTACCGCACGGCGTATGTAACGCGGTTCTGCTGCCGCATGTGCAGGTATTCAACAGCC
AGGTAGCGGCGGCTCGCCTGCGTGATTGCGCAGCGGCGATGGGCGTCGATGTATCAGATATGAGCGAGGCGGAAGGCGCG
CAGGCGTGTGTGGCGGCCATTCGCCAACTGTCGCAGAAAGTCAACATTCCGGCGGGACTGCGCGAGCTAAACGTGAAGGA
AGAAGATATCCCGGTTCTGGCGACCAATGCTCTTAAAGATGCCTGTGGTCTGACGAACCCGATTCAGGCGACTCACGATG
AGATTGTGGAAATTTATCGCGCGGCGATGTAA

Upstream 100 bases:

>100_bases
TTTATTTTTCTGACTTCTTAAAATAGTCATCGTGATCATATTATTAGGATAATTTCACCCGTATTCTTCGCACCTTATTC
TGGTAATTAAGGACAGTATA

Downstream 100 bases:

>100_bases
CGCCTTTGCCCGGTGGCGCGGACGCTTACCGGGCCTGCGTAGACGATGCAGGCCGGATAAGGCGTAATACGTTAGCTTCG
GTCGAGTTTTTGCTGCGCCA

Product: putative alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MAASTFFIPSVNVIGTDSLKNAMNTMAEYGFRRTLIVTDAMLTKLGMAGDIQKALQERDIFSVIYDGTQPNPTTSNVAAG
LKLLKENGCDSVISLGGGSPHDCAKGIALVAANGGDIRDYEGVDRSAKPQLPMIAINTTAGTASEMTRFCIITDEERHIK
MAIVDKHVTPLLSVNDSSLMVGMPKSLTAATGMDALTHAIEAYVSVAATPITDACALKAVTMIAENLVVAVEEGSNVQAR
EAMAYAQFLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAVLLPHVQVFNSQVAAARLRDCAAAMGVDVSDMSEAEGA
QACVAAIRQLSQKVNIPAGLRELNVKEEDIPVLATNALKDACGLTNPIQATHDEIVEIYRAAM

Sequences:

>Translated_383_residues
MAASTFFIPSVNVIGTDSLKNAMNTMAEYGFRRTLIVTDAMLTKLGMAGDIQKALQERDIFSVIYDGTQPNPTTSNVAAG
LKLLKENGCDSVISLGGGSPHDCAKGIALVAANGGDIRDYEGVDRSAKPQLPMIAINTTAGTASEMTRFCIITDEERHIK
MAIVDKHVTPLLSVNDSSLMVGMPKSLTAATGMDALTHAIEAYVSVAATPITDACALKAVTMIAENLVVAVEEGSNVQAR
EAMAYAQFLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAVLLPHVQVFNSQVAAARLRDCAAAMGVDVSDMSEAEGA
QACVAAIRQLSQKVNIPAGLRELNVKEEDIPVLATNALKDACGLTNPIQATHDEIVEIYRAAM
>Mature_382_residues
AASTFFIPSVNVIGTDSLKNAMNTMAEYGFRRTLIVTDAMLTKLGMAGDIQKALQERDIFSVIYDGTQPNPTTSNVAAGL
KLLKENGCDSVISLGGGSPHDCAKGIALVAANGGDIRDYEGVDRSAKPQLPMIAINTTAGTASEMTRFCIITDEERHIKM
AIVDKHVTPLLSVNDSSLMVGMPKSLTAATGMDALTHAIEAYVSVAATPITDACALKAVTMIAENLVVAVEEGSNVQARE
AMAYAQFLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAVLLPHVQVFNSQVAAARLRDCAAAMGVDVSDMSEAEGAQ
ACVAAIRQLSQKVNIPAGLRELNVKEEDIPVLATNALKDACGLTNPIQATHDEIVEIYRAAM

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=394, Percent_Identity=25.3807106598985, Blast_Score=115, Evalue=6e-26,
Organism=Escherichia coli, GI48994951, Length=383, Percent_Identity=89.556135770235, Blast_Score=712, Evalue=0.0,
Organism=Escherichia coli, GI1789163, Length=385, Percent_Identity=42.3376623376623, Blast_Score=307, Evalue=8e-85,
Organism=Escherichia coli, GI87082107, Length=378, Percent_Identity=35.978835978836, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1787493, Length=394, Percent_Identity=34.5177664974619, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1789386, Length=346, Percent_Identity=24.2774566473988, Blast_Score=91, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17537053, Length=396, Percent_Identity=24.7474747474747, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6321181, Length=379, Percent_Identity=55.4089709762533, Blast_Score=428, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24657991, Length=425, Percent_Identity=26.3529411764706, Blast_Score=122, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 40386; Mature: 40255

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAASTFFIPSVNVIGTDSLKNAMNTMAEYGFRRTLIVTDAMLTKLGMAGDIQKALQERDI
CCCCEEECCCCCEEECHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCHHHHHHHHHCCC
FSVIYDGTQPNPTTSNVAAGLKLLKENGCDSVISLGGGSPHDCAKGIALVAANGGDIRDY
EEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHCCEEEEEECCCCCCCC
EGVDRSAKPQLPMIAINTTAGTASEMTRFCIITDEERHIKMAIVDKHVTPLLSVNDSSLM
CCCCCCCCCCCCEEEEECCCCCHHHCEEEEEEECCCCEEEEEEECCCCCCEEEECCCEEE
VGMPKSLTAATGMDALTHAIEAYVSVAATPITDACALKAVTMIAENLVVAVEEGSNVQAR
EECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCEEEEEECCCCCHHH
EAMAYAQFLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAVLLPHVQVFNSQVAAARL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RDCAAAMGVDVSDMSEAEGAQACVAAIRQLSQKVNIPAGLRELNVKEEDIPVLATNALKD
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCEEEHHHHHH
ACGLTNPIQATHDEIVEIYRAAM
HHCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AASTFFIPSVNVIGTDSLKNAMNTMAEYGFRRTLIVTDAMLTKLGMAGDIQKALQERDI
CCCEEECCCCCEEECHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCHHHHHHHHHCCC
FSVIYDGTQPNPTTSNVAAGLKLLKENGCDSVISLGGGSPHDCAKGIALVAANGGDIRDY
EEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHCCEEEEEECCCCCCCC
EGVDRSAKPQLPMIAINTTAGTASEMTRFCIITDEERHIKMAIVDKHVTPLLSVNDSSLM
CCCCCCCCCCCCEEEEECCCCCHHHCEEEEEEECCCCEEEEEEECCCCCCEEEECCCEEE
VGMPKSLTAATGMDALTHAIEAYVSVAATPITDACALKAVTMIAENLVVAVEEGSNVQAR
EECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCEEEEEECCCCCHHH
EAMAYAQFLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAVLLPHVQVFNSQVAAARL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RDCAAAMGVDVSDMSEAEGAQACVAAIRQLSQKVNIPAGLRELNVKEEDIPVLATNALKD
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCEEEHHHHHH
ACGLTNPIQATHDEIVEIYRAAM
HHCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7768815 [H]