Click here to switch to the map view.

The map label for this gene is tktA [C]

Identifier: 194735363

GI number: 194735363

Start: 2457194

End: 2458024

Strand: Reverse

Name: tktA [C]

Synonym: SeSA_A2570

Alternate gene names: 194735363

Gene position: 2458024-2457194 (Counterclockwise)

Preceding gene: 194735701

Following gene: 194736021

Centisome position: 52.2

GC content: 55.96

Gene sequence:

>831_bases
ATGAACGTAACCGAAATCACCCAACTGGCGCGCGACATTCGCGTCGCCACGCTCAAATCCTTAAACCATCTTGGCTTTGG
TCACTATGGCGGCAGCATGTCGGTAGTGGAAACTCTGGCGGTTCTGTACGGCGCGGTGATGAAAATCGACCCTGCCGACC
CGGACTGGCCGGAACGCGATTACTTCGTACTGTCGAAAGGCCATGCGGGCCCCGCGTTGTACAGTACCCTGGCGATTAAA
GGCTATTTCCCGCGCGAAGAGCTGAATACGCTTAACCAGAACGGCACCCGTCTTCCCAGCCATCCGGATCGGCTAAAAAC
GCGCGGCGTGGACGCCACGACCGGCTCACTGGGACAGGGCATCTCTATTGCTGGCGGTATGGCGCTGTCGCATAAACTGG
CGCGGCGACCCAACCGGGTATTTTGCATTGTCGGCGATGGCGAGCTCAATGAAGGGCAGTGCTGGGAGGCGTTTCAGTTT
ATTGCCCACCACCGCCTGAATAATCTGACCGTTTTCATTGACTGGAATAAACAGCAGCTTGACGGCGAGCTGGAGGAGAT
TATCAATCCGTTCGATCTGGAAGGGAAATTCCGCGCGTTTGATTTCGATGTCGTCACCGTCAAAGGCGATGATATCGCCG
GACTACTGGCGGTGGTTCAGCCAGTGCCGCCCGCTGATGCCCGACCAAGGGTAGTGATCCTTGACAGCATTAAAGGGCAG
GGGGTGCCATGCCTGGAGCAGTTAACGAATTCTCACCACTTACGCCTGACGGATGGCATGAAGCAGACGCTCAATGAGGC
CATTCATCAACTGGAGGTCATGCATGATTAA

Upstream 100 bases:

>100_bases
GGCTGGTGGTGGCGCTATTCGCGCTACTGGTGGCGTACAACGTGTTGGCCAAAAACAAAAAAGCGAATGCCGAAGTGCAG
GAAAATAGCGGAGCGAAAGA

Downstream 100 bases:

>100_bases
GCTTGCGCCCGCAGGGCTTAAAGACGATATCGAAATGCGCAAAGTTTACGCCGGTTTTGTCGCCGGGCAGATTGAGGCCG
GAAGCCCAATTATTGCGCTT

Product: transketolase domain-containing protein

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MNVTEITQLARDIRVATLKSLNHLGFGHYGGSMSVVETLAVLYGAVMKIDPADPDWPERDYFVLSKGHAGPALYSTLAIK
GYFPREELNTLNQNGTRLPSHPDRLKTRGVDATTGSLGQGISIAGGMALSHKLARRPNRVFCIVGDGELNEGQCWEAFQF
IAHHRLNNLTVFIDWNKQQLDGELEEIINPFDLEGKFRAFDFDVVTVKGDDIAGLLAVVQPVPPADARPRVVILDSIKGQ
GVPCLEQLTNSHHLRLTDGMKQTLNEAIHQLEVMHD

Sequences:

>Translated_276_residues
MNVTEITQLARDIRVATLKSLNHLGFGHYGGSMSVVETLAVLYGAVMKIDPADPDWPERDYFVLSKGHAGPALYSTLAIK
GYFPREELNTLNQNGTRLPSHPDRLKTRGVDATTGSLGQGISIAGGMALSHKLARRPNRVFCIVGDGELNEGQCWEAFQF
IAHHRLNNLTVFIDWNKQQLDGELEEIINPFDLEGKFRAFDFDVVTVKGDDIAGLLAVVQPVPPADARPRVVILDSIKGQ
GVPCLEQLTNSHHLRLTDGMKQTLNEAIHQLEVMHD
>Mature_276_residues
MNVTEITQLARDIRVATLKSLNHLGFGHYGGSMSVVETLAVLYGAVMKIDPADPDWPERDYFVLSKGHAGPALYSTLAIK
GYFPREELNTLNQNGTRLPSHPDRLKTRGVDATTGSLGQGISIAGGMALSHKLARRPNRVFCIVGDGELNEGQCWEAFQF
IAHHRLNNLTVFIDWNKQQLDGELEEIINPFDLEGKFRAFDFDVVTVKGDDIAGLLAVVQPVPPADARPRVVILDSIKGQ
GVPCLEQLTNSHHLRLTDGMKQTLNEAIHQLEVMHD

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI133778974, Length=247, Percent_Identity=34.0080971659919, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI205277463, Length=267, Percent_Identity=32.5842696629214, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI4507521, Length=267, Percent_Identity=32.5842696629214, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI225637459, Length=247, Percent_Identity=27.9352226720648, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI225637461, Length=219, Percent_Identity=29.2237442922374, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI225637463, Length=217, Percent_Identity=29.0322580645161, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI48994911, Length=264, Percent_Identity=32.5757575757576, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI1788808, Length=247, Percent_Identity=32.3886639676113, Blast_Score=119, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17539652, Length=269, Percent_Identity=31.5985130111524, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6325331, Length=252, Percent_Identity=33.7301587301587, Blast_Score=122, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6319593, Length=264, Percent_Identity=30.6818181818182, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI45551847, Length=265, Percent_Identity=31.6981132075472, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI45550715, Length=265, Percent_Identity=31.6981132075472, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24666278, Length=255, Percent_Identity=34.9019607843137, Blast_Score=137, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24645119, Length=229, Percent_Identity=33.1877729257642, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 30483; Mature: 30483

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVTEITQLARDIRVATLKSLNHLGFGHYGGSMSVVETLAVLYGAVMKIDPADPDWPERD
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCCCCCCC
YFVLSKGHAGPALYSTLAIKGYFPREELNTLNQNGTRLPSHPDRLKTRGVDATTGSLGQG
EEEEECCCCCHHHHHHHHEECCCCHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCC
ISIAGGMALSHKLARRPNRVFCIVGDGELNEGQCWEAFQFIAHHRLNNLTVFIDWNKQQL
CEECCCHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHH
DGELEEIINPFDLEGKFRAFDFDVVTVKGDDIAGLLAVVQPVPPADARPRVVILDSIKGQ
CCHHHHHCCCCCCCCCEEEEEEEEEEECCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCC
GVPCLEQLTNSHHLRLTDGMKQTLNEAIHQLEVMHD
CCHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNVTEITQLARDIRVATLKSLNHLGFGHYGGSMSVVETLAVLYGAVMKIDPADPDWPERD
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCCCCCCC
YFVLSKGHAGPALYSTLAIKGYFPREELNTLNQNGTRLPSHPDRLKTRGVDATTGSLGQG
EEEEECCCCCHHHHHHHHEECCCCHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCC
ISIAGGMALSHKLARRPNRVFCIVGDGELNEGQCWEAFQFIAHHRLNNLTVFIDWNKQQL
CEECCCHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHH
DGELEEIINPFDLEGKFRAFDFDVVTVKGDDIAGLLAVVQPVPPADARPRVVILDSIKGQ
CCHHHHHCCCCCCCCCEEEEEEEEEEECCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCC
GVPCLEQLTNSHHLRLTDGMKQTLNEAIHQLEVMHD
CCHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]