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The map label for this gene is glcR [H]

Identifier: 194735012

GI number: 194735012

Start: 4282803

End: 4283561

Strand: Reverse

Name: glcR [H]

Synonym: SeSA_A4407

Alternate gene names: 194735012

Gene position: 4283561-4282803 (Counterclockwise)

Preceding gene: 194734278

Following gene: 194735926

Centisome position: 90.96

GC content: 45.98

Gene sequence:

>759_bases
ATGAATCCAATTAAAAGACGAAAACATATTCTTGATGAATTAAACAAATTCGGTGAAGTCACCGTTATTAAATTATCGGA
AATGCTCAACGTCACCTCAGAAACCATTCGTCGCGATCTCTCCTTACTGGAATCTGAGGGCAAAATCACTAAGATTCATG
GGGGCGCAGTCAAAAAGCAAGTTGTCCAGGAGGATGCGTTTAGCGCAAGAATAGAGGCGCATCGCGAAGAGAAAATAGCG
ATTGGCAAACTTGCCGCCGAAATGGTCAGTGAACGGGATACATTGTTTATTGATTCCTGTACAACTAACCTTATTCTGGC
CGAGCAATTACCGCCTCTCGCTTTTTCCGTGATTACCAATTCAGCCCTGATTGCCGATAAAATTAAAGAGCATAACCTGC
AGGCCCGCGTGTATGTATTAGGCGGCGAATATGATTACCATTTTCGCGCCAACCTCGGCGTCTCGGTGTGTCAGCAGATT
AACGCGATTCACGCGGATATCTGTTTTATTGGCGCTGGCGGCATTTCTCCCCAGCATGGCGTGTTGGTGAAGAGCTTTGA
AGAAGCCTACGTTGCCAAAGCCATGATTGCGATGAGCAAAAAATCAGTGATTCTCGCCGACCATACCAAATTTGGTCAGG
ACGGTGTGATGTGCATCGCAAGCGTAAAAGAAATCGATAACATCATCACGGATAAAGGATTTACGTCAACGGGTTATACG
CCACAGGATTTCGCCGGAAAGCTGCGGATTGCTGACTGA

Upstream 100 bases:

>100_bases
GCCACGAATGATGAGGAGGGTATCGTCCATGCGTTGGAGTGGTTGCGTTGCCTTACGCATCCAGTTACCATGCGCCAAAG
GTTGACGGCGGCGAAAGATA

Downstream 100 bases:

>100_bases
GCGCTATCCGCCCGTTGCGTATTGCCGTAGACTAAGAGCCTATCCCACCAGGCGTTATTGGCGCAGCCAGTTTGGACACG
GACAGCGCGCAAAAACCGGA

Product: DeoR family regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MNPIKRRKHILDELNKFGEVTVIKLSEMLNVTSETIRRDLSLLESEGKITKIHGGAVKKQVVQEDAFSARIEAHREEKIA
IGKLAAEMVSERDTLFIDSCTTNLILAEQLPPLAFSVITNSALIADKIKEHNLQARVYVLGGEYDYHFRANLGVSVCQQI
NAIHADICFIGAGGISPQHGVLVKSFEEAYVAKAMIAMSKKSVILADHTKFGQDGVMCIASVKEIDNIITDKGFTSTGYT
PQDFAGKLRIAD

Sequences:

>Translated_252_residues
MNPIKRRKHILDELNKFGEVTVIKLSEMLNVTSETIRRDLSLLESEGKITKIHGGAVKKQVVQEDAFSARIEAHREEKIA
IGKLAAEMVSERDTLFIDSCTTNLILAEQLPPLAFSVITNSALIADKIKEHNLQARVYVLGGEYDYHFRANLGVSVCQQI
NAIHADICFIGAGGISPQHGVLVKSFEEAYVAKAMIAMSKKSVILADHTKFGQDGVMCIASVKEIDNIITDKGFTSTGYT
PQDFAGKLRIAD
>Mature_252_residues
MNPIKRRKHILDELNKFGEVTVIKLSEMLNVTSETIRRDLSLLESEGKITKIHGGAVKKQVVQEDAFSARIEAHREEKIA
IGKLAAEMVSERDTLFIDSCTTNLILAEQLPPLAFSVITNSALIADKIKEHNLQARVYVLGGEYDYHFRANLGVSVCQQI
NAIHADICFIGAGGISPQHGVLVKSFEEAYVAKAMIAMSKKSVILADHTKFGQDGVMCIASVKEIDNIITDKGFTSTGYT
PQDFAGKLRIAD

Specific function: Plays a role in carbon catabolite repression (CCR). Specifically required for transcriptional repression of the levanase operon by glucose but not by other sugars [H]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI226510968, Length=250, Percent_Identity=30, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI87082344, Length=232, Percent_Identity=30.6034482758621, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789059, Length=241, Percent_Identity=28.6307053941909, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1788069, Length=218, Percent_Identity=31.651376146789, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1789170, Length=238, Percent_Identity=27.7310924369748, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1789829, Length=234, Percent_Identity=27.7777777777778, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1787540, Length=228, Percent_Identity=28.5087719298246, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790635, Length=236, Percent_Identity=25.4237288135593, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789519, Length=256, Percent_Identity=26.171875, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1787063, Length=232, Percent_Identity=26.2931034482759, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790753, Length=236, Percent_Identity=25.4237288135593, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 27702; Mature: 27702

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPIKRRKHILDELNKFGEVTVIKLSEMLNVTSETIRRDLSLLESEGKITKIHGGAVKKQ
CCHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHH
VVQEDAFSARIEAHREEKIAIGKLAAEMVSERDTLFIDSCTTNLILAEQLPPLAFSVITN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCHHHHHHHC
SALIADKIKEHNLQARVYVLGGEYDYHFRANLGVSVCQQINAIHADICFIGAGGISPQHG
CHHHHHHHHHCCCEEEEEEEECCEEEEEECCCCHHHHHHHHHHEEEEEEEECCCCCCCCC
VLVKSFEEAYVAKAMIAMSKKSVILADHTKFGQDGVMCIASVKEIDNIITDKGFTSTGYT
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
PQDFAGKLRIAD
CHHHCCCEEECC
>Mature Secondary Structure
MNPIKRRKHILDELNKFGEVTVIKLSEMLNVTSETIRRDLSLLESEGKITKIHGGAVKKQ
CCHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHH
VVQEDAFSARIEAHREEKIAIGKLAAEMVSERDTLFIDSCTTNLILAEQLPPLAFSVITN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCHHHHHHHC
SALIADKIKEHNLQARVYVLGGEYDYHFRANLGVSVCQQINAIHADICFIGAGGISPQHG
CHHHHHHHHHCCCEEEEEEEECCEEEEEECCCCHHHHHHHHHHEEEEEEEECCCCCCCCC
VLVKSFEEAYVAKAMIAMSKKSVILADHTKFGQDGVMCIASVKEIDNIITDKGFTSTGYT
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
PQDFAGKLRIAD
CHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]