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The map label for this gene is ghrB [H]

Identifier: 194734963

GI number: 194734963

Start: 3711678

End: 3712652

Strand: Direct

Name: ghrB [H]

Synonym: SeSA_A3841

Alternate gene names: 194734963

Gene position: 3711678-3712652 (Clockwise)

Preceding gene: 194738075

Following gene: 194736603

Centisome position: 78.82

GC content: 56.92

Gene sequence:

>975_bases
ATGAAGCCGTCCATCATTCTCTACAAAACCCTGCCTGATGATTTGCTGCATCGCCTGGAGGCGCATTTTACCGTCACCCA
GGTACCGAACCTGCATCCGGAAACGGTAGCGCGACACGCGCAGGCATTTTCCAGCGCGCAAGGCCTTCTGGGCGCCAGCG
AAACCGTTAACCGCGCGCTGCTGGAAAAAATGTCGGCGCTACGTGCGGCGTCGACCATCTCGGTGGGATACGATAATGTC
GAGGTGGACGCCCTTACTGCTCGCAAAATAGTCCTGATGCACACGCCTGCCGTTTTGACGGAAACCGTTGCCGATACGGT
GATGGCGTTGATGCTGGCTACTGCCCGCCGCGTGGTGGACGTCGCAGAACGGGTTAAAGCGGGTGAATGGACGGAAAGCA
TTGGCCCGGCGTGGTTTGGCGTCGATGTGCATCACAAAACACTCGGTATCGTTGGGATGGGGCGTATCGGGATGGCGCTG
GCGCAGCGAGCGCACTTTGGGTTTACCATGCCGGTTCTCTATCACGCCCGTCGGCGGCATCAGGAGGCGGAAGACCGGTT
TAACGCCCGCTACTGCGATCTGGATACGTTGTTGCAGGAGGCTGATTTTGTCTGCGTGATCCTGCCGCTAACGGCAGAAA
CGCGACATCTGTTTGGCGCAACACAGTTTGCCAGAATGAAATCGTCCGCCATTTTTATTAATGCCGGACGCGGCCCGGTG
GTCGATGAAAACGCGCTGATTGCCGCGCTGCAAAACGGTGAAATATATGCGGCAGGTCTGGATGTCTTTGAGCAGGAACC
GCTATCCGTGGATTCGCCCCTGCTGAACATGTCTAATGTCGTCGCGGTGCCGCATATTGGCTCGGCAACGCATGAGACGC
GCTACAACATGATGGCCTGTGCGGTGGATAATTTGATTGATGCGCTGCAGGGAAAAATAGAGAAGAACTGCGTCAATCCG
CAGGCGGCGGGATAA

Upstream 100 bases:

>100_bases
AGCGGGGAAATTGGCTGGTCGATGATGGCTAAACGGGTTAATAATAAGCCTGTTCCGGTTGGCGCATGCCGCGCTTACCT
TTTGATTTACGGAGAGTCGC

Downstream 100 bases:

>100_bases
CGCTACAGGCCCGATAAGCGCTGGCTTGCGCTTATCGGGCAGACTGTCATTACTGAGTCGCGTTTACCGCCGCCGTCCAG
GCCTGATTAAACGCCTGATG

Product: 2-ketogluconate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MKPSIILYKTLPDDLLHRLEAHFTVTQVPNLHPETVARHAQAFSSAQGLLGASETVNRALLEKMSALRAASTISVGYDNV
EVDALTARKIVLMHTPAVLTETVADTVMALMLATARRVVDVAERVKAGEWTESIGPAWFGVDVHHKTLGIVGMGRIGMAL
AQRAHFGFTMPVLYHARRRHQEAEDRFNARYCDLDTLLQEADFVCVILPLTAETRHLFGATQFARMKSSAIFINAGRGPV
VDENALIAALQNGEIYAAGLDVFEQEPLSVDSPLLNMSNVVAVPHIGSATHETRYNMMACAVDNLIDALQGKIEKNCVNP
QAAG

Sequences:

>Translated_324_residues
MKPSIILYKTLPDDLLHRLEAHFTVTQVPNLHPETVARHAQAFSSAQGLLGASETVNRALLEKMSALRAASTISVGYDNV
EVDALTARKIVLMHTPAVLTETVADTVMALMLATARRVVDVAERVKAGEWTESIGPAWFGVDVHHKTLGIVGMGRIGMAL
AQRAHFGFTMPVLYHARRRHQEAEDRFNARYCDLDTLLQEADFVCVILPLTAETRHLFGATQFARMKSSAIFINAGRGPV
VDENALIAALQNGEIYAAGLDVFEQEPLSVDSPLLNMSNVVAVPHIGSATHETRYNMMACAVDNLIDALQGKIEKNCVNP
QAAG
>Mature_324_residues
MKPSIILYKTLPDDLLHRLEAHFTVTQVPNLHPETVARHAQAFSSAQGLLGASETVNRALLEKMSALRAASTISVGYDNV
EVDALTARKIVLMHTPAVLTETVADTVMALMLATARRVVDVAERVKAGEWTESIGPAWFGVDVHHKTLGIVGMGRIGMAL
AQRAHFGFTMPVLYHARRRHQEAEDRFNARYCDLDTLLQEADFVCVILPLTAETRHLFGATQFARMKSSAIFINAGRGPV
VDENALIAALQNGEIYAAGLDVFEQEPLSVDSPLLNMSNVVAVPHIGSATHETRYNMMACAVDNLIDALQGKIEKNCVNP
QAAG

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=295, Percent_Identity=38.9830508474576, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI23308577, Length=304, Percent_Identity=29.6052631578947, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI145580578, Length=293, Percent_Identity=30.7167235494881, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI4557499, Length=293, Percent_Identity=30.7167235494881, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI145580575, Length=274, Percent_Identity=31.7518248175182, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI61743967, Length=292, Percent_Identity=31.5068493150685, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI4557497, Length=292, Percent_Identity=31.5068493150685, Blast_Score=123, Evalue=2e-28,
Organism=Escherichia coli, GI87082289, Length=323, Percent_Identity=82.3529411764706, Blast_Score=560, Evalue=1e-161,
Organism=Escherichia coli, GI1787645, Length=204, Percent_Identity=31.8627450980392, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1789279, Length=239, Percent_Identity=30.9623430962343, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI87081824, Length=156, Percent_Identity=30.1282051282051, Blast_Score=71, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=249, Percent_Identity=30.9236947791165, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI25147481, Length=275, Percent_Identity=28.3636363636364, Blast_Score=100, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6324055, Length=255, Percent_Identity=36.8627450980392, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6320925, Length=257, Percent_Identity=31.9066147859922, Blast_Score=119, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6322116, Length=242, Percent_Identity=31.404958677686, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6325144, Length=197, Percent_Identity=32.48730964467, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324964, Length=248, Percent_Identity=27.4193548387097, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6321253, Length=295, Percent_Identity=24.406779661017, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6324980, Length=170, Percent_Identity=28.2352941176471, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24585514, Length=313, Percent_Identity=38.3386581469649, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI28574282, Length=313, Percent_Identity=38.3386581469649, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI28574284, Length=313, Percent_Identity=38.3386581469649, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI45551003, Length=313, Percent_Identity=38.3386581469649, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI45552429, Length=313, Percent_Identity=38.3386581469649, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI28574286, Length=312, Percent_Identity=36.8589743589744, Blast_Score=197, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24585516, Length=250, Percent_Identity=39.2, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI28571528, Length=311, Percent_Identity=36.9774919614148, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI62472511, Length=293, Percent_Identity=31.740614334471, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646446, Length=293, Percent_Identity=31.740614334471, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646448, Length=293, Percent_Identity=31.740614334471, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646452, Length=293, Percent_Identity=31.740614334471, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646450, Length=293, Percent_Identity=31.740614334471, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI19921140, Length=249, Percent_Identity=28.9156626506024, Blast_Score=115, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 35289; Mature: 35289

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPSIILYKTLPDDLLHRLEAHFTVTQVPNLHPETVARHAQAFSSAQGLLGASETVNRAL
CCCCEEEEECCCHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
LEKMSALRAASTISVGYDNVEVDALTARKIVLMHTPAVLTETVADTVMALMLATARRVVD
HHHHHHHHHHHEEEECCCCEEEEEEECCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
VAERVKAGEWTESIGPAWFGVDVHHKTLGIVGMGRIGMALAQRAHFGFTMPVLYHARRRH
HHHHHHCCCCHHHCCCEEEEEEECCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHH
QEAEDRFNARYCDLDTLLQEADFVCVILPLTAETRHLFGATQFARMKSSAIFINAGRGPV
HHHHHHHCCEEECHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCC
VDENALIAALQNGEIYAAGLDVFEQEPLSVDSPLLNMSNVVAVPHIGSATHETRYNMMAC
CCCCCEEEEEECCEEEEECCCHHCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHH
AVDNLIDALQGKIEKNCVNPQAAG
HHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKPSIILYKTLPDDLLHRLEAHFTVTQVPNLHPETVARHAQAFSSAQGLLGASETVNRAL
CCCCEEEEECCCHHHHHHHHHCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
LEKMSALRAASTISVGYDNVEVDALTARKIVLMHTPAVLTETVADTVMALMLATARRVVD
HHHHHHHHHHHEEEECCCCEEEEEEECCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
VAERVKAGEWTESIGPAWFGVDVHHKTLGIVGMGRIGMALAQRAHFGFTMPVLYHARRRH
HHHHHHCCCCHHHCCCEEEEEEECCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHH
QEAEDRFNARYCDLDTLLQEADFVCVILPLTAETRHLFGATQFARMKSSAIFINAGRGPV
HHHHHHHCCEEECHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCC
VDENALIAALQNGEIYAAGLDVFEQEPLSVDSPLLNMSNVVAVPHIGSATHETRYNMMAC
CCCCCEEEEEECCEEEEECCCHHCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHH
AVDNLIDALQGKIEKNCVNPQAAG
HHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA