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The map label for this gene is mutL [H]

Identifier: 194734797

GI number: 194734797

Start: 4500976

End: 4502832

Strand: Direct

Name: mutL [H]

Synonym: SeSA_A4627

Alternate gene names: 194734797

Gene position: 4500976-4502832 (Clockwise)

Preceding gene: 194737594

Following gene: 194737154

Centisome position: 95.58

GC content: 58.16

Gene sequence:

>1857_bases
ATGCCGATTCAGGTTCTGCCGCCGCAGCTTGCGAACCAAATCGCCGCTGGCGAAGTGGTGGAACGCCCTGCGTCGGTTGT
TAAAGAGCTGGTAGAGAATAGTCTGGATGCAGGCGCCACCCGCGTTGATATCGACATTGAGCGTGGCGGCGCGAAGCTTA
TTCGTATTCGCGACAATGGCTGCGGCATTAAAAAAGAGGAGCTGGCGCTGGCGCTGGCTCGTCATGCCACCAGTAAGATC
GCCTCGCTTGACGATCTGGAAGCGATTATCAGTCTGGGATTTCGCGGCGAAGCGCTGGCGAGTATCAGTTCGGTCTCGCG
TTTGACGCTAACGTCGCGCACGGCGGAGCAGGCGGAAGCCTGGCAGGCGTATGCGGAAGGGCGTGACATGGACGTGACGG
TAAAACCCGCCGCGCACCCGGTCGGCACCACCCTGGAAGTTCTGGATCTCTTTTATAATACGCCCGCCCGGCGCAAATTC
ATGCGTACCGAAAAAACGGAATTTAATCACATCGATGAGATCATCCGTCGTATTGCATTGGCCCGTTTTGACGTCACGCT
TAACCTGTCGCACAACGGCAAATTGGTACGGCAGTATCGCGCTGTCGCAAAGGACGGGCAAAAAGAGCGCCGGTTAGGCG
CCATCTGCGGGACGCCGTTTCTCGAACAGGCACTGGCGATCGAGTGGCAGCATGGCGATCTGACCCTGCGCGGCTGGGTC
GCCGATCCGAATCACACCACCACGGCGTTAACGGAGATCCAGTACTGCTATGTGAATGGCCGCATGATGCGCGACCGCTT
GATCAACCATGCCATTCGCCAGGCCTGTGAAGATAAACTGGGCGCGGACCAACAGCCTGCGTTTGTGTTGTATCTGGAGA
TTGACCCGCATCAGGTGGATGTCAATGTTCATCCCGCCAAGCACGAAGTGCGTTTTCATCAATCCCGGCTGGTGCACGAC
TTCATCTATCAAGGGGTGCTGAGCGTTCTGCAACAGCAGACGGAAACGACGCTGCCGCTGGAGGATATTGCGCCAGCGCC
GCGGCATGTCCCGGAAAACCGTATCGCCGCCGGGCGCAACCATTTTGCTGTACCCGCCGAGCCAACTGCGGCGCGCGAGC
CCGCGACACCGCGTTATTCCGGCGGCGCATCGGGCGGTAACGGCGGGCGTCAGTCCGCAGGTGGTTGGCCGCACGCGCAG
CCAGGTTATCAGAAGCAGCAGGGCGAGGTTTATCGCACGCTTTTACAGACGCCGGCGACGAGCCCCGCGCCGGAGCCGGT
TGCGCCTGCGCTTGACGGACATAGCCAGAGTTTCGGTCGCGTACTGACAATAGTCGGCGGTGACTGCGCGTTGCTGGAAC
ACGCGGGGACTATCCAGCTCTTGTCGCTGCCGGTTGCGGAGCGTTGGCTGCGTCAGGCGCAGCTTACACCGGGTCAAAGT
CCGGTTTGCGCGCAGCCGTTGCTGATTCCGCTGCGTTTAAAAGTGAGCGCCGATGAAAAAGTCGCGCTGCAAAAAGCCCA
ATCTTTGTTGGGAGAATTGGGTATTGAATTTCAGTCAGATGCGCAGCATGTGACCATTCGGGCGGTGCCTTTACCCTTAC
GACAACAAAATTTACAAATCTTGATTCCTGAACTGATAGGCTACCTGGCGCAACAGACCACATTTGCAACGGTCAATATT
GCACAATGGATAGCGCGTAATGTGCAGAGCGAACATCCGCAGTGGTCGATGGCGCAGGCCATATCGCTGCTGGCGGATGT
TGAGCGGCTATGTCCGCAGCTGGTAAAAGCGCCGCCGGGTGGCCTGTTACAACCTGTTGATTTACATTCGGCGATGAACG
CCCTGAAGCATGAATGA

Upstream 100 bases:

>100_bases
TGCAGCGCATCCGATCCAGTCTGCGCCGCAGGGCGGCCCAGGCCAGACGGCCAGTACCAACCAGCCTGGCGCCATAACCG
CCGCGAATTAAGGAGATTTC

Downstream 100 bases:

>100_bases
TGTAAGCAAGGCGAGCCTGCCTAAGGCGATATTTTTGATGGGGCCGACGGCCTCCGGCAAAACGGCGCTGGCGATAGAAC
TGCGTAAAGTTTTGCCAGTA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 618; Mature: 617

Protein sequence:

>618_residues
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRVDIDIERGGAKLIRIRDNGCGIKKEELALALARHATSKI
ASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQAEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKF
MRTEKTEFNHIDEIIRRIALARFDVTLNLSHNGKLVRQYRAVAKDGQKERRLGAICGTPFLEQALAIEWQHGDLTLRGWV
ADPNHTTTALTEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHD
FIYQGVLSVLQQQTETTLPLEDIAPAPRHVPENRIAAGRNHFAVPAEPTAAREPATPRYSGGASGGNGGRQSAGGWPHAQ
PGYQKQQGEVYRTLLQTPATSPAPEPVAPALDGHSQSFGRVLTIVGGDCALLEHAGTIQLLSLPVAERWLRQAQLTPGQS
PVCAQPLLIPLRLKVSADEKVALQKAQSLLGELGIEFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAQQTTFATVNI
AQWIARNVQSEHPQWSMAQAISLLADVERLCPQLVKAPPGGLLQPVDLHSAMNALKHE

Sequences:

>Translated_618_residues
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRVDIDIERGGAKLIRIRDNGCGIKKEELALALARHATSKI
ASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQAEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKF
MRTEKTEFNHIDEIIRRIALARFDVTLNLSHNGKLVRQYRAVAKDGQKERRLGAICGTPFLEQALAIEWQHGDLTLRGWV
ADPNHTTTALTEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHD
FIYQGVLSVLQQQTETTLPLEDIAPAPRHVPENRIAAGRNHFAVPAEPTAAREPATPRYSGGASGGNGGRQSAGGWPHAQ
PGYQKQQGEVYRTLLQTPATSPAPEPVAPALDGHSQSFGRVLTIVGGDCALLEHAGTIQLLSLPVAERWLRQAQLTPGQS
PVCAQPLLIPLRLKVSADEKVALQKAQSLLGELGIEFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAQQTTFATVNI
AQWIARNVQSEHPQWSMAQAISLLADVERLCPQLVKAPPGGLLQPVDLHSAMNALKHE
>Mature_617_residues
PIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRVDIDIERGGAKLIRIRDNGCGIKKEELALALARHATSKIA
SLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQAEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFM
RTEKTEFNHIDEIIRRIALARFDVTLNLSHNGKLVRQYRAVAKDGQKERRLGAICGTPFLEQALAIEWQHGDLTLRGWVA
DPNHTTTALTEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHDF
IYQGVLSVLQQQTETTLPLEDIAPAPRHVPENRIAAGRNHFAVPAEPTAAREPATPRYSGGASGGNGGRQSAGGWPHAQP
GYQKQQGEVYRTLLQTPATSPAPEPVAPALDGHSQSFGRVLTIVGGDCALLEHAGTIQLLSLPVAERWLRQAQLTPGQSP
VCAQPLLIPLRLKVSADEKVALQKAQSLLGELGIEFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAQQTTFATVNIA
QWIARNVQSEHPQWSMAQAISLLADVERLCPQLVKAPPGGLLQPVDLHSAMNALKHE

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=339, Percent_Identity=35.1032448377581, Blast_Score=205, Evalue=1e-52,
Organism=Homo sapiens, GI4505911, Length=321, Percent_Identity=31.1526479750779, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI189458898, Length=318, Percent_Identity=31.4465408805031, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI189458896, Length=316, Percent_Identity=31.0126582278481, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI310128478, Length=333, Percent_Identity=27.3273273273273, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI4505913, Length=333, Percent_Identity=27.3273273273273, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI263191589, Length=245, Percent_Identity=29.7959183673469, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI91992160, Length=362, Percent_Identity=24.8618784530387, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI91992162, Length=362, Percent_Identity=24.8618784530387, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI310128480, Length=295, Percent_Identity=24.0677966101695, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1790612, Length=622, Percent_Identity=86.1736334405145, Blast_Score=1071, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71991825, Length=323, Percent_Identity=37.4613003095975, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17562796, Length=346, Percent_Identity=26.0115606936416, Blast_Score=119, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6323819, Length=319, Percent_Identity=35.1097178683386, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6324247, Length=365, Percent_Identity=26.8493150684932, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6325093, Length=293, Percent_Identity=25.2559726962457, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6323063, Length=382, Percent_Identity=25.6544502617801, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17136968, Length=333, Percent_Identity=34.2342342342342, Blast_Score=183, Evalue=3e-46,
Organism=Drosophila melanogaster, GI17136970, Length=359, Percent_Identity=27.0194986072423, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 67756; Mature: 67625

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRVDIDIERGGAKLIRIRDNG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECCC
CGIKKEELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQAEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFMRTEKTEFNHIDEIIRRIAL
HHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHH
ARFDVTLNLSHNGKLVRQYRAVAKDGQKERRLGAICGTPFLEQALAIEWQHGDLTLRGWV
HHEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHEEEEECCCEEEEEEE
ADPNHTTTALTEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVD
CCCCCCHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEE
VNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQTETTLPLEDIAPAPRHVPENRIAAGRN
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCHHHCCCC
HFAVPAEPTAAREPATPRYSGGASGGNGGRQSAGGWPHAQPGYQKQQGEVYRTLLQTPAT
CEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
SPAPEPVAPALDGHSQSFGRVLTIVGGDCALLEHAGTIQLLSLPVAERWLRQAQLTPGQS
CCCCCCCCCCCCCCCCCCCCEEEEECCCEEEHHCCCCEEEEECHHHHHHHHHHCCCCCCC
PVCAQPLLIPLRLKVSADEKVALQKAQSLLGELGIEFQSDAQHVTIRAVPLPLRQQNLQI
CCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCEE
LIPELIGYLAQQTTFATVNIAQWIARNVQSEHPQWSMAQAISLLADVERLCPQLVKAPPG
EHHHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
GLLQPVDLHSAMNALKHE
CCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
PIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRVDIDIERGGAKLIRIRDNG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEEECCC
CGIKKEELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQAEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFMRTEKTEFNHIDEIIRRIAL
HHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHH
ARFDVTLNLSHNGKLVRQYRAVAKDGQKERRLGAICGTPFLEQALAIEWQHGDLTLRGWV
HHEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHEEEEECCCEEEEEEE
ADPNHTTTALTEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVD
CCCCCCHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEE
VNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQTETTLPLEDIAPAPRHVPENRIAAGRN
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCHHHCCCC
HFAVPAEPTAAREPATPRYSGGASGGNGGRQSAGGWPHAQPGYQKQQGEVYRTLLQTPAT
CEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
SPAPEPVAPALDGHSQSFGRVLTIVGGDCALLEHAGTIQLLSLPVAERWLRQAQLTPGQS
CCCCCCCCCCCCCCCCCCCCEEEEECCCEEEHHCCCCEEEEECHHHHHHHHHHCCCCCCC
PVCAQPLLIPLRLKVSADEKVALQKAQSLLGELGIEFQSDAQHVTIRAVPLPLRQQNLQI
CCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCEE
LIPELIGYLAQQTTFATVNIAQWIARNVQSEHPQWSMAQAISLLADVERLCPQLVKAPPG
EHHHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
GLLQPVDLHSAMNALKHE
CCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA