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The map label for this gene is smvA [H]

Identifier: 194734786

GI number: 194734786

Start: 1627557

End: 1629044

Strand: Reverse

Name: smvA [H]

Synonym: SeSA_A1691

Alternate gene names: 194734786

Gene position: 1629044-1627557 (Counterclockwise)

Preceding gene: 194737815

Following gene: 194738237

Centisome position: 34.59

GC content: 58.0

Gene sequence:

>1488_bases
ATGTTTCGTCAGTGGTTAACGTTAGTCATTATTGTGCTGGTCTATATTCCTGTCGCCATTGATGCCACGGTCTTGCATGT
CGCCGCCCCAACACTGAGTATGACACTGGGGGCCAGCGGCAACGAGCTGCTGTGGATCATTGATATTTATTCTTTGGTTA
TGGCTGGCATGGTGTTGCCGATGGGCGCGCTTGGCGATCGTATCGGTTTTAAACGCCTGCTGATGCTGGGCGGGACGCTC
TTTGGCCTGGCGTCACTGGCGGCAGCGTTTTCGCATACCGCCAGTTGGCTTATTGCCACCAGGGTATTACTGGCTATTGG
CGCGGCGATGATTGTACCGGCGACGCTGGCCGGGATACGCGCCACCTTTTGTGAAGAGAAGCATCGCAACATGGCGCTGG
GCGTCTGGGCAGCGGTAGGTTCGGGCGGAGCGGCGTTTGGGCCGCTCATCGGCGGCATCTTATTAGAGCATTTTTACTGG
GGATCGGTTTTCCTGATCAACGTGCCGATTGTGCTGGTCGTCATGGGCTTAACCGCCCGCTATGTTCCTCGCCAGGCGGG
CCGTCGCGATCAACCGCTCAATCTTGGCCATGCGGTGATGCTGATTATTGCCATTTTGCTGTTGGTCTATAGCGCTAAAA
CCGCGCTGAAAGGGCATCTGTCGCTGTGGGTCATCTCGTTTACCCTGCTTACCGGCGCGCTGCTCCTGGGACTCTTTATC
CGCACACAGCTTGCGACATCGCGTCCGATGATTGATATGCGACTATTTACCCATCGCATTATCCTGAGCGGCGTCGTGAT
GGCGATGACCGCGATGATCACTCTGGTGGGTTTTGAGCTGCTGATGGCGCAAGAGCTGCAGTTTGTTCACGGGCTATCGC
CTTATGAGGCCGGGGTATTTATGCTGCCGGTGATGGTCGCCAGTGGATTCAGCGGGCCGATTGCGGGCGTGCTGGTCTCG
CGTCTGGGACTACGGCTGGTCGCGACGGGCGGCATGGCGTTAAGCGCGCTGAGTTTTTATGGCCTGGCGATGACGGATTT
CAGCACCCAACAATGGCAGGCCTGGGGGCTGATGGCGCTGCTGGGATTTAGCGCCGCCAGCGCATTGCTGGCTTCCACGT
CGGCAATTATGGCCGCTGCGCCGGCAGAAAAAGCGGCGGCGGCCGGCGCGATAGAAACGATGGCTTATGAACTGGGCGCG
GGACTGGGCATTGCCATTTTCGGTCTATTGTTAAGCCGTAGCTTCTCCGCGTCTATCCGTCTGCCTGCCGGGCTTGAGGC
GCAAGAGATTGCCAGAGCGTCATCTTCAATGGGAGAAGCCGTGCAGTTGGCGAATAGCCTACCGCCCACGCAGGGGCAGG
CAATACTGGACGCCGCCAGACAGGCCTTTATCTGGTCGCATAGCGTGGCGTTAAGCAGCGCCGGAAGTATGCTTCTTTTG
CTGGCGGTAGGGATGTGGTTCAGCCTGGCAAAAGCCCAACGCCGATAA

Upstream 100 bases:

>100_bases
CAATGCGCGCAGTGTAACAAAAAGCTGGACATTCGTTCAACTTACCGTAGGATCCTGAAACTGGACAAGTGTCCAAATTT
GAGTTTTTGAAGGGAGATTT

Downstream 100 bases:

>100_bases
CATAACGCCTGGTGAGATAAGCGCTTAATGCGCTAGCTGGCAGGGGGAGTCCATTTCCTCAACCTCTTTACCGCTGAGGC
GTGCGTATTGCCCCGTCAGT

Product: methyl viologen resistance protein SmvA

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MFRQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTL
FGLASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFCEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYW
GSVFLINVPIVLVVMGLTARYVPRQAGRRDQPLNLGHAVMLIIAILLLVYSAKTALKGHLSLWVISFTLLTGALLLGLFI
RTQLATSRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPYEAGVFMLPVMVASGFSGPIAGVLVS
RLGLRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPAEKAAAAGAIETMAYELGA
GLGIAIFGLLLSRSFSASIRLPAGLEAQEIARASSSMGEAVQLANSLPPTQGQAILDAARQAFIWSHSVALSSAGSMLLL
LAVGMWFSLAKAQRR

Sequences:

>Translated_495_residues
MFRQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTL
FGLASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFCEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYW
GSVFLINVPIVLVVMGLTARYVPRQAGRRDQPLNLGHAVMLIIAILLLVYSAKTALKGHLSLWVISFTLLTGALLLGLFI
RTQLATSRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPYEAGVFMLPVMVASGFSGPIAGVLVS
RLGLRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPAEKAAAAGAIETMAYELGA
GLGIAIFGLLLSRSFSASIRLPAGLEAQEIARASSSMGEAVQLANSLPPTQGQAILDAARQAFIWSHSVALSSAGSMLLL
LAVGMWFSLAKAQRR
>Mature_495_residues
MFRQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTL
FGLASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFCEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYW
GSVFLINVPIVLVVMGLTARYVPRQAGRRDQPLNLGHAVMLIIAILLLVYSAKTALKGHLSLWVISFTLLTGALLLGLFI
RTQLATSRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPYEAGVFMLPVMVASGFSGPIAGVLVS
RLGLRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPAEKAAAAGAIETMAYELGA
GLGIAIFGLLLSRSFSASIRLPAGLEAQEIARASSSMGEAVQLANSLPPTQGQAILDAARQAFIWSHSVALSSAGSMLLL
LAVGMWFSLAKAQRR

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=395, Percent_Identity=26.5822784810127, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1788710, Length=391, Percent_Identity=27.3657289002558, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1790195, Length=399, Percent_Identity=28.0701754385965, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI87081983, Length=399, Percent_Identity=26.0651629072682, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788392, Length=409, Percent_Identity=25.1833740831296, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322958, Length=515, Percent_Identity=23.3009708737864, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 52126; Mature: 52126

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCCCEEEHHHHHHHHHHHHHHC
MGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATFCEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLINVPIVLVVMGLTAR
HHHHHHHHCCCEEEHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
YVPRQAGRRDQPLNLGHAVMLIIAILLLVYSAKTALKGHLSLWVISFTLLTGALLLGLFI
HCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTQLATSRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPYEAGVF
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCHHH
MLPVMVASGFSGPIAGVLVSRLGLRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMAL
HHHHHHHCCCCCHHHHHHHHHHCHHEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LGFSAASALLASTSAIMAAAPAEKAAAAGAIETMAYELGAGLGIAIFGLLLSRSFSASIR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEE
LPAGLEAQEIARASSSMGEAVQLANSLPPTQGQAILDAARQAFIWSHSVALSSAGSMLLL
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LAVGMWFSLAKAQRR
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MFRQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCCCEEEHHHHHHHHHHHHHHC
MGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATFCEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLINVPIVLVVMGLTAR
HHHHHHHHCCCEEEHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
YVPRQAGRRDQPLNLGHAVMLIIAILLLVYSAKTALKGHLSLWVISFTLLTGALLLGLFI
HCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTQLATSRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPYEAGVF
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCHHH
MLPVMVASGFSGPIAGVLVSRLGLRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMAL
HHHHHHHCCCCCHHHHHHHHHHCHHEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LGFSAASALLASTSAIMAAAPAEKAAAAGAIETMAYELGAGLGIAIFGLLLSRSFSASIR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEE
LPAGLEAQEIARASSSMGEAVQLANSLPPTQGQAILDAARQAFIWSHSVALSSAGSMLLL
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LAVGMWFSLAKAQRR
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7926834; 11677609 [H]