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The map label for this gene is lyx [H]

Identifier: 194734656

GI number: 194734656

Start: 3739157

End: 3740653

Strand: Direct

Name: lyx [H]

Synonym: SeSA_A3872

Alternate gene names: 194734656

Gene position: 3739157-3740653 (Clockwise)

Preceding gene: 194734339

Following gene: 194737692

Centisome position: 79.4

GC content: 60.05

Gene sequence:

>1497_bases
ATGAGCAATTACTGGCTGGGGTTAGATTGTGGTGGGAGTTGGCTAAAAGCCGGGTTGTACGATGGCGCAGGCCGGGAAGT
AGCGGTGCAACGCCTGCCGCTACACGCTTTAAGCCCGCAGCCAGGCTGGGTTGAACGCGATATGACCGAACTGTGGCAAC
AGTGCGGCTCGGTCATCAACAAACTGCTGACGCACACGGGGGTGAGCGGCTCACAAATCCGCGGTCTGGGCATTTCCGCT
CAGGGTAAGGGACTGTTTCTGTTAGATAAAAGCGATCGGCCATTAGGTAAAGCGATACTCTCTTCCGACCGTCGCGCCAT
GGAAATTGTCCAGCGCTGGCAAAAAGAAGCGGTTCCGCAAAAACTCTACCCGCTGACCCGGCAAACCCTGTGGACCGGAC
ATCCGGTCTCCCTTTTACGCTGGGTAAAAGAGAATGAGCCGCAGCGCTACGCGCAGATAGGCAGCGTCATGATGACGCAT
GACTATCTGCGCTGGTGCTTAACCGGCGTGAAGGGCTGCGAAGAGAGCAACATCTCCGAGTCCAACCTCTACAACATGGC
GACGGGCCAGTACGACTCACGTCTGACCGAGTGGCTGGGCATCAGTGAAATCGATAGCGCGCTGCCCCCCGTGGTGGGTT
CAGCCGAAATATGCGGGGAGATCACCGCTCAGGCGGCCGCCATCACCGGTCTGGCGGCGGGTACCCCCGTCGTCGGCGGC
CTGTTTGACGTGGTTTCCACCGCCCTTTGCGCCGGTATTGAGGATGAATCAACGCTCAATGCGGTGATGGGGACCTGGGC
CGTCACCAGCGGCATCGCTCACGGTCTGCGCGACCATGAGGCCCACCCTTACGTCTATGGCCGCTACGTCAATGACGGGC
AGTATATCGTTCACGAAGCCAGCCCGACCTCCTCCGGCAACCTTGAATGGTTTACCGCCCAGTGGGGCGACCTCTCTTTT
GACGAGATCAATCAGGCGGTCGCCAGCCTGCCGAAAGCCGGTAGCGACCTCTTTTTTCTGCCGTTTCTCTACGGCAGCAA
TGCCGGACTGGAGATGACCTGCGGTTTTTACGGCATGCAGGCGCTGCACACCCGCGCGCACCTGCTGCAGGCGATTTATG
AAGGCGTGGTCTTCAGCCATATGACCCACCTCAACCGCATGCGTGAACGTTTTACCGACGTTTGCGCCCTGCGCGTTACC
GGCGGACCGGCCCACTCCGACGTCTGGATGCAGATGCTGGCGGACGTCAGCGGTTTACGCATTGAACTGCCGCAGGTGGA
GGAGACCGGCTGCTTCGGCGCGGCGCTGGCTGCCCGCGTCGGCACTGGCGTATATCGCGATTTCCGCGAGGCCCAACGCG
ACCTGCAGCACCCGGTGCGCACGCTGCTGCCGGACATGACCGCACACGCCCTCTACCAGCGCAAATACCGCCAATACCAG
GATTTGATTGAAGCACTACAGGGCTATCACGCCCGTATTAAGGAGCACGCATTATGA

Upstream 100 bases:

>100_bases
CTTCAGCGATGCGCTGGGCAGCCAGGTGCGCGATATGTTCCTGAAAGACAACCCGCAGGGCGCCGATCTCCTGAAAGCCG
TGGACGAGGTGCAATAAGTC

Downstream 100 bases:

>100_bases
GCCGACCATTACTGCAACTGGCGCTCGACCACACCAGTCTGGAAGCAGCCCAACGCGATGTCGCCCTACTACAGGATCAT
GTCGATATCGTTGAGGCCGG

Product: L-xylulose/3-keto-L-gulonate kinase

Products: NA

Alternate protein names: L-xylulokinase; 3-dehydro-L-gulonate kinase [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MSNYWLGLDCGGSWLKAGLYDGAGREVAVQRLPLHALSPQPGWVERDMTELWQQCGSVINKLLTHTGVSGSQIRGLGISA
QGKGLFLLDKSDRPLGKAILSSDRRAMEIVQRWQKEAVPQKLYPLTRQTLWTGHPVSLLRWVKENEPQRYAQIGSVMMTH
DYLRWCLTGVKGCEESNISESNLYNMATGQYDSRLTEWLGISEIDSALPPVVGSAEICGEITAQAAAITGLAAGTPVVGG
LFDVVSTALCAGIEDESTLNAVMGTWAVTSGIAHGLRDHEAHPYVYGRYVNDGQYIVHEASPTSSGNLEWFTAQWGDLSF
DEINQAVASLPKAGSDLFFLPFLYGSNAGLEMTCGFYGMQALHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVCALRVT
GGPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYRDFREAQRDLQHPVRTLLPDMTAHALYQRKYRQYQ
DLIEALQGYHARIKEHAL

Sequences:

>Translated_498_residues
MSNYWLGLDCGGSWLKAGLYDGAGREVAVQRLPLHALSPQPGWVERDMTELWQQCGSVINKLLTHTGVSGSQIRGLGISA
QGKGLFLLDKSDRPLGKAILSSDRRAMEIVQRWQKEAVPQKLYPLTRQTLWTGHPVSLLRWVKENEPQRYAQIGSVMMTH
DYLRWCLTGVKGCEESNISESNLYNMATGQYDSRLTEWLGISEIDSALPPVVGSAEICGEITAQAAAITGLAAGTPVVGG
LFDVVSTALCAGIEDESTLNAVMGTWAVTSGIAHGLRDHEAHPYVYGRYVNDGQYIVHEASPTSSGNLEWFTAQWGDLSF
DEINQAVASLPKAGSDLFFLPFLYGSNAGLEMTCGFYGMQALHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVCALRVT
GGPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYRDFREAQRDLQHPVRTLLPDMTAHALYQRKYRQYQ
DLIEALQGYHARIKEHAL
>Mature_497_residues
SNYWLGLDCGGSWLKAGLYDGAGREVAVQRLPLHALSPQPGWVERDMTELWQQCGSVINKLLTHTGVSGSQIRGLGISAQ
GKGLFLLDKSDRPLGKAILSSDRRAMEIVQRWQKEAVPQKLYPLTRQTLWTGHPVSLLRWVKENEPQRYAQIGSVMMTHD
YLRWCLTGVKGCEESNISESNLYNMATGQYDSRLTEWLGISEIDSALPPVVGSAEICGEITAQAAAITGLAAGTPVVGGL
FDVVSTALCAGIEDESTLNAVMGTWAVTSGIAHGLRDHEAHPYVYGRYVNDGQYIVHEASPTSSGNLEWFTAQWGDLSFD
EINQAVASLPKAGSDLFFLPFLYGSNAGLEMTCGFYGMQALHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVCALRVTG
GPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYRDFREAQRDLQHPVRTLLPDMTAHALYQRKYRQYQD
LIEALQGYHARIKEHAL

Specific function: Catalyzes the phosphorylation of L-xylulose and 3-keto- L-gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate [H]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI164663828, Length=555, Percent_Identity=23.6036036036036, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI88196792, Length=515, Percent_Identity=24.0776699029126, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI164663830, Length=579, Percent_Identity=23.3160621761658, Blast_Score=93, Evalue=7e-19,
Organism=Escherichia coli, GI1790005, Length=498, Percent_Identity=86.3453815261044, Blast_Score=901, Evalue=0.0,
Organism=Escherichia coli, GI1787789, Length=503, Percent_Identity=24.0556660039761, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1789987, Length=488, Percent_Identity=25, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1790361, Length=465, Percent_Identity=21.0752688172043, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1789168, Length=483, Percent_Identity=22.5672877846791, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17535599, Length=440, Percent_Identity=23.8636363636364, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24655555, Length=458, Percent_Identity=23.5807860262009, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24655560, Length=458, Percent_Identity=23.5807860262009, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24655570, Length=458, Percent_Identity=23.5807860262009, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24655574, Length=458, Percent_Identity=23.5807860262009, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24655565, Length=458, Percent_Identity=23.5807860262009, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21357867, Length=498, Percent_Identity=24.2971887550201, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24656367, Length=486, Percent_Identity=25.1028806584362, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24657106, Length=551, Percent_Identity=23.2304900181488, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24657102, Length=551, Percent_Identity=23.2304900181488, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.53 [H]

Molecular weight: Translated: 54976; Mature: 54845

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNYWLGLDCGGSWLKAGLYDGAGREVAVQRLPLHALSPQPGWVERDMTELWQQCGSVIN
CCCCEEEECCCCHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KLLTHTGVSGSQIRGLGISAQGKGLFLLDKSDRPLGKAILSSDRRAMEIVQRWQKEAVPQ
HHHHHCCCCCCCEECCCCCCCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHCCCH
KLYPLTRQTLWTGHPVSLLRWVKENEPQRYAQIGSVMMTHDYLRWCLTGVKGCEESNISE
HHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
SNLYNMATGQYDSRLTEWLGISEIDSALPPVVGSAEICGEITAQAAAITGLAAGTPVVGG
HHCHHCCCCCHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHH
LFDVVSTALCAGIEDESTLNAVMGTWAVTSGIAHGLRDHEAHPYVYGRYVNDGQYIVHEA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEC
SPTSSGNLEWFTAQWGDLSFDEINQAVASLPKAGSDLFFLPFLYGSNAGLEMTCGFYGMQ
CCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEEEHCCCCCCCEEECHHHHHH
ALHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVCALRVTGGPAHSDVWMQMLADVSGLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHCCCCCE
IELPQVEETGCFGAALAARVGTGVYRDFREAQRDLQHPVRTLLPDMTAHALYQRKYRQYQ
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
DLIEALQGYHARIKEHAL
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNYWLGLDCGGSWLKAGLYDGAGREVAVQRLPLHALSPQPGWVERDMTELWQQCGSVIN
CCCEEEECCCCHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KLLTHTGVSGSQIRGLGISAQGKGLFLLDKSDRPLGKAILSSDRRAMEIVQRWQKEAVPQ
HHHHHCCCCCCCEECCCCCCCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHCCCH
KLYPLTRQTLWTGHPVSLLRWVKENEPQRYAQIGSVMMTHDYLRWCLTGVKGCEESNISE
HHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
SNLYNMATGQYDSRLTEWLGISEIDSALPPVVGSAEICGEITAQAAAITGLAAGTPVVGG
HHCHHCCCCCHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHH
LFDVVSTALCAGIEDESTLNAVMGTWAVTSGIAHGLRDHEAHPYVYGRYVNDGQYIVHEA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEC
SPTSSGNLEWFTAQWGDLSFDEINQAVASLPKAGSDLFFLPFLYGSNAGLEMTCGFYGMQ
CCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEEEHCCCCCCCEEECHHHHHH
ALHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVCALRVTGGPAHSDVWMQMLADVSGLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHCCCCCE
IELPQVEETGCFGAALAARVGTGVYRDFREAQRDLQHPVRTLLPDMTAHALYQRKYRQYQ
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
DLIEALQGYHARIKEHAL
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7961955; 11741871 [H]