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The map label for this gene is murC [H]

Identifier: 194734645

GI number: 194734645

Start: 151035

End: 152510

Strand: Direct

Name: murC [H]

Synonym: SeSA_A0145

Alternate gene names: 194734645

Gene position: 151035-152510 (Clockwise)

Preceding gene: 194735154

Following gene: 194734683

Centisome position: 3.21

GC content: 56.5

Gene sequence:

>1476_bases
ATGAATACACAACAACTGGCAAAACTGCGTTCCATCGTGCCCGAAATGCGTCGCGTTCGGCACATTCACTTTGTCGGCAT
CGGTGGTGCTGGTATGGGCGGTATTGCCGAAGTTCTGGCCAATGAAGGGTATCAGATCAGTGGTTCCGATTTAGCGCCGA
ATCCGGTGACCCAGCAGTTGACGAGCCTGGGGGCGACGATTTTCTTTAATCATCGTCCGGAAAATGTGCGTGATGCCAGC
GTGGTCGTCGTTTCCAGCGCAATTTCCGCGGATAACCCGGAAATTGTCGCGGCGCATGAAGCGCGTATTCCGGTTATTCG
CCGTGCGGAAATGCTGGCGGAACTGATGCGTTTTCGCCACGGCATCGCCATTGCCGGGACGCACGGAAAAACCACAACGA
CCGCGATGGTGTCCAGTATTTATGCCGAAGCGGGGCTGGACCCGACTTTCGTGAATGGCGGACTGGTGAAAGCCGCAGGC
GTTCATGCGCGTCTGGGCCATAGTCGTTACCTGATTGCCGAGGCAGATGAGAGCGACGCATCCTTCCTGCATTTGCAGCC
GATGGTCGCGATCGTCACCAACATCGAAGCCGACCATATGGATACCTATCATGGCGACTTTGAAAATTTAAAGCAGACGT
TTATTAACTTCCTGCATAACCTGCCGTTCTACGGTCGCGCGGTAATGTGCGTCGACGATCCGGTCATCCGCGAGTTGCTG
CCGCGGGTGGGGCGTCAGACCACGACGTATGGCTTTAGCGAGGATGCTGACGTCCGCGTAGAAGATTATCAGCAGATAGG
GCCGCAGGGGCACTTTACGCTGTTGCGCCAGGGAATGCCGGATCTGCATGTCACGTTGAATGCGCCGGGTCGCCACAATG
CCCTGAATGCCGCTGCGGCAGTGGCGGTAGCGACCGAAGAAGGCATCGCCGATGACGCTATCCTGCGCGCGCTGGAAAGC
TTCCAGGGGACCGGGCGTCGTTTTGACTTCCTCGGCGAGTTCCCGCTTGAGCCGGTGAATGGTAAAGCCGGGACGGCGAT
GCTGGTGGATGACTATGGCCATCATCCGACTGAAGTAGACGCCACCATTAAAGCTGCGCGAGCAGGGTGGCCGGATAAAA
ACCTGGTGATGCTGTTTCAGCCGCACCGTTACACGCGCACGCGCGATCTGTATGACGATTTCGCCAATGTGCTGACCCAG
GTTGATGCGCTGCTGATGCTGGACGTTTACCCGGCGGGCGAAGCGCCGATTCCGGGCGCGGATAGCCGCTCTTTATGTCG
CACGATTCGTAATCGGGGAAAAATTGACCCAATTCTGGTTTCCGATCCGGCTCAGGTTGCGACAATGTTAGCGCCGGTGC
TGACGGGTAACGACTTGATATTAGTGCAAGGCGCAGGAAATGTTGGCAAAATTGCGCGTTACTTATCTGAAATCAAGCTG
AAGCCGCAAATCCAGGAGGAAGAGCAACATGGCTGA

Upstream 100 bases:

>100_bases
GCATCGCAGGGTTTTTCTACCCTCAATAATTTGGGTTGCAGGCAAGCCAACGCATCTGCAATTTGAAGTATGGCGGGTAT
TGGAGTTAATGGCGTAAAGA

Downstream 100 bases:

>100_bases
TAAAATCGCGGTCCTGTTGGGCGGAACCTCTGCGGAGCGGGACGTTTCGTTAAATTCCGGCGCGGCAGTGTTGGCCGGGT
TACGTGAAGGCGGCATTGAT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLTSLGATIFFNHRPENVRDAS
VVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAG
VHARLGHSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
PRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQGMPDLHVTLNAPGRHNALNAAAAVAVATEEGIADDAILRALES
FQGTGRRFDFLGEFPLEPVNGKAGTAMLVDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRYTRTRDLYDDFANVLTQ
VDALLMLDVYPAGEAPIPGADSRSLCRTIRNRGKIDPILVSDPAQVATMLAPVLTGNDLILVQGAGNVGKIARYLSEIKL
KPQIQEEEQHG

Sequences:

>Translated_491_residues
MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLTSLGATIFFNHRPENVRDAS
VVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAG
VHARLGHSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
PRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQGMPDLHVTLNAPGRHNALNAAAAVAVATEEGIADDAILRALES
FQGTGRRFDFLGEFPLEPVNGKAGTAMLVDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRYTRTRDLYDDFANVLTQ
VDALLMLDVYPAGEAPIPGADSRSLCRTIRNRGKIDPILVSDPAQVATMLAPVLTGNDLILVQGAGNVGKIARYLSEIKL
KPQIQEEEQHG
>Mature_491_residues
MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLTSLGATIFFNHRPENVRDAS
VVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAG
VHARLGHSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
PRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQGMPDLHVTLNAPGRHNALNAAAAVAVATEEGIADDAILRALES
FQGTGRRFDFLGEFPLEPVNGKAGTAMLVDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRYTRTRDLYDDFANVLTQ
VDALLMLDVYPAGEAPIPGADSRSLCRTIRNRGKIDPILVSDPAQVATMLAPVLTGNDLILVQGAGNVGKIARYLSEIKL
KPQIQEEEQHG

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=490, Percent_Identity=94.6938775510204, Blast_Score=875, Evalue=0.0,
Organism=Escherichia coli, GI1790680, Length=480, Percent_Identity=27.9166666666667, Blast_Score=145, Evalue=6e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 53438; Mature: 53438

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQL
CCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHCCCCEECCCCCCCCHHHHHH
TSLGATIFFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRH
HHCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHC
GIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHSRYLIAEADESDA
CEEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCCEEECCCCEECCCCEEEEEECCCCCC
SFLHLQPMVAIVTNIEADHMDTYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
CEEEHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHH
PRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQGMPDLHVTLNAPGRHNALNAAAA
HHCCCCCEECCCCCCCCCCHHHHHHCCCCCHHHHHHCCCCCEEEEECCCCCCCHHHHHHH
VAVATEEGIADDAILRALESFQGTGRRFDFLGEFPLEPVNGKAGTAMLVDDYGHHPTEVD
EEEECCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCHH
ATIKAARAGWPDKNLVMLFQPHRYTRTRDLYDDFANVLTQVDALLMLDVYPAGEAPIPGA
HHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCC
DSRSLCRTIRNRGKIDPILVSDPAQVATMLAPVLTGNDLILVQGAGNVGKIARYLSEIKL
CHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCC
KPQIQEEEQHG
CCCCCCCCCCC
>Mature Secondary Structure
MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQL
CCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHCCCCEECCCCCCCCHHHHHH
TSLGATIFFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRH
HHCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHC
GIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHSRYLIAEADESDA
CEEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCCEEECCCCEECCCCEEEEEECCCCCC
SFLHLQPMVAIVTNIEADHMDTYHGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
CEEEHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHH
PRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQGMPDLHVTLNAPGRHNALNAAAA
HHCCCCCEECCCCCCCCCCHHHHHHCCCCCHHHHHHCCCCCEEEEECCCCCCCHHHHHHH
VAVATEEGIADDAILRALESFQGTGRRFDFLGEFPLEPVNGKAGTAMLVDDYGHHPTEVD
EEEECCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCHH
ATIKAARAGWPDKNLVMLFQPHRYTRTRDLYDDFANVLTQVDALLMLDVYPAGEAPIPGA
HHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCC
DSRSLCRTIRNRGKIDPILVSDPAQVATMLAPVLTGNDLILVQGAGNVGKIARYLSEIKL
CHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCC
KPQIQEEEQHG
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA