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The map label for this gene is lldD [C]

Identifier: 194734550

GI number: 194734550

Start: 1678562

End: 1679764

Strand: Reverse

Name: lldD [C]

Synonym: SeSA_A1737

Alternate gene names: 194734550

Gene position: 1679764-1678562 (Counterclockwise)

Preceding gene: 194737479

Following gene: 194736788

Centisome position: 35.67

GC content: 48.38

Gene sequence:

>1203_bases
ATGAAAACTAATCACCTCATTCGGGTAGTGGCCTCGCTGGCGATGTTGGCAACGTCAGGCCTGGCTTATGCTGAAGAGTA
CAAAGCCAGCACGGACGAAAAAGCAATAAAAATGACGAACGTAGCCTCTCTGGAAGCGCGCGTTCAAGCCAGAATGGAGA
AAGGGGCATTTGGTTATATTCGCGGTGGAGCCGAAGATGAGAATAACCTTCGCAGCAACACCGAAAGCTTTGACAAAAAA
TATATTATGCCGCGCGTATTACAGGGCATTGAGTTAAAAGAGATCGATTTATCAACGCAGCTACTGGGTATTCCGCTTAA
AACGCCTATAATCCAGGCACCGATGGCAGCGCAGGGCCTGGCCCACGCCTCCGGAGAGTTGGCGACGGCGAAAGGCATGG
CGCAGGTCGGTTCGATTTTCTCGTTGAGTACTTATGGCAACAAGACCATCGAAGAGGTGGCTAACGTTTCCGGGAAAAAT
CCGTTCTTCTTCCAGCTTTATATGAGTAAGAATAATCAATTTAACGAATTTATTCTTGCACAAGCGGTAAAGCATGGCGC
TAAAGCGATTATTCTGACCGTAGATTCGCCTGTCGGTGGCTATCGGGAAGAAGATATTAAAAATAACTTCCAGTTCCCGT
TGGGCTTTGCAAACCTGGAAATGTTCGCCAGAAAAAATGACGATGGTTCAAAAACCGGCAAAGGGGCAGGGATAAGTGAA
ATTTACGCGCAGGCTAAACAAGCCTTTACGCCGGAGGATATTGCCTATGTACATCGTATTTCCGGTCTGCCGGTTATCGT
AAAAGGCATTCAGTCGCCGGAGGATGCTGAAATTGCTATCCAGGCCGGGGCCGCAGGAATATGGGTTTCTAATCATGGTG
GTCGTCAATTAGACAGCGGGCCGTCCTCATTCGATATGCTTCCTGCGATTGCAAAAGTTGTCAACAAGCAAGTGCCTGTT
ATTTTTGACAGCGGAGTACGCCGTGGTTCGCACGTATTCAAAGCGTTAGCCAGCGGGGCGGATATTGTGGCGGTTGGCCG
GCCTGTATTATACGGTCTTAATCTTGGCGGCGCTCAGGGTGTGGCATCAGTGATTGAACAGCTAAACAAAGAGCTGACAA
TTAACATGATGTTGGGTGGCGCCAGGAATATTGAACAAGTGAAAACGACACGCTTGTTAACTGAAAAAGAGCTGCCCCAG
TAA

Upstream 100 bases:

>100_bases
GCACCCAGTGGGGTGTAGATTATCTGGTCGATATGGGGATGACGAAAGTTGTCGATATAAAAATCCAGGCAGAAGCGGTT
AAGCAATAAAGGGAATGATG

Downstream 100 bases:

>100_bases
TATAAAGGTCGGGTACTATACCCGACCTTTTCCTGTATGATTTCCCTCAACAACGCTTCCGGTAGAAAATGACGCGCTCT
GTTTCCTCAAATCCTAACGC

Product: L-lactate oxidase

Products: NA

Alternate protein names: Lactate oxidase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MKTNHLIRVVASLAMLATSGLAYAEEYKASTDEKAIKMTNVASLEARVQARMEKGAFGYIRGGAEDENNLRSNTESFDKK
YIMPRVLQGIELKEIDLSTQLLGIPLKTPIIQAPMAAQGLAHASGELATAKGMAQVGSIFSLSTYGNKTIEEVANVSGKN
PFFFQLYMSKNNQFNEFILAQAVKHGAKAIILTVDSPVGGYREEDIKNNFQFPLGFANLEMFARKNDDGSKTGKGAGISE
IYAQAKQAFTPEDIAYVHRISGLPVIVKGIQSPEDAEIAIQAGAAGIWVSNHGGRQLDSGPSSFDMLPAIAKVVNKQVPV
IFDSGVRRGSHVFKALASGADIVAVGRPVLYGLNLGGAQGVASVIEQLNKELTINMMLGGARNIEQVKTTRLLTEKELPQ

Sequences:

>Translated_400_residues
MKTNHLIRVVASLAMLATSGLAYAEEYKASTDEKAIKMTNVASLEARVQARMEKGAFGYIRGGAEDENNLRSNTESFDKK
YIMPRVLQGIELKEIDLSTQLLGIPLKTPIIQAPMAAQGLAHASGELATAKGMAQVGSIFSLSTYGNKTIEEVANVSGKN
PFFFQLYMSKNNQFNEFILAQAVKHGAKAIILTVDSPVGGYREEDIKNNFQFPLGFANLEMFARKNDDGSKTGKGAGISE
IYAQAKQAFTPEDIAYVHRISGLPVIVKGIQSPEDAEIAIQAGAAGIWVSNHGGRQLDSGPSSFDMLPAIAKVVNKQVPV
IFDSGVRRGSHVFKALASGADIVAVGRPVLYGLNLGGAQGVASVIEQLNKELTINMMLGGARNIEQVKTTRLLTEKELPQ
>Mature_400_residues
MKTNHLIRVVASLAMLATSGLAYAEEYKASTDEKAIKMTNVASLEARVQARMEKGAFGYIRGGAEDENNLRSNTESFDKK
YIMPRVLQGIELKEIDLSTQLLGIPLKTPIIQAPMAAQGLAHASGELATAKGMAQVGSIFSLSTYGNKTIEEVANVSGKN
PFFFQLYMSKNNQFNEFILAQAVKHGAKAIILTVDSPVGGYREEDIKNNFQFPLGFANLEMFARKNDDGSKTGKGAGISE
IYAQAKQAFTPEDIAYVHRISGLPVIVKGIQSPEDAEIAIQAGAAGIWVSNHGGRQLDSGPSSFDMLPAIAKVVNKQVPV
IFDSGVRRGSHVFKALASGADIVAVGRPVLYGLNLGGAQGVASVIEQLNKELTINMMLGGARNIEQVKTTRLLTEKELPQ

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=357, Percent_Identity=36.6946778711485, Blast_Score=241, Evalue=7e-64,
Organism=Homo sapiens, GI54234014, Length=355, Percent_Identity=31.5492957746479, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI7705393, Length=355, Percent_Identity=31.5492957746479, Blast_Score=201, Evalue=1e-51,
Organism=Escherichia coli, GI1790033, Length=366, Percent_Identity=33.879781420765, Blast_Score=186, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI193208036, Length=344, Percent_Identity=36.046511627907, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI32566217, Length=252, Percent_Identity=35.7142857142857, Blast_Score=145, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6323587, Length=372, Percent_Identity=30.1075268817204, Blast_Score=159, Evalue=7e-40,
Organism=Drosophila melanogaster, GI281363140, Length=366, Percent_Identity=35.2459016393443, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI78707190, Length=366, Percent_Identity=35.2459016393443, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI78707188, Length=365, Percent_Identity=35.0684931506849, Blast_Score=224, Evalue=7e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.13.12.4 [H]

Molecular weight: Translated: 43002; Mature: 43002

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTNHLIRVVASLAMLATSGLAYAEEYKASTDEKAIKMTNVASLEARVQARMEKGAFGYI
CCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHEEHHHHHHHHHHHHHHHHCCCCEEE
RGGAEDENNLRSNTESFDKKYIMPRVLQGIELKEIDLSTQLLGIPLKTPIIQAPMAAQGL
ECCCCCCHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCHHEECCCCCCCHHCCCHHHHHH
AHASGELATAKGMAQVGSIFSLSTYGNKTIEEVANVSGKNPFFFQLYMSKNNQFNEFILA
HHCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHH
QAVKHGAKAIILTVDSPVGGYREEDIKNNFQFPLGFANLEMFARKNDDGSKTGKGAGISE
HHHHCCCEEEEEEECCCCCCCCHHHHCCCCCCCCCHHHHHHHEECCCCCCCCCCCCCHHH
IYAQAKQAFTPEDIAYVHRISGLPVIVKGIQSPEDAEIAIQAGAAGIWVSNHGGRQLDSG
HHHHHHHCCCHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEECCCEEEEECCCCCCCCCC
PSSFDMLPAIAKVVNKQVPVIFDSGVRRGSHVFKALASGADIVAVGRPVLYGLNLGGAQG
CCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCCCEEEECCCEEEEECCCCHHH
VASVIEQLNKELTINMMLGGARNIEQVKTTRLLTEKELPQ
HHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKTNHLIRVVASLAMLATSGLAYAEEYKASTDEKAIKMTNVASLEARVQARMEKGAFGYI
CCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHEEHHHHHHHHHHHHHHHHCCCCEEE
RGGAEDENNLRSNTESFDKKYIMPRVLQGIELKEIDLSTQLLGIPLKTPIIQAPMAAQGL
ECCCCCCHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCHHEECCCCCCCHHCCCHHHHHH
AHASGELATAKGMAQVGSIFSLSTYGNKTIEEVANVSGKNPFFFQLYMSKNNQFNEFILA
HHCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHH
QAVKHGAKAIILTVDSPVGGYREEDIKNNFQFPLGFANLEMFARKNDDGSKTGKGAGISE
HHHHCCCEEEEEEECCCCCCCCHHHHCCCCCCCCCHHHHHHHEECCCCCCCCCCCCCHHH
IYAQAKQAFTPEDIAYVHRISGLPVIVKGIQSPEDAEIAIQAGAAGIWVSNHGGRQLDSG
HHHHHHHCCCHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEECCCEEEEECCCCCCCCCC
PSSFDMLPAIAKVVNKQVPVIFDSGVRRGSHVFKALASGADIVAVGRPVLYGLNLGGAQG
CCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCCCEEEECCCEEEEECCCCHHH
VASVIEQLNKELTINMMLGGARNIEQVKTTRLLTEKELPQ
HHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2324094; 3571231 [H]