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The map label for this gene is ribD [H]

Identifier: 194734520

GI number: 194734520

Start: 481383

End: 482486

Strand: Direct

Name: ribD [H]

Synonym: SeSA_A0476

Alternate gene names: 194734520

Gene position: 481383-482486 (Clockwise)

Preceding gene: 194736356

Following gene: 194733994

Centisome position: 10.22

GC content: 59.69

Gene sequence:

>1104_bases
ATGCAGGATGAATTTTACATGGCGCGAGCGCTAAAACTGGCGCAGCGTGGACGTTTCACCACTCACCCGAACCCTAATGT
CGGTTGTGTCATTGTTAACAATGGCGACATCGTCGGCGAAGGTTATCACCATCGCGCCGGAGAGCCGCACGCCGAGGTTC
ATGCGCTGCGGATGGCGGGCGCAAAAGCCAAAGGCGCAACCGCCTATGTCACGCTTGAACCCTGTAGCCATCATGGGCGA
ACGCCGCCATGTTGCGATGCGCTGATTGCGGCCGGCGTCGCGCGCGTGGTCGCCGCGATGCAGGACCCGAACCCACAGGT
CGCCGGGCGCGGACTGTATCGTCTGCAACAGTCGGGTATTGCGGTCAGCCACGGGTTAATGATGAGTGAAGCGGAGGCGC
TCAATAAAGGCTTCCTCAAACGGATGCGTACCGGATTCCCTTATCTTCAGCTTAAACTGGGCGCCTCCGTGGATGGACGG
ACGGCGATGGCCAGCGGCGAAAGCCAGTGGATCACCTCGCCGCAGGCCCGGCGTGACGTTCAGCGCTTGCGTGCGCAAAG
CCACGCTATCTTAACCAGTAGCGCGACGGTATTGGCTGACGATCCGGCCTTGACGGTGCGTTGGGCGGAGTTAGACGCCT
CTACGCAGGCGTCTTACCCGCAGGAAAATCTGCGCCAGCCGGTGCGAATTGTTATCGACAGCCAAAACCGGGTAACGCCT
GCGCATCGTATTGTGCAGCAGCCTGGCGAAACGTGGATTGCGCGTACCCAGGAAGATAGCCGCGCGTGGCCCGATTCGGT
TCGTACTATCAGCGTGCCGGCGCACAACGGACATTTGGATCTGGTTGTGCTGATGATGCAGTTAGGCAGGCAGCAGATTA
ATAGCATATGGGTTGAAGCCGGACCGGGACTGGCGGGCGCGTTGCTGCAAGCCGGGCTGGTGGATGAACTGATTGTCTAT
GTCGCGCCTAAATTGTTGGGAACCCAGGCGCGGGGATTATGCGAATTGCCGGGGCTTGAGAAGCTCGCCGACGCGCCGCA
ATTTACCTTCAGCGAAATACGCCATGTCGGCCCGGATGTTTGCCTGCATATGGTGAGCGCATGA

Upstream 100 bases:

>100_bases
ACTCGATAAAGTCGCGTATATTCGCTTTGCCTCCGTCTATCGCAGTTTCGAAGATATTAAAGACTTTGGCGAAGAAATCG
CTCGCCTACAGGACTAAGCC

Downstream 100 bases:

>100_bases
GTTCTCCCGTCGAAAGGGGAGCAGCGCTCAAATTATTATGATAAAATCCGCCCCCCTGCGGGGCCAAATGAACCCTGGAA
GAGAGAATATGAACATTATT

Product: bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MQDEFYMARALKLAQRGRFTTHPNPNVGCVIVNNGDIVGEGYHHRAGEPHAEVHALRMAGAKAKGATAYVTLEPCSHHGR
TPPCCDALIAAGVARVVAAMQDPNPQVAGRGLYRLQQSGIAVSHGLMMSEAEALNKGFLKRMRTGFPYLQLKLGASVDGR
TAMASGESQWITSPQARRDVQRLRAQSHAILTSSATVLADDPALTVRWAELDASTQASYPQENLRQPVRIVIDSQNRVTP
AHRIVQQPGETWIARTQEDSRAWPDSVRTISVPAHNGHLDLVVLMMQLGRQQINSIWVEAGPGLAGALLQAGLVDELIVY
VAPKLLGTQARGLCELPGLEKLADAPQFTFSEIRHVGPDVCLHMVSA

Sequences:

>Translated_367_residues
MQDEFYMARALKLAQRGRFTTHPNPNVGCVIVNNGDIVGEGYHHRAGEPHAEVHALRMAGAKAKGATAYVTLEPCSHHGR
TPPCCDALIAAGVARVVAAMQDPNPQVAGRGLYRLQQSGIAVSHGLMMSEAEALNKGFLKRMRTGFPYLQLKLGASVDGR
TAMASGESQWITSPQARRDVQRLRAQSHAILTSSATVLADDPALTVRWAELDASTQASYPQENLRQPVRIVIDSQNRVTP
AHRIVQQPGETWIARTQEDSRAWPDSVRTISVPAHNGHLDLVVLMMQLGRQQINSIWVEAGPGLAGALLQAGLVDELIVY
VAPKLLGTQARGLCELPGLEKLADAPQFTFSEIRHVGPDVCLHMVSA
>Mature_367_residues
MQDEFYMARALKLAQRGRFTTHPNPNVGCVIVNNGDIVGEGYHHRAGEPHAEVHALRMAGAKAKGATAYVTLEPCSHHGR
TPPCCDALIAAGVARVVAAMQDPNPQVAGRGLYRLQQSGIAVSHGLMMSEAEALNKGFLKRMRTGFPYLQLKLGASVDGR
TAMASGESQWITSPQARRDVQRLRAQSHAILTSSATVLADDPALTVRWAELDASTQASYPQENLRQPVRIVIDSQNRVTP
AHRIVQQPGETWIARTQEDSRAWPDSVRTISVPAHNGHLDLVVLMMQLGRQQINSIWVEAGPGLAGALLQAGLVDELIVY
VAPKLLGTQARGLCELPGLEKLADAPQFTFSEIRHVGPDVCLHMVSA

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=367, Percent_Identity=89.3732970027248, Blast_Score=691, Evalue=0.0,
Organism=Escherichia coli, GI145693172, Length=168, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 39763; Mature: 39763

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDEFYMARALKLAQRGRFTTHPNPNVGCVIVNNGDIVGEGYHHRAGEPHAEVHALRMAG
CCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCEECCCCCCCCCCCHHHHHHHHHHC
AKAKGATAYVTLEPCSHHGRTPPCCDALIAAGVARVVAAMQDPNPQVAGRGLYRLQQSGI
CCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHCCC
AVSHGLMMSEAEALNKGFLKRMRTGFPYLQLKLGASVDGRTAMASGESQWITSPQARRDV
EEHHCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCCCCCCCCCHHHHHHH
QRLRAQSHAILTSSATVLADDPALTVRWAELDASTQASYPQENLRQPVRIVIDSQNRVTP
HHHHHHHCEEEECCCEEEECCCCEEEEEEECCCCCCCCCCHHHCCCCEEEEECCCCCCCH
AHRIVQQPGETWIARTQEDSRAWPDSVRTISVPAHNGHLDLVVLMMQLGRQQINSIWVEA
HHHHHHCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCHHHHHHEEEEC
GPGLAGALLQAGLVDELIVYVAPKLLGTQARGLCELPGLEKLADAPQFTFSEIRHVGPDV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCHHHHHHHHCCHHH
CLHMVSA
HHHHHCC
>Mature Secondary Structure
MQDEFYMARALKLAQRGRFTTHPNPNVGCVIVNNGDIVGEGYHHRAGEPHAEVHALRMAG
CCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCEECCCCCCCCCCCHHHHHHHHHHC
AKAKGATAYVTLEPCSHHGRTPPCCDALIAAGVARVVAAMQDPNPQVAGRGLYRLQQSGI
CCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHCCC
AVSHGLMMSEAEALNKGFLKRMRTGFPYLQLKLGASVDGRTAMASGESQWITSPQARRDV
EEHHCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCCCCCCCCCHHHHHHH
QRLRAQSHAILTSSATVLADDPALTVRWAELDASTQASYPQENLRQPVRIVIDSQNRVTP
HHHHHHHCEEEECCCEEEECCCCEEEEEEECCCCCCCCCCHHHCCCCEEEEECCCCCCCH
AHRIVQQPGETWIARTQEDSRAWPDSVRTISVPAHNGHLDLVVLMMQLGRQQINSIWVEA
HHHHHHCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCHHHHHHEEEEC
GPGLAGALLQAGLVDELIVYVAPKLLGTQARGLCELPGLEKLADAPQFTFSEIRHVGPDV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCHHHHHHHHCCHHH
CLHMVSA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1406588; 9278503; 9068650 [H]