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The map label for this gene is panE [C]

Identifier: 194734473

GI number: 194734473

Start: 2719581

End: 2720498

Strand: Reverse

Name: panE [C]

Synonym: SeSA_A2816

Alternate gene names: 194734473

Gene position: 2720498-2719581 (Counterclockwise)

Preceding gene: 194734416

Following gene: 194737600

Centisome position: 57.77

GC content: 48.47

Gene sequence:

>918_bases
ATGAAAATTGCAATCGCAGGTGCAGGCGCTATGGGATGTCGTTTTGGCTATATGCTGCTGGAGGCCGGGCACGACGTGAC
GCTTATCGATAGCTGGCAGGAGCATGTTGACGCTATTCGTAGCAAGGGGTTGTTTGTCGAAACGGAAACGACTCAGAAGT
ATTACCCCATCCCTGCTATGTTGGCTGATGAATCCCAGGGGGAGTTTGAGCTGGTTATTCTGTTTACCAAAGCCATGCAG
CTGGATAGCATGTTACAGCCTATTAAGCCATTACTGCCAGCCGCGAAAGTAGTGATGATTTTATCTAACGGCCTGGGAAA
TATCGAAACGCTGGAGAAATATGTCGATCGGCAGAAAATCTATGCGGGTGTGACGTTATGGTCCAGCGAACTGGAGGGGG
CTGGGCATATTATGGCCACCGGTACCGGAACGATTGAACTGCAGCCGATTGCCAGCCATGATTCGGCTCAAGAGGCTAAG
GTCATTGCCACCCTTAATAGCGCTGGATTGAATGCTGAAATAAGCCCTGACGTATTATTATCGATCTGGAAGAAAGCAGC
CTTTAATAGCGTAATGAACACCTATTGCGCGCTACTGGATTGTAATGTCGGCGGATTTGGTCAGCGGCCTGGTGCTTTAG
ATTTAGCGCAAGCGGTAGTTGATGAGTTTGTGTTAGTTGCTGCCAGCCAGAATATTCCGTTGACTGAGCAAATGGTGATG
AATACGGTGAAGAAAGTGTTCGATCCGCGTGAGAGCGGCCACCACTATCCTTCTATGCATCAGGATTTACATAAAGGCCG
ACTGACCGAAATCGACTATTTAAATGGTGCGATTGCGCGAATCGGCGCTCAGAACAATATTGCCGTACCGGTTAACAAAC
TCCTGACGCAATTGATTCACGCTAAAGAAGCGCAATAA

Upstream 100 bases:

>100_bases
GGTGCTATTGCTTATTGGAGTCGTGTTGACCCTGATAACGAAAAAATATGTCGCAACGGTTTTAGCCAAAATTTATTAAT
CAGATAATAAGGAAATAAAA

Downstream 100 bases:

>100_bases
ACTTGATAGCTCTTCTGCATGAGGCGGAAGAGCCATTTTCAAACCAGTTTTTTTACCAGCGCCTCGCTATGGCGAATACG
CTCCGGCGCCCGCTCTAAAT

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MKIAIAGAGAMGCRFGYMLLEAGHDVTLIDSWQEHVDAIRSKGLFVETETTQKYYPIPAMLADESQGEFELVILFTKAMQ
LDSMLQPIKPLLPAAKVVMILSNGLGNIETLEKYVDRQKIYAGVTLWSSELEGAGHIMATGTGTIELQPIASHDSAQEAK
VIATLNSAGLNAEISPDVLLSIWKKAAFNSVMNTYCALLDCNVGGFGQRPGALDLAQAVVDEFVLVAASQNIPLTEQMVM
NTVKKVFDPRESGHHYPSMHQDLHKGRLTEIDYLNGAIARIGAQNNIAVPVNKLLTQLIHAKEAQ

Sequences:

>Translated_305_residues
MKIAIAGAGAMGCRFGYMLLEAGHDVTLIDSWQEHVDAIRSKGLFVETETTQKYYPIPAMLADESQGEFELVILFTKAMQ
LDSMLQPIKPLLPAAKVVMILSNGLGNIETLEKYVDRQKIYAGVTLWSSELEGAGHIMATGTGTIELQPIASHDSAQEAK
VIATLNSAGLNAEISPDVLLSIWKKAAFNSVMNTYCALLDCNVGGFGQRPGALDLAQAVVDEFVLVAASQNIPLTEQMVM
NTVKKVFDPRESGHHYPSMHQDLHKGRLTEIDYLNGAIARIGAQNNIAVPVNKLLTQLIHAKEAQ
>Mature_305_residues
MKIAIAGAGAMGCRFGYMLLEAGHDVTLIDSWQEHVDAIRSKGLFVETETTQKYYPIPAMLADESQGEFELVILFTKAMQ
LDSMLQPIKPLLPAAKVVMILSNGLGNIETLEKYVDRQKIYAGVTLWSSELEGAGHIMATGTGTIELQPIASHDSAQEAK
VIATLNSAGLNAEISPDVLLSIWKKAAFNSVMNTYCALLDCNVGGFGQRPGALDLAQAVVDEFVLVAASQNIPLTEQMVM
NTVKKVFDPRESGHHYPSMHQDLHKGRLTEIDYLNGAIARIGAQNNIAVPVNKLLTQLIHAKEAQ

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=312, Percent_Identity=24.6794871794872, Blast_Score=86, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33131; Mature: 33131

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAIAGAGAMGCRFGYMLLEAGHDVTLIDSWQEHVDAIRSKGLFVETETTQKYYPIPAM
CEEEEECCCHHHHHHHHHHEECCCCEEEEHHHHHHHHHHHHCCCEEEECCCCEECCCCCE
LADESQGEFELVILFTKAMQLDSMLQPIKPLLPAAKVVMILSNGLGNIETLEKYVDRQKI
ECCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
YAGVTLWSSELEGAGHIMATGTGTIELQPIASHDSAQEAKVIATLNSAGLNAEISPDVLL
HHHHEEECCCCCCCCEEEEECCCEEEEEEECCCCCCHHCEEEEEECCCCCCCCCCHHHHH
SIWKKAAFNSVMNTYCALLDCNVGGFGQRPGALDLAQAVVDEFVLVAASQNIPLTEQMVM
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHEEEECCCCCCHHHHHH
NTVKKVFDPRESGHHYPSMHQDLHKGRLTEIDYLNGAIARIGAQNNIAVPVNKLLTQLIH
HHHHHHHCCCCCCCCCCHHHHHHHCCCCCEEHHHCCHHHHHCCCCCEECCHHHHHHHHHH
AKEAQ
HCCCC
>Mature Secondary Structure
MKIAIAGAGAMGCRFGYMLLEAGHDVTLIDSWQEHVDAIRSKGLFVETETTQKYYPIPAM
CEEEEECCCHHHHHHHHHHEECCCCEEEEHHHHHHHHHHHHCCCEEEECCCCEECCCCCE
LADESQGEFELVILFTKAMQLDSMLQPIKPLLPAAKVVMILSNGLGNIETLEKYVDRQKI
ECCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
YAGVTLWSSELEGAGHIMATGTGTIELQPIASHDSAQEAKVIATLNSAGLNAEISPDVLL
HHHHEEECCCCCCCCEEEEECCCEEEEEEECCCCCCHHCEEEEEECCCCCCCCCCHHHHH
SIWKKAAFNSVMNTYCALLDCNVGGFGQRPGALDLAQAVVDEFVLVAASQNIPLTEQMVM
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHEEEECCCCCCHHHHHH
NTVKKVFDPRESGHHYPSMHQDLHKGRLTEIDYLNGAIARIGAQNNIAVPVNKLLTQLIH
HHHHHHHCCCCCCCCCCHHHHHHHCCCCCEEHHHCCHHHHHCCCCCEECCHHHHHHHHHH
AKEAQ
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]