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The map label for this gene is acrE [H]

Identifier: 194734299

GI number: 194734299

Start: 3459309

End: 3460466

Strand: Direct

Name: acrE [H]

Synonym: SeSA_A3583

Alternate gene names: 194734299

Gene position: 3459309-3460466 (Clockwise)

Preceding gene: 194737523

Following gene: 194736548

Centisome position: 73.46

GC content: 54.92

Gene sequence:

>1158_bases
ATGACGAAACATGCCAGGTTTTCACTCCTGCCCTCATTCATCATATTCTCTGCTGCGCTGCTGGCCGGTTGTAATGACCA
GGGAGATACCCAGGCTCATGCCGGCGAGCCGCAAGTCACCGTCCATGTGGTCGAAACAGCGCCGCTAGCCGTAACGACCG
AACTTCCCGGACGTACGTCCGCATTTCGCATTGCGGAAGTTCGCCCCCAGGTGAGCGGGATCGTGCTTAAAAGAAACTTC
ACCGAAGGTAGCGATGTAGAGGCCGGGCAGTCGCTTTATCAGATCGATCCTGCCACCTATCAGGCCGATTATGACAGCGC
TAAAGGCGAACTTGCTAAAAGCGAAGCGGCTGCGGCTATCGCGCACCTGACGGTCAAACGCTATGTTCCACTGGTCGGCA
CAAAATATATCAGCCAACAGGAATATGATCAGGCGATTGCCGACGCCCGCCAGGCCGATGCCGCCGTTGTGGCGGCAAAA
GCCGCTGTTGAAAGCGCGCGTATTAACCTTGCGTATACCAAAGTCACCTCGCCCATCAGCGGGCGTATAGGAAAATCTAA
TGTGACTGAAGGCGCGCTGGTGACTAATGGTCAGTCAACTGAACTGGCTACCGTGCAACAACTCGACCCGATTTATGTCG
ACGTGACGCAATCAAGCAACGACTTTATGCGACTCAAGCAATCCGTCGAACAAGGTAACCTGCATAAAGACAGCGCCAGT
AGCACGGTTCAACTGGTAATGGAAAATGGTCAGGTCTACCCGATTAAAGGCACGCTGCAATTTTCCGACGTTACCGTAGA
TGAAAGCACCGGCTCTATCACGCTCAGGGCAGTTTTCCCTAACCCGCAACACAGTCTGCTTCCCGGTATGTTTGTGCGCG
CCCGCATTGATGAAGGCGTCCAGCCCAATGCCATCCTTGTCCCCCAGCAGGGCGTAACCCGCACGCCGCGCGGCGACGCA
ATGGTGATGGTGGTTAACGATAAAAGCCAGGTTGAAGCCCGCAATGTCGTGGCGGCTCAGGCTATTGGCGATAAATGGCT
CATCAGCGAAGGGTTAAAACCGGGCGATAAGGTCATCGTCAGCGGCTTACAAAAAGCGCGACTGGGCGTCCAGGTGAAAG
CCACTACCGATGCTCCTACAGCGAAAACGGCGCAATAA

Upstream 100 bases:

>100_bases
AATAATTTGTAGGATACCCCACTGCTATTCTATTTTTCGCGCGTTAACGCCTTACCGTTATCCGGTGAATAACGAGCTTT
CGGTTTTTTAAGGAACAGTA

Downstream 100 bases:

>100_bases
GGTAACCGTACATGGCAAACTTTTTTATTAGACGTCCTATTTTCGCCTGGGTTCTGGCCATTATCCTGATGATGGCTGGC
GCACTGGCAATAATGCAACT

Product: acriflavine resistance protein E

Products: NA

Alternate protein names: Protein envC [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MTKHARFSLLPSFIIFSAALLAGCNDQGDTQAHAGEPQVTVHVVETAPLAVTTELPGRTSAFRIAEVRPQVSGIVLKRNF
TEGSDVEAGQSLYQIDPATYQADYDSAKGELAKSEAAAAIAHLTVKRYVPLVGTKYISQQEYDQAIADARQADAAVVAAK
AAVESARINLAYTKVTSPISGRIGKSNVTEGALVTNGQSTELATVQQLDPIYVDVTQSSNDFMRLKQSVEQGNLHKDSAS
STVQLVMENGQVYPIKGTLQFSDVTVDESTGSITLRAVFPNPQHSLLPGMFVRARIDEGVQPNAILVPQQGVTRTPRGDA
MVMVVNDKSQVEARNVVAAQAIGDKWLISEGLKPGDKVIVSGLQKARLGVQVKATTDAPTAKTAQ

Sequences:

>Translated_385_residues
MTKHARFSLLPSFIIFSAALLAGCNDQGDTQAHAGEPQVTVHVVETAPLAVTTELPGRTSAFRIAEVRPQVSGIVLKRNF
TEGSDVEAGQSLYQIDPATYQADYDSAKGELAKSEAAAAIAHLTVKRYVPLVGTKYISQQEYDQAIADARQADAAVVAAK
AAVESARINLAYTKVTSPISGRIGKSNVTEGALVTNGQSTELATVQQLDPIYVDVTQSSNDFMRLKQSVEQGNLHKDSAS
STVQLVMENGQVYPIKGTLQFSDVTVDESTGSITLRAVFPNPQHSLLPGMFVRARIDEGVQPNAILVPQQGVTRTPRGDA
MVMVVNDKSQVEARNVVAAQAIGDKWLISEGLKPGDKVIVSGLQKARLGVQVKATTDAPTAKTAQ
>Mature_384_residues
TKHARFSLLPSFIIFSAALLAGCNDQGDTQAHAGEPQVTVHVVETAPLAVTTELPGRTSAFRIAEVRPQVSGIVLKRNFT
EGSDVEAGQSLYQIDPATYQADYDSAKGELAKSEAAAAIAHLTVKRYVPLVGTKYISQQEYDQAIADARQADAAVVAAKA
AVESARINLAYTKVTSPISGRIGKSNVTEGALVTNGQSTELATVQQLDPIYVDVTQSSNDFMRLKQSVEQGNLHKDSASS
TVQLVMENGQVYPIKGTLQFSDVTVDESTGSITLRAVFPNPQHSLLPGMFVRARIDEGVQPNAILVPQQGVTRTPRGDAM
VMVVNDKSQVEARNVVAAQAIGDKWLISEGLKPGDKVIVSGLQKARLGVQVKATTDAPTAKTAQ

Specific function: May affect specific membrane functions, such as septum formation during cell division, and cell membrane permeability [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789665, Length=379, Percent_Identity=88.3905013192612, Blast_Score=667, Evalue=0.0,
Organism=Escherichia coli, GI1786668, Length=375, Percent_Identity=70.1333333333333, Blast_Score=505, Evalue=1e-144,
Organism=Escherichia coli, GI1789929, Length=373, Percent_Identity=50.1340482573727, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI87082036, Length=321, Percent_Identity=29.2834890965732, Blast_Score=132, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41010; Mature: 40879

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKHARFSLLPSFIIFSAALLAGCNDQGDTQAHAGEPQVTVHVVETAPLAVTTELPGRTS
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCEEEEECCCCCCC
AFRIAEVRPQVSGIVLKRNFTEGSDVEAGQSLYQIDPATYQADYDSAKGELAKSEAAAAI
EEEEEECCCCCCEEEEEECCCCCCCCCCCCCEEEECCCEEECCCCCCCCHHHHHHHHHHH
AHLTVKRYVPLVGTKYISQQEYDQAIADARQADAAVVAAKAAVESARINLAYTKVTSPIS
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEEEEEECCCCC
GRIGKSNVTEGALVTNGQSTELATVQQLDPIYVDVTQSSNDFMRLKQSVEQGNLHKDSAS
CCCCCCCCCCCEEEECCCCCCEEHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCC
STVQLVMENGQVYPIKGTLQFSDVTVDESTGSITLRAVFPNPQHSLLPGMFVRARIDEGV
CEEEEEEECCEEEEEEEEEEEEEEEEECCCCCEEEEEECCCCCCHHCCCCEEEEECCCCC
QPNAILVPQQGVTRTPRGDAMVMVVNDKSQVEARNVVAAQAIGDKWLISEGLKPGDKVIV
CCCEEEECCCCCCCCCCCCEEEEEECCCCHHHHHHEEEEHHCCCHHHHHCCCCCCHHHHH
SGLQKARLGVQVKATTDAPTAKTAQ
HHHHHHHCCEEEEECCCCCCCCCCC
>Mature Secondary Structure 
TKHARFSLLPSFIIFSAALLAGCNDQGDTQAHAGEPQVTVHVVETAPLAVTTELPGRTS
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCEEEEECCCCCCC
AFRIAEVRPQVSGIVLKRNFTEGSDVEAGQSLYQIDPATYQADYDSAKGELAKSEAAAAI
EEEEEECCCCCCEEEEEECCCCCCCCCCCCCEEEECCCEEECCCCCCCCHHHHHHHHHHH
AHLTVKRYVPLVGTKYISQQEYDQAIADARQADAAVVAAKAAVESARINLAYTKVTSPIS
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEEEEEECCCCC
GRIGKSNVTEGALVTNGQSTELATVQQLDPIYVDVTQSSNDFMRLKQSVEQGNLHKDSAS
CCCCCCCCCCCEEEECCCCCCEEHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCC
STVQLVMENGQVYPIKGTLQFSDVTVDESTGSITLRAVFPNPQHSLLPGMFVRARIDEGV
CEEEEEEECCEEEEEEEEEEEEEEEEECCCCCEEEEEECCCCCCHHCCCCEEEEECCCCC
QPNAILVPQQGVTRTPRGDAMVMVVNDKSQVEARNVVAAQAIGDKWLISEGLKPGDKVIV
CCCEEEECCCCCCCCCCCCEEEEEECCCCHHHHHHEEEEHHCCCHHHHHCCCCCCHHHHH
SGLQKARLGVQVKATTDAPTAKTAQ
HHHHHHHCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1720861; 9278503 [H]