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The map label for this gene is prpR [H]

Identifier: 194734203

GI number: 194734203

Start: 428870

End: 430495

Strand: Reverse

Name: prpR [H]

Synonym: SeSA_A0419

Alternate gene names: 194734203

Gene position: 430495-428870 (Counterclockwise)

Preceding gene: 194737612

Following gene: 194735554

Centisome position: 9.14

GC content: 55.84

Gene sequence:

>1626_bases
ATGACGACTGCCCACAGCGCTCCGCGCGATAATAGCGATAAACCGGTGATCTGGACGGTCTCCGTAACGCGTCTGTTCGA
ACTGTTTCGGGATATCAGCCTGGAATTCGATCATCTGGCGACCATCACGCCTATTCAACTCGGCTTTGAAAAGGCGGTGA
CCTACATTCGCAAAAAACTGGCGACCGAGCGCTGCGACGCGATTATCGCGGCGGGTTCGAACGGGGCCTATTTAAAAAGT
CGCCTGTCAATACCGGTGATCCTCATCAAGCCCAGCGGATTCGATGTATTACAGGCGCTGGCGAAAGCAGGAAAGCTCAC
CTCATCTATCGGTATCGTGACCTATCAGGAGACCATTCCGGCTTTACTTGCCTTTCAGAAAACGTTTCACCTCCGTCTTG
AACAGCGAAGCTATGTCACCGAAGAGGACGCGCGCGGGCAAATTAACGAACTTAAGGCCAACGGTATTGAGGCCGTCGTC
GGCGCGGGATTGATTACCGATCTGGCGGAAGAAGCGGGAATGACTGCCATCTTTATTTATTCCGCGGCGACCGTTCGTCA
GGCTTTCCATGATGCGCTGGATATGACCCGTCTGACACGGCGCCAGCGCGTGGATTACCCATCCGGCAAGGGATTACAAA
CCCGGTATGAACTGGGCGATATACGCGGCCAGTCGCCGCAAATGGAGCAGCTCCGCCAGACGATTACGCTCTATGCCCGC
TCCCGTGCGGCAGTGCTGATTCAGGGGGAAACAGGGACCGGAAAAGAGCTGGCGGCGCAGGCGATTCACCAGACGTTTTT
TCACCGCCAGCCTCACCGTCAGAATAAGCCATCCCCTCCCTTTGTCGCCGTTAATTGCGGCGCGATTACCGAGTCGTTGC
TGGAAGCGGAACTGTTTGGTTATGAAGAGGGCGCGTTTACCGGTTCACGACGAGGAGGCCGGGCGGGGCTGTTTGAAATC
GCACACGGCGGCACGCTGTTTCTGGATGAAATCGGCGAAATGCCCTTGCCGTTGCAAACCCGACTCTTGCGCGTACTGGA
GGAAAAAGCCGTCACTCGCGTCGGCGGACACCAGCCGGTCCCGGTGGATGTCCGGGTGATCAGCGCTACGCATTGCGATC
TGGATCGGGAGATAATGCAAGGACGTTTTCGCCCCGATCTCTTTTACCGCCTGAGTATTCTGCGCCTGACGCTTCCTCCT
TTGCGCGAGCGGCAGGCTGATATTTTGCCGCTGGCGGAAAGCTTTTTAAAACAGTCGCTGGCGGCGATGGAAATTCCGTT
TACCGAATCGATACGTCATGGATTGACACAGTGTCAGCCGCTTTTGCTGGCCTGGCGCTGGCCCGGTAATATTCGCGAAC
TGCGTAATATGATGGAGCGCCTGGCACTTTTTTTAAGCGTCGATCCCGCGCCAACGCTGGACAGGCAATTTATGCGGCAG
TTATTACCTGAGCTTATGGTGAACACAGCAGAGCTGACGCCTTCAACCGTGGATGCGCACACGTTACAGGATGTACTGGC
GCGCTTTAAGGGCGATAAGAGCGCGGCGGCGCGTTATCTGGGGATTAGCCGCACCACTCTGTGGCGTCGTTTAAAAGCTG
GTGCCAAAGACCAGTCGGATAATTAA

Upstream 100 bases:

>100_bases
GTCAGCTAACGTTTCATGAAACGAATCGCCCTGTTTCATTGCAACATTTATGAAACACATTTAAAACAAAAAATCGCCCC
TTAAAGATGAACCTACTGCG

Downstream 100 bases:

>100_bases
GACAAATGACAGCGTCCTGAATGCCTGATGGCGCTACGTTTACTGCAGGCCGTCATCCGGCAAAACGGATGCCGGTTGCC
AGGAATAAATATACCCGCCG

Product: propionate catabolism operon regulatory protein PrpR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MTTAHSAPRDNSDKPVIWTVSVTRLFELFRDISLEFDHLATITPIQLGFEKAVTYIRKKLATERCDAIIAAGSNGAYLKS
RLSIPVILIKPSGFDVLQALAKAGKLTSSIGIVTYQETIPALLAFQKTFHLRLEQRSYVTEEDARGQINELKANGIEAVV
GAGLITDLAEEAGMTAIFIYSAATVRQAFHDALDMTRLTRRQRVDYPSGKGLQTRYELGDIRGQSPQMEQLRQTITLYAR
SRAAVLIQGETGTGKELAAQAIHQTFFHRQPHRQNKPSPPFVAVNCGAITESLLEAELFGYEEGAFTGSRRGGRAGLFEI
AHGGTLFLDEIGEMPLPLQTRLLRVLEEKAVTRVGGHQPVPVDVRVISATHCDLDREIMQGRFRPDLFYRLSILRLTLPP
LRERQADILPLAESFLKQSLAAMEIPFTESIRHGLTQCQPLLLAWRWPGNIRELRNMMERLALFLSVDPAPTLDRQFMRQ
LLPELMVNTAELTPSTVDAHTLQDVLARFKGDKSAAARYLGISRTTLWRRLKAGAKDQSDN

Sequences:

>Translated_541_residues
MTTAHSAPRDNSDKPVIWTVSVTRLFELFRDISLEFDHLATITPIQLGFEKAVTYIRKKLATERCDAIIAAGSNGAYLKS
RLSIPVILIKPSGFDVLQALAKAGKLTSSIGIVTYQETIPALLAFQKTFHLRLEQRSYVTEEDARGQINELKANGIEAVV
GAGLITDLAEEAGMTAIFIYSAATVRQAFHDALDMTRLTRRQRVDYPSGKGLQTRYELGDIRGQSPQMEQLRQTITLYAR
SRAAVLIQGETGTGKELAAQAIHQTFFHRQPHRQNKPSPPFVAVNCGAITESLLEAELFGYEEGAFTGSRRGGRAGLFEI
AHGGTLFLDEIGEMPLPLQTRLLRVLEEKAVTRVGGHQPVPVDVRVISATHCDLDREIMQGRFRPDLFYRLSILRLTLPP
LRERQADILPLAESFLKQSLAAMEIPFTESIRHGLTQCQPLLLAWRWPGNIRELRNMMERLALFLSVDPAPTLDRQFMRQ
LLPELMVNTAELTPSTVDAHTLQDVLARFKGDKSAAARYLGISRTTLWRRLKAGAKDQSDN
>Mature_540_residues
TTAHSAPRDNSDKPVIWTVSVTRLFELFRDISLEFDHLATITPIQLGFEKAVTYIRKKLATERCDAIIAAGSNGAYLKSR
LSIPVILIKPSGFDVLQALAKAGKLTSSIGIVTYQETIPALLAFQKTFHLRLEQRSYVTEEDARGQINELKANGIEAVVG
AGLITDLAEEAGMTAIFIYSAATVRQAFHDALDMTRLTRRQRVDYPSGKGLQTRYELGDIRGQSPQMEQLRQTITLYARS
RAAVLIQGETGTGKELAAQAIHQTFFHRQPHRQNKPSPPFVAVNCGAITESLLEAELFGYEEGAFTGSRRGGRAGLFEIA
HGGTLFLDEIGEMPLPLQTRLLRVLEEKAVTRVGGHQPVPVDVRVISATHCDLDREIMQGRFRPDLFYRLSILRLTLPPL
RERQADILPLAESFLKQSLAAMEIPFTESIRHGLTQCQPLLLAWRWPGNIRELRNMMERLALFLSVDPAPTLDRQFMRQL
LPELMVNTAELTPSTVDAHTLQDVLARFKGDKSAAARYLGISRTTLWRRLKAGAKDQSDN

Specific function: Involved in the transcriptional regulation of the propionate catabolism operon [H]

COG id: COG1221

COG function: function code KT; Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1786524, Length=526, Percent_Identity=80.4182509505704, Blast_Score=843, Evalue=0.0,
Organism=Escherichia coli, GI1788550, Length=350, Percent_Identity=41.1428571428571, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI87082117, Length=354, Percent_Identity=43.7853107344633, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1790437, Length=316, Percent_Identity=42.7215189873418, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1790299, Length=339, Percent_Identity=41.8879056047198, Blast_Score=222, Evalue=5e-59,
Organism=Escherichia coli, GI1788905, Length=326, Percent_Identity=41.7177914110429, Blast_Score=221, Evalue=8e-59,
Organism=Escherichia coli, GI1789233, Length=332, Percent_Identity=40.6626506024096, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI87082152, Length=244, Percent_Identity=46.7213114754098, Blast_Score=198, Evalue=9e-52,
Organism=Escherichia coli, GI1789087, Length=343, Percent_Identity=39.9416909620991, Blast_Score=195, Evalue=7e-51,
Organism=Escherichia coli, GI87081872, Length=245, Percent_Identity=42.4489795918367, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI1787583, Length=329, Percent_Identity=33.1306990881459, Blast_Score=161, Evalue=9e-41,
Organism=Escherichia coli, GI87081858, Length=319, Percent_Identity=31.0344827586207, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1789828, Length=283, Percent_Identity=34.982332155477, Blast_Score=131, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR012704
- InterPro:   IPR010524 [H]

Pfam domain/function: PF02954 HTH_8; PF06506 PrpR_N; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 60364; Mature: 60233

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4 ; PS00134 TRYPSIN_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAHSAPRDNSDKPVIWTVSVTRLFELFRDISLEFDHLATITPIQLGFEKAVTYIRKKL
CCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHH
ATERCDAIIAAGSNGAYLKSRLSIPVILIKPSGFDVLQALAKAGKLTSSIGIVTYQETIP
HHHHHCEEEEECCCCCEEHHCCCCEEEEECCCCHHHHHHHHHHCCHHHHCEEEEEHHHHH
ALLAFQKTFHLRLEQRSYVTEEDARGQINELKANGIEAVVGAGLITDLAEEAGMTAIFIY
HHHHHHHHHHHEEHHHHCCCCCHHCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEE
SAATVRQAFHDALDMTRLTRRQRVDYPSGKGLQTRYELGDIRGQSPQMEQLRQTITLYAR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHCCCCCCHHHHHHHHHHHHHCC
SRAAVLIQGETGTGKELAAQAIHQTFFHRQPHRQNKPSPPFVAVNCGAITESLLEAELFG
CCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHC
YEEGAFTGSRRGGRAGLFEIAHGGTLFLDEIGEMPLPLQTRLLRVLEEKAVTRVGGHQPV
CCCCCCCCCCCCCCCCEEEECCCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
PVDVRVISATHCDLDREIMQGRFRPDLFYRLSILRLTLPPLRERQADILPLAESFLKQSL
CEEEEEEEECCCCCCHHHHCCCCCCCHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHH
AAMEIPFTESIRHGLTQCQPLLLAWRWPGNIRELRNMMERLALFLSVDPAPTLDRQFMRQ
HHHCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LLPELMVNTAELTPSTVDAHTLQDVLARFKGDKSAAARYLGISRTTLWRRLKAGAKDQSD
HHHHHHHCHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCC
N
C
>Mature Secondary Structure 
TTAHSAPRDNSDKPVIWTVSVTRLFELFRDISLEFDHLATITPIQLGFEKAVTYIRKKL
CCCCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHH
ATERCDAIIAAGSNGAYLKSRLSIPVILIKPSGFDVLQALAKAGKLTSSIGIVTYQETIP
HHHHHCEEEEECCCCCEEHHCCCCEEEEECCCCHHHHHHHHHHCCHHHHCEEEEEHHHHH
ALLAFQKTFHLRLEQRSYVTEEDARGQINELKANGIEAVVGAGLITDLAEEAGMTAIFIY
HHHHHHHHHHHEEHHHHCCCCCHHCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEE
SAATVRQAFHDALDMTRLTRRQRVDYPSGKGLQTRYELGDIRGQSPQMEQLRQTITLYAR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHCCCCCCHHHHHHHHHHHHHCC
SRAAVLIQGETGTGKELAAQAIHQTFFHRQPHRQNKPSPPFVAVNCGAITESLLEAELFG
CCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHC
YEEGAFTGSRRGGRAGLFEIAHGGTLFLDEIGEMPLPLQTRLLRVLEEKAVTRVGGHQPV
CCCCCCCCCCCCCCCCEEEECCCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
PVDVRVISATHCDLDREIMQGRFRPDLFYRLSILRLTLPPLRERQADILPLAESFLKQSL
CEEEEEEEECCCCCCHHHHCCCCCCCHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHH
AAMEIPFTESIRHGLTQCQPLLLAWRWPGNIRELRNMMERLALFLSVDPAPTLDRQFMRQ
HHHCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LLPELMVNTAELTPSTVDAHTLQDVLARFKGDKSAAARYLGISRTTLWRRLKAGAKDQSD
HHHHHHHCHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9006051; 11677609 [H]