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The map label for this gene is glpK [H]

Identifier: 194734133

GI number: 194734133

Start: 3862464

End: 3863948

Strand: Reverse

Name: glpK [H]

Synonym: SeSA_A3991

Alternate gene names: 194734133

Gene position: 3863948-3862464 (Counterclockwise)

Preceding gene: 194736890

Following gene: 194734610

Centisome position: 82.05

GC content: 49.23

Gene sequence:

>1485_bases
ATGCCTGATTACCACGCAGCGCTTGTCATTGACATTGGCACAACTAACTGCAAAGTCAGCTGTTATTCCTGTCATGACGT
GTCAGTTCTGGAAGTCCGCAAGTTTCCGACGCCAATAATATCGTCGGACAAAGGCGAGGTAGATTTCGATGTCGAAGCGC
TGTGGCAGGCACTGCGACTGGTAATGGCTGAACTGGTGGCTTCAGTACCGTTTCCGGTAAAAAATATCAGTATTGCGAGT
TTCGGTGAGTCTGGTGTCTTTGTGGATAAGGAGGGCGTCATTCTTACCCCGATGCTGGCCTGGTATGATCGACGTGGTGA
ATCTTATCTCTCGTCATTAAGCAAGGCAGAGGCTGAAGAACTGTATTCTATAACGGGATTGCCACCTCACAGTAATTACT
CAGCATTTAAAATGAGATGGTTGCTTGATAACTACTCCTTGCATGAAAGAAAAGATATCTGCTGGTTACATGCACCAGAA
GTGTTGTTGTGGCGAATGACAGGTGCGAAAAAGACGGAAATATCCCTGGCCAGTAGAACGTTGTGTCTGGACATTGCTCG
CCGTACCTGGTCTCGTAATGCTGCCGGGATTCTCGGCATACCGTTCGGTGTACTGGCTCCGTTGATAAAGCCAGGTGAAG
TGGCCGGATGGGTGACGGCAACGCTTAGAGAGGAATTGGGCTTCTCTCATGAGGTAAAAGTTACCCTGGCCGGGCACGAT
CATATGGTCGGTGCCCGCGCATTACAGCTGCAACCGGGCGATGTGCTGAATTCTACTGGCACGACAGAGGGTATTTTACT
GCTGAATACACAACCAACGCTTGATGTGCAGGCTCGCAGGGATAAGCTGGCAAATGGTTGTTACTCCGATGGTGAATTTT
TCACGCTTTTCGCTTCTCTGCCTGTCGGCGGTTATGCGCTTGAATGGGTGAAAAAAACCTTTCGTTTAACTGATAAGGAA
ATAAGCACAGGCCTGGAAAAAGCCATGGAGCAATACCTCAAACCTTCCTGGTCTGTCGAGCATGTGCCGGTATTTATTCC
TCATTTGCGGGGCTCGGGTTCGCCAAATAAAAATCGGCACACCCGTGGCCTGCTTTTTGGTCTGACGGATTCACTTCCTC
CGGAGTCTCTGCTTGAGAGTGTCTTTATTGGCCTGGCGATGGAGTTTGCACACTGTCACGGGTGCTTTAATATCCCGGCG
GGCAGGACAGTAAAAGTCATTGGCCCTGCGGTGAAAAACCCATACTGGCTCCAGTTGAAGGCTGACATCCTCCAGTGTCC
AATTGAGGCCATTGCTTTTGATGAAACCGTCTCCCTTGGAGCATTGTTGATAGCCTGTCCGAATGTTGTCCCCCCGACTG
TTCCTGTGGCTGAGCGATATTTTCCTGACGCGGTTCGTTCTGCAAAGTTGAAAATATATCAGCAGCAATGGCTGTCATTT
TATCAATTTAAACTGCGGCAAGAAGGGGCGCTTATTGGTGAATAA

Upstream 100 bases:

>100_bases
CTGCTTGAAATATTCAACGGAAATATTATTGCTATCGGGCTGATTCCTGTGCTTGCGCTGATTATTTATGGTGTTTTTCG
CCTGACAAAAGGAACGGTCT

Downstream 100 bases:

>100_bases
CTGTGATAACTCAATAGTTCGATAATTTACTTACACTGCTCACATAAATATCTGGAGTTAATATGCCTTTAGTCAATGGT
AGGATCCTGCTCAATTGTAT

Product: putative sugar kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MPDYHAALVIDIGTTNCKVSCYSCHDVSVLEVRKFPTPIISSDKGEVDFDVEALWQALRLVMAELVASVPFPVKNISIAS
FGESGVFVDKEGVILTPMLAWYDRRGESYLSSLSKAEAEELYSITGLPPHSNYSAFKMRWLLDNYSLHERKDICWLHAPE
VLLWRMTGAKKTEISLASRTLCLDIARRTWSRNAAGILGIPFGVLAPLIKPGEVAGWVTATLREELGFSHEVKVTLAGHD
HMVGARALQLQPGDVLNSTGTTEGILLLNTQPTLDVQARRDKLANGCYSDGEFFTLFASLPVGGYALEWVKKTFRLTDKE
ISTGLEKAMEQYLKPSWSVEHVPVFIPHLRGSGSPNKNRHTRGLLFGLTDSLPPESLLESVFIGLAMEFAHCHGCFNIPA
GRTVKVIGPAVKNPYWLQLKADILQCPIEAIAFDETVSLGALLIACPNVVPPTVPVAERYFPDAVRSAKLKIYQQQWLSF
YQFKLRQEGALIGE

Sequences:

>Translated_494_residues
MPDYHAALVIDIGTTNCKVSCYSCHDVSVLEVRKFPTPIISSDKGEVDFDVEALWQALRLVMAELVASVPFPVKNISIAS
FGESGVFVDKEGVILTPMLAWYDRRGESYLSSLSKAEAEELYSITGLPPHSNYSAFKMRWLLDNYSLHERKDICWLHAPE
VLLWRMTGAKKTEISLASRTLCLDIARRTWSRNAAGILGIPFGVLAPLIKPGEVAGWVTATLREELGFSHEVKVTLAGHD
HMVGARALQLQPGDVLNSTGTTEGILLLNTQPTLDVQARRDKLANGCYSDGEFFTLFASLPVGGYALEWVKKTFRLTDKE
ISTGLEKAMEQYLKPSWSVEHVPVFIPHLRGSGSPNKNRHTRGLLFGLTDSLPPESLLESVFIGLAMEFAHCHGCFNIPA
GRTVKVIGPAVKNPYWLQLKADILQCPIEAIAFDETVSLGALLIACPNVVPPTVPVAERYFPDAVRSAKLKIYQQQWLSF
YQFKLRQEGALIGE
>Mature_493_residues
PDYHAALVIDIGTTNCKVSCYSCHDVSVLEVRKFPTPIISSDKGEVDFDVEALWQALRLVMAELVASVPFPVKNISIASF
GESGVFVDKEGVILTPMLAWYDRRGESYLSSLSKAEAEELYSITGLPPHSNYSAFKMRWLLDNYSLHERKDICWLHAPEV
LLWRMTGAKKTEISLASRTLCLDIARRTWSRNAAGILGIPFGVLAPLIKPGEVAGWVTATLREELGFSHEVKVTLAGHDH
MVGARALQLQPGDVLNSTGTTEGILLLNTQPTLDVQARRDKLANGCYSDGEFFTLFASLPVGGYALEWVKKTFRLTDKEI
STGLEKAMEQYLKPSWSVEHVPVFIPHLRGSGSPNKNRHTRGLLFGLTDSLPPESLLESVFIGLAMEFAHCHGCFNIPAG
RTVKVIGPAVKNPYWLQLKADILQCPIEAIAFDETVSLGALLIACPNVVPPTVPVAERYFPDAVRSAKLKIYQQQWLSFY
QFKLRQEGALIGE

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI42794763, Length=387, Percent_Identity=24.8062015503876, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI189409120, Length=384, Percent_Identity=25.2604166666667, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI4504007, Length=384, Percent_Identity=25.2604166666667, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI41393575, Length=376, Percent_Identity=23.936170212766, Blast_Score=83, Evalue=8e-16,
Organism=Escherichia coli, GI1789168, Length=455, Percent_Identity=23.2967032967033, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1789987, Length=499, Percent_Identity=23.6472945891784, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1790361, Length=464, Percent_Identity=21.7672413793103, Blast_Score=92, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17535599, Length=371, Percent_Identity=25.0673854447439, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI17864214, Length=394, Percent_Identity=25.3807106598985, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24654573, Length=394, Percent_Identity=25.3807106598985, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24655555, Length=466, Percent_Identity=21.4592274678112, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24655560, Length=466, Percent_Identity=21.4592274678112, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24655570, Length=466, Percent_Identity=21.4592274678112, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24655574, Length=466, Percent_Identity=21.4592274678112, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24655565, Length=466, Percent_Identity=21.4592274678112, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 54687; Mature: 54555

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDYHAALVIDIGTTNCKVSCYSCHDVSVLEVRKFPTPIISSDKGEVDFDVEALWQALRL
CCCCEEEEEEEECCCCEEEEEEECCCCEEEEHHCCCCCCCCCCCCCEEECHHHHHHHHHH
VMAELVASVPFPVKNISIASFGESGVFVDKEGVILTPMLAWYDRRGESYLSSLSKAEAEE
HHHHHHHHCCCCCCCCEEEECCCCCEEECCCCEEEEHHHHHHHCCCHHHHHHHHHHHHHH
LYSITGLPPHSNYSAFKMRWLLDNYSLHERKDICWLHAPEVLLWRMTGAKKTEISLASRT
HHEECCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCEEEEEECCCCCCCHHHHHHH
LCLDIARRTWSRNAAGILGIPFGVLAPLIKPGEVAGWVTATLREELGFSHEVKVTLAGHD
HHHHHHHHHHCCCCCCEEECCHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCC
HMVGARALQLQPGDVLNSTGTTEGILLLNTQPTLDVQARRDKLANGCYSDGEFFTLFASL
CCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEEEEC
PVGGYALEWVKKTFRLTDKEISTGLEKAMEQYLKPSWSVEHVPVFIPHLRGSGSPNKNRH
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCC
TRGLLFGLTDSLPPESLLESVFIGLAMEFAHCHGCFNIPAGRTVKVIGPAVKNPYWLQLK
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEECCCCCCCEEEEEE
ADILQCPIEAIAFDETVSLGALLIACPNVVPPTVPVAERYFPDAVRSAKLKIYQQQWLSF
HHHHHCCHHHHCCCCHHHHCCCEEECCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHH
YQFKLRQEGALIGE
HHHHHHHCCCCCCC
>Mature Secondary Structure 
PDYHAALVIDIGTTNCKVSCYSCHDVSVLEVRKFPTPIISSDKGEVDFDVEALWQALRL
CCCEEEEEEEECCCCEEEEEEECCCCEEEEHHCCCCCCCCCCCCCEEECHHHHHHHHHH
VMAELVASVPFPVKNISIASFGESGVFVDKEGVILTPMLAWYDRRGESYLSSLSKAEAEE
HHHHHHHHCCCCCCCCEEEECCCCCEEECCCCEEEEHHHHHHHCCCHHHHHHHHHHHHHH
LYSITGLPPHSNYSAFKMRWLLDNYSLHERKDICWLHAPEVLLWRMTGAKKTEISLASRT
HHEECCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCEEEEEECCCCCCCHHHHHHH
LCLDIARRTWSRNAAGILGIPFGVLAPLIKPGEVAGWVTATLREELGFSHEVKVTLAGHD
HHHHHHHHHHCCCCCCEEECCHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCC
HMVGARALQLQPGDVLNSTGTTEGILLLNTQPTLDVQARRDKLANGCYSDGEFFTLFASL
CCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEEEEC
PVGGYALEWVKKTFRLTDKEISTGLEKAMEQYLKPSWSVEHVPVFIPHLRGSGSPNKNRH
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCC
TRGLLFGLTDSLPPESLLESVFIGLAMEFAHCHGCFNIPAGRTVKVIGPAVKNPYWLQLK
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEECCCCCCCEEEEEE
ADILQCPIEAIAFDETVSLGALLIACPNVVPPTVPVAERYFPDAVRSAKLKIYQQQWLSF
HHHHHCCHHHHCCCCHHHHCCCEEECCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHH
YQFKLRQEGALIGE
HHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]